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P70304 (P70304_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Pik3r1 MGI 97583
OrganismMus musculus (Mouse) EMBL AAC52847.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length724 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   DomainSH3 domain SAAS SAAS000980
   Molecular functionKinase EMBL AAC52847.1
Transferase
Gene Ontology (GO)
   Biological_processB cell differentiation

Inferred from mutant phenotype PubMed 9988280. Source: MGI

NFAT protein import into nucleus

Inferred from mutant phenotype PubMed 17242187. Source: MGI

cellular response to UV

Inferred from mutant phenotype PubMed 17242187. Source: MGI

extrinsic apoptotic signaling pathway via death domain receptors

Inferred from mutant phenotype PubMed 15039234. Source: MGI

intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from mutant phenotype PubMed 17242187. Source: MGI

negative regulation of apoptotic process

Inferred from direct assay PubMed 15192701. Source: MGI

negative regulation of cell-matrix adhesion

Inferred from genetic interaction PubMed 17053831. Source: MGI

negative regulation of osteoclast differentiation

Inferred from genetic interaction PubMed 17053831. Source: MGI

phosphatidylinositol-3-phosphate biosynthetic process

Traceable author statement PubMed 9988280. Source: GOC

positive regulation of cell migration

Inferred from genetic interaction PubMed 17053831. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 17242187. Source: MGI

positive regulation of tumor necrosis factor production

Inferred from mutant phenotype PubMed 17242187. Source: MGI

protein phosphorylation

Inferred from direct assay PubMed 15192701. Source: MGI

   Cellular_componentphosphatidylinositol 3-kinase complex

Traceable author statement PubMed 9988280. Source: MGI

   Molecular_function1-phosphatidylinositol-3-kinase activity

Traceable author statement PubMed 9988280. Source: MGI

phosphatidylinositol 3-kinase regulator activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
P70304 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: BCC21211D46F1C17

FASTA72483,501
        10         20         30         40         50         60 
MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP EDIGWLNGYN 

        70         80         90        100        110        120 
ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG SSKTEADTEQ QALPLPDLAE 

       130        140        150        160        170        180 
QFAPPDVAPP LLIKLLEAIE KKGLECSTLY RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH 

       190        200        210        220        230        240 
VLADAFKRYL ADLPNPVIPV AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL 

       250        260        270        280        290        300 
QYLLKHFFKL SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE 

       310        320        330        340        350        360 
RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA 

       370        380        390        400        410        420 
STKMHGDYTL TPRKGGNNKL IKIFHRDGKY GFSDPLTFNS VVELINHYRN ESLAQYNPKL 

       430        440        450        460        470        480 
DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY TRTSQEIQMK 

       490        500        510        520        530        540 
RTAIEAFNET IKIFEEQCQT QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID 

       550        560        570        580        590        600 
SRRRLEEDLK KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 

       610        620        630        640        650        660 
ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS 

       670        680        690        700        710        720 
VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA 


QQRR 

« Hide

References

[1]"Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene."
Fruman D.A., Cantley L.C., Carpenter C.L.
Genomics 37:113-121(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain EMBL AAC52847.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U50413 mRNA. Translation: AAC52847.1.
PIRA38747.
UniGeneMm.259333.

3D structure databases

ProteinModelPortalP70304.
SMRP70304. Positions 1-84, 115-309, 325-600, 614-724.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-118N.
IntActP70304. 2 interactions.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97583. Pik3r1.

Phylogenomic databases

HOVERGENHBG082100.
InParanoidP70304.

Gene expression databases

GenevestigatorP70304.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProIPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR10155. PTHR10155. 1 hit.
PfamPF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTSM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEPS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPIK3R1. mouse.
NextBio294779.
SOURCESearch...

Entry information

Entry nameP70304_MOUSE
AccessionPrimary (citable) accession number: P70304
Entry history
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)