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Protein

Fibroblast growth factor 11

Gene

Fgf11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probably involved in nervous system development and function.

Keywords - Molecular functioni

Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 11
Short name:
FGF-11
Alternative name(s):
Fibroblast growth factor homologous factor 3
Short name:
FHF-3
Gene namesi
Name:Fgf11
Synonyms:Fhf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109167. Fgf11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 225225Fibroblast growth factor 11PRO_0000147603Add
BLAST

Proteomic databases

PaxDbiP70378.
PeptideAtlasiP70378.
PRIDEiP70378.

PTM databases

iPTMnetiP70378.
PhosphoSiteiP70378.

Expressioni

Tissue specificityi

Brain and eye, and in a segmental pattern of the embryonic body wall. In adult olfactory bulb, hippocampus and most concentrated in Purkinje cell layer of the cerebellum.

Gene expression databases

BgeeiP70378.
CleanExiMM_FGF11.
ExpressionAtlasiP70378. baseline and differential.
GenevisibleiP70378. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099645.

Structurei

3D structure databases

ProteinModelPortaliP70378.
SMRiP70378. Positions 66-203.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiP70378.
KOiK04358.
OMAiCRSGRAW.
PhylomeDBiP70378.
TreeFamiTF317805.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028253. FGF11.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF67. PTHR11486:SF67. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70378-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALASSLIR QKREVREPGG SRPVSAQRRV CPRGTKSLCQ KQLLILLSKV
60 70 80 90 100
RLCGGRPTRQ DRGPEPQLKG IVTKLFCRQG FYLQANPDGS IQGTPEDTSS
110 120 130 140 150
FTHFNLIPVG LRVVTIQSAK LGHYMAMNAE GLLYSSPHFT AECRFKECVF
160 170 180 190 200
ENYYVLYASA LYRQRRSGRA WYLGLDKEGR VMKGNRVKKT KAAAHFVPKL
210 220
LEVAMYREPS LHSVPETSPS SPPAH
Length:225
Mass (Da):25,178
Last modified:February 1, 1997 - v1
Checksum:iF1F3E3FECEC6D441
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66203 mRNA. Translation: AAB18919.1.
AL603707 Genomic DNA. Translation: CAI51960.1.
CCDSiCCDS24911.1.
RefSeqiNP_001278033.1. NM_001291104.1.
NP_034328.1. NM_010198.2.
XP_011247026.1. XM_011248724.1.
UniGeneiMm.269011.

Genome annotation databases

EnsembliENSMUST00000102585; ENSMUSP00000099645; ENSMUSG00000042826.
GeneIDi14166.
KEGGimmu:14166.
UCSCiuc007jrr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U66203 mRNA. Translation: AAB18919.1.
AL603707 Genomic DNA. Translation: CAI51960.1.
CCDSiCCDS24911.1.
RefSeqiNP_001278033.1. NM_001291104.1.
NP_034328.1. NM_010198.2.
XP_011247026.1. XM_011248724.1.
UniGeneiMm.269011.

3D structure databases

ProteinModelPortaliP70378.
SMRiP70378. Positions 66-203.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099645.

PTM databases

iPTMnetiP70378.
PhosphoSiteiP70378.

Proteomic databases

PaxDbiP70378.
PeptideAtlasiP70378.
PRIDEiP70378.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102585; ENSMUSP00000099645; ENSMUSG00000042826.
GeneIDi14166.
KEGGimmu:14166.
UCSCiuc007jrr.2. mouse.

Organism-specific databases

CTDi2256.
MGIiMGI:109167. Fgf11.

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000290676.
HOVERGENiHBG007580.
InParanoidiP70378.
KOiK04358.
OMAiCRSGRAW.
PhylomeDBiP70378.
TreeFamiTF317805.

Enzyme and pathway databases

ReactomeiR-MMU-5576892. Phase 0 - rapid depolarisation.

Miscellaneous databases

PROiP70378.
SOURCEiSearch...

Gene expression databases

BgeeiP70378.
CleanExiMM_FGF11.
ExpressionAtlasiP70378. baseline and differential.
GenevisibleiP70378. MM.

Family and domain databases

InterProiIPR008996. Cytokine_IL1-like.
IPR028253. FGF11.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF67. PTHR11486:SF67. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development."
    Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H., Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Eye.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiFGF11_MOUSE
AccessioniPrimary (citable) accession number: P70378
Secondary accession number(s): Q5F291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.