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P70385 (DHB3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Testosterone 17-beta-dehydrogenase 3

EC=1.1.1.64
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 3
Short name=17-beta-HSD 3
Testicular 17-beta-hydroxysteroid dehydrogenase
Gene names
Name:Hsd17b3
Synonyms:Edh17b3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Favors the reduction of androstenedione to testosterone. Uses NADPH while the two other EDH17B enzymes use NADH By similarity.

Catalytic activity

Testosterone + NADP+ = androst-4-ene-3,17-dione + NADPH.

Pathway

Hormone biosynthesis; testosterone biosynthesis.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305Testosterone 17-beta-dehydrogenase 3
PRO_0000054574

Regions

Nucleotide binding44 – 7330NADP By similarity

Sites

Active site1941Proton acceptor By similarity
Binding site1811Substrate By similarity

Experimental info

Sequence conflict951C → G in AAB06793. Ref.1
Sequence conflict1211I → N in AAB06793. Ref.1
Sequence conflict1421T → S in AAB06793. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P70385 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 8EA9966B2777064D

FASTA30534,330
        10         20         30         40         50         60 
MEKLFIAAGL FVGLVCLVKC MRFSQHLFLR FCKALPSSFL RSMGQWAVIT GAGDGIGKAY 

        70         80         90        100        110        120 
SFELARHGLN VVLISRTLEK LQTIAEEIER TTGSCVKIVQ ADFTREDIYD HIKEHLEGLE 

       130        140        150        160        170        180 
IGILVNNVGM LPSFFPSHFL STSGESQNLI HCNITSVVKM TQLVLKHMES RRKGLILNIS 

       190        200        210        220        230        240 
SGAALRPWPL YSLYSASKAF VYTFSKALSV EYRDKGIIIQ VLTPYSISTP MTKYLNNKMT 

       250        260        270        280        290        300 
KTADEFVKES LKYVTIGAES CGCLAHEIIA IILNRIPSRI FYSSTAQRFL LTRYSDYLKR 


NISNR 

« Hide

References

« Hide 'large scale' references
[1]"Sequence of mouse 17beta-hydroxysteroid dehydrogenase type 3 cDNA and tissue distribution of the type 1 and type 3 isoform mRNAs."
Sha J.A., Dudley K., Rajapaksha W.R.A.K.J.S., O'Shaughnessy P.J.
J. Steroid Biochem. Mol. Biol. 60:19-24(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 81-90, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U66827 mRNA. Translation: AAB06793.1.
CT009717 Genomic DNA. No translation available.
CH466631 Genomic DNA. Translation: EDL16224.1.
CCDSCCDS26594.1.
RefSeqNP_032317.2. NM_008291.3.
UniGeneMm.5109.

3D structure databases

ProteinModelPortalP70385.
SMRP70385. Positions 47-290.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000044217.

Chemistry

BindingDBP70385.
ChEMBLCHEMBL1932905.

PTM databases

PhosphoSiteP70385.

Proteomic databases

PRIDEP70385.

Protocols and materials databases

DNASU15487.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039832; ENSMUSP00000044217; ENSMUSG00000033122.
ENSMUST00000166224; ENSMUSP00000132011; ENSMUSG00000033122.
GeneID15487.
KEGGmmu:15487.
UCSCuc007qyf.1. mouse.

Organism-specific databases

CTD3293.
MGIMGI:107177. Hsd17b3.

Phylogenomic databases

eggNOGCOG0300.
GeneTreeENSGT00390000010069.
HOGENOMHOG000039237.
HOVERGENHBG005478.
InParanoidP70385.
KOK10207.
OMAXVLTPYA.
OrthoDBEOG7CZK63.
TreeFamTF314591.

Enzyme and pathway databases

UniPathwayUPA00367.

Gene expression databases

CleanExMM_HSD17B3.
GenevestigatorP70385.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288354.
PROP70385.
SOURCESearch...

Entry information

Entry nameDHB3_MOUSE
AccessionPrimary (citable) accession number: P70385
Secondary accession number(s): G3UWF9
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot