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Protein

Nuclear transcription factor Y subunit gamma

Gene

Nfyc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.

GO - Molecular functioni

  • DNA binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-2426168. Activation of gene expression by SREBF (SREBP).

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear transcription factor Y subunit gamma
Alternative name(s):
CAAT box DNA-binding protein subunit C
Nuclear transcription factor Y subunit C
Short name:
NF-YC
Gene namesi
Name:Nfyc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:107901. Nfyc.

Subcellular locationi

GO - Cellular componenti

  • CCAAT-binding factor complex Source: MGI
  • nucleoplasm Source: MGI
  • nucleus Source: MGI
  • protein-DNA complex Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Nuclear transcription factor Y subunit gammaPRO_0000218247Add
BLAST

Proteomic databases

EPDiP70353.
MaxQBiP70353.
PaxDbiP70353.
PeptideAtlasiP70353.
PRIDEiP70353.

PTM databases

PhosphoSiteiP70353.

Expressioni

Gene expression databases

BgeeiP70353.
CleanExiMM_NFYC.
ExpressionAtlasiP70353. baseline and differential.
GenevisibleiP70353. MM.

Interactioni

Subunit structurei

Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding (By similarity).By similarity

Protein-protein interaction databases

BioGridi201762. 22 interactions.
IntActiP70353. 22 interactions.
STRINGi10090.ENSMUSP00000047441.

Structurei

3D structure databases

ProteinModelPortaliP70353.
SMRiP70353. Positions 6-120.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NFYC/HAP5 subunit family.Curated

Phylogenomic databases

eggNOGiKOG1657. Eukaryota.
COG5208. LUCA.
GeneTreeiENSGT00530000063560.
HOGENOMiHOG000231074.
HOVERGENiHBG002885.
InParanoidiP70353.
KOiK08066.
OMAiQGTPITS.
OrthoDBiEOG7BGHNS.
PhylomeDBiP70353.
TreeFamiTF354207.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR027170. NFYC/HAP5_su.
[Graphical view]
PANTHERiPTHR10252:SF8. PTHR10252:SF8. 1 hit.
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

P70353-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK
60 70 80 90 100
IMKLDEDVKM ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND
110 120 130 140 150
IAMAITKFDQ FDFLIDIVPR DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ
160 170 180 190 200
QPTAVQVQGQ QQGQQTTSST TTIQPGQIII AQPQQGQTTP VTMQVGEGQQ
210 220 230 240 250
VQIVQAQPQG QAQQTQSGTG QTMQVMQQII TNTGEIQQIP VQLNAGQLQY
260 270 280 290 300
IRLAQPVSGT QVVQGQIQTL ATNAQQITQT EVQQGQQQFS QFTDGQQLYQ
310 320 330
IQQVTMPAGQ DLAQPMFIQS ANQPSDGQTP QVTGD
Length:335
Mass (Da):37,254
Last modified:November 8, 2005 - v2
Checksum:iD14620C1773C31E5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti72 – 721A → G in AAC52892 (PubMed:8910521).Curated
Sequence conflicti87 – 871H → R in AAC52892 (PubMed:8910521).Curated
Sequence conflicti95 – 951T → P in AAC52892 (PubMed:8910521).Curated
Sequence conflicti163 – 1631G → P in AAC52892 (PubMed:8910521).Curated
Sequence conflicti236 – 2361I → T in AAC52892 (PubMed:8910521).Curated
Sequence conflicti246 – 2461G → A in AAC52892 (PubMed:8910521).Curated
Sequence conflicti287 – 2871Q → E in AAC52892 (PubMed:8910521).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62297 mRNA. Translation: AAC52892.1.
AB006181 mRNA. Translation: BAA22216.1.
BC020117 mRNA. Translation: AAH20117.1.
BC085261 mRNA. Translation: AAH85261.1.
CCDSiCCDS18594.1.
RefSeqiNP_001041633.1. NM_001048168.2.
NP_001264024.1. NM_001277095.1.
NP_032718.2. NM_008692.4.
XP_006502909.1. XM_006502846.1.
XP_006502916.1. XM_006502853.2.
UniGeneiMm.435590.
Mm.450444.
Mm.477613.

Genome annotation databases

EnsembliENSMUST00000043429; ENSMUSP00000047441; ENSMUSG00000032897.
ENSMUST00000097906; ENSMUSP00000095516; ENSMUSG00000032897.
ENSMUST00000118902; ENSMUSP00000112610; ENSMUSG00000032897.
ENSMUST00000120779; ENSMUSP00000112810; ENSMUSG00000032897.
GeneIDi18046.
KEGGimmu:18046.
UCSCiuc008unn.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U62297 mRNA. Translation: AAC52892.1.
AB006181 mRNA. Translation: BAA22216.1.
BC020117 mRNA. Translation: AAH20117.1.
BC085261 mRNA. Translation: AAH85261.1.
CCDSiCCDS18594.1.
RefSeqiNP_001041633.1. NM_001048168.2.
NP_001264024.1. NM_001277095.1.
NP_032718.2. NM_008692.4.
XP_006502909.1. XM_006502846.1.
XP_006502916.1. XM_006502853.2.
UniGeneiMm.435590.
Mm.450444.
Mm.477613.

3D structure databases

ProteinModelPortaliP70353.
SMRiP70353. Positions 6-120.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201762. 22 interactions.
IntActiP70353. 22 interactions.
STRINGi10090.ENSMUSP00000047441.

PTM databases

PhosphoSiteiP70353.

Proteomic databases

EPDiP70353.
MaxQBiP70353.
PaxDbiP70353.
PeptideAtlasiP70353.
PRIDEiP70353.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043429; ENSMUSP00000047441; ENSMUSG00000032897.
ENSMUST00000097906; ENSMUSP00000095516; ENSMUSG00000032897.
ENSMUST00000118902; ENSMUSP00000112610; ENSMUSG00000032897.
ENSMUST00000120779; ENSMUSP00000112810; ENSMUSG00000032897.
GeneIDi18046.
KEGGimmu:18046.
UCSCiuc008unn.2. mouse.

Organism-specific databases

CTDi4802.
MGIiMGI:107901. Nfyc.

Phylogenomic databases

eggNOGiKOG1657. Eukaryota.
COG5208. LUCA.
GeneTreeiENSGT00530000063560.
HOGENOMiHOG000231074.
HOVERGENiHBG002885.
InParanoidiP70353.
KOiK08066.
OMAiQGTPITS.
OrthoDBiEOG7BGHNS.
PhylomeDBiP70353.
TreeFamiTF354207.

Enzyme and pathway databases

ReactomeiR-MMU-2426168. Activation of gene expression by SREBF (SREBP).

Miscellaneous databases

ChiTaRSiNfyc. mouse.
PROiP70353.
SOURCEiSearch...

Gene expression databases

BgeeiP70353.
CleanExiMM_NFYC.
ExpressionAtlasiP70353. baseline and differential.
GenevisibleiP70353. MM.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR003958. CBFA_NFYB_domain.
IPR009072. Histone-fold.
IPR027170. NFYC/HAP5_su.
[Graphical view]
PANTHERiPTHR10252:SF8. PTHR10252:SF8. 1 hit.
PfamiPF00808. CBFD_NFYB_HMF. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Subunit association and DNA binding activity of the heterotrimeric transcription factor NF-Y is regulated by cellular redox."
    Nakshatri H., Bhat-Nakshatri P., Currie R.A.
    J. Biol. Chem. 271:28784-28791(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Binding of NF-Y transcription factor to one of the Cis-elements in the myeloperoxidase gene promoter that responds to granulocyte colony-stimulating factor."
    Orita T., Shimozaki K., Murakami H., Nagata S.
    J. Biol. Chem. 272:23216-23223(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Czech II and FVB/N.
    Tissue: Colon and Mammary tumor.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiNFYC_MOUSE
AccessioniPrimary (citable) accession number: P70353
Secondary accession number(s): O35088, Q6GU21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: November 8, 2005
Last modified: July 6, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.