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P70380

- IL18_MOUSE

UniProt

P70380 - IL18_MOUSE

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Protein

Interleukin-18

Gene

Il18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
  3. immune response Source: MGI
  4. inflammatory response Source: MGI
  5. interferon-gamma biosynthetic process Source: UniProtKB
  6. interleukin-13 biosynthetic process Source: UniProtKB
  7. natural killer cell activation Source: MGI
  8. positive regulation of activated T cell proliferation Source: UniProtKB
  9. positive regulation of gene expression Source: MGI
  10. positive regulation of interferon-gamma production Source: MGI
  11. positive regulation of NF-kappaB import into nucleus Source: MGI
  12. regulation of cell adhesion Source: UniProtKB
  13. sleep Source: UniProtKB
  14. T-helper 1 type immune response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiREACT_198700. Interleukin-1 processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:Il18
Synonyms:Igif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:107936. Il18.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 3535PRO_0000015345Add
BLAST
Chaini36 – 192157Interleukin-18PRO_0000015346Add
BLAST

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.By similarity

Proteomic databases

MaxQBiP70380.
PaxDbiP70380.
PRIDEiP70380.

PTM databases

PhosphoSiteiP70380.

Expressioni

Gene expression databases

BgeeiP70380.
CleanExiMM_IL18.
ExpressionAtlasiP70380. baseline and differential.
GenevestigatoriP70380.

Interactioni

Protein-protein interaction databases

DIPiDIP-950N.

Structurei

3D structure databases

ProteinModelPortaliP70380.
SMRiP70380. Positions 37-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiNOG77229.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiP70380.
KOiK05482.
PhylomeDBiP70380.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70380-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAMSEDSCV NFKEMMFIDN TLYFIPEENG DLESDNFGRL HCTTAVIRNI
60 70 80 90 100
NDQVLFVDKR QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV
110 120 130 140 150
KDSKMSTLSC KNKIISFEEM DPPENIDDIQ SDLIFFQKRV PGHNKMEFES
160 170 180 190
SLYEGHFLAC QKEDDAFKLI LKKKDENGDK SVMFTLTNLH QS
Length:192
Mass (Da):22,135
Last modified:July 15, 1998 - v2
Checksum:i8FED938473874D63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1853MFT → IS in AAB49753. (PubMed:9022080)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49949 mRNA. Translation: BAA08705.1.
BC024384 mRNA. Translation: AAH24384.1.
U66244 mRNA. Translation: AAB49753.1.
CCDSiCCDS40622.1.
PIRiS60226.
RefSeqiNP_032386.1. NM_008360.1.
XP_006510089.1. XM_006510026.1.
XP_006510090.1. XM_006510027.1.
XP_006510091.1. XM_006510028.1.
UniGeneiMm.1410.

Genome annotation databases

EnsembliENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217.
GeneIDi16173.
KEGGimmu:16173.
UCSCiuc009pju.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49949 mRNA. Translation: BAA08705.1 .
BC024384 mRNA. Translation: AAH24384.1 .
U66244 mRNA. Translation: AAB49753.1 .
CCDSi CCDS40622.1.
PIRi S60226.
RefSeqi NP_032386.1. NM_008360.1.
XP_006510089.1. XM_006510026.1.
XP_006510090.1. XM_006510027.1.
XP_006510091.1. XM_006510028.1.
UniGenei Mm.1410.

3D structure databases

ProteinModelPortali P70380.
SMRi P70380. Positions 37-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-950N.

PTM databases

PhosphoSitei P70380.

Proteomic databases

MaxQBi P70380.
PaxDbi P70380.
PRIDEi P70380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000180021 ; ENSMUSP00000137193 ; ENSMUSG00000039217 .
GeneIDi 16173.
KEGGi mmu:16173.
UCSCi uc009pju.1. mouse.

Organism-specific databases

CTDi 3606.
MGIi MGI:107936. Il18.

Phylogenomic databases

eggNOGi NOG77229.
HOGENOMi HOG000048723.
HOVERGENi HBG000388.
InParanoidi P70380.
KOi K05482.
PhylomeDBi P70380.

Enzyme and pathway databases

Reactomei REACT_198700. Interleukin-1 processing.

Miscellaneous databases

NextBioi 289025.
PROi P70380.
SOURCEi Search...

Gene expression databases

Bgeei P70380.
CleanExi MM_IL18.
ExpressionAtlasi P70380. baseline and differential.
Genevestigatori P70380.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view ]
PANTHERi PTHR11326. PTHR11326. 1 hit.
Pfami PF00340. IL1. 1 hit.
[Graphical view ]
PIRSFi PIRSF015162. Interleukin_18. 1 hit.
PRINTSi PR01933. INTRLEUKIN18.
SUPFAMi SSF50353. SSF50353. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2."
    Rothe H., Jenkins N.A., Copeland N.G., Kolb H.
    J. Clin. Invest. 99:469-474(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-191.
    Strain: NOD.
    Tissue: Pancreas.

Entry informationi

Entry nameiIL18_MOUSE
AccessioniPrimary (citable) accession number: P70380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: October 29, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3