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P70318 (TIAR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nucleolysin TIAR
Alternative name(s):
TIA-1-related protein
Gene names
Name:Tial1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis By similarity.

Subcellular location

Cytoplasm. Nucleus. Cytoplasmic granule. Note: The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules. Ref.2

Tissue specificity

Expressed both in primordial germ cells (PGCs) and in neighboring somatic cells. Ref.2

Post-translational modification

Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA By similarity.

Sequence similarities

Contains 3 RRM (RNA recognition motif) domains.

Binary interactions

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Nucleolysin TIAR
PRO_0000081979

Regions

Domain9 – 10294RRM 1
Domain114 – 19279RRM 2
Domain222 – 29473RRM 3

Amino acid modifications

Modified residue1391N6-acetyllysine By similarity
Modified residue2181Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
P70318 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 66E6AF14B9EBE77A

FASTA39243,389
        10         20         30         40         50         60 
MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEQPDSRRV NSSVGFSVLQ 

        70         80         90        100        110        120 
HTSNDPYCFV EFYEHRDAAA ALAAMNGRKI LGKEVKVNWA TTPSSQKKDT SNHFHVFVGD 

       130        140        150        160        170        180 
LSPEITTEDI KSAFAPFGKI SDARVVKDMA TGKSKGYGFV SFYNKLDAEN AIVHMGGQWL 

       190        200        210        220        230        240 
GGRQIRTNWA TRKPPAPKST QETNTKQLRF EDVVNQSSPK NCTVYCGGIA SGLTDQLMRQ 

       250        260        270        280        290        300 
TFSPFGQIME IRVFPEKGYS FVRFSTHESA AHAIVSVNGT TIEGHVVKCY WGKESPDMTK 

       310        320        330        340        350        360 
NFQQVDYSQW GQWSQVYGNP QQYGQYMANG WQVPPYGVYG QPWNQQGFGV DQSPSAAWMG 

       370        380        390 
GFGAQPPQGQ APPPVIPPPN QAGYGMASFP TQ 

« Hide

References

[1]"Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR."
Beck A.R.P., Medley O.G., O'Brien S., Anderson P., Streuli M.
Nucleic Acids Res. 24:3829-3836(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3."
Yamaji M., Tanaka T., Shigeta M., Chuma S., Saga Y., Saitou M.
Reproduction 139:381-393(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U55861 mRNA. Translation: AAC52870.1.
CCDSCCDS21897.1.
PIRS72436.
RefSeqNP_033409.1. NM_009383.2.
UniGeneMm.242072.

3D structure databases

ProteinModelPortalP70318.
SMRP70318. Positions 1-299.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204192. 3 interactions.
IntActP70318. 27 interactions.
MINTMINT-4137828.

PTM databases

PhosphoSiteP70318.

Proteomic databases

MaxQBP70318.
PaxDbP70318.
PRIDEP70318.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000106226; ENSMUSP00000101833; ENSMUSG00000030846.
GeneID21843.
KEGGmmu:21843.
UCSCuc009jyy.1. mouse.

Organism-specific databases

CTD7073.
MGIMGI:107913. Tial1.

Phylogenomic databases

eggNOGCOG0724.
HOGENOMHOG000206748.
HOVERGENHBG105006.
InParanoidP70318.
KOK13201.
OMACKMITEM.
OrthoDBEOG7XH6QJ.
PhylomeDBP70318.
TreeFamTF312915.

Gene expression databases

ArrayExpressP70318.
BgeeP70318.
GenevestigatorP70318.

Family and domain databases

Gene3D3.30.70.330. 3 hits.
InterProIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTSM00360. RRM. 3 hits.
[Graphical view]
PROSITEPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSTIAL1. mouse.
NextBio301310.
PROP70318.
SOURCESearch...

Entry information

Entry nameTIAR_MOUSE
AccessionPrimary (citable) accession number: P70318
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot