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Protein

Interleukin-18

Gene

Il18

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

GO - Molecular functioni

  • cytokine activity Source: MGI

GO - Biological processi

  • angiogenesis Source: UniProtKB
  • cellular response to organic cyclic compound Source: MGI
  • extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
  • immune response Source: MGI
  • inflammatory response Source: MGI
  • interferon-gamma biosynthetic process Source: UniProtKB
  • interleukin-13 biosynthetic process Source: UniProtKB
  • lipopolysaccharide-mediated signaling pathway Source: MGI
  • MAPK cascade Source: MGI
  • natural killer cell activation Source: MGI
  • negative regulation of myoblast differentiation Source: MGI
  • positive regulation of activated T cell proliferation Source: UniProtKB
  • positive regulation of gene expression Source: MGI
  • positive regulation of granulocyte macrophage colony-stimulating factor production Source: MGI
  • positive regulation of interferon-gamma production Source: MGI
  • positive regulation of interleukin-17 production Source: MGI
  • positive regulation of natural killer cell proliferation Source: MGI
  • positive regulation of NF-kappaB import into nucleus Source: MGI
  • positive regulation of NK T cell proliferation Source: MGI
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: MGI
  • regulation of cell adhesion Source: UniProtKB
  • sleep Source: UniProtKB
  • T-helper 1 type immune response Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiR-MMU-448706. Interleukin-1 processing.
R-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:Il18
Synonyms:Igif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107936. Il18.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular space Source: MGI
  • intracellular Source: GOC
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 3535PRO_0000015345Add
BLAST
Chaini36 – 192157Interleukin-18PRO_0000015346Add
BLAST

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form.By similarity

Proteomic databases

PaxDbiP70380.
PRIDEiP70380.

PTM databases

PhosphoSiteiP70380.

Expressioni

Gene expression databases

BgeeiP70380.
CleanExiMM_IL18.
ExpressionAtlasiP70380. baseline and differential.
GenevisibleiP70380. MM.

Interactioni

GO - Molecular functioni

  • cytokine activity Source: MGI

Protein-protein interaction databases

DIPiDIP-950N.
STRINGi10090.ENSMUSP00000137193.

Structurei

3D structure databases

ProteinModelPortaliP70380.
SMRiP70380. Positions 37-188.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiP70380.
KOiK05482.
PhylomeDBiP70380.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70380-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMSEDSCV NFKEMMFIDN TLYFIPEENG DLESDNFGRL HCTTAVIRNI
60 70 80 90 100
NDQVLFVDKR QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV
110 120 130 140 150
KDSKMSTLSC KNKIISFEEM DPPENIDDIQ SDLIFFQKRV PGHNKMEFES
160 170 180 190
SLYEGHFLAC QKEDDAFKLI LKKKDENGDK SVMFTLTNLH QS
Length:192
Mass (Da):22,135
Last modified:July 15, 1998 - v2
Checksum:i8FED938473874D63
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1853MFT → IS in AAB49753 (PubMed:9022080).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49949 mRNA. Translation: BAA08705.1.
BC024384 mRNA. Translation: AAH24384.1.
U66244 mRNA. Translation: AAB49753.1.
CCDSiCCDS40622.1.
PIRiS60226.
RefSeqiNP_032386.1. NM_008360.1.
XP_006510089.1. XM_006510026.1.
XP_006510090.1. XM_006510027.2.
XP_006510091.1. XM_006510028.2.
UniGeneiMm.1410.

Genome annotation databases

EnsembliENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217.
GeneIDi16173.
KEGGimmu:16173.
UCSCiuc009pju.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49949 mRNA. Translation: BAA08705.1.
BC024384 mRNA. Translation: AAH24384.1.
U66244 mRNA. Translation: AAB49753.1.
CCDSiCCDS40622.1.
PIRiS60226.
RefSeqiNP_032386.1. NM_008360.1.
XP_006510089.1. XM_006510026.1.
XP_006510090.1. XM_006510027.2.
XP_006510091.1. XM_006510028.2.
UniGeneiMm.1410.

3D structure databases

ProteinModelPortaliP70380.
SMRiP70380. Positions 37-188.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-950N.
STRINGi10090.ENSMUSP00000137193.

PTM databases

PhosphoSiteiP70380.

Proteomic databases

PaxDbiP70380.
PRIDEiP70380.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217.
GeneIDi16173.
KEGGimmu:16173.
UCSCiuc009pju.1. mouse.

Organism-specific databases

CTDi3606.
MGIiMGI:107936. Il18.

Phylogenomic databases

eggNOGiENOG410J3U9. Eukaryota.
ENOG410ZGS8. LUCA.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiP70380.
KOiK05482.
PhylomeDBiP70380.

Enzyme and pathway databases

ReactomeiR-MMU-448706. Interleukin-1 processing.
R-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiP70380.
SOURCEiSearch...

Gene expression databases

BgeeiP70380.
CleanExiMM_IL18.
ExpressionAtlasiP70380. baseline and differential.
GenevisibleiP70380. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2."
    Rothe H., Jenkins N.A., Copeland N.G., Kolb H.
    J. Clin. Invest. 99:469-474(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-191.
    Strain: NOD.
    Tissue: Pancreas.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Spleen.

Entry informationi

Entry nameiIL18_MOUSE
AccessioniPrimary (citable) accession number: P70380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: June 8, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.