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Reviewed, UniProtKB/Swiss-Prot P70338 (GFI1_MOUSE)

Last modified June 16, 2009. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Zinc finger protein Gfi-1
Alternative name(s):
    Growth factor independent protein 1
Gene names
Name: Gfi1
Synonyms: Gfi-1
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T-cells. May be involved in tumor progression. Represses ELA2 transcription By similarity.

Subunit structure

Interacts with U2AF1L4. Ref.3

Subcellular location

Nucleus.

Domain

The Gly/Ala-rich region may indicate that Gfi-1 is a repressor of its target genes.

Sequence similarities

Contains 6 C2H2-type zinc fingers.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Zinc finger protein Gfi-1
PRO_0000047194

Regions

Zinc finger256 – 27924C2H2-type 1
Zinc finger285 – 30723C2H2-type 2
Zinc finger313 – 33523C2H2-type 3
Zinc finger341 – 36323C2H2-type 4
Zinc finger369 – 39123C2H2-type 5
Zinc finger397 – 42024C2H2-type 6
Compositional bias159 – 21052Ala/Gly-rich

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Sequences

Sequence LengthMass (Da)Tools
P70338-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 8FDAB5BB4886D056

FASTA42345,875
        10         20         30         40         50         60 
MPRSFLVKSK KAHSYHQPRS PGPDYSLRLE TVPAPGRAEG GAVSAGESKM EPRERLSPDS 

        70         80         90        100        110        120 
QLTEAPDRAS ASPNSCEGSV CDPCSEFEDF WRPPSPSVSP ASEKSLCRSL DEAQPYTLPF 

       130        140        150        160        170        180 
KPYAWSGLAG SDLRHLVQSY RQCSALERSA GLSLFCERGS EPGRPAARYG PEQAAGGAGA 

       190        200        210        220        230        240 
GQPGSCGVAG GATSAAGLGL YGDFAPAAAG LYERPSTAAG RLYQDHGHEL HADKSVGVKV 

       250        260        270        280        290        300 
ESELLCTRLL LGGGSYKCIK CSKVFSTPHG LEVHVRRSHS GTRPFACEMC GKTFGHAVSL 

       310        320        330        340        350        360 
EQHKAVHSQE RSFDCKICGK SFKRSSTLST HLLIHSDTRP YPCQYCGKRF HQKSDMKKHT 

       370        380        390        400        410        420 
FIHTGEKPHK CQVCGKAFSQ SSNLITHSRK HTGFKPFGCD LCGKGFQRKV DLRRHRETQH 


GLK

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References

[1]"Characterization of pal-1, a common proviral insertion site in murine leukemia virus-induced lymphomas of c-myc and Pim-1 transgenic mice."
Scheijen B., Jonkers J., Acton D., Berns A.
J. Virol. 71:9-16(1997) [PubMed: 8985317] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Thymus.
[2]"Zinc finger protein GFI-1 cooperates with myc and pim-1 in T-cell lymphomagenesis by reducing the requirements for IL-2."
Zornig M., Schmidt T., Karsunky H., Grzeschiczek A., Moroy T.
Oncogene 12:1789-1801(1996) [PubMed: 8622900] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Auxiliary splice factor U2AF26 and transcription factor Gfi1 cooperate directly in regulating CD45 alternative splicing."
Heyd F., ten Dam G., Moeroey T.
Nat. Immunol. 7:859-867(2006) [PubMed: 16819553] [Abstract]
Cited for: INTERACTION WITH U2AF1L4.
+Additional computationally mapped references.

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Cross-references

Sequence databases

U58973 mRNA. Translation: AAC52960.1.
U58972 mRNA. Translation: AAC52959.1.
U78312 mRNA. Translation: AAB36829.1.
IPIIPI00622035.
RefSeqNP_034408.1.
UniGeneMm.2078
Mm.453139

3D structure databases

HSSPHSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBaseSearch...

PTM databases

PhosphoSiteP70338.

Proteomic databases

PRIDEP70338.

Genome annotation databases

EnsemblENSMUSG00000029275. Mus musculus. [Contig view]
GeneID14581.
KEGGmmu:14581.

Organism-specific databases

MGIMGI:103170. Gfi1.

Phylogenomic databases

HOVERGENP70338.

Gene expression databases

ArrayExpressP70338.
BgeeP70338.
CleanExMM_GFI1.
GermOnlineENSMUSG00000029275. Mus musculus.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
IPR001878. Znf_CCHC.
[Graphical view]
Gene3DG3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 3 hits.
PfamPF00096. zf-C2H2. 6 hits.
[Graphical view]
ProDomPD000003. Znf_C2H2. 2 hits.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00355. ZnF_C2H2. 6 hits.
SM00343. ZnF_C2HC. 1 hit.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 6 hits.
PS50157. ZINC_FINGER_C2H2_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio286310.
SOURCESearch...

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Entry information

Entry nameGFI1_MOUSE
AccessionPrimary (citable) accession number: P70338
Secondary accession number(s): O09063
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: June 16, 2009
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents