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Protein
Submitted name:

Phosphoinositide 3-kinase p85alpha

Gene

Pik3r1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: MGI
  2. ErbB-3 class receptor binding Source: MGI
  3. insulin binding Source: MGI
  4. insulin-like growth factor receptor binding Source: MGI
  5. insulin receptor binding Source: MGI
  6. neurotrophin TRKA receptor binding Source: MGI
  7. phosphatidylinositol 3-kinase regulator activity Source: InterPro
  8. protein phosphatase binding Source: MGI
  9. transcription factor binding Source: MGI

GO - Biological processi

  1. B cell differentiation Source: MGI
  2. cellular response to UV Source: MGI
  3. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  4. growth hormone receptor signaling pathway Source: MGI
  5. insulin-like growth factor receptor signaling pathway Source: MGI
  6. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  7. negative regulation of apoptotic process Source: MGI
  8. negative regulation of cell-matrix adhesion Source: MGI
  9. negative regulation of osteoclast differentiation Source: MGI
  10. NFAT protein import into nucleus Source: MGI
  11. phosphatidylinositol 3-kinase signaling Source: MGI
  12. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  13. positive regulation of cell migration Source: MGI
  14. positive regulation of endoplasmic reticulum unfolded protein response Source: MGI
  15. positive regulation of RNA splicing Source: MGI
  16. positive regulation of transcription factor import into nucleus Source: MGI
  17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  18. positive regulation of tumor necrosis factor production Source: MGI
  19. protein phosphorylation Source: MGI
  20. protein stabilization Source: MGI
  21. response to endoplasmic reticulum stress Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphoinositide 3-kinase p85alphaImported
Gene namesi
Name:Pik3r1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97583. Pik3r1.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. cytoplasm Source: MGI
  3. membrane Source: MGI
  4. phosphatidylinositol 3-kinase complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriP70304.

Interactioni

Protein-protein interaction databases

DIPiDIP-118N.
IntActiP70304. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP70304.
SMRiP70304. Positions 1-84, 115-309, 325-600, 614-724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

HOVERGENiHBG082100.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70304-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP
60 70 80 90 100
EDIGWLNGYN ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG
110 120 130 140 150
SSKTEADTEQ QALPLPDLAE QFAPPDVAPP LLIKLLEAIE KKGLECSTLY
160 170 180 190 200
RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH VLADAFKRYL ADLPNPVIPV
210 220 230 240 250
AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL QYLLKHFFKL
260 270 280 290 300
SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE
310 320 330 340 350
RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT
360 370 380 390 400
ADGTFLVRDA STKMHGDYTL TPRKGGNNKL IKIFHRDGKY GFSDPLTFNS
410 420 430 440 450
VVELINHYRN ESLAQYNPKL DVKLLYPVSK YQQDQVVKED NIEAVGKKLH
460 470 480 490 500
EYNTQFQEKS REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT
510 520 530 540 550
QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID SRRRLEEDLK
560 570 580 590 600
KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN
610 620 630 640 650
ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE
660 670 680 690 700
SSKQGCYACS VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH
710 720
TSLVQHNDSL NVTLAYPVYA QQRR
Length:724
Mass (Da):83,501
Last modified:February 1, 1997 - v1
Checksum:iBCC21211D46F1C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50413 mRNA. Translation: AAC52847.1.
PIRiA38747.
UniGeneiMm.259333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50413 mRNA. Translation: AAC52847.1.
PIRiA38747.
UniGeneiMm.259333.

3D structure databases

ProteinModelPortaliP70304.
SMRiP70304. Positions 1-84, 115-309, 325-600, 614-724.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-118N.
IntActiP70304. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97583. Pik3r1.

Phylogenomic databases

HOVERGENiHBG082100.

Miscellaneous databases

ChiTaRSiPik3r1. mouse.
NextBioi294779.
SOURCEiSearch...

Gene expression databases

GenevestigatoriP70304.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene."
    Fruman D.A., Cantley L.C., Carpenter C.L.
    Genomics 37:113-121(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiP70304_MOUSE
AccessioniPrimary (citable) accession number: P70304
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: March 4, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.