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P70385

- DHB3_MOUSE

UniProt

P70385 - DHB3_MOUSE

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Protein

Testosterone 17-beta-dehydrogenase 3

Gene

Hsd17b3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH (By similarity).By similarity

Catalytic activityi

Testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei181 – 1811SubstrateBy similarity
Active sitei194 – 1941Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi44 – 7330NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. testosterone 17-beta-dehydrogenase (NADP+) activity Source: UniProtKB-EC

GO - Biological processi

  1. testosterone biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

ReactomeiREACT_220332. Androgen biosynthesis.
UniPathwayiUPA00367.

Names & Taxonomyi

Protein namesi
Recommended name:
Testosterone 17-beta-dehydrogenase 3 (EC:1.1.1.64)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 3
Short name:
17-beta-HSD 3
Testicular 17-beta-hydroxysteroid dehydrogenase
Gene namesi
Name:Hsd17b3
Synonyms:Edh17b3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:107177. Hsd17b3.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 305305Testosterone 17-beta-dehydrogenase 3PRO_0000054574Add
BLAST

Proteomic databases

PRIDEiP70385.

PTM databases

PhosphoSiteiP70385.

Expressioni

Gene expression databases

CleanExiMM_HSD17B3.
GenevestigatoriP70385.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044217.

Structurei

3D structure databases

ProteinModelPortaliP70385.
SMRiP70385. Positions 48-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0300.
GeneTreeiENSGT00390000010069.
HOGENOMiHOG000039237.
HOVERGENiHBG005478.
InParanoidiP70385.
KOiK10207.
OMAiXVLTPYA.
OrthoDBiEOG7CZK63.
TreeFamiTF314591.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70385-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKLFIAAGL FVGLVCLVKC MRFSQHLFLR FCKALPSSFL RSMGQWAVIT
60 70 80 90 100
GAGDGIGKAY SFELARHGLN VVLISRTLEK LQTIAEEIER TTGSCVKIVQ
110 120 130 140 150
ADFTREDIYD HIKEHLEGLE IGILVNNVGM LPSFFPSHFL STSGESQNLI
160 170 180 190 200
HCNITSVVKM TQLVLKHMES RRKGLILNIS SGAALRPWPL YSLYSASKAF
210 220 230 240 250
VYTFSKALSV EYRDKGIIIQ VLTPYSISTP MTKYLNNKMT KTADEFVKES
260 270 280 290 300
LKYVTIGAES CGCLAHEIIA IILNRIPSRI FYSSTAQRFL LTRYSDYLKR

NISNR
Length:305
Mass (Da):34,330
Last modified:October 3, 2012 - v2
Checksum:i8EA9966B2777064D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951C → G in AAB06793. (PubMed:9182854)Curated
Sequence conflicti121 – 1211I → N in AAB06793. (PubMed:9182854)Curated
Sequence conflicti142 – 1421T → S in AAB06793. (PubMed:9182854)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66827 mRNA. Translation: AAB06793.1.
CT009717 Genomic DNA. No translation available.
CH466631 Genomic DNA. Translation: EDL16224.1.
CCDSiCCDS26594.1.
RefSeqiNP_032317.2. NM_008291.3.
UniGeneiMm.5109.

Genome annotation databases

EnsembliENSMUST00000039832; ENSMUSP00000044217; ENSMUSG00000033122.
ENSMUST00000166224; ENSMUSP00000132011; ENSMUSG00000033122.
GeneIDi15487.
KEGGimmu:15487.
UCSCiuc007qyf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66827 mRNA. Translation: AAB06793.1 .
CT009717 Genomic DNA. No translation available.
CH466631 Genomic DNA. Translation: EDL16224.1 .
CCDSi CCDS26594.1.
RefSeqi NP_032317.2. NM_008291.3.
UniGenei Mm.5109.

3D structure databases

ProteinModelPortali P70385.
SMRi P70385. Positions 48-257.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000044217.

Chemistry

ChEMBLi CHEMBL1932905.

PTM databases

PhosphoSitei P70385.

Proteomic databases

PRIDEi P70385.

Protocols and materials databases

DNASUi 15487.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039832 ; ENSMUSP00000044217 ; ENSMUSG00000033122 .
ENSMUST00000166224 ; ENSMUSP00000132011 ; ENSMUSG00000033122 .
GeneIDi 15487.
KEGGi mmu:15487.
UCSCi uc007qyf.1. mouse.

Organism-specific databases

CTDi 3293.
MGIi MGI:107177. Hsd17b3.

Phylogenomic databases

eggNOGi COG0300.
GeneTreei ENSGT00390000010069.
HOGENOMi HOG000039237.
HOVERGENi HBG005478.
InParanoidi P70385.
KOi K10207.
OMAi XVLTPYA.
OrthoDBi EOG7CZK63.
TreeFami TF314591.

Enzyme and pathway databases

UniPathwayi UPA00367 .
Reactomei REACT_220332. Androgen biosynthesis.

Miscellaneous databases

NextBioi 288354.
PROi P70385.
SOURCEi Search...

Gene expression databases

CleanExi MM_HSD17B3.
Genevestigatori P70385.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA and tissue distribution of the type 1 and type 3 isoform mRNAs."
    Sha J.A., Dudley K., Rajapaksha W.R.A.K.J.S., O'Shaughnessy P.J.
    J. Steroid Biochem. Mol. Biol. 60:19-24(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 81-90, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiDHB3_MOUSE
AccessioniPrimary (citable) accession number: P70385
Secondary accession number(s): G3UWF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: November 26, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3