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P70380 (IL18_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-18

Short name=IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name=IFN-gamma-inducing factor
Interleukin-1 gamma
Short name=IL-1 gamma
Gene names
Name:Il18
Synonyms:Igif
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length192 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

Subcellular location

Secreted.

Post-translational modification

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form By similarity.

Sequence similarities

Belongs to the IL-1 family.

Ontologies

Keywords
   Cellular componentSecreted
   Molecular functionCytokine
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: Ensembl

T-helper 1 type immune response

Inferred from sequence or structural similarity PubMed 8766574. Source: UniProtKB

angiogenesis

Inferred from sequence or structural similarity PubMed 11466388. Source: UniProtKB

cellular response to organic cyclic compound

Inferred from electronic annotation. Source: Ensembl

extrinsic apoptotic signaling pathway via death domain receptors

Traceable author statement PubMed 11714750. Source: UniProtKB

immune response

Traceable author statement PubMed 12048345. Source: MGI

inflammatory response

Inferred from genetic interaction PubMed 23132931. Source: MGI

interferon-gamma biosynthetic process

Inferred from mutant phenotype PubMed 11907086. Source: UniProtKB

interleukin-13 biosynthetic process

Traceable author statement PubMed 11716531. Source: UniProtKB

lipopolysaccharide-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

natural killer cell activation

Inferred from direct assay PubMed 10227969. Source: MGI

positive regulation of NF-kappaB import into nucleus

Inferred from direct assay PubMed 10227969. Source: MGI

positive regulation of NK T cell proliferation

Inferred from electronic annotation. Source: Ensembl

positive regulation of activated T cell proliferation

Inferred from sequence or structural similarity PubMed 8766574. Source: UniProtKB

positive regulation of gene expression

Inferred from direct assay PubMed 19666510. Source: MGI

positive regulation of granulocyte macrophage colony-stimulating factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of interferon-gamma production

Inferred from direct assay PubMed 10227969PubMed 11894097PubMed 11894098. Source: MGI

positive regulation of interleukin-17 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of natural killer cell proliferation

Inferred from electronic annotation. Source: Ensembl

regulation of cell adhesion

Inferred from sequence or structural similarity PubMed 11477102. Source: UniProtKB

sleep

Inferred from sequence or structural similarity PubMed 11506998. Source: UniProtKB

   Cellular_componentextracellular space

Inferred from direct assay PubMed 15220916PubMed 16949315. Source: MGI

   Molecular_functioncytokine activity

Inferred from direct assay PubMed 11894098. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – 3535
PRO_0000015345
Chain36 – 192157Interleukin-18
PRO_0000015346

Experimental info

Sequence conflict183 – 1853MFT → IS in AAB49753. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P70380 [UniParc].

Last modified July 15, 1998. Version 2.
Checksum: 8FED938473874D63

FASTA19222,135
        10         20         30         40         50         60 
MAAMSEDSCV NFKEMMFIDN TLYFIPEENG DLESDNFGRL HCTTAVIRNI NDQVLFVDKR 

        70         80         90        100        110        120 
QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV KDSKMSTLSC KNKIISFEEM 

       130        140        150        160        170        180 
DPPENIDDIQ SDLIFFQKRV PGHNKMEFES SLYEGHFLAC QKEDDAFKLI LKKKDENGDK 

       190 
SVMFTLTNLH QS 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a new cytokine that induces IFN-gamma production by T cells."
Okamura H., Tsutui H., Komatsu T., Yutsudo M., Hakura A., Tanimoto T., Torigoe K., Okura T., Nukada Y., Hattori K., Akita K., Namba M., Tanabe F., Konishi K., Fukuda S., Kurimoto M.
Nature 378:88-91(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Liver.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
[3]"Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2."
Rothe H., Jenkins N.A., Copeland N.G., Kolb H.
J. Clin. Invest. 99:469-474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-191.
Strain: NOD.
Tissue: Pancreas.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D49949 mRNA. Translation: BAA08705.1.
BC024384 mRNA. Translation: AAH24384.1.
U66244 mRNA. Translation: AAB49753.1.
PIRS60226.
RefSeqNP_032386.1. NM_008360.1.
XP_006510089.1. XM_006510026.1.
XP_006510090.1. XM_006510027.1.
XP_006510091.1. XM_006510028.1.
UniGeneMm.1410.

3D structure databases

ProteinModelPortalP70380.
SMRP70380. Positions 37-188.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-950N.

PTM databases

PhosphoSiteP70380.

Proteomic databases

PaxDbP70380.
PRIDEP70380.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217.
GeneID16173.
KEGGmmu:16173.
UCSCuc009pju.1. mouse.

Organism-specific databases

CTD3606.
MGIMGI:107936. Il18.

Phylogenomic databases

eggNOGNOG77229.
HOGENOMHOG000048723.
HOVERGENHBG000388.
InParanoidP70380.
KOK05482.
PhylomeDBP70380.

Gene expression databases

BgeeP70380.
CleanExMM_IL18.
GenevestigatorP70380.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR000975. IL-1.
IPR015529. IL-18.
[Graphical view]
PANTHERPTHR11326. PTHR11326. 1 hit.
PfamPF00340. IL1. 1 hit.
[Graphical view]
PIRSFPIRSF015162. Interleukin_18. 1 hit.
PRINTSPR01933. INTRLEUKIN18.
SMARTSM00125. IL1. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
ProtoNetSearch...

Other

NextBio289025.
PROP70380.
SOURCESearch...

Entry information

Entry nameIL18_MOUSE
AccessionPrimary (citable) accession number: P70380
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: April 16, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot