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Protein

Ecto-ADP-ribosyltransferase 5

Gene

Art5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

NAD+ + protein-L-arginine = nicotinamide + N(omega)-(ADP-D-ribosyl)-protein-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei100 – 1001NADBy similarity
Binding sitei161 – 1611NADBy similarity
Binding sitei181 – 1811NADBy similarity
Binding sitei215 – 2151NADBy similarity
Active sitei229 – 2291By similarity

GO - Molecular functioni

  • NAD(P)+-protein-arginine ADP-ribosyltransferase activity Source: UniProtKB-EC
  • NAD+ ADP-ribosyltransferase activity Source: MGI
  • NAD+ nucleosidase activity Source: MGI

GO - Biological processi

  • protein ADP-ribosylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

BRENDAi2.4.2.31. 3474.

Names & Taxonomyi

Protein namesi
Recommended name:
Ecto-ADP-ribosyltransferase 5 (EC:2.4.2.31)
Alternative name(s):
ADP-ribosyltransferase C2 and C3 toxin-like 5
Short name:
ARTC5
Mono(ADP-ribosyl)transferase 5
NAD(P)(+)--arginine ADP-ribosyltransferase 5
YAC-2
Gene namesi
Name:Art5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107948. Art5.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence analysisAdd
BLAST
Chaini24 – 309286Ecto-ADP-ribosyltransferase 5PRO_0000019334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 259By similarity
Glycosylationi102 – 1021N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP70352.
PRIDEiP70352.

Expressioni

Tissue specificityi

Abundantly expressed in testis. Lower levels in cardiac and skeletal muscle.

Gene expression databases

BgeeiP70352.
CleanExiMM_ART5.
ExpressionAtlasiP70352. baseline and differential.
GenevisibleiP70352. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091678.

Structurei

3D structure databases

ProteinModelPortaliP70352.
SMRiP70352. Positions 27-261.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVE0. Eukaryota.
ENOG4111WZG. LUCA.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiP70352.
KOiK19977.
OMAiLHFEPKR.
OrthoDBiEOG7D85WV.
TreeFamiTF335356.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70352-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MILEDLLMVL SCLSLHALWK VRAVPILPLS LVPDTFDDAY VGCSEEMEEK
60 70 80 90 100
AGLLLKEEMA RHALLRESWE AAQEAWAHRR HKLTLPPGFK AQHGVAIMVY
110 120 130 140 150
TNSSNTLYWE LNQAVRTGGG SRELYMRHFP FKALHFYLTR ALQLLRGSGG
160 170 180 190 200
CSRGPGEVVF RGVGSLHFEP KRLGDSVRLG QFTSSSVDER VARRFGNATF
210 220 230 240 250
FNLRTCFGAP IQALSVFPEE REVLIPPHEV FLVTGFSQDG AQSIVTLWSY
260 270 280 290 300
DQTCSHFNCA YLGGEKRRGC VSSRAVGQPE APSTEALALQ SGKTLLLDPR

KLQLSRAGP
Length:309
Mass (Da):34,333
Last modified:July 27, 2011 - v3
Checksum:i847F80B5F221D049
GO
Isoform 2 (identifier: P70352-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-264: Missing.

Show »
Length:164
Mass (Da):18,185
Checksum:i97C9324DB761C47F
GO
Isoform 3 (identifier: P70352-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-212: Missing.

Show »
Length:211
Mass (Da):23,457
Checksum:iE2E737F9B0A2C9A4
GO
Isoform 4 (identifier: P70352-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-124: GSREL → VVCLP
     125-309: Missing.

Show »
Length:124
Mass (Da):13,941
Checksum:iAD3B11C24F85B75F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti65 – 8319LRESW…RRHKL → PAPILGSSTRGLGTPASQA in AAC52773 (PubMed:8703012).CuratedAdd
BLAST
Sequence conflicti248 – 2481W → S in AAC52773 (PubMed:8703012).Curated
Sequence conflicti248 – 2481W → S in CAC48193 (PubMed:11587854).Curated
Sequence conflicti248 – 2481W → S in CAC50567 (PubMed:11587854).Curated
Sequence conflicti268 – 2681R → H in AAC52773 (PubMed:8703012).Curated
Sequence conflicti268 – 2681R → H in CAC48193 (PubMed:11587854).Curated
Sequence conflicti268 – 2681R → H in CAC50566 (PubMed:11587854).Curated
Sequence conflicti268 – 2681R → H in CAC50567 (PubMed:11587854).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei115 – 21298Missing in isoform 3. CuratedVSP_003381Add
BLAST
Alternative sequencei120 – 264145Missing in isoform 2. CuratedVSP_003380Add
BLAST
Alternative sequencei120 – 1245GSREL → VVCLP in isoform 4. CuratedVSP_003382
Alternative sequencei125 – 309185Missing in isoform 4. CuratedVSP_003383Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60881 mRNA. Translation: AAC52773.1.
AJ295722 Genomic DNA. Translation: CAC48193.1.
AJ297547 mRNA. Translation: CAC50566.1.
AJ297548 mRNA. Translation: CAC50567.1.
AJ295843 mRNA. Translation: CAC69242.1.
AC132297 Genomic DNA. No translation available.
CCDSiCCDS21525.1. [P70352-1]
RefSeqiNP_001278283.1. NM_001291354.1. [P70352-1]
NP_031517.2. NM_007491.2. [P70352-1]
XP_006507322.1. XM_006507259.2. [P70352-3]
XP_006507323.1. XM_006507260.2. [P70352-3]
XP_006507326.1. XM_006507263.2. [P70352-4]
UniGeneiMm.2816.

Genome annotation databases

EnsembliENSMUST00000094128; ENSMUSP00000091678; ENSMUSG00000070424. [P70352-1]
ENSMUST00000106934; ENSMUSP00000102547; ENSMUSG00000070424. [P70352-3]
ENSMUST00000106935; ENSMUSP00000102548; ENSMUSG00000070424. [P70352-2]
ENSMUST00000106937; ENSMUSP00000102550; ENSMUSG00000070424. [P70352-1]
GeneIDi11875.
KEGGimmu:11875.
UCSCiuc009iqp.2. mouse. [P70352-3]
uc012fqt.1. mouse. [P70352-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60881 mRNA. Translation: AAC52773.1.
AJ295722 Genomic DNA. Translation: CAC48193.1.
AJ297547 mRNA. Translation: CAC50566.1.
AJ297548 mRNA. Translation: CAC50567.1.
AJ295843 mRNA. Translation: CAC69242.1.
AC132297 Genomic DNA. No translation available.
CCDSiCCDS21525.1. [P70352-1]
RefSeqiNP_001278283.1. NM_001291354.1. [P70352-1]
NP_031517.2. NM_007491.2. [P70352-1]
XP_006507322.1. XM_006507259.2. [P70352-3]
XP_006507323.1. XM_006507260.2. [P70352-3]
XP_006507326.1. XM_006507263.2. [P70352-4]
UniGeneiMm.2816.

3D structure databases

ProteinModelPortaliP70352.
SMRiP70352. Positions 27-261.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000091678.

Proteomic databases

PaxDbiP70352.
PRIDEiP70352.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094128; ENSMUSP00000091678; ENSMUSG00000070424. [P70352-1]
ENSMUST00000106934; ENSMUSP00000102547; ENSMUSG00000070424. [P70352-3]
ENSMUST00000106935; ENSMUSP00000102548; ENSMUSG00000070424. [P70352-2]
ENSMUST00000106937; ENSMUSP00000102550; ENSMUSG00000070424. [P70352-1]
GeneIDi11875.
KEGGimmu:11875.
UCSCiuc009iqp.2. mouse. [P70352-3]
uc012fqt.1. mouse. [P70352-1]

Organism-specific databases

CTDi116969.
MGIiMGI:107948. Art5.

Phylogenomic databases

eggNOGiENOG410IVE0. Eukaryota.
ENOG4111WZG. LUCA.
GeneTreeiENSGT00530000062975.
HOGENOMiHOG000273888.
HOVERGENiHBG004464.
InParanoidiP70352.
KOiK19977.
OMAiLHFEPKR.
OrthoDBiEOG7D85WV.
TreeFamiTF335356.

Enzyme and pathway databases

BRENDAi2.4.2.31. 3474.

Miscellaneous databases

NextBioi279895.
PROiP70352.
SOURCEiSearch...

Gene expression databases

BgeeiP70352.
CleanExiMM_ART5.
ExpressionAtlasiP70352. baseline and differential.
GenevisibleiP70352. MM.

Family and domain databases

InterProiIPR000768. ART.
[Graphical view]
PfamiPF01129. ART. 1 hit.
[Graphical view]
PRINTSiPR00970. RIBTRNSFRASE.
PROSITEiPS01291. ART. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a novel membrane-associated lymphocyte NAD:arginine ADP-ribosyltransferase."
    Okazaki I.J., Kim H.-J., Moss J.
    J. Biol. Chem. 271:22052-22057(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Lymphoma.
  2. "Structure, chromosomal localization, and expression of the gene for mouse ecto-mono(ADP-ribosyl)transferase ART5."
    Glowacki G., Braren R., Cetkovic-Cvrlje M., Leiter E.H., Haag F., Koch-Nolte F.
    Gene 275:267-277(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 1; 2; 3 AND 4).
    Strain: 129/Ola.
    Tissue: Testis.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiNAR5_MOUSE
AccessioniPrimary (citable) accession number: P70352
Secondary accession number(s): E9QM95
, Q91VF7, Q91X06, Q91X07, Q921A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.