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Protein

Fibroblast growth factor 14

Gene

Fgf14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • chemical synaptic transmission Source: MGI
  • JNK cascade Source: MGI
  • nervous system development Source: InterPro
  • neuromuscular process Source: MGI
  • positive regulation of high voltage-gated calcium channel activity Source: MGI
  • positive regulation of sodium ion transport Source: MGI
  • regulation of postsynaptic membrane potential Source: MGI
  • regulation of synaptic plasticity Source: MGI
  • regulation of synaptic vesicle recycling Source: MGI

Keywordsi

Molecular functionGrowth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 14
Short name:
FGF-14
Alternative name(s):
Fibroblast growth factor homologous factor 4
Short name:
FHF-4
Gene namesi
Name:Fgf14
Synonyms:Fhf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109189 Fgf14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476111 – 247Fibroblast growth factor 14Add BLAST247

Proteomic databases

PaxDbiP70379
PRIDEiP70379

PTM databases

iPTMnetiP70379
PhosphoSitePlusiP70379

Expressioni

Tissue specificityi

Brain and testis; widely distributed in the developing nervous system. In adult, high levels in the granular layer of the cerebellum, less in hippocampus and olfactory bulb.

Gene expression databases

CleanExiMM_FGF14

Interactioni

Subunit structurei

Interacts with SCN8A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP70379, 2 interactors
STRINGi10090.ENSMUSP00000093185

Structurei

3D structure databases

ProteinModelPortaliP70379
SMRiP70379
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
HOGENOMiHOG000290676
HOVERGENiHBG007580
InParanoidiP70379
KOiK22413

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028284 FGF14
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF18 PTHR11486:SF18, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLF NGNLVDIFSK
60 70 80 90 100
VRIFGLKKRR LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN
110 120 130 140 150
STLFNLIPVG LRVVAIQGVK TGLYIAMNGE GYLYPSELFT PECKFKESVF
160 170 180 190 200
ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ VMKGNRVKKT KPAAHFLPKP
210 220 230 240
LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP VNKCKTT
Length:247
Mass (Da):27,764
Last modified:February 1, 1997 - v1
Checksum:i372C6FC0BDC72FDA
GO
Isoform 2 (identifier: P70379-2) [UniParc]FASTAAdd to basket
Also known as: FGF-14C

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:163
Mass (Da):17,911
Checksum:iD62199DE5A55833B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40F → C in BAC27049 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0015301 – 84Missing in isoform 2. 1 PublicationAdd BLAST84

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66204 mRNA Translation: AAB18920.1
AB029498 mRNA Translation: BAA89483.1
AK030616 mRNA Translation: BAC27049.1
BC107003 mRNA Translation: AAI07004.1
RefSeqiNP_034331.2, NM_010201.4
XP_011243254.1, XM_011244952.2 [P70379-2]
UniGeneiMm.206362

Genome annotation databases

GeneIDi14169
KEGGimmu:14169
UCSCiuc007vbv.2 mouse [P70379-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFGF14_MOUSE
AccessioniPrimary (citable) accession number: P70379
Secondary accession number(s): Q3KNZ6, Q8BST0, Q9JHL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 20, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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