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P70318

- TIAR_MOUSE

UniProt

P70318 - TIAR_MOUSE

Protein

Nucleolysin TIAR

Gene

Tial1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis By similarity.By similarity

    GO - Molecular functioni

    1. AU-rich element binding Source: MGI
    2. nucleotide binding Source: InterPro
    3. protein binding Source: IntAct

    GO - Biological processi

    1. apoptotic process Source: UniProtKB-KW
    2. germ cell development Source: MGI
    3. positive regulation of cell proliferation Source: MGI
    4. stem cell division Source: MGI

    Keywords - Biological processi

    Apoptosis

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nucleolysin TIAR
    Alternative name(s):
    TIA-1-related protein
    Gene namesi
    Name:Tial1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:107913. Tial1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication. Cytoplasmic granule 1 Publication
    Note: The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS3 in the stress granules.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic stress granule Source: UniProtKB
    3. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Nucleolysin TIARPRO_0000081979Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei139 – 1391N6-acetyllysineBy similarity
    Modified residuei218 – 2181PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP70318.
    PaxDbiP70318.
    PRIDEiP70318.

    PTM databases

    PhosphoSiteiP70318.

    Expressioni

    Tissue specificityi

    Expressed both in primordial germ cells (PGCs) and in neighboring somatic cells.1 Publication

    Gene expression databases

    ArrayExpressiP70318.
    BgeeiP70318.
    GenevestigatoriP70318.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Ddx21Q8K2L42EBI-299820,EBI-7977861
    HnrnpmQ3THB32EBI-299820,EBI-4282050
    Srsf1Q6PDM23EBI-299820,EBI-2550360

    Protein-protein interaction databases

    BioGridi204192. 3 interactions.
    IntActiP70318. 27 interactions.
    MINTiMINT-4137828.

    Structurei

    3D structure databases

    ProteinModelPortaliP70318.
    SMRiP70318. Positions 1-299.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 10294RRM 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini114 – 19279RRM 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini222 – 29473RRM 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG0724.
    HOGENOMiHOG000206748.
    HOVERGENiHBG105006.
    InParanoidiP70318.
    KOiK13201.
    OMAiCKMITEM.
    OrthoDBiEOG7XH6QJ.
    PhylomeDBiP70318.
    TreeFamiTF312915.

    Family and domain databases

    Gene3Di3.30.70.330. 3 hits.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view]
    PfamiPF00076. RRM_1. 3 hits.
    [Graphical view]
    SMARTiSM00360. RRM. 3 hits.
    [Graphical view]
    PROSITEiPS50102. RRM. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70318-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEDDGQPRT LYVGNLSRDV TEVLILQLFS QIGPCKSCKM ITEQPDSRRV    50
    NSSVGFSVLQ HTSNDPYCFV EFYEHRDAAA ALAAMNGRKI LGKEVKVNWA 100
    TTPSSQKKDT SNHFHVFVGD LSPEITTEDI KSAFAPFGKI SDARVVKDMA 150
    TGKSKGYGFV SFYNKLDAEN AIVHMGGQWL GGRQIRTNWA TRKPPAPKST 200
    QETNTKQLRF EDVVNQSSPK NCTVYCGGIA SGLTDQLMRQ TFSPFGQIME 250
    IRVFPEKGYS FVRFSTHESA AHAIVSVNGT TIEGHVVKCY WGKESPDMTK 300
    NFQQVDYSQW GQWSQVYGNP QQYGQYMANG WQVPPYGVYG QPWNQQGFGV 350
    DQSPSAAWMG GFGAQPPQGQ APPPVIPPPN QAGYGMASFP TQ 392
    Length:392
    Mass (Da):43,389
    Last modified:February 1, 1997 - v1
    Checksum:i66E6AF14B9EBE77A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55861 mRNA. Translation: AAC52870.1.
    CCDSiCCDS21897.1.
    PIRiS72436.
    RefSeqiNP_033409.1. NM_009383.2.
    UniGeneiMm.242072.

    Genome annotation databases

    EnsembliENSMUST00000106226; ENSMUSP00000101833; ENSMUSG00000030846.
    GeneIDi21843.
    KEGGimmu:21843.
    UCSCiuc009jyy.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55861 mRNA. Translation: AAC52870.1 .
    CCDSi CCDS21897.1.
    PIRi S72436.
    RefSeqi NP_033409.1. NM_009383.2.
    UniGenei Mm.242072.

    3D structure databases

    ProteinModelPortali P70318.
    SMRi P70318. Positions 1-299.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204192. 3 interactions.
    IntActi P70318. 27 interactions.
    MINTi MINT-4137828.

    PTM databases

    PhosphoSitei P70318.

    Proteomic databases

    MaxQBi P70318.
    PaxDbi P70318.
    PRIDEi P70318.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000106226 ; ENSMUSP00000101833 ; ENSMUSG00000030846 .
    GeneIDi 21843.
    KEGGi mmu:21843.
    UCSCi uc009jyy.1. mouse.

    Organism-specific databases

    CTDi 7073.
    MGIi MGI:107913. Tial1.

    Phylogenomic databases

    eggNOGi COG0724.
    HOGENOMi HOG000206748.
    HOVERGENi HBG105006.
    InParanoidi P70318.
    KOi K13201.
    OMAi CKMITEM.
    OrthoDBi EOG7XH6QJ.
    PhylomeDBi P70318.
    TreeFami TF312915.

    Miscellaneous databases

    ChiTaRSi TIAL1. mouse.
    NextBioi 301310.
    PROi P70318.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70318.
    Bgeei P70318.
    Genevestigatori P70318.

    Family and domain databases

    Gene3Di 3.30.70.330. 3 hits.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    [Graphical view ]
    Pfami PF00076. RRM_1. 3 hits.
    [Graphical view ]
    SMARTi SM00360. RRM. 3 hits.
    [Graphical view ]
    PROSITEi PS50102. RRM. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure, tissue distribution and genomic organization of the murine RRM-type RNA binding proteins TIA-1 and TIAR."
      Beck A.R.P., Medley O.G., O'Brien S., Anderson P., Streuli M.
      Nucleic Acids Res. 24:3829-3836(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3."
      Yamaji M., Tanaka T., Shigeta M., Chuma S., Saga Y., Saitou M.
      Reproduction 139:381-393(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiTIAR_MOUSE
    AccessioniPrimary (citable) accession number: P70318
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 107 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3