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P70310

- NTR2_MOUSE

UniProt

P70310 - NTR2_MOUSE

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Protein

Neurotensin receptor type 2

Gene

Ntsr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

GO - Molecular functioni

  1. G-protein coupled neurotensin receptor activity Source: MGI

GO - Biological processi

  1. neuropeptide signaling pathway Source: GOC
  2. phospholipase C-activating G-protein coupled receptor signaling pathway Source: MGI
  3. regulation of membrane potential Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotensin receptor type 2
Short name:
NT-R-2
Short name:
NTR2
Alternative name(s):
Low-affinity levocabastine-sensitive neurotensin receptor
NTRL
Gene namesi
Name:Ntsr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:108018. Ntsr2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Neurotensin receptor type 2PRO_0000069950Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi108 ↔ 194PROSITE-ProRule annotation
Lipidationi377 – 3771S-palmitoyl cysteineSequence Analysis

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate

Proteomic databases

PRIDEiP70310.

PTM databases

PhosphoSiteiP70310.

Expressioni

Tissue specificityi

Expressed maximally in the cerebellum, hyppocampus, piriform cortex and neocortex of adult brain.

Developmental stagei

Expressed poorly in 7-day-old brain. Expression increases at day 15 to reach a maximal level in 35-day-old brain.

Gene expression databases

CleanExiMM_NTSR2.
ExpressionAtlasiP70310. baseline and differential.
GenevestigatoriP70310.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP70310.
SMRiP70310. Positions 23-374.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3232ExtracellularSequence AnalysisAdd
BLAST
Topological domaini56 – 649CytoplasmicSequence Analysis
Topological domaini88 – 10922ExtracellularSequence AnalysisAdd
BLAST
Topological domaini132 – 15423CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini177 – 21741ExtracellularSequence AnalysisAdd
BLAST
Topological domaini238 – 29760CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini319 – 33719ExtracellularSequence AnalysisAdd
BLAST
Topological domaini359 – 41658CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei33 – 5523Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei65 – 8723Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei155 – 17622Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei218 – 23720Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei298 – 31821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei338 – 35821Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG303702.
GeneTreeiENSGT00700000104070.
HOGENOMiHOG000231271.
HOVERGENiHBG098285.
InParanoidiP70310.
KOiK04212.
OMAiWAKVLFT.
OrthoDBiEOG7S21Z8.
TreeFamiTF337167.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70310-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METSSLWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFALGTAGN
60 70 80 90 100
ALSVHVVLKA RAGRPGRLRY HVLSLALSAL LLLLISVPME LYNFVWSHYP
110 120 130 140 150
WVFGDLGCRG YYFVRELCAY ATVLSVASLS AERCLAVCQP LRARRLLTPR
160 170 180 190 200
RTRRLLSLVW VASLGLALPM AVIMGQKHEM ERADGEPEPA SRVCTVLVSR
210 220 230 240 250
ATLQVFIQVN VLVSFVLPLA LTAFLNGITV NHLVALYSQV PSASAQVNSI
260 270 280 290 300
PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR
310 320 330 340 350
AIVAVYVICW LPYHARRLMY CYIPDDGWTD ELYDFYHYFY MVTNTLFYVS
360 370 380 390 400
SAVTPVLYNA VSSSFRKLFL ESLSSLCGEQ RSVVPLPQEA PESTTSTYSF
410
RLWGSPRNPS LGEIQV
Length:416
Mass (Da):46,376
Last modified:October 16, 2013 - v2
Checksum:i290F8CCB726694B4
GO

Sequence cautioni

The sequence AAB17285.1 differs from that shown. Reason: Frameshift at positions 202, 207, 210 and 219.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti62 – 621A → T in AAB17285. (PubMed:8795617)Curated
Sequence conflicti153 – 1531R → C in AAB17285. (PubMed:8795617)Curated
Sequence conflicti224 – 2241F → I in AAB17285. (PubMed:8795617)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51908 mRNA. Translation: AAB17285.1. Frameshift.
AB041827 mRNA. Translation: BAB79257.1.
AK158943 mRNA. Translation: BAE34736.1.
AC122228 Genomic DNA. No translation available.
BC141019 mRNA. Translation: AAI41020.1.
CCDSiCCDS36407.1.
RefSeqiNP_032773.2. NM_008747.2.
UniGeneiMm.281715.

Genome annotation databases

EnsembliENSMUST00000111064; ENSMUSP00000106693; ENSMUSG00000020591.
GeneIDi18217.
KEGGimmu:18217.
UCSCiuc007nbw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U51908 mRNA. Translation: AAB17285.1 . Frameshift.
AB041827 mRNA. Translation: BAB79257.1 .
AK158943 mRNA. Translation: BAE34736.1 .
AC122228 Genomic DNA. No translation available.
BC141019 mRNA. Translation: AAI41020.1 .
CCDSi CCDS36407.1.
RefSeqi NP_032773.2. NM_008747.2.
UniGenei Mm.281715.

3D structure databases

ProteinModelPortali P70310.
SMRi P70310. Positions 23-374.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P70310.
GuidetoPHARMACOLOGYi 310.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P70310.

Proteomic databases

PRIDEi P70310.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000111064 ; ENSMUSP00000106693 ; ENSMUSG00000020591 .
GeneIDi 18217.
KEGGi mmu:18217.
UCSCi uc007nbw.1. mouse.

Organism-specific databases

CTDi 23620.
MGIi MGI:108018. Ntsr2.

Phylogenomic databases

eggNOGi NOG303702.
GeneTreei ENSGT00700000104070.
HOGENOMi HOG000231271.
HOVERGENi HBG098285.
InParanoidi P70310.
KOi K04212.
OMAi WAKVLFT.
OrthoDBi EOG7S21Z8.
TreeFami TF337167.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 293628.
PROi P70310.
SOURCEi Search...

Gene expression databases

CleanExi MM_NTSR2.
ExpressionAtlasi P70310. baseline and differential.
Genevestigatori P70310.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain."
    Mazella J., Botto J.-M., Guillemare E., Coppola T., Sarret P., Vincent J.-P.
    J. Neurosci. 16:5613-5620(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "Mouse neurotensin receptor 2 gene (Ntsr2): genomic organization, transcriptional regulation and genetic mapping on chromosome 12."
    Sun Y.J., Maeno H., Aoki S., Wada K.
    Brain Res. Mol. Brain Res. 95:167-171(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Visual cortex.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiNTR2_MOUSE
AccessioniPrimary (citable) accession number: P70310
Secondary accession number(s): Q8VIF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 16, 2013
Last modified: October 29, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3