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P70304

- P70304_MOUSE

UniProt

P70304 - P70304_MOUSE

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Protein
Submitted name:

Phosphoinositide 3-kinase p85alpha

Gene

Pik3r1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. 1-phosphatidylinositol-3-kinase activity Source: MGI
  2. phosphatidylinositol 3-kinase regulator activity Source: InterPro

GO - Biological processi

  1. B cell differentiation Source: MGI
  2. cellular response to UV Source: MGI
  3. extrinsic apoptotic signaling pathway via death domain receptors Source: MGI
  4. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  5. negative regulation of apoptotic process Source: MGI
  6. negative regulation of cell-matrix adhesion Source: MGI
  7. negative regulation of osteoclast differentiation Source: MGI
  8. NFAT protein import into nucleus Source: MGI
  9. phosphatidylinositol-3-phosphate biosynthetic process Source: GOC
  10. positive regulation of cell migration Source: MGI
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. positive regulation of tumor necrosis factor production Source: MGI
  13. protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphoinositide 3-kinase p85alphaImported
Gene namesi
Name:Pik3r1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97583. Pik3r1.

Subcellular locationi

GO - Cellular componenti

  1. cell-cell junction Source: MGI
  2. phosphatidylinositol 3-kinase complex Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriP70304.

Interactioni

Protein-protein interaction databases

DIPiDIP-118N.
IntActiP70304. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP70304.
SMRiP70304. Positions 1-84, 115-309, 325-600, 614-724.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

SH3 domainSAAS annotation

Phylogenomic databases

HOVERGENiHBG082100.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProiIPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR10155. PTHR10155. 1 hit.
PfamiPF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view]
PRINTSiPR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTiSM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEiPS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70304-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAEGYQYRA LYDYKKEREE DIDLHLGDIL TVNKGSLVAL GFSDGQEARP
60 70 80 90 100
EDIGWLNGYN ETTGERGDFP GTYVEYIGRK RISPPTPKPR PPRPLPVAPG
110 120 130 140 150
SSKTEADTEQ QALPLPDLAE QFAPPDVAPP LLIKLLEAIE KKGLECSTLY
160 170 180 190 200
RTQSSSNPAE LRQLLDCDAA SVDLEMIDVH VLADAFKRYL ADLPNPVIPV
210 220 230 240 250
AVYNEMMSLA QELQSPEDCI QLLKKLIRLP NIPHQCWLTL QYLLKHFFKL
260 270 280 290 300
SQASSKNLLN ARVLSEIFSP VLFRFPAASS DNTEHLIKAI EILISTEWNE
310 320 330 340 350
RQPAPALPPK PPKPTTVANN SMNNNMSLQD AEWYWGDISR EEVNEKLRDT
360 370 380 390 400
ADGTFLVRDA STKMHGDYTL TPRKGGNNKL IKIFHRDGKY GFSDPLTFNS
410 420 430 440 450
VVELINHYRN ESLAQYNPKL DVKLLYPVSK YQQDQVVKED NIEAVGKKLH
460 470 480 490 500
EYNTQFQEKS REYDRLYEEY TRTSQEIQMK RTAIEAFNET IKIFEEQCQT
510 520 530 540 550
QERYSKEYIE KFKREGNEKE IQRIMHNHDK LKSRISEIID SRRRLEEDLK
560 570 580 590 600
KQAAEYREID KRMNSIKPDL IQLRKTRDQY LMWLTQKGVR QKKLNEWLGN
610 620 630 640 650
ENTEDQYSLV EDDEDLPHHD EKTWNVGSSN RNKAENLLRG KRDGTFLVRE
660 670 680 690 700
SSKQGCYACS VVVDGEVKHC VINKTATGYG FAEPYNLYSS LKELVLHYQH
710 720
TSLVQHNDSL NVTLAYPVYA QQRR
Length:724
Mass (Da):83,501
Last modified:February 1, 1997 - v1
Checksum:iBCC21211D46F1C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50413 mRNA. Translation: AAC52847.1.
PIRiA38747.
UniGeneiMm.259333.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50413 mRNA. Translation: AAC52847.1 .
PIRi A38747.
UniGenei Mm.259333.

3D structure databases

ProteinModelPortali P70304.
SMRi P70304. Positions 1-84, 115-309, 325-600, 614-724.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-118N.
IntActi P70304. 2 interactions.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97583. Pik3r1.

Phylogenomic databases

HOVERGENi HBG082100.

Miscellaneous databases

ChiTaRSi Pik3r1. mouse.
NextBioi 294779.
SOURCEi Search...

Gene expression databases

Genevestigatori P70304.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
3.30.505.10. 2 hits.
InterProi IPR001720. PI3kinase_P85.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR10155. PTHR10155. 1 hit.
Pfami PF00620. RhoGAP. 1 hit.
PF00017. SH2. 2 hits.
PF07653. SH3_2. 1 hit.
[Graphical view ]
PRINTSi PR00678. PI3KINASEP85.
PR00401. SH2DOMAIN.
SMARTi SM00324. RhoGAP. 1 hit.
SM00252. SH2. 2 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 2 hits.
PROSITEi PS50238. RHOGAP. 1 hit.
PS50001. SH2. 2 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene."
    Fruman D.A., Cantley L.C., Carpenter C.L.
    Genomics 37:113-121(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiP70304_MOUSE
AccessioniPrimary (citable) accession number: P70304
Entry historyi
Integrated into UniProtKB/TrEMBL: February 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)