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Protein

Receptor-type tyrosine-protein phosphatase V

Gene

Ptprv

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in the maintenance of pluripotency. Down-regulated during differentiation.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1316SubstrateBy similarity1
Active sitei1350Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1394SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

  • cellular lipid catabolic process Source: MGI
  • cellular response to insulin stimulus Source: MGI
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: MGI
  • glucose homeostasis Source: MGI
  • mitotic G1 DNA damage checkpoint Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of insulin secretion Source: MGI
  • pancreas development Source: MGI
  • protein carboxylation Source: MGI
  • type B pancreatic cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase V (EC:3.1.3.48)
Short name:
R-PTP-V
Alternative name(s):
Embryonic stem cell protein-tyrosine phosphatase
Short name:
ES cell phosphatase
Gene namesi
Name:Ptprv
Synonyms:Esp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:108027. Ptprv.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 1077ExtracellularSequence analysisAdd BLAST1059
Transmembranei1078 – 1100HelicalSequence analysisAdd BLAST23
Topological domaini1101 – 1705CytoplasmicSequence analysisAdd BLAST605

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000002546619 – 1705Receptor-type tyrosine-protein phosphatase VAdd BLAST1687

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi74N-linked (GlcNAc...)Sequence analysis1
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1
Glycosylationi117N-linked (GlcNAc...)Sequence analysis1
Glycosylationi174N-linked (GlcNAc...)Sequence analysis1
Glycosylationi239N-linked (GlcNAc...)Sequence analysis1
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi345N-linked (GlcNAc...)Sequence analysis1
Glycosylationi431N-linked (GlcNAc...)Sequence analysis1
Glycosylationi551N-linked (GlcNAc...)Sequence analysis1
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1
Glycosylationi620N-linked (GlcNAc...)Sequence analysis1
Glycosylationi649N-linked (GlcNAc...)Sequence analysis1
Glycosylationi663N-linked (GlcNAc...)Sequence analysis1
Glycosylationi737N-linked (GlcNAc...)Sequence analysis1
Glycosylationi851N-linked (GlcNAc...)Sequence analysis1
Glycosylationi882N-linked (GlcNAc...)Sequence analysis1
Glycosylationi970N-linked (GlcNAc...)Sequence analysis1
Glycosylationi982N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PeptideAtlasiP70289.
PRIDEiP70289.

Expressioni

Developmental stagei

Detectable in the epiblast of oocytes and throughout early mouse embryo development. In adult, expression is localized in gonadal germ cells.

Gene expression databases

CleanExiMM_PTPRV.

Structurei

3D structure databases

ProteinModelPortaliP70289.
SMRiP70289.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 129Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini130 – 222Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST93
Domaini218 – 305Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST88
Domaini306 – 388Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST83
Domaini393 – 454Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST62
Domaini475 – 569Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST95
Domaini565 – 654Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini655 – 749Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST95
Domaini744 – 831Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST88
Domaini832 – 926Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST95
Domaini1150 – 1409Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST260
Domaini1427 – 1695Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1350 – 1356Substrate bindingBy similarity7

Sequence similaritiesi

Contains 10 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053764.
InParanoidiP70289.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 6 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 8 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70289-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRPLILLAAL LWLQDSLAQE DVCSSLDGSP DRQGGGPPLS VSVTSRGRPT
60 70 80 90 100
SLFLSWVAAE PGGFDYALCL RAMNLSGFPE GQQLQAHTNE SSFEFHGLVP
110 120 130 140 150
GSRYQLELTV LRPCWQNVTI TLTARTAPTV VRGLQLHSTG SPASLEASWS
160 170 180 190 200
DASGDQDSYQ LLLYHPESHT LACNVSVSPD TLSYNFGDLL PGSQYVLEVI
210 220 230 240 250
TWAGSLHAKT SILQWTEPVP PDHLRVRALG TSSLQAFWNS SEGATWFHLI
260 270 280 290 300
LTDLLEGTNL TKVVRQGIST HTFLRLSPGT PYQLKICAAA GPHQIWGPNA
310 320 330 340 350
TEWTYPSYPS DLVLTPLWNE LWASWKAGQG ARDGYVLKLS GPVENTTTLG
360 370 380 390 400
PEECNAVFPG PLPPGHYTLG LRVLAGPYDA WVEGSIWLAE SAARPMEVPG
410 420 430 440 450
ARLWLEGLEA TKQPGRRALL YSVDAPGLLG NISVSSGATH VTFCGLVPGA
460 470 480 490 500
HYRVDIASSM GDITQSLTGY TSPLPPQSLE IISRNSPSDL TIGWAPAPGQ
510 520 530 540 550
MEGYKVTWHQ DGSQRSPGDL VDLGPDISSL TLKSLVPGSC YTVSAWAWSG
560 570 580 590 600
NLSSDSQKIH SCTRPAPPTN LSLGFAHQPA TLRASWCHPP GGRDAFQLRL
610 620 630 640 650
YRLRPLTLES EKILSQEAQN FSWAQLPAGY EFQVQLSTLW GSEESGSANT
660 670 680 690 700
TGWTPPSAPT LVNVTSEAPT QLHVSWVHAA GDRSSYQVTL YQESTRTATS
710 720 730 740 750
IVGPKADSTS FWGLTPGTKY KVEAISWAGP LYTAAANVSA WTYPLTPNEL
760 770 780 790 800
LASMQAGSAV VNLAWPSGPL GRGTCHAQLS DAGHLSWEQP LSLGQDLLML
810 820 830 840 850
RNLIPGHTVS LSVKCRAGPL QASTHPLVLS VEPGPVEDVF CQPEATYLSL
860 870 880 890 900
NWTMPTGDVA VCLVEVEQLV PGGSAHFVFQ VNTSEDALLL PNLTPTTSYR
910 920 930 940 950
LSLTVLGGNR QWSRAVTLVC TTSAEVWHPP ELAEAPQVEL GTGMGVTVTR
960 970 980 990 1000
GMFGKDDGQI QWYGIIATIN MTLAQPSQEA INHTWYDHYY RGHDSYLALL
1010 1020 1030 1040 1050
FPNPFYPEPW AVPRSWTVPV GTEDCDNTQE ICNGHLKPGF QYRFSIAAFS
1060 1070 1080 1090 1100
RLSSPETILA FSAFSEPQAS ISLVAMPLTV MMGTVVGCII IVCAVLCLLC
1110 1120 1130 1140 1150
RRGLKGPRSE KNGFSQELMP YNLWRTHRPI PSHSFRQSYE AKSARAHQAF
1160 1170 1180 1190 1200
FQEFEELKEV GKDQPRLEAE HPANITKNRY PHVLPYDHSR VRLTQLSGEP
1210 1220 1230 1240 1250
HSDYINANFI PGYSHPQEII ATQGPLKKTV EDFWRLVWEQ QVHVIIMLTV
1260 1270 1280 1290 1300
GMENGRVLCE HYWPVNSTPV THGHITTHLL AEESEDEWTR REFQLQHGAE
1310 1320 1330 1340 1350
QKQRRVKQLQ FTTWPDHSVP EAPSSLLAFV ELVQEEVKAT QGKGPILVHC
1360 1370 1380 1390 1400
SAGVGRTGTF VALLPAVRQL EEEQVVDVFN TVYILRLHRP LMIQTLSQYI
1410 1420 1430 1440 1450
FLHSCLLNKI LEGPSDASDS GPIPVMNFAQ ACAKRAANAN AGFLKEYRLL
1460 1470 1480 1490 1500
KQAIKDETGS LLPSPDYNQN SIASCHHSQE QLALVEESPA DNMLAASLFP
1510 1520 1530 1540 1550
GGPSGRDHVV LTGSAGPKEL WEMVWEHGAY VLVSLGLPDT KEKPQDIWPM
1560 1570 1580 1590 1600
EMQPIVTDMV TVHRVAESNT AGWPSTLIRV IHGDSGTERQ VQCLQFPHCE
1610 1620 1630 1640 1650
TGSELPANTL LTFLDAVGQC CSRGNSKKPG TLLSHSSKVT NQLSTFLAME
1660 1670 1680 1690 1700
QLLQQAGTER TVDVFSVALK QTQACAVKTP TLEQYIYLYN CLNSALRNRL

PRARK
Length:1,705
Mass (Da):186,796
Last modified:February 1, 1997 - v1
Checksum:i2783755F15387D5B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36488 mRNA. Translation: AAC52868.1.
UniGeneiMm.4450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36488 mRNA. Translation: AAC52868.1.
UniGeneiMm.4450.

3D structure databases

ProteinModelPortaliP70289.
SMRiP70289.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiP70289.
PRIDEiP70289.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:108027. Ptprv.

Phylogenomic databases

HOVERGENiHBG053764.
InParanoidiP70289.

Miscellaneous databases

PROiP70289.
SOURCEiSearch...

Gene expression databases

CleanExiMM_PTPRV.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 6 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 8 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRV_MOUSE
AccessioniPrimary (citable) accession number: P70289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.