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P70340

- SMAD1_MOUSE

UniProt

P70340 - SMAD1_MOUSE

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Protein

Mothers against decapentaplegic homolog 1

Gene

Smad1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity). May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Zinc
Metal bindingi109 – 1091Zinc
Metal bindingi121 – 1211Zinc
Metal bindingi126 – 1261Zinc

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. RNA polymerase II core promoter sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. BMP signaling pathway Source: UniProtKB
  2. bone development Source: MGI
  3. cardiac muscle cell proliferation Source: MGI
  4. cartilage development Source: MGI
  5. cellular response to BMP stimulus Source: BHF-UCL
  6. cellular response to organic cyclic compound Source: MGI
  7. embryonic pattern specification Source: UniProtKB
  8. gamete generation Source: MGI
  9. hindbrain development Source: MGI
  10. homeostatic process Source: MGI
  11. inflammatory response Source: UniProtKB
  12. MAPK cascade Source: MGI
  13. mesodermal cell fate commitment Source: MGI
  14. midbrain development Source: MGI
  15. negative regulation of cell proliferation Source: MGI
  16. negative regulation of muscle cell apoptotic process Source: Ensembl
  17. osteoblast fate commitment Source: MGI
  18. positive regulation of cartilage development Source: MGI
  19. positive regulation of dendrite morphogenesis Source: Ensembl
  20. positive regulation of gene expression Source: MGI
  21. positive regulation of osteoblast differentiation Source: MGI
  22. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  23. positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus Source: BHF-UCL
  24. protein phosphorylation Source: MGI
  25. regulation of transcription from RNA polymerase II promoter Source: MGI
  26. response to drug Source: Ensembl
  27. response to organonitrogen compound Source: Ensembl
  28. SMAD protein complex assembly Source: Ensembl
  29. transcription, DNA-templated Source: UniProtKB-KW
  30. transforming growth factor beta receptor signaling pathway Source: InterPro
  31. ureteric bud development Source: UniProtKB
  32. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_220505. Signaling by BMP.

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homolog 1
Short name:
MAD homolog 1
Short name:
Mothers against DPP homolog 1
Alternative name(s):
Dwarfin-A
Short name:
Dwf-A
Mothers-against-DPP-related 1
Short name:
Mad-related protein 1
Short name:
mMad1
SMAD family member 1
Short name:
SMAD 1
Short name:
Smad1
Gene namesi
Name:Smad1
Synonyms:Madh1, Madr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:109452. Smad1.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity
Note: In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Colocalizes with LEMD3 at the nucleus inner membrane (By similarity).By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. mitochondrion Source: Ensembl
  3. nuclear inner membrane Source: Ensembl
  4. nucleus Source: UniProtKB
  5. protein complex Source: MGI
  6. transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 465465Mothers against decapentaplegic homolog 1PRO_0000090848Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei322 – 3221Phosphothreonine; by MINK1, TNIK and MAP4K4
Modified residuei463 – 4631PhosphoserinePROSITE-ProRule annotation
Modified residuei465 – 4651PhosphoserinePROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated on serine by BMP type 1 receptor kinase.By similarity
Ubiquitinated by SMAD-specific E3 ubiquitin ligase SMURF1, leading to its degradation. Monoubiquitinated, leading to prevent DNA-binding. Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP70340.
PaxDbiP70340.
PRIDEiP70340.

PTM databases

PhosphoSiteiP70340.

Expressioni

Tissue specificityi

Ubiquitous.

Developmental stagei

Ubiquitously expressed during embryogenesis. Expression starts in some seminiferous tubules at 2 weeks of age. After mid-puberty a stage-specific expression is established. During the cycling of the seminiferous epithelium, expression initiates in the pachytene spermatocytes of stage V seminiferous tubules, peaks at stage X, then decreases as pachytene spermatocytes differentiate into secondary spermatocytes and then round spermatids.

Gene expression databases

BgeeiP70340.
CleanExiMM_SMAD1.
ExpressionAtlasiP70340. baseline and differential.
GenevestigatoriP70340.

Interactioni

Subunit structurei

May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2, USP15 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with SKOR1. Interacts (via MH2 domain) with LEMD3. Binding to LEMD3 results in at least a partial reduction of receptor-mediated phosphorylation (By similarity). Also interacts with HGS, NANOG and ZCCHC12. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome (By similarity). Found in a complex with SMAD4 and YY1. Interacts (via MH2 domain) with FAM83G (via MH2 domain); in a SMAD4-independent manner.By similarity5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Map3k7Q620733EBI-6992047,EBI-1775345

Protein-protein interaction databases

BioGridi201274. 34 interactions.
IntActiP70340. 7 interactions.
MINTiMINT-99213.

Structurei

Secondary structure

1
465
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 198
Helixi25 – 4117
Helixi47 – 5610
Beta strandi66 – 683
Beta strandi71 – 733
Beta strandi75 – 773
Beta strandi80 – 823
Helixi84 – 929
Helixi100 – 1023
Beta strandi103 – 1053
Helixi113 – 1153
Beta strandi118 – 1214
Helixi124 – 1263
Beta strandi127 – 1293

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KMPX-ray2.70A/B9-132[»]
ProteinModelPortaliP70340.
SMRiP70340. Positions 9-132, 268-465.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP70340.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 136125MH1PROSITE-ProRule annotationAdd
BLAST
Domaini271 – 465195MH2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 457Poly-Lys

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.Curated
Contains 1 MH1 (MAD homology 1) domain.PROSITE-ProRule annotation
Contains 1 MH2 (MAD homology 2) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG330956.
GeneTreeiENSGT00760000119091.
HOGENOMiHOG000286018.
HOVERGENiHBG053353.
InParanoidiP70340.
KOiK04676.
OMAiPRNSEFN.
OrthoDBiEOG7W1540.
TreeFamiTF314923.

Family and domain databases

Gene3Di2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProiIPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view]
PANTHERiPTHR13703. PTHR13703. 1 hit.
PfamiPF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view]
SUPFAMiSSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEiPS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70340-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVTSLFSFT SPAVKRLLGW KQGDEEEKWA EKAVDALVKK LKKKKGAMEE
60 70 80 90 100
LEKALSCPGQ PSNCVTIPRS LDGRLQVSHR KGLPHVIYCR VWRWPDLQSH
110 120 130 140 150
HELKPLECCE FPFGSKQKEV CINPYHYKRV ESPVLPPVLV PRHSEYNPQH
160 170 180 190 200
SLLAQFRNLG QNEPHMPLNA TFPDSFQQPN SHPFPHSPNS SYPNSPGGSS
210 220 230 240 250
STYPHSPTSS DPGSPFQMPA DTPPPAYLPP EDPMAQDGSQ PMDTNMMAPP
260 270 280 290 300
LPAEISRGDV QAVAYEEPKH WCSIVYYELN NRVGEAFHAS STSVLVDGFT
310 320 330 340 350
DPSNNKNRFC LGLLSNVNRN STIENTRRHI GKGVHLYYVG GEVYAECLSD
360 370 380 390 400
SSIFVQSRNC NYHHGFHPTT VCKIPSGCSL KIFNNQEFAQ LLAQSVNHGF
410 420 430 440 450
ETVYELTKMC TIRMSFVKGW GAEYHRQDVT STPCWIEIHL HGPLQWLDKV
460
LTQMGSPHNP ISSVS
Length:465
Mass (Da):52,157
Last modified:July 27, 2011 - v2
Checksum:i07A56FBEE79A1C2A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti95 – 951P → S in AAC52785. (PubMed:8799132)Curated
Sequence conflicti95 – 951P → S in AAG41407. (PubMed:11111041)Curated
Sequence conflicti142 – 1421R → K in AAC52785. (PubMed:8799132)Curated
Sequence conflicti142 – 1421R → K in AAG41407. (PubMed:11111041)Curated
Sequence conflicti199 – 2002SS → QG in AAB18256. (PubMed:9076678)Curated
Sequence conflicti393 – 3931A → E in AAB18256. (PubMed:9076678)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58992 mRNA. Translation: AAC52785.1.
U74359 mRNA. Translation: AAB18256.1.
AF295768
, AF295763, AF295764, AF295765, AF295766, AF295767 Genomic DNA. Translation: AAG41407.1.
AK017583 mRNA. Translation: BAB30820.1.
AK054104 mRNA. Translation: BAC35658.1.
BC058693 mRNA. Translation: AAH58693.1.
CCDSiCCDS22437.1.
RefSeqiNP_032565.2. NM_008539.3.
XP_006530809.1. XM_006530746.1.
UniGeneiMm.223717.

Genome annotation databases

EnsembliENSMUST00000066091; ENSMUSP00000071035; ENSMUSG00000031681.
GeneIDi17125.
KEGGimmu:17125.
UCSCiuc009mip.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U58992 mRNA. Translation: AAC52785.1 .
U74359 mRNA. Translation: AAB18256.1 .
AF295768
, AF295763 , AF295764 , AF295765 , AF295766 , AF295767 Genomic DNA. Translation: AAG41407.1 .
AK017583 mRNA. Translation: BAB30820.1 .
AK054104 mRNA. Translation: BAC35658.1 .
BC058693 mRNA. Translation: AAH58693.1 .
CCDSi CCDS22437.1.
RefSeqi NP_032565.2. NM_008539.3.
XP_006530809.1. XM_006530746.1.
UniGenei Mm.223717.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3KMP X-ray 2.70 A/B 9-132 [» ]
ProteinModelPortali P70340.
SMRi P70340. Positions 9-132, 268-465.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201274. 34 interactions.
IntActi P70340. 7 interactions.
MINTi MINT-99213.

PTM databases

PhosphoSitei P70340.

Proteomic databases

MaxQBi P70340.
PaxDbi P70340.
PRIDEi P70340.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066091 ; ENSMUSP00000071035 ; ENSMUSG00000031681 .
GeneIDi 17125.
KEGGi mmu:17125.
UCSCi uc009mip.2. mouse.

Organism-specific databases

CTDi 4086.
MGIi MGI:109452. Smad1.

Phylogenomic databases

eggNOGi NOG330956.
GeneTreei ENSGT00760000119091.
HOGENOMi HOG000286018.
HOVERGENi HBG053353.
InParanoidi P70340.
KOi K04676.
OMAi PRNSEFN.
OrthoDBi EOG7W1540.
TreeFami TF314923.

Enzyme and pathway databases

Reactomei REACT_220505. Signaling by BMP.

Miscellaneous databases

ChiTaRSi SMAD1. mouse.
EvolutionaryTracei P70340.
NextBioi 291304.
PROi P70340.
SOURCEi Search...

Gene expression databases

Bgeei P70340.
CleanExi MM_SMAD1.
ExpressionAtlasi P70340. baseline and differential.
Genevestigatori P70340.

Family and domain databases

Gene3Di 2.60.200.10. 1 hit.
3.90.520.10. 1 hit.
InterProi IPR013790. Dwarfin.
IPR003619. MAD_homology1_Dwarfin-type.
IPR013019. MAD_homology_MH1.
IPR017855. SMAD_dom-like.
IPR001132. SMAD_dom_Dwarfin-type.
IPR008984. SMAD_FHA_domain.
[Graphical view ]
PANTHERi PTHR13703. PTHR13703. 1 hit.
Pfami PF03165. MH1. 1 hit.
PF03166. MH2. 1 hit.
[Graphical view ]
SMARTi SM00523. DWA. 1 hit.
SM00524. DWB. 1 hit.
[Graphical view ]
SUPFAMi SSF49879. SSF49879. 1 hit.
SSF56366. SSF56366. 1 hit.
PROSITEi PS51075. MH1. 1 hit.
PS51076. MH2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian dwarfins are phosphorylated in response to transforming growth factor beta and are implicated in control of cell growth."
    Yingling J.M., Das P., Savage C., Zhang M., Padgett R.W., Wang X.-F.
    Proc. Natl. Acad. Sci. U.S.A. 93:8940-8944(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.
  2. "Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse."
    Zhao G.-Q., Hogan B.L.M.
    Mech. Dev. 61:63-73(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic heart.
  3. "Characterization of the mouse Smad1 gene and its expression pattern in adult mouse tissues."
    Huang S., Flanders K.C., Roberts A.B.
    Gene 258:43-53(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo and Oviduct.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  6. "Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA."
    Miura S., Takeshita T., Asao H., Kimura Y., Murata K., Sasaki Y., Hanai J., Beppu H., Tsukazaki T., Wrana J.L., Miyazono K., Sugamura K.
    Mol. Cell. Biol. 20:9346-9355(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HGS.
  7. "SMAD-mediated modulation of YY1 activity regulates the BMP response and cardiac-specific expression of a GATA4/5/6-dependent chick Nkx2.5 enhancer."
    Lee K.H., Evans S., Ruan T.Y., Lassar A.B.
    Development 131:4709-4723(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH SMAD4 AND YY1.
  8. "Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells."
    Suzuki A., Raya A., Kawakami Y., Morita M., Matsui T., Nakashima K., Gage F.H., Rodriguez-Esteban C., Izpisua Belmonte J.C.
    Proc. Natl. Acad. Sci. U.S.A. 103:10294-10299(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NANOG.
  9. "Sizn1 is a novel protein that functions as a transcriptional coactivator of bone morphogenic protein signaling."
    Cho G., Lim Y., Zand D., Golden J.A.
    Mol. Cell. Biol. 28:1565-1572(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZCCHC12.
  10. "Structure of Smad1 MH1/DNA complex reveals distinctive rearrangements of BMP and TGF-beta effectors."
    Baburajendran N., Palasingam P., Narasimhan K., Sun W., Prabhakar S., Jauch R., Kolatkar P.R.
    Nucleic Acids Res. 38:3477-3488(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 9-132 IN COMPLEX WITH DNA, ZINC_BINDING SITES, SUBUNIT.

Entry informationi

Entry nameiSMAD1_MOUSE
AccessioniPrimary (citable) accession number: P70340
Secondary accession number(s): P70442, Q6GT95, Q9CYK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 147 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3