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P70333

- HNRH2_MOUSE

UniProt

P70333 - HNRH2_MOUSE

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Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

Hnrnph2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity).By similarity

GO - Molecular functioni

  1. nucleotide binding Source: InterPro
  2. poly(A) RNA binding Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiREACT_233950. Processing of Capped Intron-Containing Pre-mRNA.
REACT_260226. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H2
Short name:
hnRNP H2
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein H'
Short name:
hnRNP H'
Cleaved into the following chain:
Gene namesi
Name:Hnrnph2
Synonyms:Hnrph2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1201779. Hnrnph2.

Subcellular locationi

Nucleusnucleoplasm By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 449449Heterogeneous nuclear ribonucleoprotein H2PRO_0000081860Add
BLAST
Initiator methioninei1 – 11Removed; alternateBy similarity
Chaini2 – 449448Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedPRO_0000423274Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity
Modified residuei23 – 231PhosphoserineBy similarity
Modified residuei63 – 631PhosphoserineBy similarity
Modified residuei233 – 2331Dimethylated arginine; alternateBy similarity
Modified residuei233 – 2331Omega-N-methylarginine; alternateBy similarity
Modified residuei246 – 2461PhosphotyrosineBy similarity
Modified residuei310 – 3101PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP70333.
PaxDbiP70333.
PRIDEiP70333.

PTM databases

PhosphoSiteiP70333.

Expressioni

Gene expression databases

BgeeiP70333.
ExpressionAtlasiP70333. baseline and differential.
GenevestigatoriP70333.

Interactioni

Subunit structurei

Interacts with TXNL4/DIM1.By similarity

Protein-protein interaction databases

BioGridi207865. 14 interactions.
IntActiP70333. 3 interactions.
MINTiMINT-4097696.

Structurei

3D structure databases

ProteinModelPortaliP70333.
SMRiP70333. Positions 4-193, 277-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini11 – 9080RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini111 – 18878RRM 2PROSITE-ProRule annotationAdd
BLAST
Repeati234 – 249161-1Add
BLAST
Domaini289 – 36476RRM 3PROSITE-ProRule annotationAdd
BLAST
Repeati354 – 372192-1Add
BLAST
Repeati374 – 392192-2Add
BLAST
Repeati418 – 433161-2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni234 – 4332002 X 16 AA Gly-rich approximate repeatsAdd
BLAST
Regioni354 – 392392 X 19 AA perfect repeatsAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG262593.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP70333.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG7BS4BZ.
PhylomeDBiP70333.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70333-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMLSTEGREG FVVKVRGLPW SCSAEEVMRF FSDCKIQNGT SGVRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMTMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Length:449
Mass (Da):49,280
Last modified:February 1, 1997 - v1
Checksum:i2ED0A7A87A7EDF5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58105 Genomic DNA. Translation: AAB47243.1.
AK077716 mRNA. Translation: BAC36976.1.
AK164115 mRNA. Translation: BAE37634.1.
AK168116 mRNA. Translation: BAE40087.1.
AK169104 mRNA. Translation: BAE40886.1.
BC005461 mRNA. Translation: AAH05461.1.
CCDSiCCDS30397.1.
RefSeqiNP_063921.1. NM_019868.3.
XP_006528646.1. XM_006528583.1.
UniGeneiMm.315909.

Genome annotation databases

EnsembliENSMUST00000050331; ENSMUSP00000108827; ENSMUSG00000045427.
ENSMUST00000059297; ENSMUSP00000050838; ENSMUSG00000045427.
ENSMUST00000074950; ENSMUSP00000074483; ENSMUSG00000045427.
ENSMUST00000113202; ENSMUSP00000108828; ENSMUSG00000045427.
ENSMUST00000113203; ENSMUSP00000108829; ENSMUSG00000045427.
GeneIDi56258.
KEGGimmu:56258.
UCSCiuc009ugh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58105 Genomic DNA. Translation: AAB47243.1 .
AK077716 mRNA. Translation: BAC36976.1 .
AK164115 mRNA. Translation: BAE37634.1 .
AK168116 mRNA. Translation: BAE40087.1 .
AK169104 mRNA. Translation: BAE40886.1 .
BC005461 mRNA. Translation: AAH05461.1 .
CCDSi CCDS30397.1.
RefSeqi NP_063921.1. NM_019868.3.
XP_006528646.1. XM_006528583.1.
UniGenei Mm.315909.

3D structure databases

ProteinModelPortali P70333.
SMRi P70333. Positions 4-193, 277-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207865. 14 interactions.
IntActi P70333. 3 interactions.
MINTi MINT-4097696.

PTM databases

PhosphoSitei P70333.

Proteomic databases

MaxQBi P70333.
PaxDbi P70333.
PRIDEi P70333.

Protocols and materials databases

DNASUi 56258.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000050331 ; ENSMUSP00000108827 ; ENSMUSG00000045427 .
ENSMUST00000059297 ; ENSMUSP00000050838 ; ENSMUSG00000045427 .
ENSMUST00000074950 ; ENSMUSP00000074483 ; ENSMUSG00000045427 .
ENSMUST00000113202 ; ENSMUSP00000108828 ; ENSMUSG00000045427 .
ENSMUST00000113203 ; ENSMUSP00000108829 ; ENSMUSG00000045427 .
GeneIDi 56258.
KEGGi mmu:56258.
UCSCi uc009ugh.1. mouse.

Organism-specific databases

CTDi 3188.
MGIi MGI:1201779. Hnrnph2.

Phylogenomic databases

eggNOGi NOG262593.
GeneTreei ENSGT00760000119102.
HOGENOMi HOG000220896.
HOVERGENi HBG055557.
InParanoidi P70333.
KOi K12898.
OMAi PPRKLMT.
OrthoDBi EOG7BS4BZ.
PhylomeDBi P70333.
TreeFami TF316157.

Enzyme and pathway databases

Reactomei REACT_233950. Processing of Capped Intron-Containing Pre-mRNA.
REACT_260226. mRNA Splicing - Major Pathway.

Miscellaneous databases

NextBioi 312148.
PROi P70333.
SOURCEi Search...

Gene expression databases

Bgeei P70333.
ExpressionAtlasi P70333. baseline and differential.
Genevestigatori P70333.

Family and domain databases

Gene3Di 3.30.70.330. 3 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view ]
Pfami PF08080. zf-RNPHF. 1 hit.
[Graphical view ]
SMARTi SM00360. RRM. 3 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci."
    Oeltjen J.C., Liu X., Lu J., Allen R.C., Muzny D.M., Belmont J.W., Gibbs R.A.
    Mamm. Genome 6:334-338(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: C129.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: BALB/c and C57BL/6J.
    Tissue: Kidney and Spinal cord.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Mammary gland.

Entry informationi

Entry nameiHNRH2_MOUSE
AccessioniPrimary (citable) accession number: P70333
Secondary accession number(s): Q3THV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3