ID   AUP1_MOUSE              Reviewed;         410 AA.
AC   P70295;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   13-OCT-2009, entry version 68.
DE   RecName: Full=Ancient ubiquitous protein 1;
GN   Name=Aup1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   MEDLINE=96411699; PubMed=8812468; DOI=10.1006/geno.1996.0477;
RA   Jang W., Weber J.S., Bashir R., Bushby K., Meisler M.H.;
RT   "Aup1, a novel gene on mouse chromosome 6 and human chromosome 2p13.";
RL   Genomics 36:366-368(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Mammary gland;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in the translocation of terminally
CC       misfolded proteins from the endoplasmic reticulum lumen to the
CC       cytoplasm and their degradation by the proteasome (By similarity).
CC   -!- SUBUNIT: Identified in a complex that contains SEL1L, OS9,
CC       FAF2/UBXD8, UBE2J1/UBC6E and AUP1. Interacts with the cytoplasmic
CC       tail of ITGA2B, ITGA1, ITGA2, ITGA5, ITGAV and ITGAM (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass
CC       type III membrane protein; Cytoplasmic side (By similarity).
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the AUP1 family.
CC   -!- SIMILARITY: Contains 1 CUE domain.
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DR   EMBL; U41736; AAC52839.1; -; mRNA.
DR   EMBL; BC016485; AAH16485.1; -; mRNA.
DR   IPI; IPI00137725; -.
DR   UniGene; Mm.386752; -.
DR   STRING; P70295; -.
DR   PhosphoSite; P70295; -.
DR   PRIDE; P70295; -.
DR   Ensembl; ENSMUST00000092618; ENSMUSP00000090281; ENSMUSG00000068328; Mus musculus.
DR   MGI; MGI:107789; Aup1.
DR   HOVERGEN; P70295; -.
DR   ArrayExpress; P70295; -.
DR   Bgee; P70295; -.
DR   CleanEx; MM_AUP1; -.
DR   Genevestigator; P70295; -.
DR   GermOnline; ENSMUSG00000068328; Mus musculus.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009898; C:internal side of plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008415; F:acyltransferase activity; IEA:InterPro.
DR   GO; GO:0019941; P:modification-dependent protein catabolic pr...; IEA:UniProtKB-KW.
DR   InterPro; IPR002123; Acyltransferase.
DR   InterPro; IPR003892; CUE.
DR   Pfam; PF02845; CUE; 1.
DR   SMART; SM00546; CUE; 1.
DR   SMART; SM00563; PlsC; 1.
DR   PROSITE; PS51140; CUE; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Membrane; Phosphoprotein; Transmembrane;
KW   Ubl conjugation pathway.
FT   CHAIN         1    410       Ancient ubiquitous protein 1.
FT                                /FTId=PRO_0000020766.
FT   TOPO_DOM      1     20       Lumenal (Potential).
FT   TRANSMEM     21     41       Signal-anchor for type III membrane
FT                                protein (Potential).
FT   TOPO_DOM     42    410       Cytoplasmic (Potential).
FT   DOMAIN      296    338       CUE.
FT   MOD_RES     292    292       Phosphoserine (By similarity).
FT   MOD_RES     356    356       Phosphoserine (By similarity).
FT   MOD_RES     363    363       Phosphoserine (By similarity).
FT   MOD_RES     367    367       Phosphothreonine (By similarity).
SQ   SEQUENCE   410 AA;  46121 MW;  E7D070CEB296BD5B CRC64;
     MEPPPAPGPE RLFDSHRLPS DGFLLLALLL YAPVGLCLLV LRLFLGLHVF LVSCALPDSV
     LRRFVVRTMC AVLGLVARQE DSGLRDHRVR VLISNHVTPF DHNIVNLLTT CSTPLLNSPP
     SFVCWSRGFM EMDRRVELVE SLKKFCASTR LPPTPLLLFP EEEATNGREG LLRFSSWPFS
     IQDVVQPLTL QVQRPLVSVT VSDASWVSEL LWSLFVPFTV YQVRWLHPIR RQLGEESEEF
     ALRVQQLVAK ELGQIGTRLT PADKAEHMKR QRHPRLRPQS VQSSFPSPPS PSSDVQLTTL
     AHRVKEVLPH VPLNVIQRDL ARTGCVDLTI TNLLEGAVAF MPEDVTEGSQ SPPAPSAPKF
     PSSGLATPQP TALTFAKSSW ARQESLQERK QALYEYARRR FRERQAQEAE
//