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P70310 (NTR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotensin receptor type 2

Short name=NT-R-2
Short name=NTR2
Alternative name(s):
Low-affinity levocabastine-sensitive neurotensin receptor
NTRL
Gene names
Name:Ntsr2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Expressed maximally in the cerebellum, hyppocampus, piriform cortex and neocortex of adult brain.

Developmental stage

Expressed poorly in 7-day-old brain. Expression increases at day 15 to reach a maximal level in 35-day-old brain.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family. Neurotensin receptor subfamily. NTSR2 sub-subfamily.

Sequence caution

The sequence AAB17285.1 differs from that shown. Reason: Frameshift at positions 202, 207, 210 and 219.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Neurotensin receptor type 2
PRO_0000069950

Regions

Topological domain1 – 3232Extracellular Potential
Transmembrane33 – 5523Helical; Name=1; Potential
Topological domain56 – 649Cytoplasmic Potential
Transmembrane65 – 8723Helical; Name=2; Potential
Topological domain88 – 10922Extracellular Potential
Transmembrane110 – 13122Helical; Name=3; Potential
Topological domain132 – 15423Cytoplasmic Potential
Transmembrane155 – 17622Helical; Name=4; Potential
Topological domain177 – 21741Extracellular Potential
Transmembrane218 – 23720Helical; Name=5; Potential
Topological domain238 – 29760Cytoplasmic Potential
Transmembrane298 – 31821Helical; Name=6; Potential
Topological domain319 – 33719Extracellular Potential
Transmembrane338 – 35821Helical; Name=7; Potential
Topological domain359 – 41658Cytoplasmic Potential

Amino acid modifications

Lipidation3771S-palmitoyl cysteine Potential
Disulfide bond108 ↔ 194 By similarity

Experimental info

Sequence conflict621A → T in AAB17285. Ref.1
Sequence conflict1531R → C in AAB17285. Ref.1
Sequence conflict2241F → I in AAB17285. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P70310 [UniParc].

Last modified October 16, 2013. Version 2.
Checksum: 290F8CCB726694B4

FASTA41646,376
        10         20         30         40         50         60 
METSSLWPPR PSPSAGLSLE ARLGVDTRLW AKVLFTALYS LIFALGTAGN ALSVHVVLKA 

        70         80         90        100        110        120 
RAGRPGRLRY HVLSLALSAL LLLLISVPME LYNFVWSHYP WVFGDLGCRG YYFVRELCAY 

       130        140        150        160        170        180 
ATVLSVASLS AERCLAVCQP LRARRLLTPR RTRRLLSLVW VASLGLALPM AVIMGQKHEM 

       190        200        210        220        230        240 
ERADGEPEPA SRVCTVLVSR ATLQVFIQVN VLVSFVLPLA LTAFLNGITV NHLVALYSQV 

       250        260        270        280        290        300 
PSASAQVNSI PSRLELLSEE GLLGFITWRK TLSLGVQASL VRHKDASQIR SLQHSAQVLR 

       310        320        330        340        350        360 
AIVAVYVICW LPYHARRLMY CYIPDDGWTD ELYDFYHYFY MVTNTLFYVS SAVTPVLYNA 

       370        380        390        400        410 
VSSSFRKLFL ESLSSLCGEQ RSVVPLPQEA PESTTSTYSF RLWGSPRNPS LGEIQV 

« Hide

References

« Hide 'large scale' references
[1]"Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain."
Mazella J., Botto J.-M., Guillemare E., Coppola T., Sarret P., Vincent J.-P.
J. Neurosci. 16:5613-5620(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"Mouse neurotensin receptor 2 gene (Ntsr2): genomic organization, transcriptional regulation and genetic mapping on chromosome 12."
Sun Y.J., Maeno H., Aoki S., Wada K.
Brain Res. Mol. Brain Res. 95:167-171(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6J.
Tissue: Brain.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Visual cortex.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U51908 mRNA. Translation: AAB17285.1. Frameshift.
AB041827 mRNA. Translation: BAB79257.1.
AK158943 mRNA. Translation: BAE34736.1.
AC122228 Genomic DNA. No translation available.
BC141019 mRNA. Translation: AAI41020.1.
CCDSCCDS36407.1.
RefSeqNP_032773.2. NM_008747.2.
UniGeneMm.281715.

3D structure databases

ProteinModelPortalP70310.
SMRP70310. Positions 23-374.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP70310.
GuidetoPHARMACOLOGY310.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP70310.

Proteomic databases

PRIDEP70310.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111064; ENSMUSP00000106693; ENSMUSG00000020591.
GeneID18217.
KEGGmmu:18217.
UCSCuc007nbw.1. mouse.

Organism-specific databases

CTD23620.
MGIMGI:108018. Ntsr2.

Phylogenomic databases

eggNOGNOG303702.
GeneTreeENSGT00700000104470.
HOGENOMHOG000231271.
HOVERGENHBG098285.
KOK04212.
OMAWAKVLFT.
OrthoDBEOG7S21Z8.
TreeFamTF337167.

Gene expression databases

CleanExMM_NTSR2.
GenevestigatorP70310.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003986. NT2_rcpt.
IPR003984. NT_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01479. NEUROTENSINR.
PR01481. NEUROTENSN2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio293628.
PROP70310.
SOURCESearch...

Entry information

Entry nameNTR2_MOUSE
AccessionPrimary (citable) accession number: P70310
Secondary accession number(s): Q8VIF5
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 16, 2013
Last modified: July 9, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries