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Protein

Homeobox protein Hox-B13

Gene

Hoxb13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi218 – 27760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • angiogenesis Source: Ensembl
  • epithelial cell maturation involved in prostate gland development Source: MGI
  • morphogenesis of an epithelium Source: MGI
  • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  • regulation of growth Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • response to testosterone Source: Ensembl
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B13
Gene namesi
Name:Hoxb13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:107730. Hoxb13.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: MGI
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 286286Homeobox protein Hox-B13PRO_0000200161Add
BLAST

Proteomic databases

PRIDEiP70321.

PTM databases

PhosphoSiteiP70321.

Expressioni

Tissue specificityi

Exhibits both spatial and temporal colinearity within the main body axis. At E12.5, is detected in hindgut, urogenital tract, spinal chord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule.

Gene expression databases

BgeeiP70321.
CleanExiMM_HOXB13.
GenevestigatoriP70321.

Interactioni

Protein-protein interaction databases

BioGridi200376. 4 interactions.
IntActiP70321. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP70321.
SMRiP70321. Positions 212-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG276440.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP70321.
OMAiHPPDGCA.
OrthoDBiEOG7SJD53.
PhylomeDBiP70321.
TreeFamiTF330813.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70321-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGNYATLD GAKDIEGLLG AGGGRNLVSH SSPLASHPAA PTLMPTVNYA
60 70 80 90 100
PLDLPGSAEP PKQCHPCPGV PQGASPAPVP YGYFGGGYYS CRVSRSSLKP
110 120 130 140 150
CAQTAALATY PSETPAPGEE YPSRPTEFAF YPGYPGPYQP MASYLDVSVV
160 170 180 190 200
QTLGAPGEPR HDSLLPVDSY QPWALAGGWN SQMCCQGEQN PPGPFWKAAF
210 220 230 240 250
AEPSVQHPPP DGCAFRRGRK KRIPYSKGQL RELEREYAAN KFITKDKRRK
260 270 280
ISAATSLSER QITIWFQNRR VKEKKVLAKV KTSTTP
Length:286
Mass (Da):30,963
Last modified:February 1, 1997 - v1
Checksum:i1A6BFB4C4720E25F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57051 mRNA. Translation: AAC52769.1.
BC013639 mRNA. Translation: AAH13639.1.
BC051087 mRNA. Translation: AAH51087.2.
BC058813 mRNA. Translation: AAH58813.1.
CCDSiCCDS25291.1.
RefSeqiNP_032293.1. NM_008267.3.
UniGeneiMm.57221.

Genome annotation databases

EnsembliENSMUST00000062709; ENSMUSP00000056315; ENSMUSG00000049604.
GeneIDi15408.
KEGGimmu:15408.
UCSCiuc007lbk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57051 mRNA. Translation: AAC52769.1.
BC013639 mRNA. Translation: AAH13639.1.
BC051087 mRNA. Translation: AAH51087.2.
BC058813 mRNA. Translation: AAH58813.1.
CCDSiCCDS25291.1.
RefSeqiNP_032293.1. NM_008267.3.
UniGeneiMm.57221.

3D structure databases

ProteinModelPortaliP70321.
SMRiP70321. Positions 212-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200376. 4 interactions.
IntActiP70321. 1 interaction.

PTM databases

PhosphoSiteiP70321.

Proteomic databases

PRIDEiP70321.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062709; ENSMUSP00000056315; ENSMUSG00000049604.
GeneIDi15408.
KEGGimmu:15408.
UCSCiuc007lbk.1. mouse.

Organism-specific databases

CTDi10481.
MGIiMGI:107730. Hoxb13.

Phylogenomic databases

eggNOGiNOG276440.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP70321.
OMAiHPPDGCA.
OrthoDBiEOG7SJD53.
PhylomeDBiP70321.
TreeFamiTF330813.

Miscellaneous databases

NextBioi288124.
PROiP70321.
SOURCEiSearch...

Gene expression databases

BgeeiP70321.
CleanExiMM_HOXB13.
GenevestigatoriP70321.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity."
    Zeltser L.M., Desplan C., Heintz N.
    Development 122:2475-2484(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiHXB13_MOUSE
AccessioniPrimary (citable) accession number: P70321
Secondary accession number(s): Q80Y12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.