P70304 (P70304_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Phosphoinositide 3-kinase p85alpha EMBL AAC52847.1

Gene names

Name:

Pik3r1 MGI 97583

Organism

Mus musculus (Mouse) EMBL AAC52847.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	724 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	SH3 domain SAAS SAAS000980
Molecular function	Kinase EMBL AAC52847.1 Transferase
Gene Ontology (GO)
Biological_process	B cell differentiation Inferred from mutant phenotype PubMed 9988280. Source: MGI NFAT protein import into nucleus Inferred from mutant phenotype PubMed 17242187. Source: MGI cellular response to UV Inferred from mutant phenotype PubMed 17242187. Source: MGI negative regulation of apoptotic process Inferred from direct assay PubMed 15192701. Source: MGI negative regulation of cell-matrix adhesion Inferred from genetic interaction PubMed 17053831. Source: MGI negative regulation of osteoclast differentiation Inferred from genetic interaction PubMed 17053831. Source: MGI positive regulation of apoptotic process Inferred from mutant phenotype PubMed 17242187. Source: MGI positive regulation of cell migration Inferred from genetic interaction PubMed 17053831. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 17242187. Source: MGI protein phosphorylation Inferred from direct assay PubMed 15192701. Source: MGI regulation of phosphatidylinositol 3-kinase activity Inferred from electronic annotation. Source: GOC signal transduction Inferred from electronic annotation. Source: InterPro
Cellular_component	phosphatidylinositol 3-kinase complex Traceable author statement PubMed 9988280. Source: MGI
Molecular_function	1-phosphatidylinositol-3-kinase activity Traceable author statement PubMed 9988280. Source: MGI phosphatidylinositol 3-kinase regulator activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	P70304 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: BCC21211D46F1C17	FASTA	724	83,501
	10 20 30 40 50 60 MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP EDIGWLNGYN 70 80 90 100 110 120 ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG SSKTEADTEQ QALPLPDLAE 130 140 150 160 170 180 QFAPPDVAPP LLIKLLEAIE KKGLECSTLY RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH 190 200 210 220 230 240 VLADAFKRYL ADLPNPVIPV AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL 250 260 270 280 290 300 QYLLKHFFKL SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE 310 320 330 340 350 360 RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT ADGTFLVRDA 370 380 390 400 410 420 STKMHGDYTL TPRKGGNNKL IKIFHRDGKY GFSDPLTFNS VVELINHYRN ESLAQYNPKL 430 440 450 460 470 480 DVKLLYPVSK YQQDQVVKED NIEAVGKKLH EYNTQFQEKS REYDRLYEEY TRTSQEIQMK 490 500 510 520 530 540 RTAIEAFNET IKIFEEQCQT QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID 550 560 570 580 590 600 SRRRLEEDLK KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN 610 620 630 640 650 660 ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE SSKQGCYACS 670 680 690 700 710 720 VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH TSLVQHNDSL NVTLAYPVYA QQRR

References

[1]	"Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene." Fruman D.A., Cantley L.C., Carpenter C.L. Genomics 37:113-121(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Brain EMBL AAC52847.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U50413 mRNA. Translation: AAC52847.1.
IPI	IPI00263878.
PIR	A38747.
RefSeq	NP_001020126.1. NM_001024955.1. NP_001070963.1. NM_001077495.1.
UniGene	Mm.259333.
3D structure databases
HSSP	HSSP built from PDB template 1BFI based on UniProtKB P23727.
ProteinModelPortal	P70304.
SMR	P70304. Positions 1-84, 115-309, 325-600, 614-724.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-118N.
IntAct	P70304. 2 interactions.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	18708.
KEGG	mmu:18708.
Organism-specific databases
CTD	5295.
MGI	MGI:97583. Pik3r1.
Phylogenomic databases
HOVERGEN	HBG082100.
InParanoid	P70304.
KO	K02649.
Gene expression databases
Genevestigator	P70304.
Family and domain databases
Gene3D	1.10.555.10. 1 hit. 3.30.505.10. 2 hits.
InterPro	IPR001720. PI3kinase_P85. IPR008936. Rho_GTPase_activation_prot. IPR000198. RhoGAP_dom. IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain. [Graphical view]
PANTHER	PTHR10155. PTHR10155. 1 hit.
Pfam	PF00620. RhoGAP. 1 hit. PF00017. SH2. 2 hits. PF07653. SH3_2. 1 hit. [Graphical view]
PRINTS	PR00678. PI3KINASEP85. PR00401. SH2DOMAIN.
SMART	SM00324. RhoGAP. 1 hit. SM00252. SH2. 2 hits. SM00326. SH3. 1 hit. [Graphical view]
SUPFAM	SSF48350. Rho_GAP. 1 hit. SSF50044. SH3. 1 hit.
PROSITE	PS50238. RHOGAP. 1 hit. PS50001. SH2. 2 hits. PS50002. SH3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	PIK3R1. mouse.
NextBio	294779.
SOURCE	Search...

Entry information

Entry name

P70304_MOUSE

Accession

Primary (citable) accession number: P70304

Entry history

Integrated into UniProtKB/TrEMBL:	February 1, 1997
Last sequence update:	February 1, 1997
Last modified:	April 3, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)