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P70321

- HXB13_MOUSE

UniProt

P70321 - HXB13_MOUSE

Protein

Homeobox protein Hox-B13

Gene

Hoxb13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi218 – 27760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. sequence-specific DNA binding Source: InterPro
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. epithelial cell maturation involved in prostate gland development Source: MGI
    3. morphogenesis of an epithelium Source: MGI
    4. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
    5. regulation of growth Source: MGI
    6. response to testosterone Source: Ensembl
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B13
    Gene namesi
    Name:Hoxb13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:107730. Hoxb13.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 286286Homeobox protein Hox-B13PRO_0000200161Add
    BLAST

    Proteomic databases

    PRIDEiP70321.

    PTM databases

    PhosphoSiteiP70321.

    Expressioni

    Tissue specificityi

    Exhibits both spatial and temporal colinearity within the main body axis. At E12.5, is detected in hindgut, urogenital tract, spinal chord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule.

    Gene expression databases

    BgeeiP70321.
    CleanExiMM_HOXB13.
    GenevestigatoriP70321.

    Interactioni

    Protein-protein interaction databases

    BioGridi200376. 4 interactions.
    IntActiP70321. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP70321.
    SMRiP70321. Positions 212-275.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG276440.
    GeneTreeiENSGT00730000110374.
    HOGENOMiHOG000231176.
    HOVERGENiHBG106958.
    InParanoidiP70321.
    OMAiHPPDGCA.
    OrthoDBiEOG7SJD53.
    PhylomeDBiP70321.
    TreeFamiTF330813.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70321-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGNYATLD GAKDIEGLLG AGGGRNLVSH SSPLASHPAA PTLMPTVNYA    50
    PLDLPGSAEP PKQCHPCPGV PQGASPAPVP YGYFGGGYYS CRVSRSSLKP 100
    CAQTAALATY PSETPAPGEE YPSRPTEFAF YPGYPGPYQP MASYLDVSVV 150
    QTLGAPGEPR HDSLLPVDSY QPWALAGGWN SQMCCQGEQN PPGPFWKAAF 200
    AEPSVQHPPP DGCAFRRGRK KRIPYSKGQL RELEREYAAN KFITKDKRRK 250
    ISAATSLSER QITIWFQNRR VKEKKVLAKV KTSTTP 286
    Length:286
    Mass (Da):30,963
    Last modified:February 1, 1997 - v1
    Checksum:i1A6BFB4C4720E25F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57051 mRNA. Translation: AAC52769.1.
    BC013639 mRNA. Translation: AAH13639.1.
    BC051087 mRNA. Translation: AAH51087.2.
    BC058813 mRNA. Translation: AAH58813.1.
    CCDSiCCDS25291.1.
    RefSeqiNP_032293.1. NM_008267.3.
    UniGeneiMm.57221.

    Genome annotation databases

    EnsembliENSMUST00000062709; ENSMUSP00000056315; ENSMUSG00000049604.
    GeneIDi15408.
    KEGGimmu:15408.
    UCSCiuc007lbk.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57051 mRNA. Translation: AAC52769.1 .
    BC013639 mRNA. Translation: AAH13639.1 .
    BC051087 mRNA. Translation: AAH51087.2 .
    BC058813 mRNA. Translation: AAH58813.1 .
    CCDSi CCDS25291.1.
    RefSeqi NP_032293.1. NM_008267.3.
    UniGenei Mm.57221.

    3D structure databases

    ProteinModelPortali P70321.
    SMRi P70321. Positions 212-275.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200376. 4 interactions.
    IntActi P70321. 1 interaction.

    PTM databases

    PhosphoSitei P70321.

    Proteomic databases

    PRIDEi P70321.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000062709 ; ENSMUSP00000056315 ; ENSMUSG00000049604 .
    GeneIDi 15408.
    KEGGi mmu:15408.
    UCSCi uc007lbk.1. mouse.

    Organism-specific databases

    CTDi 10481.
    MGIi MGI:107730. Hoxb13.

    Phylogenomic databases

    eggNOGi NOG276440.
    GeneTreei ENSGT00730000110374.
    HOGENOMi HOG000231176.
    HOVERGENi HBG106958.
    InParanoidi P70321.
    OMAi HPPDGCA.
    OrthoDBi EOG7SJD53.
    PhylomeDBi P70321.
    TreeFami TF330813.

    Miscellaneous databases

    NextBioi 288124.
    PROi P70321.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70321.
    CleanExi MM_HOXB13.
    Genevestigatori P70321.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity."
      Zeltser L.M., Desplan C., Heintz N.
      Development 122:2475-2484(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiHXB13_MOUSE
    AccessioniPrimary (citable) accession number: P70321
    Secondary accession number(s): Q80Y12
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3