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P70304

- P70304_MOUSE

UniProt

P70304 - P70304_MOUSE

Protein
Submitted name:

Phosphoinositide 3-kinase p85alpha

Gene

Pik3r1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. 1-phosphatidylinositol-3-kinase activity Source: MGI
    2. phosphatidylinositol 3-kinase regulator activity Source: InterPro
    3. protein binding Source: MGI

    GO - Biological processi

    1. B cell differentiation Source: MGI
    2. cellular response to UV Source: MGI
    3. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
    4. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    5. negative regulation of apoptotic process Source: MGI
    6. negative regulation of cell-matrix adhesion Source: MGI
    7. negative regulation of osteoclast differentiation Source: MGI
    8. NFAT protein import into nucleus Source: MGI
    9. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
    10. positive regulation of cell migration Source: MGI
    11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    12. positive regulation of tumor necrosis factor production Source: MGI
    13. protein phosphorylation Source: MGI

    Keywords - Molecular functioni

    KinaseImported, Transferase

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Phosphoinositide 3-kinase p85alphaImported
    Gene namesi
    Name:Pik3r1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97583. Pik3r1.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: MGI
    2. phosphatidylinositol 3-kinase complex Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriP70304.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-118N.
    IntActiP70304. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP70304.
    SMRiP70304. Positions 1-84, 115-309, 325-600, 614-724.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    SH3 domainSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG082100.
    InParanoidiP70304.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    3.30.505.10. 2 hits.
    InterProiIPR001720. PI3kinase_P85.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR10155. PTHR10155. 1 hit.
    PfamiPF00620. RhoGAP. 1 hit.
    PF00017. SH2. 2 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view]
    PRINTSiPR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTiSM00324. RhoGAP. 1 hit.
    SM00252. SH2. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEiPS50238. RHOGAP. 1 hit.
    PS50001. SH2. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70304-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP    50
    EDIGWLNGYN ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG 100
    SSKTEADTEQ QALPLPDLAE QFAPPDVAPP LLIKLLEAIE KKGLECSTLY 150
    RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH VLADAFKRYL ADLPNPVIPV 200
    AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL QYLLKHFFKL 250
    SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE 300
    RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT 350
    ADGTFLVRDA STKMHGDYTL TPRKGGNNKL IKIFHRDGKY GFSDPLTFNS 400
    VVELINHYRN ESLAQYNPKL DVKLLYPVSK YQQDQVVKED NIEAVGKKLH 450
    EYNTQFQEKS REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT 500
    QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID SRRRLEEDLK 550
    KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 600
    ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE 650
    SSKQGCYACS VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH 700
    TSLVQHNDSL NVTLAYPVYA QQRR 724
    Length:724
    Mass (Da):83,501
    Last modified:February 1, 1997 - v1
    Checksum:iBCC21211D46F1C17
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50413 mRNA. Translation: AAC52847.1.
    PIRiA38747.
    UniGeneiMm.259333.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50413 mRNA. Translation: AAC52847.1 .
    PIRi A38747.
    UniGenei Mm.259333.

    3D structure databases

    ProteinModelPortali P70304.
    SMRi P70304. Positions 1-84, 115-309, 325-600, 614-724.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-118N.
    IntActi P70304. 2 interactions.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97583. Pik3r1.

    Phylogenomic databases

    HOVERGENi HBG082100.
    InParanoidi P70304.

    Miscellaneous databases

    ChiTaRSi PIK3R1. mouse.
    NextBioi 294779.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori P70304.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    3.30.505.10. 2 hits.
    InterProi IPR001720. PI3kinase_P85.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    IPR000980. SH2.
    IPR011511. SH3_2.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR10155. PTHR10155. 1 hit.
    Pfami PF00620. RhoGAP. 1 hit.
    PF00017. SH2. 2 hits.
    PF07653. SH3_2. 1 hit.
    [Graphical view ]
    PRINTSi PR00678. PI3KINASEP85.
    PR00401. SH2DOMAIN.
    SMARTi SM00324. RhoGAP. 1 hit.
    SM00252. SH2. 2 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 2 hits.
    PROSITEi PS50238. RHOGAP. 1 hit.
    PS50001. SH2. 2 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene."
      Fruman D.A., Cantley L.C., Carpenter C.L.
      Genomics 37:113-121(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiP70304_MOUSE
    AccessioniPrimary (citable) accession number: P70304
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)