P70321 (HXB13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B13

Gene names

Name:

Hoxb13

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	286 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Tissue specificity	Exhibits both spatial and temporal colinearity within the main body axis. At E12.5, is detected in hindgut, urogenital tract, spinal chord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from electronic annotation. Source: Compara epithelial cell maturation involved in prostate gland development Inferred from mutant phenotype PubMed 12668621. Source: MGI prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Inferred from genetic interaction PubMed 12620974. Source: MGI regulation of growth Inferred from mutant phenotype PubMed 12679105. Source: MGI response to testosterone stimulus Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor complex Inferred from direct assay PubMed 9343407. Source: MGI
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 286	286	Homeobox protein Hox-B13		PRO_0000200161
Regions
	DNA binding	218 – 277	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	P70321 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 1A6BFB4C4720E25F	FASTA	286	30,963
	10 20 30 40 50 60 MEPGNYATLD GAKDIEGLLG AGGGRNLVSH SSPLASHPAA PTLMPTVNYA PLDLPGSAEP 70 80 90 100 110 120 PKQCHPCPGV PQGASPAPVP YGYFGGGYYS CRVSRSSLKP CAQTAALATY PSETPAPGEE 130 140 150 160 170 180 YPSRPTEFAF YPGYPGPYQP MASYLDVSVV QTLGAPGEPR HDSLLPVDSY QPWALAGGWN 190 200 210 220 230 240 SQMCCQGEQN PPGPFWKAAF AEPSVQHPPP DGCAFRRGRK KRIPYSKGQL RELEREYAAN 250 260 270 280 KFITKDKRRK ISAATSLSER QITIWFQNRR VKEKKVLAKV KTSTTP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity." Zeltser L.M., Desplan C., Heintz N. Development 122:2475-2484(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Colon.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57051 mRNA. Translation: AAC52769.1. BC013639 mRNA. Translation: AAH13639.1. BC051087 mRNA. Translation: AAH51087.2. BC058813 mRNA. Translation: AAH58813.1.
IPI	IPI00108110.
RefSeq	NP_032293.1. NM_008267.3.
UniGene	Mm.57221.
3D structure databases
ProteinModelPortal	P70321.
SMR	P70321. Positions 212-275.
ModBase	Search...
Protein-protein interaction databases
IntAct	P70321. 1 interaction.
PTM databases
PhosphoSite	P70321.
Proteomic databases
PRIDE	P70321.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000062709; ENSMUSP00000056315; ENSMUSG00000049604.
GeneID	15408.
KEGG	mmu:15408.
Organism-specific databases
CTD	10481.
MGI	MGI:107730. Hoxb13.
Phylogenomic databases
eggNOG	NOG276440.
GeneTree	ENSGT00670000097683.
HOGENOM	HOG000231176.
HOVERGEN	HBG106958.
InParanoid	P70321.
OMA	EGCAFRR.
OrthoDB	EOG4J6RRD.
Gene expression databases
ArrayExpress	P70321.
Bgee	P70321.
CleanEx	MM_HOXB13.
Genevestigator	P70321.
GermOnline	ENSMUSG00000049604. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR022067. HoxA13_N. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF12284. HoxA13_N. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288124.
SOURCE	Search...

Entry information

Entry name

HXB13_MOUSE

Accession

Primary (citable) accession number: P70321
Secondary accession number(s): Q80Y12

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	April 3, 2013
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program