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P70333

- HNRH2_MOUSE

UniProt

P70333 - HNRH2_MOUSE

Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

Hnrnph2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) By similarity.By similarity

    GO - Molecular functioni

    1. nucleotide binding Source: InterPro
    2. RNA binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ribonucleoprotein

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heterogeneous nuclear ribonucleoprotein H2
    Short name:
    hnRNP H2
    Alternative name(s):
    Heterogeneous nuclear ribonucleoprotein H'
    Short name:
    hnRNP H'
    Cleaved into the following chain:
    Gene namesi
    Name:Hnrnph2
    Synonyms:Hnrph2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1201779. Hnrnph2.

    Subcellular locationi

    Nucleusnucleoplasm By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. nucleoplasm Source: UniProtKB-SubCell
    4. ribonucleoprotein complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 449449Heterogeneous nuclear ribonucleoprotein H2PRO_0000081860Add
    BLAST
    Initiator methioninei1 – 11Removed; alternateBy similarity
    Chaini2 – 449448Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedPRO_0000423274Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei2 – 21N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity
    Modified residuei23 – 231PhosphoserineBy similarity
    Modified residuei63 – 631PhosphoserineBy similarity
    Modified residuei233 – 2331Dimethylated arginine; alternateBy similarity
    Modified residuei233 – 2331Omega-N-methylarginine; alternateBy similarity
    Modified residuei246 – 2461PhosphotyrosineBy similarity
    Modified residuei310 – 3101PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiP70333.
    PaxDbiP70333.
    PRIDEiP70333.

    PTM databases

    PhosphoSiteiP70333.

    Expressioni

    Gene expression databases

    BgeeiP70333.
    GenevestigatoriP70333.

    Interactioni

    Subunit structurei

    Interacts with TXNL4/DIM1.By similarity

    Protein-protein interaction databases

    BioGridi207865. 14 interactions.
    IntActiP70333. 3 interactions.
    MINTiMINT-4097696.

    Structurei

    3D structure databases

    ProteinModelPortaliP70333.
    SMRiP70333. Positions 4-193, 277-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini11 – 9080RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini111 – 18878RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Repeati234 – 249161-1Add
    BLAST
    Domaini289 – 36476RRM 3PROSITE-ProRule annotationAdd
    BLAST
    Repeati354 – 372192-1Add
    BLAST
    Repeati374 – 392192-2Add
    BLAST
    Repeati418 – 433161-2Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni234 – 4332002 X 16 AA Gly-rich approximate repeatsAdd
    BLAST
    Regioni354 – 392392 X 19 AA perfect repeatsAdd
    BLAST

    Sequence similaritiesi

    Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG262593.
    GeneTreeiENSGT00620000087736.
    HOGENOMiHOG000220896.
    HOVERGENiHBG055557.
    InParanoidiP70333.
    KOiK12898.
    OMAiPPRKLMT.
    OrthoDBiEOG7BS4BZ.
    PhylomeDBiP70333.
    TreeFamiTF316157.

    Family and domain databases

    Gene3Di3.30.70.330. 3 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR012996. Znf_CHHC.
    [Graphical view]
    PfamiPF08080. zf-RNPHF. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 3 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70333-1 [UniParc]FASTAAdd to Basket

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    MMLSTEGREG FVVKVRGLPW SCSAEEVMRF FSDCKIQNGT SGVRFIYTRE    50
    GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT 100
    GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR 150
    STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK 200
    LMTMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN 250
    DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA 300
    TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA 350
    NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM 400
    GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA 449
    Length:449
    Mass (Da):49,280
    Last modified:February 1, 1997 - v1
    Checksum:i2ED0A7A87A7EDF5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58105 Genomic DNA. Translation: AAB47243.1.
    AK077716 mRNA. Translation: BAC36976.1.
    AK164115 mRNA. Translation: BAE37634.1.
    AK168116 mRNA. Translation: BAE40087.1.
    AK169104 mRNA. Translation: BAE40886.1.
    BC005461 mRNA. Translation: AAH05461.1.
    CCDSiCCDS30397.1.
    RefSeqiNP_063921.1. NM_019868.3.
    XP_006528646.1. XM_006528583.1.
    UniGeneiMm.315909.

    Genome annotation databases

    EnsembliENSMUST00000050331; ENSMUSP00000108827; ENSMUSG00000045427.
    ENSMUST00000059297; ENSMUSP00000050838; ENSMUSG00000045427.
    ENSMUST00000074950; ENSMUSP00000074483; ENSMUSG00000045427.
    ENSMUST00000113202; ENSMUSP00000108828; ENSMUSG00000045427.
    ENSMUST00000113203; ENSMUSP00000108829; ENSMUSG00000045427.
    GeneIDi56258.
    KEGGimmu:56258.
    UCSCiuc009ugh.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U58105 Genomic DNA. Translation: AAB47243.1 .
    AK077716 mRNA. Translation: BAC36976.1 .
    AK164115 mRNA. Translation: BAE37634.1 .
    AK168116 mRNA. Translation: BAE40087.1 .
    AK169104 mRNA. Translation: BAE40886.1 .
    BC005461 mRNA. Translation: AAH05461.1 .
    CCDSi CCDS30397.1.
    RefSeqi NP_063921.1. NM_019868.3.
    XP_006528646.1. XM_006528583.1.
    UniGenei Mm.315909.

    3D structure databases

    ProteinModelPortali P70333.
    SMRi P70333. Positions 4-193, 277-401.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207865. 14 interactions.
    IntActi P70333. 3 interactions.
    MINTi MINT-4097696.

    PTM databases

    PhosphoSitei P70333.

    Proteomic databases

    MaxQBi P70333.
    PaxDbi P70333.
    PRIDEi P70333.

    Protocols and materials databases

    DNASUi 56258.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000050331 ; ENSMUSP00000108827 ; ENSMUSG00000045427 .
    ENSMUST00000059297 ; ENSMUSP00000050838 ; ENSMUSG00000045427 .
    ENSMUST00000074950 ; ENSMUSP00000074483 ; ENSMUSG00000045427 .
    ENSMUST00000113202 ; ENSMUSP00000108828 ; ENSMUSG00000045427 .
    ENSMUST00000113203 ; ENSMUSP00000108829 ; ENSMUSG00000045427 .
    GeneIDi 56258.
    KEGGi mmu:56258.
    UCSCi uc009ugh.1. mouse.

    Organism-specific databases

    CTDi 3188.
    MGIi MGI:1201779. Hnrnph2.

    Phylogenomic databases

    eggNOGi NOG262593.
    GeneTreei ENSGT00620000087736.
    HOGENOMi HOG000220896.
    HOVERGENi HBG055557.
    InParanoidi P70333.
    KOi K12898.
    OMAi PPRKLMT.
    OrthoDBi EOG7BS4BZ.
    PhylomeDBi P70333.
    TreeFami TF316157.

    Miscellaneous databases

    NextBioi 312148.
    PROi P70333.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70333.
    Genevestigatori P70333.

    Family and domain databases

    Gene3Di 3.30.70.330. 3 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR012996. Znf_CHHC.
    [Graphical view ]
    Pfami PF08080. zf-RNPHF. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 3 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci."
      Oeltjen J.C., Liu X., Lu J., Allen R.C., Muzny D.M., Belmont J.W., Gibbs R.A.
      Mamm. Genome 6:334-338(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: C129.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: BALB/c and C57BL/6J.
      Tissue: Kidney and Spinal cord.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiHNRH2_MOUSE
    AccessioniPrimary (citable) accession number: P70333
    Secondary accession number(s): Q3THV9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 114 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3