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P70321 (HXB13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B13
Gene names
Name:Hoxb13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length286 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Tissue specificity

Exhibits both spatial and temporal colinearity within the main body axis. At E12.5, is detected in hindgut, urogenital tract, spinal chord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 286286Homeobox protein Hox-B13
PRO_0000200161

Regions

DNA binding218 – 27760Homeobox

Sequences

Sequence LengthMass (Da)Tools
P70321 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 1A6BFB4C4720E25F

FASTA28630,963
        10         20         30         40         50         60 
MEPGNYATLD GAKDIEGLLG AGGGRNLVSH SSPLASHPAA PTLMPTVNYA PLDLPGSAEP 

        70         80         90        100        110        120 
PKQCHPCPGV PQGASPAPVP YGYFGGGYYS CRVSRSSLKP CAQTAALATY PSETPAPGEE 

       130        140        150        160        170        180 
YPSRPTEFAF YPGYPGPYQP MASYLDVSVV QTLGAPGEPR HDSLLPVDSY QPWALAGGWN 

       190        200        210        220        230        240 
SQMCCQGEQN PPGPFWKAAF AEPSVQHPPP DGCAFRRGRK KRIPYSKGQL RELEREYAAN 

       250        260        270        280 
KFITKDKRRK ISAATSLSER QITIWFQNRR VKEKKVLAKV KTSTTP 

« Hide

References

« Hide 'large scale' references
[1]"Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity."
Zeltser L.M., Desplan C., Heintz N.
Development 122:2475-2484(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U57051 mRNA. Translation: AAC52769.1.
BC013639 mRNA. Translation: AAH13639.1.
BC051087 mRNA. Translation: AAH51087.2.
BC058813 mRNA. Translation: AAH58813.1.
RefSeqNP_032293.1. NM_008267.3.
UniGeneMm.57221.

3D structure databases

ProteinModelPortalP70321.
SMRP70321. Positions 212-275.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200376. 4 interactions.
IntActP70321. 1 interaction.

PTM databases

PhosphoSiteP70321.

Proteomic databases

PRIDEP70321.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000062709; ENSMUSP00000056315; ENSMUSG00000049604.
GeneID15408.
KEGGmmu:15408.
UCSCuc007lbk.1. mouse.

Organism-specific databases

CTD10481.
MGIMGI:107730. Hoxb13.

Phylogenomic databases

eggNOGNOG276440.
GeneTreeENSGT00730000110374.
HOGENOMHOG000231176.
HOVERGENHBG106958.
InParanoidP70321.
OMAHPPDGCA.
OrthoDBEOG7SJD53.
PhylomeDBP70321.
TreeFamTF330813.

Gene expression databases

BgeeP70321.
CleanExMM_HOXB13.
GenevestigatorP70321.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288124.
PROP70321.
SOURCESearch...

Entry information

Entry nameHXB13_MOUSE
AccessionPrimary (citable) accession number: P70321
Secondary accession number(s): Q80Y12
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries