Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heterogeneous nuclear ribonucleoprotein H2

Gene

Hnrnph2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Binds poly(RG) (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H2
Short name:
hnRNP H2
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein H'
Short name:
hnRNP H'
Cleaved into the following chain:
Gene namesi
Name:Hnrnph2
Synonyms:Hnrph2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1201779. Hnrnph2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818601 – 449Heterogeneous nuclear ribonucleoprotein H2Add BLAST449
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00004343862 – 449Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H2, N-terminally processedBy similarity1
Modified residuei23PhosphoserineBy similarity1
Modified residuei54PhosphoserineBy similarity1
Modified residuei63PhosphoserineBy similarity1
Modified residuei90PhosphoserineCombined sources1
Modified residuei233Dimethylated arginine; alternateBy similarity1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1
Modified residuei246PhosphotyrosineBy similarity1
Modified residuei310PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP70333.
MaxQBiP70333.
PaxDbiP70333.
PeptideAtlasiP70333.
PRIDEiP70333.

PTM databases

iPTMnetiP70333.
PhosphoSitePlusiP70333.

Expressioni

Gene expression databases

BgeeiENSMUSG00000045427.
GenevisibleiP70333. MM.

Interactioni

Subunit structurei

Interacts with TXNL4/DIM1.By similarity

Protein-protein interaction databases

BioGridi207865. 8 interactors.
IntActiP70333. 4 interactors.
MINTiMINT-4097696.
STRINGi10090.ENSMUSP00000050838.

Structurei

3D structure databases

ProteinModelPortaliP70333.
SMRiP70333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP70333.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP70333.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLSTEGREG FVVKVRGLPW SCSAEEVMRF FSDCKIQNGT SGVRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNS VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG MTLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMTMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYGGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG SSFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPMRVHIE IGPDGRVTGE ADVEFATHED AVAAMAKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGTSGG AYDHSYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDYQSNLA
Length:449
Mass (Da):49,280
Last modified:February 1, 1997 - v1
Checksum:i2ED0A7A87A7EDF5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58105 Genomic DNA. Translation: AAB47243.1.
AK077716 mRNA. Translation: BAC36976.1.
AK164115 mRNA. Translation: BAE37634.1.
AK168116 mRNA. Translation: BAE40087.1.
AK169104 mRNA. Translation: BAE40886.1.
BC005461 mRNA. Translation: AAH05461.1.
CCDSiCCDS30397.1.
RefSeqiNP_001300645.1. NM_001313716.1.
NP_001300646.1. NM_001313717.1.
NP_063921.1. NM_019868.4.
UniGeneiMm.315909.

Genome annotation databases

EnsembliENSMUST00000050331; ENSMUSP00000108827; ENSMUSG00000045427.
ENSMUST00000059297; ENSMUSP00000050838; ENSMUSG00000045427.
ENSMUST00000074950; ENSMUSP00000074483; ENSMUSG00000045427.
ENSMUST00000113202; ENSMUSP00000108828; ENSMUSG00000045427.
ENSMUST00000113203; ENSMUSP00000108829; ENSMUSG00000045427.
GeneIDi56258.
KEGGimmu:56258.
UCSCiuc009ugh.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58105 Genomic DNA. Translation: AAB47243.1.
AK077716 mRNA. Translation: BAC36976.1.
AK164115 mRNA. Translation: BAE37634.1.
AK168116 mRNA. Translation: BAE40087.1.
AK169104 mRNA. Translation: BAE40886.1.
BC005461 mRNA. Translation: AAH05461.1.
CCDSiCCDS30397.1.
RefSeqiNP_001300645.1. NM_001313716.1.
NP_001300646.1. NM_001313717.1.
NP_063921.1. NM_019868.4.
UniGeneiMm.315909.

3D structure databases

ProteinModelPortaliP70333.
SMRiP70333.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207865. 8 interactors.
IntActiP70333. 4 interactors.
MINTiMINT-4097696.
STRINGi10090.ENSMUSP00000050838.

PTM databases

iPTMnetiP70333.
PhosphoSitePlusiP70333.

Proteomic databases

EPDiP70333.
MaxQBiP70333.
PaxDbiP70333.
PeptideAtlasiP70333.
PRIDEiP70333.

Protocols and materials databases

DNASUi56258.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050331; ENSMUSP00000108827; ENSMUSG00000045427.
ENSMUST00000059297; ENSMUSP00000050838; ENSMUSG00000045427.
ENSMUST00000074950; ENSMUSP00000074483; ENSMUSG00000045427.
ENSMUST00000113202; ENSMUSP00000108828; ENSMUSG00000045427.
ENSMUST00000113203; ENSMUSP00000108829; ENSMUSG00000045427.
GeneIDi56258.
KEGGimmu:56258.
UCSCiuc009ugh.1. mouse.

Organism-specific databases

CTDi3188.
MGIiMGI:1201779. Hnrnph2.

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP70333.
KOiK12898.
OMAiPPRKLMT.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP70333.
TreeFamiTF316157.

Enzyme and pathway databases

ReactomeiR-MMU-72163. mRNA Splicing - Major Pathway.
R-MMU-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

PROiP70333.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045427.
GenevisibleiP70333. MM.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH2_MOUSE
AccessioniPrimary (citable) accession number: P70333
Secondary accession number(s): Q3THV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.