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P70326

- TBX5_MOUSE

UniProt

P70326 - TBX5_MOUSE

Protein

T-box transcription factor TBX5

Gene

Tbx5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (01 Dec 2000)
      Previous versions | rss
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    Functioni

    Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi58 – 238181T-boxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: MGI
    3. RNA polymerase II regulatory region sequence-specific DNA binding Source: BHF-UCL
    4. RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: MGI
    5. sequence-specific DNA binding Source: UniProtKB
    6. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. apoptotic nuclear changes Source: Ensembl
    2. atrial septum development Source: MGI
    3. atrial septum morphogenesis Source: MGI
    4. atrioventricular valve morphogenesis Source: MGI
    5. bundle of His development Source: MGI
    6. cardiac left ventricle formation Source: BHF-UCL
    7. cardiac muscle cell differentiation Source: BHF-UCL
    8. cell-cell signaling Source: UniProtKB
    9. embryonic forelimb morphogenesis Source: UniProtKB
    10. embryonic limb morphogenesis Source: UniProtKB
    11. endocardial cushion development Source: MGI
    12. forelimb morphogenesis Source: MGI
    13. heart development Source: UniProtKB
    14. lung development Source: MGI
    15. morphogenesis of an epithelium Source: MGI
    16. negative regulation of cardiac muscle cell proliferation Source: UniProtKB
    17. negative regulation of cell migration Source: UniProtKB
    18. negative regulation of cell proliferation Source: UniProtKB
    19. pattern specification process Source: MGI
    20. pericardium development Source: UniProtKB
    21. positive regulation of cardiac muscle cell proliferation Source: MGI
    22. positive regulation of cardioblast differentiation Source: UniProtKB
    23. positive regulation of secondary heart field cardioblast proliferation Source: MGI
    24. positive regulation of transcription, DNA-templated Source: UniProtKB
    25. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    26. regulation of execution phase of apoptosis Source: UniProtKB
    27. regulation of transcription, DNA-templated Source: MGI
    28. ventricular cardiac muscle tissue development Source: MGI
    29. ventricular septum development Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    T-box transcription factor TBX5
    Short name:
    T-box protein 5
    Gene namesi
    Name:Tbx5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:102541. Tbx5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 518518T-box transcription factor TBX5PRO_0000184436Add
    BLAST

    Proteomic databases

    PaxDbiP70326.
    PRIDEiP70326.

    PTM databases

    PhosphoSiteiP70326.

    Expressioni

    Developmental stagei

    First expressed at day 7.5, exclusively in the allantois. At day 8.5, expressed only in the sinous venosus of the developing heart. At day 9.5, expression observed in the forelimb bud, optic vesicle and sinous venosus. By day 12.5, expression is limited to the retina, the body wall and the mesenchyme of the lung, of the mandible and of that surrounding the trachea.1 Publication

    Gene expression databases

    ArrayExpressiP70326.
    BgeeiP70326.
    CleanExiMM_TBX5.
    GenevestigatoriP70326.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    BioGridi203990. 3 interactions.
    DIPiDIP-48887N.
    IntActiP70326. 1 interaction.
    MINTiMINT-4137187.

    Structurei

    3D structure databases

    ProteinModelPortaliP70326.
    SMRiP70326. Positions 52-230.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG320009.
    HOGENOMiHOG000286001.
    HOVERGENiHBG007310.
    InParanoidiP70326.
    KOiK10179.
    OMAiSKDLPCD.
    OrthoDBiEOG7GN2PM.
    PhylomeDBiP70326.
    TreeFamiTF106341.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70326-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADTDEGFGL ARTPLEPDSK DRSCDSKPES ALGAPSKSPS SPQAAFTQQG    50
    MEGIKVFLHE RELWLKFHEV GTEMIITKAG RRMFPSYKVK VTGLNPKTKY 100
    ILLMDIVPAD DHRYKFADNK WSVTGKAEPA MPGRLYVHPD SPATGAHWMR 150
    QLVSFQKLKL TNNHLDPFGH IILNSMHKYQ PRLHIVKADE NNGFGSKNTA 200
    FCTHVFPETA FIAVTSYQNH KITQLKIENN PFAKGFRGSD DLELHRMSRM 250
    QSKEYPVVPR STVRHKVTSN HSPFSSETRA LSTSSNLGSQ YQCENGVSGP 300
    SQDLLPPPNP YPLAQEHSQI YHCTKRKDEE CSSTEHPYKK PYMETSPSEE 350
    DTFYRSGYPQ QQGLSTSYRT ESAQRQACMY ASSAPPSEPV PSLEDISCNT 400
    WPSMPSYSSC TVTTVQPMDR LPYQHFSAHF TSGPLVPRLA GMANHGSPQL 450
    GEGMFQHQTS VAHQPVVRQC GPQTGLQSPG GLQPPEFLYT HGVPRTLSPH 500
    QYHSVHGVGM VPEWSENS 518
    Length:518
    Mass (Da):57,832
    Last modified:December 1, 2000 - v2
    Checksum:i4990A802EB56624B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti68 – 714HEVG → RSGV in AAC53109. (PubMed:8878690)Curated
    Sequence conflicti81 – 811R → G in AAC53109. (PubMed:8878690)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140427 mRNA. Translation: AAF00112.1.
    U57330 mRNA. Translation: AAC53109.1.
    CCDSiCCDS19615.1.
    PIRiS72231.
    RefSeqiNP_035667.1. NM_011537.3.
    XP_006530343.1. XM_006530280.1.
    XP_006530344.1. XM_006530281.1.
    XP_006530345.1. XM_006530282.1.
    XP_006530346.1. XM_006530283.1.
    UniGeneiMm.103636.

    Genome annotation databases

    EnsembliENSMUST00000018407; ENSMUSP00000018407; ENSMUSG00000018263.
    GeneIDi21388.
    KEGGimmu:21388.
    UCSCiuc008zgz.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF140427 mRNA. Translation: AAF00112.1 .
    U57330 mRNA. Translation: AAC53109.1 .
    CCDSi CCDS19615.1.
    PIRi S72231.
    RefSeqi NP_035667.1. NM_011537.3.
    XP_006530343.1. XM_006530280.1.
    XP_006530344.1. XM_006530281.1.
    XP_006530345.1. XM_006530282.1.
    XP_006530346.1. XM_006530283.1.
    UniGenei Mm.103636.

    3D structure databases

    ProteinModelPortali P70326.
    SMRi P70326. Positions 52-230.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203990. 3 interactions.
    DIPi DIP-48887N.
    IntActi P70326. 1 interaction.
    MINTi MINT-4137187.

    PTM databases

    PhosphoSitei P70326.

    Proteomic databases

    PaxDbi P70326.
    PRIDEi P70326.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000018407 ; ENSMUSP00000018407 ; ENSMUSG00000018263 .
    GeneIDi 21388.
    KEGGi mmu:21388.
    UCSCi uc008zgz.2. mouse.

    Organism-specific databases

    CTDi 6910.
    MGIi MGI:102541. Tbx5.

    Phylogenomic databases

    eggNOGi NOG320009.
    HOGENOMi HOG000286001.
    HOVERGENi HBG007310.
    InParanoidi P70326.
    KOi K10179.
    OMAi SKDLPCD.
    OrthoDBi EOG7GN2PM.
    PhylomeDBi P70326.
    TreeFami TF106341.

    Enzyme and pathway databases

    Reactomei REACT_196516. YAP1- and WWTR1 (TAZ)-stimulated gene expression.

    Miscellaneous databases

    NextBioi 300636.
    PROi P70326.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70326.
    Bgeei P70326.
    CleanExi MM_TBX5.
    Genevestigatori P70326.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome."
      Bruneau B.G., Logan M., Davis N., Levi T., Tabin C.J., Seidman J.G., Seidman C.E.
      Dev. Biol. 211:100-108(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Limb.
    2. "Evolution of mouse T-box genes by tandem duplication and cluster dispersion."
      Agulnik S.I., Garvey N., Hancock S., Ruvinsky I., Chapman D.L., Agulnik I., Bollag R.J., Papaioannou V.E., Silver L.M.
      Genetics 144:249-254(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 63-246.
      Tissue: Embryo.
    3. Cited for: DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiTBX5_MOUSE
    AccessioniPrimary (citable) accession number: P70326
    Secondary accession number(s): Q9R003
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: December 1, 2000
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3