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P70318

- TIAR_MOUSE

UniProt

P70318 - TIAR_MOUSE

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Protein

Nucleolysin TIAR

Gene

Tial1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis By similarity.By similarity

GO - Molecular functioni

  1. AU-rich element binding Source: MGI
  2. nucleotide binding Source: InterPro
  3. poly(A) RNA binding Source: Ensembl

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. germ cell development Source: MGI
  3. positive regulation of cell proliferation Source: MGI
  4. stem cell division Source: MGI
Complete GO annotation...

Keywords - Biological processi

Apoptosis

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleolysin TIAR
Alternative name(s):
TIA-1-related protein
Gene namesi
Name:Tial1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:107913. Tial1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication. Cytoplasmic granule 1 Publication
Note: The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic stress granule Source: UniProtKB
  3. extracellular vesicular exosome Source: Ensembl
  4. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Nucleolysin TIARPRO_0000081979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei139 – 1391N6-acetyllysineBy similarity
Modified residuei218 – 2181PhosphoserineBy similarity

Post-translational modificationi

Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP70318.
PaxDbiP70318.
PRIDEiP70318.

PTM databases

PhosphoSiteiP70318.

Expressioni

Tissue specificityi

Expressed both in primordial germ cells (PGCs) and in neighboring somatic cells.1 Publication

Gene expression databases

BgeeiP70318.
ExpressionAtlasiP70318. baseline and differential.
GenevestigatoriP70318.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Ddx21Q8K2L42EBI-299820,EBI-7977861
HnrnpmQ3THB32EBI-299820,EBI-4282050
Srsf1Q6PDM23EBI-299820,EBI-2550360

Protein-protein interaction databases

BioGridi204192. 3 interactions.
IntActiP70318. 27 interactions.
MINTiMINT-4137828.

Structurei

3D structure databases

ProteinModelPortaliP70318.
SMRiP70318. Positions 1-299.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 10294RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini114 – 19279RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini222 – 29473RRM 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0724.
HOGENOMiHOG000206748.
HOVERGENiHBG105006.
InParanoidiP70318.
KOiK13201.
OMAiCKMITEM.
OrthoDBiEOG7XH6QJ.
PhylomeDBiP70318.
TreeFamiTF312915.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70318-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEQPDSRRV
60 70 80 90 100
NSSVGFSVLQ HTSNDPYCFV EFYEHRDAAA ALAAMNGRKI LGKEVKVNWA
110 120 130 140 150
TTPSSQKKDT SNHFHVFVGD LSPEITTEDI KSAFAPFGKI SDARVVKDMA
160 170 180 190 200
TGKSKGYGFV SFYNKLDAEN AIVHMGGQWL GGRQIRTNWA TRKPPAPKST
210 220 230 240 250
QETNTKQLRF EDVVNQSSPK NCTVYCGGIA SGLTDQLMRQ TFSPFGQIME
260 270 280 290 300
IRVFPEKGYS FVRFSTHESA AHAIVSVNGT TIEGHVVKCY WGKESPDMTK
310 320 330 340 350
NFQQVDYSQW GQWSQVYGNP QQYGQYMANG WQVPPYGVYG QPWNQQGFGV
360 370 380 390
DQSPSAAWMG GFGAQPPQGQ APPPVIPPPN QAGYGMASFP TQ
Length:392
Mass (Da):43,389
Last modified:February 1, 1997 - v1
Checksum:i66E6AF14B9EBE77A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U55861 mRNA. Translation: AAC52870.1.
CCDSiCCDS21897.1.
PIRiS72436.
RefSeqiNP_033409.1. NM_009383.2.
UniGeneiMm.242072.

Genome annotation databases

EnsembliENSMUST00000106226; ENSMUSP00000101833; ENSMUSG00000030846.
GeneIDi21843.
KEGGimmu:21843.
UCSCiuc009jyy.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U55861 mRNA. Translation: AAC52870.1 .
CCDSi CCDS21897.1.
PIRi S72436.
RefSeqi NP_033409.1. NM_009383.2.
UniGenei Mm.242072.

3D structure databases

ProteinModelPortali P70318.
SMRi P70318. Positions 1-299.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204192. 3 interactions.
IntActi P70318. 27 interactions.
MINTi MINT-4137828.

PTM databases

PhosphoSitei P70318.

Proteomic databases

MaxQBi P70318.
PaxDbi P70318.
PRIDEi P70318.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000106226 ; ENSMUSP00000101833 ; ENSMUSG00000030846 .
GeneIDi 21843.
KEGGi mmu:21843.
UCSCi uc009jyy.1. mouse.

Organism-specific databases

CTDi 7073.
MGIi MGI:107913. Tial1.

Phylogenomic databases

eggNOGi COG0724.
HOGENOMi HOG000206748.
HOVERGENi HBG105006.
InParanoidi P70318.
KOi K13201.
OMAi CKMITEM.
OrthoDBi EOG7XH6QJ.
PhylomeDBi P70318.
TreeFami TF312915.

Miscellaneous databases

ChiTaRSi TIAL1. mouse.
NextBioi 301310.
PROi P70318.
SOURCEi Search...

Gene expression databases

Bgeei P70318.
ExpressionAtlasi P70318. baseline and differential.
Genevestigatori P70318.

Family and domain databases

Gene3Di 3.30.70.330. 3 hits.
InterProi IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view ]
Pfami PF00076. RRM_1. 3 hits.
[Graphical view ]
SMARTi SM00360. RRM. 3 hits.
[Graphical view ]
PROSITEi PS50102. RRM. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR."
    Beck A.R.P., Medley O.G., O'Brien S., Anderson P., Streuli M.
    Nucleic Acids Res. 24:3829-3836(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3."
    Yamaji M., Tanaka T., Shigeta M., Chuma S., Saga Y., Saitou M.
    Reproduction 139:381-393(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTIAR_MOUSE
AccessioniPrimary (citable) accession number: P70318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3