SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P70387

- HFE_MOUSE

UniProt

P70387 - HFE_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Hereditary hemochromatosis protein homolog

Gene
Hfe, Mr2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to transferrin receptor (TFR) and reduces its affinity for iron-loaded transferrin By similarity.

GO - Molecular functioni

  1. antigen binding Source: RefGenome
  2. peptide antigen binding Source: InterPro
  3. receptor binding Source: RefGenome

GO - Biological processi

  1. antigen processing and presentation Source: RefGenome
  2. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  3. cellular response to iron ion starvation Source: Ensembl
  4. female pregnancy Source: Ensembl
  5. hormone biosynthetic process Source: MGI
  6. immune response Source: InterPro
  7. iron ion homeostasis Source: MGI
  8. iron ion import into cell Source: MGI
  9. multicellular organismal iron ion homeostasis Source: MGI
  10. positive regulation of T cell mediated cytotoxicity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Hereditary hemochromatosis protein homolog
Gene namesi
Name:Hfe
Synonyms:Mr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:109191. Hfe.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 318294Extracellular Reviewed predictionAdd
BLAST
Transmembranei319 – 33921Helical; Reviewed predictionAdd
BLAST
Topological domaini340 – 35920Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. apical part of cell Source: Ensembl
  2. basal part of cell Source: Ensembl
  3. cytoplasmic vesicle Source: Ensembl
  4. early endosome Source: Ensembl
  5. integral component of membrane Source: UniProtKB-KW
  6. MHC class I protein complex Source: UniProtKB-KW
  7. perinuclear region of cytoplasm Source: Ensembl
  8. plasma membrane Source: RefGenome
  9. recycling endosome Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 359335Hereditary hemochromatosis protein homologPRO_0000018894Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi114 – 1141N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi136 ↔ 199 By similarity
Glycosylationi142 – 1421N-linked (GlcNAc...) Reviewed prediction
Glycosylationi166 – 1661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi237 ↔ 294 By similarity
Glycosylationi246 – 2461N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP70387.
PRIDEiP70387.

PTM databases

PhosphoSiteiP70387.

Expressioni

Gene expression databases

ArrayExpressiP70387.
BgeeiP70387.
CleanExiMM_HFE.
GenevestigatoriP70387.

Interactioni

Subunit structurei

Binds TFR through the extracellular domain.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000089298.

Structurei

3D structure databases

ProteinModelPortaliP70387.
SMRiP70387. Positions 30-309.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini219 – 30890Ig-like C1-typeAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni25 – 126102Alpha-1Add
BLAST
Regioni127 – 21791Alpha-2Add
BLAST
Regioni218 – 30992Alpha-3Add
BLAST
Regioni310 – 3189Connecting peptide

Sequence similaritiesi

Belongs to the MHC class I family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41118.
GeneTreeiENSGT00750000117285.
HOGENOMiHOG000296917.
HOVERGENiHBG016709.
InParanoidiQ9D754.
OMAiNHSKVTK.
TreeFamiTF336617.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70387-1 [UniParc]FASTAAdd to Basket

« Hide

MSLSAGLPVR PLLLLLLLLW SVAPQALPPR SHSLRYLFMG ASEPDLGLPL    50
FEARGYVDDQ LFVSYNHESR RAEPRAPWIL EQTSSQLWLH LSQSLKGWDY 100
MFIVDFWTIM GNYNHSKVTK LGVVSESHIL QVVLGCEVHE DNSTSGFWRY 150
GYDGQDHLEF CPKTLNWSAA EPGAWATKVE WDEHKIRAKQ NRDYLEKDCP 200
EQLKRLLELG RGVLGQQVPT LVKVTRHWAS TGTSLRCQAL DFFPQNITMR 250
WLKDNQPLDA KDVNPEKVLP NGDETYQGWL TLAVAPGDET RFTCQVEHPG 300
LDQPLTASWE PLQSQAMIIG IISGVTVCAI FLVGILFLIL RKRKASGGTM 350
GGYVLTDCE 359
Length:359
Mass (Da):40,534
Last modified:July 27, 2011 - v2
Checksum:i586657B7F9FF20B4
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti327 – 3271V → I in AAC03447. 1 Publication
Sequence conflicti327 – 3271V → I in AAB07525. 1 Publication
Sequence conflicti327 – 3271V → I in AAI16745. 1 Publication
Sequence conflicti327 – 3271V → I in AAI16747. 1 Publication
Sequence conflicti327 – 3271V → I in CAA73197. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007558 Genomic DNA. Translation: AAC03447.1.
U66849 mRNA. Translation: AAB07525.1.
AK009581 mRNA. Translation: BAB26373.1.
AK150697 mRNA. Translation: BAE29776.1.
AL590388 Genomic DNA. Translation: CAI25849.2.
CH466561 Genomic DNA. Translation: EDL32544.1.
BC116744 mRNA. Translation: AAI16745.1.
BC116746 mRNA. Translation: AAI16747.1.
Y12650 Genomic DNA. Translation: CAA73197.1.
U80604 Genomic DNA. Translation: AAB51504.1.
CCDSiCCDS26360.1.
PIRiJC5382.
RefSeqiNP_034554.2. NM_010424.4.
UniGeneiMm.2681.

Genome annotation databases

EnsembliENSMUST00000091706; ENSMUSP00000089298; ENSMUSG00000006611.
GeneIDi15216.
KEGGimmu:15216.
UCSCiuc007pup.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF007558 Genomic DNA. Translation: AAC03447.1 .
U66849 mRNA. Translation: AAB07525.1 .
AK009581 mRNA. Translation: BAB26373.1 .
AK150697 mRNA. Translation: BAE29776.1 .
AL590388 Genomic DNA. Translation: CAI25849.2 .
CH466561 Genomic DNA. Translation: EDL32544.1 .
BC116744 mRNA. Translation: AAI16745.1 .
BC116746 mRNA. Translation: AAI16747.1 .
Y12650 Genomic DNA. Translation: CAA73197.1 .
U80604 Genomic DNA. Translation: AAB51504.1 .
CCDSi CCDS26360.1.
PIRi JC5382.
RefSeqi NP_034554.2. NM_010424.4.
UniGenei Mm.2681.

3D structure databases

ProteinModelPortali P70387.
SMRi P70387. Positions 30-309.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000089298.

PTM databases

PhosphoSitei P70387.

Proteomic databases

PaxDbi P70387.
PRIDEi P70387.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000091706 ; ENSMUSP00000089298 ; ENSMUSG00000006611 .
GeneIDi 15216.
KEGGi mmu:15216.
UCSCi uc007pup.1. mouse.

Organism-specific databases

CTDi 3077.
MGIi MGI:109191. Hfe.

Phylogenomic databases

eggNOGi NOG41118.
GeneTreei ENSGT00750000117285.
HOGENOMi HOG000296917.
HOVERGENi HBG016709.
InParanoidi Q9D754.
OMAi NHSKVTK.
TreeFami TF336617.

Miscellaneous databases

NextBioi 287795.
PROi P70387.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70387.
Bgeei P70387.
CleanExi MM_HFE.
Genevestigatori P70387.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. Hashimoto K.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Lung.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone marrow and Tongue.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  7. "Identification of a mouse homolog for the human hereditary haemochromatosis candidate gene."
    Hashimoto K., Hirai M., Kurosawa Y.
    Biochem. Biophys. Res. Commun. 230:35-39(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 37-211.
    Strain: BALB/c.
    Tissue: Liver.
  8. Albig W., Drabent B., Doenecke D.
    Submitted (MAY-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-359.
    Strain: 129.

Entry informationi

Entry nameiHFE_MOUSE
AccessioniPrimary (citable) accession number: P70387
Secondary accession number(s): Q14AQ5, Q5SZ90, Q9D754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi