Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P70380

- IL18_MOUSE

UniProt

P70380 - IL18_MOUSE

Protein

Interleukin-18

Gene

Il18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. cellular response to organic cyclic compound Source: Ensembl
    3. extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
    4. immune response Source: MGI
    5. inflammatory response Source: MGI
    6. interferon-gamma biosynthetic process Source: UniProtKB
    7. interleukin-13 biosynthetic process Source: UniProtKB
    8. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    9. MAPK cascade Source: Ensembl
    10. natural killer cell activation Source: MGI
    11. positive regulation of activated T cell proliferation Source: UniProtKB
    12. positive regulation of gene expression Source: MGI
    13. positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
    14. positive regulation of interferon-gamma production Source: MGI
    15. positive regulation of interleukin-17 production Source: Ensembl
    16. positive regulation of natural killer cell proliferation Source: Ensembl
    17. positive regulation of NF-kappaB import into nucleus Source: MGI
    18. positive regulation of NK T cell proliferation Source: Ensembl
    19. regulation of cell adhesion Source: UniProtKB
    20. sleep Source: UniProtKB
    21. T-helper 1 type immune response Source: UniProtKB

    Keywords - Molecular functioni

    Cytokine

    Enzyme and pathway databases

    ReactomeiREACT_198700. Interleukin-1 processing.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Interleukin-18
    Short name:
    IL-18
    Alternative name(s):
    Interferon gamma-inducing factor
    Short name:
    IFN-gamma-inducing factor
    Interleukin-1 gamma
    Short name:
    IL-1 gamma
    Gene namesi
    Name:Il18
    Synonyms:Igif
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 9

    Organism-specific databases

    MGIiMGI:107936. Il18.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Propeptidei1 – 3535PRO_0000015345Add
    BLAST
    Chaini36 – 192157Interleukin-18PRO_0000015346Add
    BLAST

    Post-translational modificationi

    The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.By similarity

    Proteomic databases

    MaxQBiP70380.
    PaxDbiP70380.
    PRIDEiP70380.

    PTM databases

    PhosphoSiteiP70380.

    Expressioni

    Gene expression databases

    BgeeiP70380.
    CleanExiMM_IL18.
    GenevestigatoriP70380.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-950N.

    Structurei

    3D structure databases

    ProteinModelPortaliP70380.
    SMRiP70380. Positions 37-188.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the IL-1 family.Curated

    Phylogenomic databases

    eggNOGiNOG77229.
    HOGENOMiHOG000048723.
    HOVERGENiHBG000388.
    InParanoidiP70380.
    KOiK05482.
    PhylomeDBiP70380.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR015529. IL-18.
    IPR000975. IL-1_fam.
    [Graphical view]
    PANTHERiPTHR11326. PTHR11326. 1 hit.
    PfamiPF00340. IL1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015162. Interleukin_18. 1 hit.
    PRINTSiPR01933. INTRLEUKIN18.
    SUPFAMiSSF50353. SSF50353. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70380-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAMSEDSCV NFKEMMFIDN TLYFIPEENG DLESDNFGRL HCTTAVIRNI    50
    NDQVLFVDKR QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV 100
    KDSKMSTLSC KNKIISFEEM DPPENIDDIQ SDLIFFQKRV PGHNKMEFES 150
    SLYEGHFLAC QKEDDAFKLI LKKKDENGDK SVMFTLTNLH QS 192
    Length:192
    Mass (Da):22,135
    Last modified:July 15, 1998 - v2
    Checksum:i8FED938473874D63
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti183 – 1853MFT → IS in AAB49753. (PubMed:9022080)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49949 mRNA. Translation: BAA08705.1.
    BC024384 mRNA. Translation: AAH24384.1.
    U66244 mRNA. Translation: AAB49753.1.
    CCDSiCCDS40622.1.
    PIRiS60226.
    RefSeqiNP_032386.1. NM_008360.1.
    XP_006510089.1. XM_006510026.1.
    XP_006510090.1. XM_006510027.1.
    XP_006510091.1. XM_006510028.1.
    UniGeneiMm.1410.

    Genome annotation databases

    EnsembliENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217.
    GeneIDi16173.
    KEGGimmu:16173.
    UCSCiuc009pju.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D49949 mRNA. Translation: BAA08705.1 .
    BC024384 mRNA. Translation: AAH24384.1 .
    U66244 mRNA. Translation: AAB49753.1 .
    CCDSi CCDS40622.1.
    PIRi S60226.
    RefSeqi NP_032386.1. NM_008360.1.
    XP_006510089.1. XM_006510026.1.
    XP_006510090.1. XM_006510027.1.
    XP_006510091.1. XM_006510028.1.
    UniGenei Mm.1410.

    3D structure databases

    ProteinModelPortali P70380.
    SMRi P70380. Positions 37-188.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-950N.

    PTM databases

    PhosphoSitei P70380.

    Proteomic databases

    MaxQBi P70380.
    PaxDbi P70380.
    PRIDEi P70380.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000180021 ; ENSMUSP00000137193 ; ENSMUSG00000039217 .
    GeneIDi 16173.
    KEGGi mmu:16173.
    UCSCi uc009pju.1. mouse.

    Organism-specific databases

    CTDi 3606.
    MGIi MGI:107936. Il18.

    Phylogenomic databases

    eggNOGi NOG77229.
    HOGENOMi HOG000048723.
    HOVERGENi HBG000388.
    InParanoidi P70380.
    KOi K05482.
    PhylomeDBi P70380.

    Enzyme and pathway databases

    Reactomei REACT_198700. Interleukin-1 processing.

    Miscellaneous databases

    NextBioi 289025.
    PROi P70380.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70380.
    CleanExi MM_IL18.
    Genevestigatori P70380.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR015529. IL-18.
    IPR000975. IL-1_fam.
    [Graphical view ]
    PANTHERi PTHR11326. PTHR11326. 1 hit.
    Pfami PF00340. IL1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015162. Interleukin_18. 1 hit.
    PRINTSi PR01933. INTRLEUKIN18.
    SUPFAMi SSF50353. SSF50353. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.
    3. "Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2."
      Rothe H., Jenkins N.A., Copeland N.G., Kolb H.
      J. Clin. Invest. 99:469-474(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-191.
      Strain: NOD.
      Tissue: Pancreas.

    Entry informationi

    Entry nameiIL18_MOUSE
    AccessioniPrimary (citable) accession number: P70380
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 114 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3