SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P70304

- P70304_MOUSE

UniProt

P70304 - P70304_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Phosphoinositide 3-kinase p85alpha
Gene
Pik3r1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: MGI
  2. phosphatidylinositol 3-kinase regulator activity Source: InterPro
  3. protein binding Source: MGI

GO - Biological processi

  1. B cell differentiation Source: MGI
  2. NFAT protein import into nucleus Source: MGI
  3. cellular response to UV Source: MGI
  4. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  5. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  6. negative regulation of apoptotic process Source: MGI
  7. negative regulation of cell-matrix adhesion Source: MGI
  8. negative regulation of osteoclast differentiation Source: MGI
  9. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  10. positive regulation of cell migration Source: MGI
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. positive regulation of tumor necrosis factor production Source: MGI
  13. protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphoinositide 3-kinase p85alphaImported
Gene namesi
Name:Pik3r1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97583. Pik3r1.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. phosphatidylinositol 3-kinase complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriP70304.

Interactioni

Protein-protein interaction databases

DIPiDIP-118N.
IntActiP70304. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP70304.
SMRiP70304. Positions 1-84, 115-309, 325-600, 614-724.

Family & Domainsi

Keywords - Domaini

SH3 domainSAAS annotations

Phylogenomic databases

HOVERGENiHBG082100.
InParanoidiP70304.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70304-1 [UniParc]FASTAAdd to Basket

« Hide

MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP    50
EDIGWLNGYN ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG 100
SSKTEADTEQ QALPLPDLAE QFAPPDVAPP LLIKLLEAIE KKGLECSTLY 150
RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH VLADAFKRYL ADLPNPVIPV 200
AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL QYLLKHFFKL 250
SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE 300
RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT 350
ADGTFLVRDA STKMHGDYTL TPRKGGNNKL IKIFHRDGKY GFSDPLTFNS 400
VVELINHYRN ESLAQYNPKL DVKLLYPVSK YQQDQVVKED NIEAVGKKLH 450
EYNTQFQEKS REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT 500
QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID SRRRLEEDLK 550
KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 600
ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE 650
SSKQGCYACS VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH 700
TSLVQHNDSL NVTLAYPVYA QQRR 724
Length:724
Mass (Da):83,501
Last modified:February 1, 1997 - v1
Checksum:iBCC21211D46F1C17
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U50413 mRNA. Translation: AAC52847.1.
PIRiA38747.
UniGeneiMm.259333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U50413 mRNA. Translation: AAC52847.1 .
PIRi A38747.
UniGenei Mm.259333.

3D structure databases

ProteinModelPortali P70304.
SMRi P70304. Positions 1-84, 115-309, 325-600, 614-724.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-118N.
IntActi P70304. 2 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97583. Pik3r1.

Phylogenomic databases

HOVERGENi HBG082100.
InParanoidi P70304.

Miscellaneous databases

ChiTaRSi PIK3R1. mouse.
NextBioi 294779.
SOURCEi Search...

Gene expression databases

Genevestigatori P70304.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProi IPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR10155. PTHR10155. 1 hit.
Pfami PF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view ]
PRINTSi PR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTi SM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene."
    Fruman D.A., Cantley L.C., Carpenter C.L.
    Genomics 37:113-121(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiP70304_MOUSE
AccessioniPrimary (citable) accession number: P70304
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi