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P70380

- IL18_MOUSE

UniProt

P70380 - IL18_MOUSE

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Protein
Interleukin-18
Gene
Il18, Igif
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.

GO - Molecular functioni

  1. cytokine activity Source: MGI

GO - Biological processi

  1. MAPK cascade Source: Ensembl
  2. T-helper 1 type immune response Source: UniProtKB
  3. angiogenesis Source: UniProtKB
  4. cellular response to organic cyclic compound Source: Ensembl
  5. extrinsic apoptotic signaling pathway via death domain receptors Source: UniProtKB
  6. immune response Source: MGI
  7. inflammatory response Source: MGI
  8. interferon-gamma biosynthetic process Source: UniProtKB
  9. interleukin-13 biosynthetic process Source: UniProtKB
  10. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  11. natural killer cell activation Source: MGI
  12. positive regulation of NF-kappaB import into nucleus Source: MGI
  13. positive regulation of NK T cell proliferation Source: Ensembl
  14. positive regulation of activated T cell proliferation Source: UniProtKB
  15. positive regulation of gene expression Source: MGI
  16. positive regulation of granulocyte macrophage colony-stimulating factor production Source: Ensembl
  17. positive regulation of interferon-gamma production Source: MGI
  18. positive regulation of interleukin-17 production Source: Ensembl
  19. positive regulation of natural killer cell proliferation Source: Ensembl
  20. regulation of cell adhesion Source: UniProtKB
  21. sleep Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Enzyme and pathway databases

ReactomeiREACT_198700. Interleukin-1 processing.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-18
Short name:
IL-18
Alternative name(s):
Interferon gamma-inducing factor
Short name:
IFN-gamma-inducing factor
Interleukin-1 gamma
Short name:
IL-1 gamma
Gene namesi
Name:Il18
Synonyms:Igif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 9

Organism-specific databases

MGIiMGI:107936. Il18.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Propeptidei1 – 3535
PRO_0000015345Add
BLAST
Chaini36 – 192157Interleukin-18
PRO_0000015346Add
BLAST

Post-translational modificationi

The pro-IL-18 precursor is processed by CASP1 or CASP4 to yield the active form By similarity.

Proteomic databases

MaxQBiP70380.
PaxDbiP70380.
PRIDEiP70380.

PTM databases

PhosphoSiteiP70380.

Expressioni

Gene expression databases

BgeeiP70380.
CleanExiMM_IL18.
GenevestigatoriP70380.

Interactioni

Protein-protein interaction databases

DIPiDIP-950N.

Structurei

3D structure databases

ProteinModelPortaliP70380.
SMRiP70380. Positions 37-188.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.

Phylogenomic databases

eggNOGiNOG77229.
HOGENOMiHOG000048723.
HOVERGENiHBG000388.
InParanoidiP70380.
KOiK05482.
PhylomeDBiP70380.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view]
PANTHERiPTHR11326. PTHR11326. 1 hit.
PfamiPF00340. IL1. 1 hit.
[Graphical view]
PIRSFiPIRSF015162. Interleukin_18. 1 hit.
PRINTSiPR01933. INTRLEUKIN18.
SUPFAMiSSF50353. SSF50353. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70380-1 [UniParc]FASTAAdd to Basket

« Hide

MAAMSEDSCV NFKEMMFIDN TLYFIPEENG DLESDNFGRL HCTTAVIRNI    50
NDQVLFVDKR QPVFEDMTDI DQSASEPQTR LIIYMYKDSE VRGLAVTLSV 100
KDSKMSTLSC KNKIISFEEM DPPENIDDIQ SDLIFFQKRV PGHNKMEFES 150
SLYEGHFLAC QKEDDAFKLI LKKKDENGDK SVMFTLTNLH QS 192
Length:192
Mass (Da):22,135
Last modified:July 15, 1998 - v2
Checksum:i8FED938473874D63
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti183 – 1853MFT → IS in AAB49753. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49949 mRNA. Translation: BAA08705.1.
BC024384 mRNA. Translation: AAH24384.1.
U66244 mRNA. Translation: AAB49753.1.
CCDSiCCDS40622.1.
PIRiS60226.
RefSeqiNP_032386.1. NM_008360.1.
XP_006510089.1. XM_006510026.1.
XP_006510090.1. XM_006510027.1.
XP_006510091.1. XM_006510028.1.
UniGeneiMm.1410.

Genome annotation databases

EnsembliENSMUST00000180021; ENSMUSP00000137193; ENSMUSG00000039217.
GeneIDi16173.
KEGGimmu:16173.
UCSCiuc009pju.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D49949 mRNA. Translation: BAA08705.1 .
BC024384 mRNA. Translation: AAH24384.1 .
U66244 mRNA. Translation: AAB49753.1 .
CCDSi CCDS40622.1.
PIRi S60226.
RefSeqi NP_032386.1. NM_008360.1.
XP_006510089.1. XM_006510026.1.
XP_006510090.1. XM_006510027.1.
XP_006510091.1. XM_006510028.1.
UniGenei Mm.1410.

3D structure databases

ProteinModelPortali P70380.
SMRi P70380. Positions 37-188.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-950N.

PTM databases

PhosphoSitei P70380.

Proteomic databases

MaxQBi P70380.
PaxDbi P70380.
PRIDEi P70380.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000180021 ; ENSMUSP00000137193 ; ENSMUSG00000039217 .
GeneIDi 16173.
KEGGi mmu:16173.
UCSCi uc009pju.1. mouse.

Organism-specific databases

CTDi 3606.
MGIi MGI:107936. Il18.

Phylogenomic databases

eggNOGi NOG77229.
HOGENOMi HOG000048723.
HOVERGENi HBG000388.
InParanoidi P70380.
KOi K05482.
PhylomeDBi P70380.

Enzyme and pathway databases

Reactomei REACT_198700. Interleukin-1 processing.

Miscellaneous databases

NextBioi 289025.
PROi P70380.
SOURCEi Search...

Gene expression databases

Bgeei P70380.
CleanExi MM_IL18.
Genevestigatori P70380.

Family and domain databases

InterProi IPR008996. Cytokine_IL1-like.
IPR015529. IL-18.
IPR000975. IL-1_fam.
[Graphical view ]
PANTHERi PTHR11326. PTHR11326. 1 hit.
Pfami PF00340. IL1. 1 hit.
[Graphical view ]
PIRSFi PIRSF015162. Interleukin_18. 1 hit.
PRINTSi PR01933. INTRLEUKIN18.
SUPFAMi SSF50353. SSF50353. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.
  3. "Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2."
    Rothe H., Jenkins N.A., Copeland N.G., Kolb H.
    J. Clin. Invest. 99:469-474(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-191.
    Strain: NOD.
    Tissue: Pancreas.

Entry informationi

Entry nameiIL18_MOUSE
AccessioniPrimary (citable) accession number: P70380
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 3, 2014
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi