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Protein

Fibroblast growth factor 14

Gene

Fgf14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.

GO - Molecular functioni

GO - Biological processi

  • adult locomotory behavior Source: MGI
  • JNK cascade Source: MGI
  • nervous system development Source: InterPro
  • neuromuscular process Source: MGI
  • positive regulation of defense response to virus by host Source: MGI
  • positive regulation of high voltage-gated calcium channel activity Source: MGI
  • positive regulation of sodium ion transport Source: MGI
  • regulation of postsynaptic membrane potential Source: MGI
  • regulation of synaptic plasticity Source: MGI
  • regulation of synaptic vesicle recycling Source: MGI
  • synaptic transmission Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 14
Short name:
FGF-14
Alternative name(s):
Fibroblast growth factor homologous factor 4
Short name:
FHF-4
Gene namesi
Name:Fgf14
Synonyms:Fhf4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109189. Fgf14.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: MGI
  • extracellular region Source: InterPro
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 247247Fibroblast growth factor 14PRO_0000147611Add
BLAST

Proteomic databases

PaxDbiP70379.
PRIDEiP70379.

PTM databases

PhosphoSiteiP70379.

Expressioni

Tissue specificityi

Brain and testis; widely distributed in the developing nervous system. In adult, high levels in the granular layer of the cerebellum, less in hippocampus and olfactory bulb.

Gene expression databases

BgeeiP70379.
CleanExiMM_FGF14.
ExpressionAtlasiP70379. baseline and differential.
GenevisibleiP70379. MM.

Interactioni

Protein-protein interaction databases

IntActiP70379. 1 interaction.
STRINGi10090.ENSMUSP00000093185.

Structurei

3D structure databases

ProteinModelPortaliP70379.
SMRiP70379. Positions 66-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG308177.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiP70379.
KOiK04358.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028284. FGF14.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF18. PTHR11486:SF18. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70379-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAIASGLI RQKRQAREQH WDRPSASRRR SSPSKNRGLF NGNLVDIFSK
60 70 80 90 100
VRIFGLKKRR LRRQDPQLKG IVTRLYCRQG YYLQMHPDGA LDGTKDDSTN
110 120 130 140 150
STLFNLIPVG LRVVAIQGVK TGLYIAMNGE GYLYPSELFT PECKFKESVF
160 170 180 190 200
ENYYVIYSSM LYRQQESGRA WFLGLNKEGQ VMKGNRVKKT KPAAHFLPKP
210 220 230 240
LEVAMYREPS LHDVGETVPK AGVTPSKSTS ASAIMNGGKP VNKCKTT
Length:247
Mass (Da):27,764
Last modified:February 1, 1997 - v1
Checksum:i372C6FC0BDC72FDA
GO
Isoform 2 (identifier: P70379-2) [UniParc]FASTAAdd to basket

Also known as: FGF-14C

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Show »
Length:163
Mass (Da):17,911
Checksum:iD62199DE5A55833B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti40 – 401F → C in BAC27049 (PubMed:16141072).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform 2. 1 PublicationVSP_001530Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66204 mRNA. Translation: AAB18920.1.
AB029498 mRNA. Translation: BAA89483.1.
AK030616 mRNA. Translation: BAC27049.1.
BC107003 mRNA. Translation: AAI07004.1.
RefSeqiNP_034331.2. NM_010201.4.
UniGeneiMm.206362.

Genome annotation databases

GeneIDi14169.
KEGGimmu:14169.
UCSCiuc007vbv.2. mouse. [P70379-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66204 mRNA. Translation: AAB18920.1.
AB029498 mRNA. Translation: BAA89483.1.
AK030616 mRNA. Translation: BAC27049.1.
BC107003 mRNA. Translation: AAI07004.1.
RefSeqiNP_034331.2. NM_010201.4.
UniGeneiMm.206362.

3D structure databases

ProteinModelPortaliP70379.
SMRiP70379. Positions 66-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70379. 1 interaction.
STRINGi10090.ENSMUSP00000093185.

PTM databases

PhosphoSiteiP70379.

Proteomic databases

PaxDbiP70379.
PRIDEiP70379.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi14169.
KEGGimmu:14169.
UCSCiuc007vbv.2. mouse. [P70379-1]

Organism-specific databases

CTDi2259.
MGIiMGI:109189. Fgf14.

Phylogenomic databases

eggNOGiNOG308177.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiP70379.
KOiK04358.

Miscellaneous databases

NextBioi285324.
PROiP70379.
SOURCEiSearch...

Gene expression databases

BgeeiP70379.
CleanExiMM_FGF14.
ExpressionAtlasiP70379. baseline and differential.
GenevisibleiP70379. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028284. FGF14.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF18. PTHR11486:SF18. 1 hit.
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
    Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Eye.
  2. "Stage-specific expression of a novel isoform of mouse FGF-14 (FHF-4) in spermatocytes."
    Yamamoto S., Mikami T., Konishi M., Itoh N.
    Biochim. Biophys. Acta 1490:121-124(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Pituitary.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).

Entry informationi

Entry nameiFGF14_MOUSE
AccessioniPrimary (citable) accession number: P70379
Secondary accession number(s): Q3KNZ6, Q8BST0, Q9JHL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: June 24, 2015
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.