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Protein

T-box transcription factor TBX4

Gene

Tbx4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi76 – 256181T-boxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: MGI
  • embryonic limb morphogenesis Source: MGI
  • limb morphogenesis Source: UniProtKB
  • lung development Source: MGI
  • morphogenesis of an epithelium Source: MGI
  • skeletal system morphogenesis Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX4
Short name:
T-box protein 4
Gene namesi
Name:Tbx4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:102556. Tbx4.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552T-box transcription factor TBX4PRO_0000184434Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei514 – 5141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP70325.
PRIDEiP70325.

PTM databases

iPTMnetiP70325.
PhosphoSiteiP70325.

Expressioni

Developmental stagei

First expressed at day 7.5, exclusively in the allantois where expression continues through day 8.5. At day 9.5, expression is found in the genital papilla, body wall and limb buds (higher levels in hindlimb). At day 12.5, expressed in the mesenchyme of the mandibular arch, of the lung and of that surrounding the trachea. Also found in the sinus venosus/common atrium of the developing heart.1 Publication

Gene expression databases

BgeeiENSMUSG00000000094.
CleanExiMM_TBX4.
ExpressionAtlasiP70325. baseline and differential.
GenevisibleiP70325. MM.

Interactioni

Protein-protein interaction databases

BioGridi203989. 1 interaction.
STRINGi10090.ENSMUSP00000000096.

Structurei

3D structure databases

ProteinModelPortaliP70325.
SMRiP70325. Positions 70-248.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000286001.
HOVERGENiHBG007310.
InParanoidiP70325.
KOiK10178.
OMAiCLKRRAD.
OrthoDBiEOG091G0I8R.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70325-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLQDKGLSES EEAFRAPGPA LGEASNTSTT NAPEPALATP GLSGAALSSP
60 70 80 90 100
PGQGADVAAA AAAAAEQTIE NIKVGLHEKE LWKKFHEAGT EMIITKAGRR
110 120 130 140 150
MFPSYKVKVT GMNPKTKYIL LIDIVPADDH RYKFCDNKWM VAGKAEPAMP
160 170 180 190 200
GRLYVHPDSP ATGAHWMRQL VSFQKLKLTN NHLDPFGHII LNSMHKYQPR
210 220 230 240 250
LHIVKADENN AFGSKNTAFC THVFPETSFI SVTSYQNHKI TQLKIENNPF
260 270 280 290 300
AKGFRGSDDS DLRVARLQSK EYPVISKSIM RQRLVSSQLS AKPDVSPLHS
310 320 330 340 350
AHQALQHYQY ENGAHMQFAA AEPQDLPLNT FPTQRDSSLF YHCLKRRDSA
360 370 380 390 400
RHLDLPCKRS YLETPSSVGD DHYFRSPPPY DQQMLSPSYC SEVTPREACM
410 420 430 440 450
YSSSGPEIAG VSAVDDLPPP PLSCNMWTSV SPYTSYSVQT METVPYQPFP
460 470 480 490 500
AHFTATTVMP RLPTIAAQSA QPPGNAHFSV YNQLSQSQVR ERGPSASFPR
510 520 530 540 550
ERGLPGMCER KPPSPHLNTA NEFLYSQSFS LTRESSLQYH SGMGTVENWT

DG
Length:552
Mass (Da):61,101
Last modified:July 27, 2011 - v3
Checksum:i6F4E24171A1B4716
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 672EQ → DE in AAL77209 (Ref. 1) Curated
Sequence conflicti148 – 1481Missing in AAC53108 (PubMed:8878690).Curated
Sequence conflicti269 – 2691S → R in AAL77209 (Ref. 1) Curated
Sequence conflicti301 – 3011A → G in AAL77209 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY075134 mRNA. Translation: AAL77209.1.
AL592465 Genomic DNA. Translation: CAI25365.1.
CH466556 Genomic DNA. Translation: EDL15777.1.
U57329 mRNA. Translation: AAC53108.1.
CCDSiCCDS25196.1.
PIRiS72230.
RefSeqiNP_035666.2. NM_011536.2.
XP_006532843.1. XM_006532780.2.
UniGeneiMm.275336.

Genome annotation databases

EnsembliENSMUST00000000096; ENSMUSP00000000096; ENSMUSG00000000094.
ENSMUST00000108047; ENSMUSP00000103682; ENSMUSG00000000094.
GeneIDi21387.
KEGGimmu:21387.
UCSCiuc007ksc.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY075134 mRNA. Translation: AAL77209.1.
AL592465 Genomic DNA. Translation: CAI25365.1.
CH466556 Genomic DNA. Translation: EDL15777.1.
U57329 mRNA. Translation: AAC53108.1.
CCDSiCCDS25196.1.
PIRiS72230.
RefSeqiNP_035666.2. NM_011536.2.
XP_006532843.1. XM_006532780.2.
UniGeneiMm.275336.

3D structure databases

ProteinModelPortaliP70325.
SMRiP70325. Positions 70-248.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203989. 1 interaction.
STRINGi10090.ENSMUSP00000000096.

PTM databases

iPTMnetiP70325.
PhosphoSiteiP70325.

Proteomic databases

PaxDbiP70325.
PRIDEiP70325.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000096; ENSMUSP00000000096; ENSMUSG00000000094.
ENSMUST00000108047; ENSMUSP00000103682; ENSMUSG00000000094.
GeneIDi21387.
KEGGimmu:21387.
UCSCiuc007ksc.2. mouse.

Organism-specific databases

CTDi9496.
MGIiMGI:102556. Tbx4.

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000286001.
HOVERGENiHBG007310.
InParanoidiP70325.
KOiK10178.
OMAiCLKRRAD.
OrthoDBiEOG091G0I8R.

Miscellaneous databases

PROiP70325.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000094.
CleanExiMM_TBX4.
ExpressionAtlasiP70325. baseline and differential.
GenevisibleiP70325. MM.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 1 hit.
PfamiPF00907. T-box. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBX4_MOUSE
AccessioniPrimary (citable) accession number: P70325
Secondary accession number(s): B1AQT9, Q8R5F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.