SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P70298

- CUX2_MOUSE

UniProt

P70298 - CUX2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Homeobox protein cut-like 2
Gene
Cux2, Cutl2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi482 – 56988CUT 1
Add
BLAST
DNA bindingi828 – 91588CUT 2
Add
BLAST
DNA bindingi983 – 107088CUT 3
Add
BLAST
DNA bindingi1113 – 117260Homeobox
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProt
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. cellular response to organic substance Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. positive regulation of dendrite morphogenesis Source: UniProt
  4. positive regulation of dendritic spine morphogenesis Source: UniProt
  5. positive regulation of excitatory postsynaptic membrane potential Source: UniProt
  6. positive regulation of gene expression Source: UniProt
  7. positive regulation of synapse assembly Source: UniProt
  8. short-term memory Source: UniProt
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein Cux-2
Gene namesi
Name:Cux2
Synonyms:Cutl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:107321. Cux2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14261426Homeobox protein cut-like 2
PRO_0000202397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiP70298.

PTM databases

PhosphoSiteiP70298.

Expressioni

Tissue specificityi

Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.

Gene expression databases

ArrayExpressiP70298.
BgeeiP70298.
CleanExiMM_CUX2.
GenevestigatoriP70298.

Interactioni

Protein-protein interaction databases

IntActiP70298. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP70298.
SMRiP70298. Positions 487-569, 828-912, 977-1070.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili131 – 311181 Reviewed prediction
Add
BLAST
Coiled coili587 – 65569 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG325167.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000143386.
HOVERGENiHBG051268.
InParanoidiQ6P1E6.
KOiK09313.
OMAiLVFPPAF.
OrthoDBiEOG7VTDMF.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70298-1 [UniParc]FASTAAdd to Basket

« Hide

MVAPVLKSFQ AEVVALSKRS REAEAAFLSV YKQLIEAPDP VPSFEVARTL     50
DDRLQRPSFD PSGQRLQDVH IAWKRCPEPP SAREQNEGTC PTGHTPANGN 100
HLPGPEDTLV TDTLLQKNEA ERQKGLQEVH ITLAARLGEA EEKIKVLHSA 150
LKATQTELLE LRRKYDEEAA SKADEVGLIM TNLEKANQRA EAAQREVESL 200
REQLASVNSS IRLACCSPQG PSGEKVSFAL CSGPRLEAAL ASKDREILRL 250
LKDAQQLRHS LQELEEVSAN QIADLERQLA AKSEAIEKLQ EKLEAQADYE 300
EIKTELSILR AMKLASSTCS LPQTLAKPDD PLLVAKDVFF PTQKFLLEKP 350
ALLASPEEDP SEDDSIKGSL GTEPPYPPQL PPPPGPEDPL SPSPAQPLLG 400
PSLGPDGPRT FSLSPFPSLA PGERLAGDSL LSKHMMGPAA FKGETGNLLA 450
FPPTFYGGAK PPSAPAASVP CPEPTGAPEA VDGAGPEEEQ LDTAEIAFQV 500
KEQLLKHNIG QRVFGHYVLG LSQGSVSEIL ARPKPWRKLT VKGKEPFIKM 550
KQFLSDEQNV LALRTIQVRQ RGSITPRIRT PETGSDDAIK SILEQAKKEI 600
ESQKGGESKN SPASVSIPNG TASSSTSEDA IKNILEQARR EMQAQQQALL 650
EMESGPRGRS VPPSPPERPS PATASQNGAL TCVKQEDGGG GSGSSSTVQA 700
PLAVLSPAAF VQRIIRKVKS EIGDAGYFDH HWASDRGLLS RPYASVSPSL 750
SSSSSYSGQP NGRAWPRGDE ATIAPEDEAA MGEDEAPRVG ELKAEAGAPE 800
VGGGRLPYYP AYVPRTLKPT VPPLTPEQYE LYMYREVDTL ELTRQVKEKL 850
AKNGICQRIF GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL 900
SDQLGQGQGQ APTQQPSASQ ASPTEPTSSP SPPPSPTEPE KTSQEPLGLS 950
LESSKENQQP EGRASSSLGG KPFSSSQAAG GIQEMVAMSP ELDTYSITKR 1000
VKEVLTDNNL GQRLFGESIL GLTQGSVSDL LSRPKPWHKL SLKGREPFVR 1050
MQLWLSDPHN VEKLRDMKKL EKKAYLKRRY GLIGTGSDSE SPAAHSECPS 1100
PCLQPQELSL MQAKKPRVVL APAEKEALRK AYQLEPYPSQ QTIELLSFQL 1150
NLKTNTVINW FHNYRSRMRR EMLVEGTQDD PDFDPSGGPN VLTPGHTHRE 1200
PTPQSPDSET EDQKPPMKSL ELQEPEGPLQ RAAPDRALVK IKQEEGLEVD 1250
GDSQPQDVGD PDRGQDGPKE EHTHPLGNSD LSELAPGPFL SGTPNPDCPS 1300
LHNPQEKGTG EQVHSEPLSF KSTSESSCCS LEGPPNSPSV ISSPDLTTCV 1350
SPAPSSSAPI SPSLPGAPPA KVPSTSPTGD TAAALHPSTK VNPNLQRRHE 1400
KMANLNSIIY RLERAANREE VLEWEF 1426
Length:1,426
Mass (Da):154,664
Last modified:July 27, 2011 - v2
Checksum:i485B87D1C88D2577
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991S → G in AAC52762. 1 Publication
Sequence conflicti209 – 2091S → N in AAC52762. 1 Publication
Sequence conflicti324 – 3241T → M in AAC52762. 1 Publication
Sequence conflicti410 – 4101T → N in AAC52762. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U45665 mRNA. Translation: AAC52762.1.
BC065113 mRNA. Translation: AAH65113.1.
CCDSiCCDS39251.1.
PIRiT30817.
RefSeqiNP_031830.2. NM_007804.2.
XP_006530222.1. XM_006530159.1.
UniGeneiMm.156172.
Mm.332661.

Genome annotation databases

EnsembliENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589.
ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589.
ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589.
GeneIDi13048.
KEGGimmu:13048.
UCSCiuc008zkm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U45665 mRNA. Translation: AAC52762.1 .
BC065113 mRNA. Translation: AAH65113.1 .
CCDSi CCDS39251.1.
PIRi T30817.
RefSeqi NP_031830.2. NM_007804.2.
XP_006530222.1. XM_006530159.1.
UniGenei Mm.156172.
Mm.332661.

3D structure databases

ProteinModelPortali P70298.
SMRi P70298. Positions 487-569, 828-912, 977-1070.
ModBasei Search...

Protein-protein interaction databases

IntActi P70298. 1 interaction.

PTM databases

PhosphoSitei P70298.

Proteomic databases

PRIDEi P70298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000086317 ; ENSMUSP00000083497 ; ENSMUSG00000042589 .
ENSMUST00000111752 ; ENSMUSP00000107381 ; ENSMUSG00000042589 .
ENSMUST00000168288 ; ENSMUSP00000130302 ; ENSMUSG00000042589 .
GeneIDi 13048.
KEGGi mmu:13048.
UCSCi uc008zkm.1. mouse.

Organism-specific databases

CTDi 23316.
MGIi MGI:107321. Cux2.

Phylogenomic databases

eggNOGi NOG325167.
GeneTreei ENSGT00530000063019.
HOGENOMi HOG000143386.
HOVERGENi HBG051268.
InParanoidi Q6P1E6.
KOi K09313.
OMAi LVFPPAF.
OrthoDBi EOG7VTDMF.
TreeFami TF318206.

Miscellaneous databases

NextBioi 282958.
PROi P70298.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70298.
Bgeei P70298.
CleanExi MM_CUX2.
Genevestigatori P70298.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProi IPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEi PS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut."
    Quaggin S.E., Vanden Heuvel G.B., Golden K., Bodmer R., Igarashi P.
    J. Biol. Chem. 271:22624-22634(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCUX2_MOUSE
AccessioniPrimary (citable) accession number: P70298
Secondary accession number(s): Q6P1E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi