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Protein

Fibroblast growth factor 14

Gene

Fgf14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • chemical synaptic transmission Source: MGI
  • JNK cascade Source: MGI
  • nervous system development Source: InterPro
  • neuromuscular process Source: MGI
  • positive regulation of high voltage-gated calcium channel activity Source: MGI
  • positive regulation of sodium ion transport Source: MGI
  • regulation of postsynaptic membrane potential Source: MGI
  • regulation of synaptic plasticity Source: MGI
  • regulation of synaptic vesicle recycling Source: MGI

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 14
Short name:
FGF-14
Alternative name(s):
Fibroblast growth factor homologous factor 4
Short name:
FHF-4
Gene namesi
Name:Fgf14
Synonyms:Fhf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109189. Fgf14.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476111 – 247Fibroblast growth factor 14Add BLAST247

Proteomic databases

PaxDbiP70379.
PRIDEiP70379.

PTM databases

iPTMnetiP70379.
PhosphoSitePlusiP70379.

Expressioni

Tissue specificityi

Brain and testis; widely distributed in the developing nervous system. In adult, high levels in the granular layer of the cerebellum, less in hippocampus and olfactory bulb.

Gene expression databases

CleanExiMM_FGF14.

Interactioni

Subunit structurei

Interacts with SCN8A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP70379. 2 interactors.
STRINGi10090.ENSMUSP00000093185.

Structurei

3D structure databases

ProteinModelPortaliP70379.
SMRiP70379.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiP70379.
KOiK04358.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiView protein in InterPro
IPR028284. FGF14.
IPR002209. Fibroblast_GF_fam.
IPR008996. IL1/FGF.
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF18. PTHR11486:SF18. 1 hit.
PfamiView protein in Pfam
PF00167. FGF. 1 hit.
PRINTSiPR00263. HBGFFGF.
SMARTiView protein in SMART
SM00442. FGF. 1 hit.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00247. HBGF_FGF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLF NGNLVDIFSK
60 70 80 90 100
VRIFGLKKRR LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN
110 120 130 140 150
STLFNLIPVG LRVVAIQGVK TGLYIAMNGE GYLYPSELFT PECKFKESVF
160 170 180 190 200
ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ VMKGNRVKKT KPAAHFLPKP
210 220 230 240
LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP VNKCKTT
Length:247
Mass (Da):27,764
Last modified:February 1, 1997 - v1
Checksum:i372C6FC0BDC72FDA
GO
Isoform 2 (identifier: P70379-2) [UniParc]FASTAAdd to basket
Also known as: FGF-14C

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:163
Mass (Da):17,911
Checksum:iD62199DE5A55833B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40F → C in BAC27049 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0015301 – 84Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66204 mRNA. Translation: AAB18920.1.
AB029498 mRNA. Translation: BAA89483.1.
AK030616 mRNA. Translation: BAC27049.1.
BC107003 mRNA. Translation: AAI07004.1.
RefSeqiNP_034331.2. NM_010201.4.
XP_011243254.1. XM_011244952.2. [P70379-2]
UniGeneiMm.206362.

Genome annotation databases

GeneIDi14169.
KEGGimmu:14169.
UCSCiuc007vbv.2. mouse. [P70379-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFGF14_MOUSE
AccessioniPrimary (citable) accession number: P70379
Secondary accession number(s): Q3KNZ6, Q8BST0, Q9JHL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 25, 2017
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families