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Protein

55 kDa erythrocyte membrane protein

Gene

Mpp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.1 Publication

GO - Biological processi

  • regulation of neutrophil chemotaxis Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
55 kDa erythrocyte membrane protein
Short name:
p55
Alternative name(s):
Membrane protein, palmitoylated 1
Gene namesi
Name:Mpp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:105941 Mpp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Neutrophils form multiple transient pseudopods upon chemotactic stimulation, and do not migrate efficiently in vitro.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000945662 – 46655 kDa erythrocyte membrane proteinAdd BLAST465

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylthreonineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei19PhosphoserineBy similarity1
Modified residuei49PhosphothreonineBy similarity1
Modified residuei52PhosphoserineCombined sources1
Modified residuei57PhosphoserineCombined sources1
Modified residuei110PhosphoserineCombined sources1
Modified residuei243PhosphoserineBy similarity1

Post-translational modificationi

Extensively palmitoylated by ZDHHC17, palmitoylation is essential for membrane organization and is crucial for proper erythrocytes morphology.By similarity

Keywords - PTMi

Acetylation, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

EPDiP70290
PaxDbiP70290
PeptideAtlasiP70290
PRIDEiP70290

PTM databases

iPTMnetiP70290
PhosphoSitePlusiP70290
SwissPalmiP70290

Expressioni

Tissue specificityi

Abundantly expressed in the erythrocytes (at protein level).1 Publication

Developmental stagei

During development of the retina, expression is highest in the inner, neuroblastic layer, while at later stages it is also present in the photoreceptor cell layer. Detected in the eye from E14.5 onwards. Highly expressed in the liver and primitive gut, and at lower levels in the umbilical vein, the ventricular layer of the CNS and upper/lower jaw region. At E14.5 and E16.5, expression in the liver and stomach is maintained. In addition, expression is present in bone structures (e.g. zygomatic bone, lower jawbone), cranial nerve ganglia [e.g. trigeminal (V) ganglion] and cochlea. The expression in the eye is seen in the neuroblastic layer. At E16.5 and E18.5, a slightly higher expression is seen in the neuroblastic layer. At E16.5, strong expression in the upper part of the gut is maintained and with the onset of ossification, expression is seen in all bone structures of the body. At P7 and P90, expression in the eye is seen in the ganglion cell layer, the inner nuclear layer (INL) and photoreceptor cell layer.1 Publication

Gene expression databases

BgeeiENSMUSG00000031402
CleanExiMM_MPP1
ExpressionAtlasiP70290 baseline and differential
GenevisibleiP70290 MM

Interactioni

Subunit structurei

Heterodimer with MPP5. Interacts with DLG5 and NF2. Interacts (via guanylate kinase-like domain) with WHRN (via third PDZ domain).2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
WhrnQ80VW54EBI-8315951,EBI-7417603

Protein-protein interaction databases

DIPiDIP-61219N
IntActiP70290, 5 interactors
MINTiP70290
STRINGi10090.ENSMUSP00000033775

Structurei

3D structure databases

ProteinModelPortaliP70290
SMRiP70290
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini71 – 152PDZPROSITE-ProRule annotationAdd BLAST82
Domaini158 – 228SH3PROSITE-ProRule annotationAdd BLAST71
Domaini282 – 451Guanylate kinase-likePROSITE-ProRule annotationAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni268 – 466Interaction with MPP5By similarityAdd BLAST199

Sequence similaritiesi

Belongs to the MAGUK family.Curated

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG0609 Eukaryota
COG0194 LUCA
GeneTreeiENSGT00760000118866
HOGENOMiHOG000233034
HOVERGENiHBG001858
InParanoidiP70290
KOiK21880
OMAiFVYPAPY
OrthoDBiEOG091G065I
PhylomeDBiP70290
TreeFamiTF314263

Family and domain databases

CDDicd12080 SH3_MPP1, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR020590 Guanylate_kinase_CS
IPR035475 MPP1_SH3
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70290-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKSSEGEG GNSMRTALSD LYLEHLLQKR NRPETSLNQS NVTTEDMYTN
60 70 80 90 100
GSPAPGSPAH AKGQEARRVR LIQFEKITEE PMGITLKLNE KQSCTVARIL
110 120 130 140 150
HGGMIHRQGS LHVGDEILEI NGTNVTNHSV DQLQKAMKET KGMISLKVIA
160 170 180 190 200
NQQSRLPALQ MFMRAQFDYD PQKDNLIPCK EAGLKFVTGD IIQIINKDDS
210 220 230 240 250
NWWQGRVEGS SKESAGLIPS PELQEWRVAS VAHSAPSEAP SCSPFGKKKK
260 270 280 290 300
CKDKYLAKHS SIFDQLDVVS YEEVVRLPAF KRKTLVLIGA SGVGRSHIKN
310 320 330 340 350
GLLSHNPEKF AYPAPYTTRP PKKSEEDGKE YHFISTEEMT KNISANEFLE
360 370 380 390 400
FGSYQGNMFG TKFETVHQIH KQDKIAILDI EPQTLKTVRT AELSPFIVFI
410 420 430 440 450
APTDQGTQTE ALQQLQKDSE AIRSQYAHYF DLSLVNNSVD ETLKKLQEAF
460
DQACSSPQWV PVSWVY
Length:466
Mass (Da):52,227
Last modified:February 1, 1997 - v1
Checksum:i8724DE75A717A464
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38196 mRNA Translation: AAC52970.1
BC013444 mRNA Translation: AAH13444.1
CCDSiCCDS30236.1
RefSeqiNP_032647.1, NM_008621.3
UniGeneiMm.391267

Genome annotation databases

EnsembliENSMUST00000033775; ENSMUSP00000033775; ENSMUSG00000031402
GeneIDi17524
KEGGimmu:17524
UCSCiuc009tpp.1 mouse

Similar proteinsi

Entry informationi

Entry nameiEM55_MOUSE
AccessioniPrimary (citable) accession number: P70290
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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