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P70298

- CUX2_MOUSE

UniProt

P70298 - CUX2_MOUSE

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Protein

Homeobox protein cut-like 2

Gene

Cux2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi482 – 56988CUT 1PROSITE-ProRule annotationAdd
BLAST
DNA bindingi828 – 91588CUT 2PROSITE-ProRule annotationAdd
BLAST
DNA bindingi983 – 107088CUT 3PROSITE-ProRule annotationAdd
BLAST
DNA bindingi1113 – 117260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProt

GO - Biological processi

  1. cellular response to organic substance Source: MGI
  2. negative regulation of transcription, DNA-templated Source: MGI
  3. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. positive regulation of dendrite morphogenesis Source: UniProt
  5. positive regulation of dendritic spine morphogenesis Source: UniProt
  6. positive regulation of excitatory postsynaptic membrane potential Source: UniProt
  7. positive regulation of gene expression Source: UniProt
  8. positive regulation of synapse assembly Source: UniProt
  9. short-term memory Source: UniProt
  10. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein Cux-2
Gene namesi
Name:Cux2
Synonyms:Cutl2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:107321. Cux2.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14261426Homeobox protein cut-like 2PRO_0000202397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei81 – 811PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP70298.
PRIDEiP70298.

PTM databases

PhosphoSiteiP70298.

Expressioni

Tissue specificityi

Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.

Gene expression databases

BgeeiP70298.
CleanExiMM_CUX2.
ExpressionAtlasiP70298. baseline and differential.
GenevestigatoriP70298.

Interactioni

Protein-protein interaction databases

IntActiP70298. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP70298.
SMRiP70298. Positions 487-569, 828-912, 977-1070.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili131 – 311181Sequence AnalysisAdd
BLAST
Coiled coili587 – 65569Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Homeobox, Repeat

Phylogenomic databases

eggNOGiNOG325167.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000143386.
HOVERGENiHBG051268.
InParanoidiP70298.
KOiK09313.
OMAiLVFPPAF.
OrthoDBiEOG7VTDMF.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProiIPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEiPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70298-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAPVLKSFQ AEVVALSKRS REAEAAFLSV YKQLIEAPDP VPSFEVARTL
60 70 80 90 100
DDRLQRPSFD PSGQRLQDVH IAWKRCPEPP SAREQNEGTC PTGHTPANGN
110 120 130 140 150
HLPGPEDTLV TDTLLQKNEA ERQKGLQEVH ITLAARLGEA EEKIKVLHSA
160 170 180 190 200
LKATQTELLE LRRKYDEEAA SKADEVGLIM TNLEKANQRA EAAQREVESL
210 220 230 240 250
REQLASVNSS IRLACCSPQG PSGEKVSFAL CSGPRLEAAL ASKDREILRL
260 270 280 290 300
LKDAQQLRHS LQELEEVSAN QIADLERQLA AKSEAIEKLQ EKLEAQADYE
310 320 330 340 350
EIKTELSILR AMKLASSTCS LPQTLAKPDD PLLVAKDVFF PTQKFLLEKP
360 370 380 390 400
ALLASPEEDP SEDDSIKGSL GTEPPYPPQL PPPPGPEDPL SPSPAQPLLG
410 420 430 440 450
PSLGPDGPRT FSLSPFPSLA PGERLAGDSL LSKHMMGPAA FKGETGNLLA
460 470 480 490 500
FPPTFYGGAK PPSAPAASVP CPEPTGAPEA VDGAGPEEEQ LDTAEIAFQV
510 520 530 540 550
KEQLLKHNIG QRVFGHYVLG LSQGSVSEIL ARPKPWRKLT VKGKEPFIKM
560 570 580 590 600
KQFLSDEQNV LALRTIQVRQ RGSITPRIRT PETGSDDAIK SILEQAKKEI
610 620 630 640 650
ESQKGGESKN SPASVSIPNG TASSSTSEDA IKNILEQARR EMQAQQQALL
660 670 680 690 700
EMESGPRGRS VPPSPPERPS PATASQNGAL TCVKQEDGGG GSGSSSTVQA
710 720 730 740 750
PLAVLSPAAF VQRIIRKVKS EIGDAGYFDH HWASDRGLLS RPYASVSPSL
760 770 780 790 800
SSSSSYSGQP NGRAWPRGDE ATIAPEDEAA MGEDEAPRVG ELKAEAGAPE
810 820 830 840 850
VGGGRLPYYP AYVPRTLKPT VPPLTPEQYE LYMYREVDTL ELTRQVKEKL
860 870 880 890 900
AKNGICQRIF GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL
910 920 930 940 950
SDQLGQGQGQ APTQQPSASQ ASPTEPTSSP SPPPSPTEPE KTSQEPLGLS
960 970 980 990 1000
LESSKENQQP EGRASSSLGG KPFSSSQAAG GIQEMVAMSP ELDTYSITKR
1010 1020 1030 1040 1050
VKEVLTDNNL GQRLFGESIL GLTQGSVSDL LSRPKPWHKL SLKGREPFVR
1060 1070 1080 1090 1100
MQLWLSDPHN VEKLRDMKKL EKKAYLKRRY GLIGTGSDSE SPAAHSECPS
1110 1120 1130 1140 1150
PCLQPQELSL MQAKKPRVVL APAEKEALRK AYQLEPYPSQ QTIELLSFQL
1160 1170 1180 1190 1200
NLKTNTVINW FHNYRSRMRR EMLVEGTQDD PDFDPSGGPN VLTPGHTHRE
1210 1220 1230 1240 1250
PTPQSPDSET EDQKPPMKSL ELQEPEGPLQ RAAPDRALVK IKQEEGLEVD
1260 1270 1280 1290 1300
GDSQPQDVGD PDRGQDGPKE EHTHPLGNSD LSELAPGPFL SGTPNPDCPS
1310 1320 1330 1340 1350
LHNPQEKGTG EQVHSEPLSF KSTSESSCCS LEGPPNSPSV ISSPDLTTCV
1360 1370 1380 1390 1400
SPAPSSSAPI SPSLPGAPPA KVPSTSPTGD TAAALHPSTK VNPNLQRRHE
1410 1420
KMANLNSIIY RLERAANREE VLEWEF
Length:1,426
Mass (Da):154,664
Last modified:July 27, 2011 - v2
Checksum:i485B87D1C88D2577
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991S → G in AAC52762. (PubMed:8798433)Curated
Sequence conflicti209 – 2091S → N in AAC52762. (PubMed:8798433)Curated
Sequence conflicti324 – 3241T → M in AAC52762. (PubMed:8798433)Curated
Sequence conflicti410 – 4101T → N in AAC52762. (PubMed:8798433)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45665 mRNA. Translation: AAC52762.1.
BC065113 mRNA. Translation: AAH65113.1.
CCDSiCCDS39251.1.
PIRiT30817.
RefSeqiNP_031830.2. NM_007804.2.
XP_006530222.1. XM_006530159.1.
UniGeneiMm.156172.
Mm.332661.

Genome annotation databases

EnsembliENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589.
ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589.
ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589.
GeneIDi13048.
KEGGimmu:13048.
UCSCiuc008zkm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45665 mRNA. Translation: AAC52762.1 .
BC065113 mRNA. Translation: AAH65113.1 .
CCDSi CCDS39251.1.
PIRi T30817.
RefSeqi NP_031830.2. NM_007804.2.
XP_006530222.1. XM_006530159.1.
UniGenei Mm.156172.
Mm.332661.

3D structure databases

ProteinModelPortali P70298.
SMRi P70298. Positions 487-569, 828-912, 977-1070.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P70298. 1 interaction.

PTM databases

PhosphoSitei P70298.

Proteomic databases

MaxQBi P70298.
PRIDEi P70298.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000086317 ; ENSMUSP00000083497 ; ENSMUSG00000042589 .
ENSMUST00000111752 ; ENSMUSP00000107381 ; ENSMUSG00000042589 .
ENSMUST00000168288 ; ENSMUSP00000130302 ; ENSMUSG00000042589 .
GeneIDi 13048.
KEGGi mmu:13048.
UCSCi uc008zkm.1. mouse.

Organism-specific databases

CTDi 23316.
MGIi MGI:107321. Cux2.

Phylogenomic databases

eggNOGi NOG325167.
GeneTreei ENSGT00530000063019.
HOGENOMi HOG000143386.
HOVERGENi HBG051268.
InParanoidi P70298.
KOi K09313.
OMAi LVFPPAF.
OrthoDBi EOG7VTDMF.
TreeFami TF318206.

Miscellaneous databases

ChiTaRSi Cux2. mouse.
NextBioi 282958.
PROi P70298.
SOURCEi Search...

Gene expression databases

Bgeei P70298.
CleanExi MM_CUX2.
ExpressionAtlasi P70298. baseline and differential.
Genevestigatori P70298.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProi IPR003350. CUT_dom.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view ]
Pfami PF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEi PS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut."
    Quaggin S.E., Vanden Heuvel G.B., Golden K., Bodmer R., Igarashi P.
    J. Biol. Chem. 271:22624-22634(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.

Entry informationi

Entry nameiCUX2_MOUSE
AccessioniPrimary (citable) accession number: P70298
Secondary accession number(s): Q6P1E6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3