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Protein

Fibroblast growth factor 11

Gene

Fgf11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.

GO - Molecular functioni

Keywordsi

Molecular functionGrowth factor

Enzyme and pathway databases

ReactomeiR-MMU-5576892 Phase 0 - rapid depolarisation

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 11
Short name:
FGF-11
Alternative name(s):
Fibroblast growth factor homologous factor 3
Short name:
FHF-3
Gene namesi
Name:Fgf11
Synonyms:Fhf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109167 Fgf11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001476031 – 225Fibroblast growth factor 11Add BLAST225

Proteomic databases

PaxDbiP70378
PeptideAtlasiP70378
PRIDEiP70378

PTM databases

iPTMnetiP70378
PhosphoSitePlusiP70378

Expressioni

Tissue specificityi

Brain and eye, and in a segmental pattern of the embryonic body wall. In adult olfactory bulb, hippocampus and most concentrated in Purkinje cell layer of the cerebellum.

Gene expression databases

BgeeiENSMUSG00000042826
CleanExiMM_FGF11
ExpressionAtlasiP70378 baseline and differential
GenevisibleiP70378 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099645

Structurei

3D structure databases

ProteinModelPortaliP70378
SMRiP70378
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000290676
HOVERGENiHBG007580
InParanoidiP70378
KOiK22413
OMAiCRHGFYL
OrthoDBiEOG091G0NAY
PhylomeDBiP70378
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028253 FGF11
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF67 PTHR11486:SF67, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequencei

Sequence statusi: Complete.

P70378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV
60 70 80 90 100
RLCGGRPTRQ DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS
110 120 130 140 150
FTHFNLIPVG LRVVTIQSAK LGHYMAMNAE GLLYSSPHFT AECRFKECVF
160 170 180 190 200
ENYYVLYASA LYRQRRSGRA WYLGLDKEGR VMKGNRVKKT KAAAHFVPKL
210 220
LEVAMYREPS LHSVPETSPS SPPAH
Length:225
Mass (Da):25,178
Last modified:February 1, 1997 - v1
Checksum:iF1F3E3FECEC6D441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66203 mRNA Translation: AAB18919.1
AL603707 Genomic DNA No translation available.
CCDSiCCDS24911.1
RefSeqiNP_001278033.1, NM_001291104.1
NP_034328.1, NM_010198.2
XP_011247026.1, XM_011248724.2
UniGeneiMm.269011

Genome annotation databases

EnsembliENSMUST00000102585; ENSMUSP00000099645; ENSMUSG00000042826
GeneIDi14166
KEGGimmu:14166
UCSCiuc007jrr.2 mouse

Similar proteinsi

Entry informationi

Entry nameiFGF11_MOUSE
AccessioniPrimary (citable) accession number: P70378
Secondary accession number(s): Q5F291
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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