Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P70298 (CUX2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein cut-like 2
Alternative name(s):
Homeobox protein Cux-2
Gene names
Name:Cux2
Synonyms:Cutl2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1426 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May be a transcription factor involved in neural specification. Binds to DNA in a sequence-specific manner.

Subcellular location

Nucleus.

Tissue specificity

Restricted to neural tissues. Expressed exclusively in the central and peripheral nervous systems.

Sequence similarities

Belongs to the CUT homeobox family.

Contains 3 CUT DNA-binding domains.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainCoiled coil
Homeobox
Repeat
   LigandDNA-binding
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular response to organic substance

Inferred from direct assay PubMed 18794345. Source: MGI

negative regulation of transcription, DNA-templated

Inferred from direct assay PubMed 15656993. Source: MGI

positive regulation of dendrite morphogenesis

Inferred from mutant phenotype PubMed 20510857. Source: UniProt

positive regulation of dendritic spine morphogenesis

Inferred from mutant phenotype PubMed 20510857. Source: UniProt

positive regulation of excitatory postsynaptic membrane potential

Inferred from mutant phenotype PubMed 20510857. Source: UniProt

positive regulation of gene expression

Inferred from mutant phenotype PubMed 20510857. Source: UniProt

positive regulation of synapse assembly

Inferred from mutant phenotype PubMed 20510857. Source: UniProt

short-term memory

Inferred from mutant phenotype PubMed 20510857. Source: UniProt

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 15656993PubMed 17412818. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 15656993. Source: MGI

RNA polymerase II regulatory region sequence-specific DNA binding

Inferred from mutant phenotype PubMed 20510857. Source: UniProt

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14261426Homeobox protein cut-like 2
PRO_0000202397

Regions

DNA binding482 – 56988CUT 1
DNA binding828 – 91588CUT 2
DNA binding983 – 107088CUT 3
DNA binding1113 – 117260Homeobox
Coiled coil131 – 311181 Potential
Coiled coil587 – 65569 Potential

Amino acid modifications

Modified residue811Phosphoserine By similarity

Experimental info

Sequence conflict1991S → G in AAC52762. Ref.1
Sequence conflict2091S → N in AAC52762. Ref.1
Sequence conflict3241T → M in AAC52762. Ref.1
Sequence conflict4101T → N in AAC52762. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P70298 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 485B87D1C88D2577

FASTA1,426154,664
        10         20         30         40         50         60 
MVAPVLKSFQ AEVVALSKRS REAEAAFLSV YKQLIEAPDP VPSFEVARTL DDRLQRPSFD 

        70         80         90        100        110        120 
PSGQRLQDVH IAWKRCPEPP SAREQNEGTC PTGHTPANGN HLPGPEDTLV TDTLLQKNEA 

       130        140        150        160        170        180 
ERQKGLQEVH ITLAARLGEA EEKIKVLHSA LKATQTELLE LRRKYDEEAA SKADEVGLIM 

       190        200        210        220        230        240 
TNLEKANQRA EAAQREVESL REQLASVNSS IRLACCSPQG PSGEKVSFAL CSGPRLEAAL 

       250        260        270        280        290        300 
ASKDREILRL LKDAQQLRHS LQELEEVSAN QIADLERQLA AKSEAIEKLQ EKLEAQADYE 

       310        320        330        340        350        360 
EIKTELSILR AMKLASSTCS LPQTLAKPDD PLLVAKDVFF PTQKFLLEKP ALLASPEEDP 

       370        380        390        400        410        420 
SEDDSIKGSL GTEPPYPPQL PPPPGPEDPL SPSPAQPLLG PSLGPDGPRT FSLSPFPSLA 

       430        440        450        460        470        480 
PGERLAGDSL LSKHMMGPAA FKGETGNLLA FPPTFYGGAK PPSAPAASVP CPEPTGAPEA 

       490        500        510        520        530        540 
VDGAGPEEEQ LDTAEIAFQV KEQLLKHNIG QRVFGHYVLG LSQGSVSEIL ARPKPWRKLT 

       550        560        570        580        590        600 
VKGKEPFIKM KQFLSDEQNV LALRTIQVRQ RGSITPRIRT PETGSDDAIK SILEQAKKEI 

       610        620        630        640        650        660 
ESQKGGESKN SPASVSIPNG TASSSTSEDA IKNILEQARR EMQAQQQALL EMESGPRGRS 

       670        680        690        700        710        720 
VPPSPPERPS PATASQNGAL TCVKQEDGGG GSGSSSTVQA PLAVLSPAAF VQRIIRKVKS 

       730        740        750        760        770        780 
EIGDAGYFDH HWASDRGLLS RPYASVSPSL SSSSSYSGQP NGRAWPRGDE ATIAPEDEAA 

       790        800        810        820        830        840 
MGEDEAPRVG ELKAEAGAPE VGGGRLPYYP AYVPRTLKPT VPPLTPEQYE LYMYREVDTL 

       850        860        870        880        890        900 
ELTRQVKEKL AKNGICQRIF GEKVLGLSQG SVSDMLSRPK PWSKLTQKGR EPFIRMQLWL 

       910        920        930        940        950        960 
SDQLGQGQGQ APTQQPSASQ ASPTEPTSSP SPPPSPTEPE KTSQEPLGLS LESSKENQQP 

       970        980        990       1000       1010       1020 
EGRASSSLGG KPFSSSQAAG GIQEMVAMSP ELDTYSITKR VKEVLTDNNL GQRLFGESIL 

      1030       1040       1050       1060       1070       1080 
GLTQGSVSDL LSRPKPWHKL SLKGREPFVR MQLWLSDPHN VEKLRDMKKL EKKAYLKRRY 

      1090       1100       1110       1120       1130       1140 
GLIGTGSDSE SPAAHSECPS PCLQPQELSL MQAKKPRVVL APAEKEALRK AYQLEPYPSQ 

      1150       1160       1170       1180       1190       1200 
QTIELLSFQL NLKTNTVINW FHNYRSRMRR EMLVEGTQDD PDFDPSGGPN VLTPGHTHRE 

      1210       1220       1230       1240       1250       1260 
PTPQSPDSET EDQKPPMKSL ELQEPEGPLQ RAAPDRALVK IKQEEGLEVD GDSQPQDVGD 

      1270       1280       1290       1300       1310       1320 
PDRGQDGPKE EHTHPLGNSD LSELAPGPFL SGTPNPDCPS LHNPQEKGTG EQVHSEPLSF 

      1330       1340       1350       1360       1370       1380 
KSTSESSCCS LEGPPNSPSV ISSPDLTTCV SPAPSSSAPI SPSLPGAPPA KVPSTSPTGD 

      1390       1400       1410       1420 
TAAALHPSTK VNPNLQRRHE KMANLNSIIY RLERAANREE VLEWEF 

« Hide

References

« Hide 'large scale' references
[1]"Primary structure, neural-specific expression, and chromosomal localization of Cux-2, a second murine homeobox gene related to Drosophila cut."
Quaggin S.E., Vanden Heuvel G.B., Golden K., Bodmer R., Igarashi P.
J. Biol. Chem. 271:22624-22634(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U45665 mRNA. Translation: AAC52762.1.
BC065113 mRNA. Translation: AAH65113.1.
CCDSCCDS39251.1.
PIRT30817.
RefSeqNP_031830.2. NM_007804.2.
XP_006530222.1. XM_006530159.1.
UniGeneMm.156172.
Mm.332661.

3D structure databases

ProteinModelPortalP70298.
SMRP70298. Positions 487-569, 828-912, 977-1070.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP70298. 1 interaction.

PTM databases

PhosphoSiteP70298.

Proteomic databases

PRIDEP70298.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000086317; ENSMUSP00000083497; ENSMUSG00000042589.
ENSMUST00000111752; ENSMUSP00000107381; ENSMUSG00000042589.
ENSMUST00000168288; ENSMUSP00000130302; ENSMUSG00000042589.
GeneID13048.
KEGGmmu:13048.
UCSCuc008zkm.1. mouse.

Organism-specific databases

CTD23316.
MGIMGI:107321. Cux2.

Phylogenomic databases

eggNOGNOG325167.
GeneTreeENSGT00530000063019.
HOGENOMHOG000143386.
HOVERGENHBG051268.
InParanoidQ6P1E6.
KOK09313.
OMALVFPPAF.
OrthoDBEOG7VTDMF.
TreeFamTF318206.

Gene expression databases

ArrayExpressP70298.
BgeeP70298.
CleanExMM_CUX2.
GenevestigatorP70298.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
1.10.260.40. 3 hits.
InterProIPR003350. Hmoeo_CUT.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamPF02376. CUT. 3 hits.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 3 hits.
PROSITEPS51042. CUT. 3 hits.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282958.
PROP70298.
SOURCESearch...

Entry information

Entry nameCUX2_MOUSE
AccessionPrimary (citable) accession number: P70298
Secondary accession number(s): Q6P1E6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot