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Protein

Ubiquitin fusion degradation protein 1 homolog

Gene

Ufd1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). It may be involved in the development of some ectoderm-derived structures.By similarity

Pathwayi: proteasomal ubiquitin-dependent pathway

This protein is involved in the pathway proteasomal ubiquitin-dependent pathway, which is part of Protein degradation.
View all proteins of this organism that are known to be involved in the pathway proteasomal ubiquitin-dependent pathway and in Protein degradation.

GO - Molecular functioni

  • K48-linked polyubiquitin binding Source: ParkinsonsUK-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-110320. Translesion Synthesis by POLH.
UniPathwayiUPA00144.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin fusion degradation protein 1 homolog
Short name:
UB fusion protein 1
Gene namesi
Name:Ufd1l
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:109353. Ufd1l.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • cytosol Source: UniProtKB-SubCell
  • nucleus Source: MGI
  • UFD1-NPL4 complex Source: ParkinsonsUK-UCL
  • VCP-NPL4-UFD1 AAA ATPase complex Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Ubiquitin fusion degradation protein 1 homologPRO_0000194985Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei129 – 1291PhosphoserineBy similarity
Modified residuei231 – 2311PhosphoserineBy similarity
Modified residuei245 – 2451PhosphoserineBy similarity
Modified residuei247 – 2471PhosphoserineCombined sources
Modified residuei299 – 2991PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP70362.
MaxQBiP70362.
PaxDbiP70362.
PeptideAtlasiP70362.
PRIDEiP70362.

2D gel databases

REPRODUCTION-2DPAGEP70362.

PTM databases

iPTMnetiP70362.
PhosphoSiteiP70362.

Expressioni

Developmental stagei

Expressed at high levels in the otocyst (between E9.5 and E11.5 embryos fading away after E12) and in the developing eye. Lower expression is found in different sites of the embryos such as developing brain, the lungs and the cardiac outflow tract.

Gene expression databases

BgeeiENSMUSG00000005262.
CleanExiMM_UFD1L.
ExpressionAtlasiP70362. baseline and differential.
GenevisibleiP70362. MM.

Interactioni

Subunit structurei

Heterodimer with NPLOC4, this heterodimer binds VCP and inhibits Golgi membrane fusion. Interacts with USP13 (By similarity).By similarity

GO - Molecular functioni

  • K48-linked polyubiquitin binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi204430. 6 interactions.
DIPiDIP-60008N.
IntActiP70362. 2 interactions.
STRINGi10090.ENSMUSP00000005394.

Structurei

3D structure databases

ProteinModelPortaliP70362.
SMRiP70362. Positions 11-193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UFD1 family.Curated

Phylogenomic databases

eggNOGiKOG1816. Eukaryota.
COG5140. LUCA.
GeneTreeiENSGT00390000002408.
HOGENOMiHOG000212737.
HOVERGENiHBG001266.
InParanoidiP70362.
KOiK14016.
OMAiADHSSYA.
OrthoDBiEOG091G0KO7.
PhylomeDBiP70362.
TreeFamiTF314581.

Family and domain databases

InterProiIPR004854. UFD1.
[Graphical view]
PANTHERiPTHR12555. PTHR12555. 1 hit.
PfamiPF03152. UFD1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70362-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP
60 70 80 90 100
SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ
110 120 130 140 150
NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRNFA
160 170 180 190 200
CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP
210 220 230 240 250
ERPVQHEESI EGEADHSGYA GEVGFRAFSG SGNRLDGKKK GVEPSPSPIK
260 270 280 290 300
PGDIKRGIPN YEFKLGKITF IRNSRPLVKK VEEDEAGGRF IAFSGEGQSL

RKKGRKP
Length:307
Mass (Da):34,481
Last modified:July 27, 2011 - v2
Checksum:iC85E06B1B910485D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1521L → M in AAD08719 (PubMed:9063746).Curated
Sequence conflicti201 – 2011E → K in AAD08719 (PubMed:9063746).Curated
Sequence conflicti291 – 2911I → V in AAD08719 (PubMed:9063746).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64445 mRNA. Translation: AAD08719.1.
AK147138 mRNA. Translation: BAE27708.1.
AK169062 mRNA. Translation: BAE40849.1.
CH466521 Genomic DNA. Translation: EDK97535.1.
BC006630 mRNA. Translation: AAH06630.1.
CCDSiCCDS28028.1.
RefSeqiNP_035802.3. NM_011672.4.
XP_006522068.1. XM_006522005.2.
XP_006536881.1. XM_006536818.2.
UniGeneiMm.237594.

Genome annotation databases

EnsembliENSMUST00000005394; ENSMUSP00000005394; ENSMUSG00000005262.
ENSMUST00000115578; ENSMUSP00000111241; ENSMUSG00000005262.
GeneIDi22230.
KEGGimmu:22230.
UCSCiuc007yon.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U64445 mRNA. Translation: AAD08719.1.
AK147138 mRNA. Translation: BAE27708.1.
AK169062 mRNA. Translation: BAE40849.1.
CH466521 Genomic DNA. Translation: EDK97535.1.
BC006630 mRNA. Translation: AAH06630.1.
CCDSiCCDS28028.1.
RefSeqiNP_035802.3. NM_011672.4.
XP_006522068.1. XM_006522005.2.
XP_006536881.1. XM_006536818.2.
UniGeneiMm.237594.

3D structure databases

ProteinModelPortaliP70362.
SMRiP70362. Positions 11-193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204430. 6 interactions.
DIPiDIP-60008N.
IntActiP70362. 2 interactions.
STRINGi10090.ENSMUSP00000005394.

PTM databases

iPTMnetiP70362.
PhosphoSiteiP70362.

2D gel databases

REPRODUCTION-2DPAGEP70362.

Proteomic databases

EPDiP70362.
MaxQBiP70362.
PaxDbiP70362.
PeptideAtlasiP70362.
PRIDEiP70362.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000005394; ENSMUSP00000005394; ENSMUSG00000005262.
ENSMUST00000115578; ENSMUSP00000111241; ENSMUSG00000005262.
GeneIDi22230.
KEGGimmu:22230.
UCSCiuc007yon.2. mouse.

Organism-specific databases

CTDi7353.
MGIiMGI:109353. Ufd1l.

Phylogenomic databases

eggNOGiKOG1816. Eukaryota.
COG5140. LUCA.
GeneTreeiENSGT00390000002408.
HOGENOMiHOG000212737.
HOVERGENiHBG001266.
InParanoidiP70362.
KOiK14016.
OMAiADHSSYA.
OrthoDBiEOG091G0KO7.
PhylomeDBiP70362.
TreeFamiTF314581.

Enzyme and pathway databases

UniPathwayiUPA00144.
ReactomeiR-MMU-110320. Translesion Synthesis by POLH.

Miscellaneous databases

PROiP70362.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000005262.
CleanExiMM_UFD1L.
ExpressionAtlasiP70362. baseline and differential.
GenevisibleiP70362. MM.

Family and domain databases

InterProiIPR004854. UFD1.
[Graphical view]
PANTHERiPTHR12555. PTHR12555. 1 hit.
PfamiPF03152. UFD1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUFD1_MOUSE
AccessioniPrimary (citable) accession number: P70362
Secondary accession number(s): Q923C4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.