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P70298

- CUX2_MOUSE

UniProt

P70298 - CUX2_MOUSE

Protein

Homeobox protein cut-like 2

Gene

Cux2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi482 – 56988CUT 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi828 – 91588CUT 2PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi983 – 107088CUT 3PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi1113 – 117260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. RNA polymerase II regulatory region sequence-specific DNA binding Source: UniProt
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. cellular response to organic substance Source: MGI
    2. negative regulation of transcription, DNA-templated Source: MGI
    3. positive regulation of dendrite morphogenesis Source: UniProt
    4. positive regulation of dendritic spine morphogenesis Source: UniProt
    5. positive regulation of excitatory postsynaptic membrane potential Source: UniProt
    6. positive regulation of gene expression Source: UniProt
    7. positive regulation of synapse assembly Source: UniProt
    8. short-term memory Source: UniProt
    9. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein cut-like 2
    Alternative name(s):
    Homeobox protein Cux-2
    Gene namesi
    Name:Cux2
    Synonyms:Cutl2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:107321. Cux2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 14261426Homeobox protein cut-like 2PRO_0000202397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei81 – 811PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiP70298.

    PTM databases

    PhosphoSiteiP70298.

    Expressioni

    Tissue specificityi

    Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.

    Gene expression databases

    ArrayExpressiP70298.
    BgeeiP70298.
    CleanExiMM_CUX2.
    GenevestigatoriP70298.

    Interactioni

    Protein-protein interaction databases

    IntActiP70298. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP70298.
    SMRiP70298. Positions 487-569, 828-912, 977-1070.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili131 – 311181Sequence AnalysisAdd
    BLAST
    Coiled coili587 – 65569Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CUT homeobox family.Curated
    Contains 3 CUT DNA-binding domains.PROSITE-ProRule annotation
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Homeobox, Repeat

    Phylogenomic databases

    eggNOGiNOG325167.
    GeneTreeiENSGT00530000063019.
    HOGENOMiHOG000143386.
    HOVERGENiHBG051268.
    InParanoidiQ6P1E6.
    KOiK09313.
    OMAiLVFPPAF.
    OrthoDBiEOG7VTDMF.
    TreeFamiTF318206.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 3 hits.
    InterProiIPR003350. Hmoeo_CUT.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view]
    PfamiPF02376. CUT. 3 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 3 hits.
    PROSITEiPS51042. CUT. 3 hits.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70298-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAPVLKSFQ AEVVALSKRS REAEAAFLSV YKQLIEAPDP VPSFEVARTL     50
    DDRLQRPSFD PSGQRLQDVH IAWKRCPEPP SAREQNEGTC PTGHTPANGN 100
    HLPGPEDTLV TDTLLQKNEA ERQKGLQEVH ITLAARLGEA EEKIKVLHSA 150
    LKATQTELLE LRRKYDEEAA SKADEVGLIM TNLEKANQRA EAAQREVESL 200
    REQLASVNSS IRLACCSPQG PSGEKVSFAL CSGPRLEAAL ASKDREILRL 250
    LKDAQQLRHS LQELEEVSAN QIADLERQLA AKSEAIEKLQ EKLEAQADYE 300
    EIKTELSILR AMKLASSTCS LPQTLAKPDD PLLVAKDVFF PTQKFLLEKP 350
    ALLASPEEDP SEDDSIKGSL GTEPPYPPQL PPPPGPEDPL SPSPAQPLLG 400
    PSLGPDGPRT FSLSPFPSLA PGERLAGDSL LSKHMMGPAA FKGETGNLLA 450
    FPPTFYGGAK PPSAPAASVP CPEPTGAPEA VDGAGPEEEQ LDTAEIAFQV 500
    KEQLLKHNIG QRVFGHYVLG LSQGSVSEIL ARPKPWRKLT VKGKEPFIKM 550
    KQFLSDEQNV LALRTIQVRQ RGSITPRIRT PETGSDDAIK SILEQAKKEI 600
    ESQKGGESKN SPASVSIPNG TASSSTSEDA IKNILEQARR EMQAQQQALL 650
    EMESGPRGRS VPPSPPERPS PATASQNGAL TCVKQEDGGG GSGSSSTVQA 700
    PLAVLSPAAF VQRIIRKVKS EIGDAGYFDH HWASDRGLLS RPYASVSPSL 750
    SSSSSYSGQP NGRAWPRGDE ATIAPEDEAA MGEDEAPRVG ELKAEAGAPE 800
    VGGGRLPYYP AYVPRTLKPT VPPLTPEQYE LYMYREVDTL ELTRQVKEKL 850
    AKNGICQRIF GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL 900
    SDQLGQGQGQ APTQQPSASQ ASPTEPTSSP SPPPSPTEPE KTSQEPLGLS 950
    LESSKENQQP EGRASSSLGG KPFSSSQAAG GIQEMVAMSP ELDTYSITKR 1000
    VKEVLTDNNL GQRLFGESIL GLTQGSVSDL LSRPKPWHKL SLKGREPFVR 1050
    MQLWLSDPHN VEKLRDMKKL EKKAYLKRRY GLIGTGSDSE SPAAHSECPS 1100
    PCLQPQELSL MQAKKPRVVL APAEKEALRK AYQLEPYPSQ QTIELLSFQL 1150
    NLKTNTVINW FHNYRSRMRR EMLVEGTQDD PDFDPSGGPN VLTPGHTHRE 1200
    PTPQSPDSET EDQKPPMKSL ELQEPEGPLQ RAAPDRALVK IKQEEGLEVD 1250
    GDSQPQDVGD PDRGQDGPKE EHTHPLGNSD LSELAPGPFL SGTPNPDCPS 1300
    LHNPQEKGTG EQVHSEPLSF KSTSESSCCS LEGPPNSPSV ISSPDLTTCV 1350
    SPAPSSSAPI SPSLPGAPPA KVPSTSPTGD TAAALHPSTK VNPNLQRRHE 1400
    KMANLNSIIY RLERAANREE VLEWEF 1426
    Length:1,426
    Mass (Da):154,664
    Last modified:July 27, 2011 - v2
    Checksum:i485B87D1C88D2577
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti199 – 1991S → G in AAC52762. (PubMed:8798433)Curated
    Sequence conflicti209 – 2091S → N in AAC52762. (PubMed:8798433)Curated
    Sequence conflicti324 – 3241T → M in AAC52762. (PubMed:8798433)Curated
    Sequence conflicti410 – 4101T → N in AAC52762. (PubMed:8798433)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U45665 mRNA. Translation: AAC52762.1.
    BC065113 mRNA. Translation: AAH65113.1.
    CCDSiCCDS39251.1.
    PIRiT30817.
    RefSeqiNP_031830.2. NM_007804.2.
    XP_006530222.1. XM_006530159.1.
    UniGeneiMm.156172.
    Mm.332661.

    Genome annotation databases

    EnsembliENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589.
    ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589.
    ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589.
    GeneIDi13048.
    KEGGimmu:13048.
    UCSCiuc008zkm.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U45665 mRNA. Translation: AAC52762.1 .
    BC065113 mRNA. Translation: AAH65113.1 .
    CCDSi CCDS39251.1.
    PIRi T30817.
    RefSeqi NP_031830.2. NM_007804.2.
    XP_006530222.1. XM_006530159.1.
    UniGenei Mm.156172.
    Mm.332661.

    3D structure databases

    ProteinModelPortali P70298.
    SMRi P70298. Positions 487-569, 828-912, 977-1070.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P70298. 1 interaction.

    PTM databases

    PhosphoSitei P70298.

    Proteomic databases

    PRIDEi P70298.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000086317 ; ENSMUSP00000083497 ; ENSMUSG00000042589 .
    ENSMUST00000111752 ; ENSMUSP00000107381 ; ENSMUSG00000042589 .
    ENSMUST00000168288 ; ENSMUSP00000130302 ; ENSMUSG00000042589 .
    GeneIDi 13048.
    KEGGi mmu:13048.
    UCSCi uc008zkm.1. mouse.

    Organism-specific databases

    CTDi 23316.
    MGIi MGI:107321. Cux2.

    Phylogenomic databases

    eggNOGi NOG325167.
    GeneTreei ENSGT00530000063019.
    HOGENOMi HOG000143386.
    HOVERGENi HBG051268.
    InParanoidi Q6P1E6.
    KOi K09313.
    OMAi LVFPPAF.
    OrthoDBi EOG7VTDMF.
    TreeFami TF318206.

    Miscellaneous databases

    NextBioi 282958.
    PROi P70298.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70298.
    Bgeei P70298.
    CleanExi MM_CUX2.
    Genevestigatori P70298.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 3 hits.
    InterProi IPR003350. Hmoeo_CUT.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    [Graphical view ]
    Pfami PF02376. CUT. 3 hits.
    PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 3 hits.
    PROSITEi PS51042. CUT. 3 hits.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut."
      Quaggin S.E., Vanden Heuvel G.B., Golden K., Bodmer R., Igarashi P.
      J. Biol. Chem. 271:22624-22634(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.

    Entry informationi

    Entry nameiCUX2_MOUSE
    AccessioniPrimary (citable) accession number: P70298
    Secondary accession number(s): Q6P1E6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3