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Protein

ELAV-like protein 1

Gene

Elavl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (PubMed:24394384). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (By similarity). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (PubMed:21402775).By similarity2 Publications

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • double-stranded RNA binding Source: MGI
  • miRNA binding Source: UniProtKB
  • mRNA 3'-UTR AU-rich region binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: UniProtKB
  • mRNA binding Source: UniProtKB
  • protein homodimerization activity Source: MGI
  • protein kinase binding Source: MGI
  • RNA binding Source: UniProtKB

GO - Biological processi

  • 3'-UTR-mediated mRNA stabilization Source: UniProtKB
  • mRNA stabilization Source: UniProtKB
  • negative regulation of gene silencing by miRNA Source: UniProtKB
  • positive regulation of translation Source: MGI
  • protein homooligomerization Source: UniProtKB
  • regulation of stem cell population maintenance Source: UniProtKB

Keywordsi

Molecular functionRNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-450520 HuR (ELAVL1) binds and stabilizes mRNA
R-MMU-72163 mRNA Splicing - Major Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
ELAV-like protein 1
Alternative name(s):
Elav-like generic protein
Hu-antigen R
Short name:
HuR
MelG
Gene namesi
Name:Elavl1
Synonyms:Elra, Hua
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1100851 Elavl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000815782 – 326ELAV-like protein 1Add BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei100PhosphoserineBy similarity1
Modified residuei158PhosphoserineBy similarity1
Cross-linki191Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei197PhosphoserineBy similarity1
Modified residuei202PhosphoserineCombined sources1
Modified residuei206Omega-N-methylarginineCombined sources1
Modified residuei217Omega-N-methylarginine; alternateCombined sources1
Modified residuei217Omega-N-methylated arginine; by CARM1; alternate1 Publication1
Modified residuei221PhosphoserineBy similarity1
Modified residuei318PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by MAPKAPK2. Phosphorylated by PRKCD.By similarity
Methylated at Arg-217 by CARM1 in T-cells in response to LPS challenge.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP70372
MaxQBiP70372
PaxDbiP70372
PeptideAtlasiP70372
PRIDEiP70372
TopDownProteomicsiP70372

PTM databases

iPTMnetiP70372
PhosphoSitePlusiP70372
SwissPalmiP70372

Expressioni

Gene expression databases

BgeeiENSMUSG00000040028
GenevisibleiP70372 MM

Interactioni

Subunit structurei

Monomer and homodimer (in vitro). Interacts with ANP32A (By similarity). Interacts with ZNF385A; the interaction is indirect and mRNA-dependent and may regulate p53/TP53 expression (PubMed:21402775). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Interacts with AGO1 and AGO2. Interacts with IGF2BP2 and IGF2BP3. Interacts with HNRNPL (By similarity).By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200482, 18 interactors
DIPiDIP-46480N
IntActiP70372, 20 interactors
MINTiP70372
STRINGi10090.ENSMUSP00000096549

Structurei

3D structure databases

ProteinModelPortaliP70372
SMRiP70372
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 98RRM 1PROSITE-ProRule annotationAdd BLAST79
Domaini106 – 186RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini244 – 322RRM 3PROSITE-ProRule annotationAdd BLAST79

Domaini

The first RRM (RNA recognition motif) domain is essential for binding to AU-rich elements.By similarity

Sequence similaritiesi

Belongs to the RRM elav family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0145 Eukaryota
ENOG410XP7S LUCA
GeneTreeiENSGT00760000118913
HOGENOMiHOG000231162
HOVERGENiHBG002295
InParanoidiP70372
KOiK13088
OMAiANPNQVK
OrthoDBiEOG091G0G9L
TreeFamiTF313377

Family and domain databases

CDDicd12650 RRM1_Hu, 1 hit
cd12773 RRM2_HuR, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR006548 ELAD_HU_SF
IPR034775 ELAV/Hu_RRM1
IPR002343 Hud_Sxl_RNA
IPR034996 HuR_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PRINTSiPR00961 HUDSXLRNA
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
TIGRFAMsiTIGR01661 ELAV_HUD_SF, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70372-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNGYEDHMA EDCRDDIGRT NLIVNYLPQN MTQEELRSLF SSIGEVESAK
60 70 80 90 100
LIRDKVAGHS LGYGFVNYVT AKDAERAIST LNGLRLQSKT IKVSYARPSS
110 120 130 140 150
EVIKDANLYI SGLPRTMTQK DVEDMFSRFG RIINSRVLVD QTTGLSRGVA
160 170 180 190 200
FIRFDKRSEA EEAITSFNGH KPPGSSEPIT VKFAANPNQN KNMALLSQLY
210 220 230 240 250
HSPARRFGGP VHHQAQRFRF SPMGVDHMSG ISGVNVPGNA SSGWCIFIYN
260 270 280 290 300
LGQDADEGIL WQMFGPFGAV TNVKVIRDFN TNKCKGFGFV TMTNYEEAAM
310 320
AIASLNGYRL GDKILQVSFK TNKSHK
Length:326
Mass (Da):36,169
Last modified:July 27, 2011 - v2
Checksum:i74A98DEE5B921AF6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3N → G in AAB17967 (PubMed:9763509).Curated1
Sequence conflicti15D → G in AAB17967 (PubMed:9763509).Curated1
Sequence conflicti168N → I in AAB17967 (PubMed:9763509).Curated1
Sequence conflicti168N → I in AAA96941 (PubMed:7753842).Curated1
Sequence conflicti298A → S in AAB17967 (PubMed:9763509).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65735 mRNA Translation: AAB17967.1
AK080365 mRNA Translation: BAC37892.1
CH466566 Genomic DNA Translation: EDL21996.1
CH466566 Genomic DNA Translation: EDL21997.1
U17595 mRNA Translation: AAA96941.1
CCDSiCCDS22084.1
PIRiI49144
RefSeqiNP_034615.2, NM_010485.3
XP_006508761.1, XM_006508698.3
UniGeneiMm.119162

Genome annotation databases

EnsembliENSMUST00000098950; ENSMUSP00000096549; ENSMUSG00000040028
ENSMUST00000209010; ENSMUSP00000146866; ENSMUSG00000040028
GeneIDi15568
KEGGimmu:15568
UCSCiuc009kts.1 mouse

Similar proteinsi

Entry informationi

Entry nameiELAV1_MOUSE
AccessioniPrimary (citable) accession number: P70372
Secondary accession number(s): Q60745, Q78QY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: July 27, 2011
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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