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P70333 (HNRH2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Heterogeneous nuclear ribonucleoprotein H2

Short name=hnRNP H2
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein H'
Short name=hnRNP H'
Gene names
Name:Hnrnph2
Synonyms:Hnrph2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length449 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) By similarity.

Subunit structure

Interacts with TXNL4/DIM1 By similarity.

Subcellular location

Nucleusnucleoplasm By similarity.

Sequence similarities

Contains 3 RRM (RNA recognition motif) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 449449Heterogeneous nuclear ribonucleoprotein H2
PRO_0000081860
Initiator methionine11Removed; alternate By similarity
Chain2 – 449448Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed
PRO_0000423274

Regions

Domain11 – 9080RRM 1
Domain111 – 18878RRM 2
Repeat234 – 249161-1
Domain289 – 36476RRM 3
Repeat354 – 372192-1
Repeat374 – 392192-2
Repeat418 – 433161-2
Region234 – 4332002 X 16 AA Gly-rich approximate repeats
Region354 – 392392 X 19 AA perfect repeats

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue21N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processed By similarity
Modified residue231Phosphoserine By similarity
Modified residue631Phosphoserine By similarity
Modified residue2331Dimethylated arginine; alternate By similarity
Modified residue2331Omega-N-methylarginine; alternate By similarity
Modified residue2461Phosphotyrosine By similarity
Modified residue3101Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P70333 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 2ED0A7A87A7EDF5E

FASTA44949,280
        10         20         30         40         50         60 
MMLSTEGREG FVVKVRGLPW SCSAEEVMRF FSDCKIQNGT SGVRFIYTRE GRPSGEAFVE 

        70         80         90        100        110        120 
LESEDEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT GPNSPDTAND GFVRLRGLPF 

       130        140        150        160        170        180 
GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR STGEAFVQFA SQEIAEKALK KHKERIGHRY 

       190        200        210        220        230        240 
IEIFKSSRAE VRTHYDPPRK LMTMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY 

       250        260        270        280        290        300 
GGYDDYGGYN DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA 

       310        320        330        340        350        360 
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA NMQHRYVELF 

       370        380        390        400        410        420 
LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM GLSNQSSYGG PASQQLSGGY 

       430        440 
GGGYGGQSSM SGYDQVLQEN SSDYQSNLA 

« Hide

References

« Hide 'large scale' references
[1]"Sixty-nine kilobases of contiguous human genomic sequence containing the alpha-galactosidase A and Bruton's tyrosine kinase loci."
Oeltjen J.C., Liu X., Lu J., Allen R.C., Muzny D.M., Belmont J.W., Gibbs R.A.
Mamm. Genome 6:334-338(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: C129.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: BALB/c and C57BL/6J.
Tissue: Kidney and Spinal cord.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U58105 Genomic DNA. Translation: AAB47243.1.
AK077716 mRNA. Translation: BAC36976.1.
AK164115 mRNA. Translation: BAE37634.1.
AK168116 mRNA. Translation: BAE40087.1.
AK169104 mRNA. Translation: BAE40886.1.
BC005461 mRNA. Translation: AAH05461.1.
RefSeqNP_063921.1. NM_019868.3.
XP_006528646.1. XM_006528583.1.
UniGeneMm.315909.

3D structure databases

ProteinModelPortalP70333.
SMRP70333. Positions 4-193, 277-401.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207865. 13 interactions.
IntActP70333. 3 interactions.
MINTMINT-4097696.

PTM databases

PhosphoSiteP70333.

Proteomic databases

PaxDbP70333.
PRIDEP70333.

Protocols and materials databases

DNASU56258.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000050331; ENSMUSP00000108827; ENSMUSG00000045427.
ENSMUST00000059297; ENSMUSP00000050838; ENSMUSG00000045427.
ENSMUST00000074950; ENSMUSP00000074483; ENSMUSG00000045427.
ENSMUST00000113202; ENSMUSP00000108828; ENSMUSG00000045427.
ENSMUST00000113203; ENSMUSP00000108829; ENSMUSG00000045427.
GeneID56258.
KEGGmmu:56258.
UCSCuc009ugh.1. mouse.

Organism-specific databases

CTD3188.
MGIMGI:1201779. Hnrnph2.

Phylogenomic databases

eggNOGNOG262593.
GeneTreeENSGT00620000087736.
HOGENOMHOG000220896.
HOVERGENHBG055557.
InParanoidP70333.
KOK12898.
OMAPPRKLMT.
OrthoDBEOG7BS4BZ.
PhylomeDBP70333.
TreeFamTF316157.

Gene expression databases

BgeeP70333.
GenevestigatorP70333.

Family and domain databases

Gene3D3.30.70.330. 3 hits.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamPF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTSM00360. RRM. 3 hits.
[Graphical view]
PROSITEPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio312148.
PROP70333.
SOURCESearch...

Entry information

Entry nameHNRH2_MOUSE
AccessionPrimary (citable) accession number: P70333
Secondary accession number(s): Q3THV9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot