Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P70379

- FGF14_MOUSE

UniProt

P70379 - FGF14_MOUSE

Protein

Fibroblast growth factor 14

Gene

Fgf14

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probably involved in nervous system development and function.

    GO - Biological processi

    1. adult locomotory behavior Source: MGI
    2. nervous system development Source: InterPro
    3. neuromuscular process Source: MGI
    4. positive regulation of sodium ion transport Source: MGI
    5. synaptic transmission Source: MGI

    Keywords - Molecular functioni

    Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fibroblast growth factor 14
    Short name:
    FGF-14
    Alternative name(s):
    Fibroblast growth factor homologous factor 4
    Short name:
    FHF-4
    Gene namesi
    Name:Fgf14
    Synonyms:Fhf4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:109189. Fgf14.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 247247Fibroblast growth factor 14PRO_0000147611Add
    BLAST

    Proteomic databases

    PaxDbiP70379.
    PRIDEiP70379.

    PTM databases

    PhosphoSiteiP70379.

    Expressioni

    Tissue specificityi

    Brain and testis; widely distributed in the developing nervous system. In adult, high levels in the granular layer of the cerebellum, less in hippocampus and olfactory bulb.

    Gene expression databases

    BgeeiP70379.
    CleanExiMM_FGF14.
    GenevestigatoriP70379.

    Interactioni

    Protein-protein interaction databases

    IntActiP70379. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP70379.
    SMRiP70379. Positions 66-203.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG308177.
    GeneTreeiENSGT00730000110666.
    HOGENOMiHOG000290676.
    HOVERGENiHBG007580.
    InParanoidiQ3KNZ6.
    KOiK04358.

    Family and domain databases

    InterProiIPR008996. Cytokine_IL1-like.
    IPR028284. FGF14.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view]
    PANTHERiPTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF18. PTHR11486:SF18. 1 hit.
    PfamiPF00167. FGF. 1 hit.
    [Graphical view]
    PRINTSiPR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTiSM00442. FGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF50353. SSF50353. 1 hit.
    PROSITEiPS00247. HBGF_FGF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P70379-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLF NGNLVDIFSK    50
    VRIFGLKKRR LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN 100
    STLFNLIPVG LRVVAIQGVK TGLYIAMNGE GYLYPSELFT PECKFKESVF 150
    ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ VMKGNRVKKT KPAAHFLPKP 200
    LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP VNKCKTT 247
    Length:247
    Mass (Da):27,764
    Last modified:February 1, 1997 - v1
    Checksum:i372C6FC0BDC72FDA
    GO
    Isoform 2 (identifier: P70379-2) [UniParc]FASTAAdd to Basket

    Also known as: FGF-14C

    The sequence of this isoform differs from the canonical sequence as follows:
         1-84: Missing.

    Show »
    Length:163
    Mass (Da):17,911
    Checksum:iD62199DE5A55833B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti40 – 401F → C in BAC27049. (PubMed:16141072)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8484Missing in isoform 2. 1 PublicationVSP_001530Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66204 mRNA. Translation: AAB18920.1.
    AB029498 mRNA. Translation: BAA89483.1.
    AK030616 mRNA. Translation: BAC27049.1.
    BC107003 mRNA. Translation: AAI07004.1.
    RefSeqiNP_034331.2. NM_010201.4.
    XP_006518611.1. XM_006518548.1. [P70379-2]
    UniGeneiMm.206362.

    Genome annotation databases

    EnsembliENSMUST00000026631; ENSMUSP00000026631; ENSMUSG00000025551.
    GeneIDi14169.
    KEGGimmu:14169.
    UCSCiuc007vbv.2. mouse. [P70379-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U66204 mRNA. Translation: AAB18920.1 .
    AB029498 mRNA. Translation: BAA89483.1 .
    AK030616 mRNA. Translation: BAC27049.1 .
    BC107003 mRNA. Translation: AAI07004.1 .
    RefSeqi NP_034331.2. NM_010201.4.
    XP_006518611.1. XM_006518548.1. [P70379-2 ]
    UniGenei Mm.206362.

    3D structure databases

    ProteinModelPortali P70379.
    SMRi P70379. Positions 66-203.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P70379. 1 interaction.

    PTM databases

    PhosphoSitei P70379.

    Proteomic databases

    PaxDbi P70379.
    PRIDEi P70379.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000026631 ; ENSMUSP00000026631 ; ENSMUSG00000025551 .
    GeneIDi 14169.
    KEGGi mmu:14169.
    UCSCi uc007vbv.2. mouse. [P70379-1 ]

    Organism-specific databases

    CTDi 2259.
    MGIi MGI:109189. Fgf14.

    Phylogenomic databases

    eggNOGi NOG308177.
    GeneTreei ENSGT00730000110666.
    HOGENOMi HOG000290676.
    HOVERGENi HBG007580.
    InParanoidi Q3KNZ6.
    KOi K04358.

    Miscellaneous databases

    NextBioi 285324.
    PROi P70379.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70379.
    CleanExi MM_FGF14.
    Genevestigatori P70379.

    Family and domain databases

    InterProi IPR008996. Cytokine_IL1-like.
    IPR028284. FGF14.
    IPR002209. Fibroblast_GF_fam.
    IPR028142. IL-1_fam/FGF_fam.
    [Graphical view ]
    PANTHERi PTHR11486. PTHR11486. 1 hit.
    PTHR11486:SF18. PTHR11486:SF18. 1 hit.
    Pfami PF00167. FGF. 1 hit.
    [Graphical view ]
    PRINTSi PR00263. HBGFFGF.
    PR00262. IL1HBGF.
    SMARTi SM00442. FGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50353. SSF50353. 1 hit.
    PROSITEi PS00247. HBGF_FGF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
      Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
      Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Eye.
    2. "Stage-specific expression of a novel isoform of mouse FGF-14 (FHF-4) in spermatocytes."
      Yamamoto S., Mikami T., Konishi M., Itoh N.
      Biochim. Biophys. Acta 1490:121-124(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Pituitary.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

    Entry informationi

    Entry nameiFGF14_MOUSE
    AccessioniPrimary (citable) accession number: P70379
    Secondary accession number(s): Q3KNZ6, Q8BST0, Q9JHL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 112 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3