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P70289 (PTPRV_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase V
Short name=R-PTP-V
EC=3.1.3.48
Alternative name(s):
Embryonic stem cell protein-tyrosine phosphatase
Short name=ES cell phosphatase
Gene names
Name:Ptprv
Synonyms:Esp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1705 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in the maintenance of pluripotency. Down-regulated during differentiation.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subcellular location

Membrane; Single-pass type I membrane protein.

Developmental stage

Detectable in the epiblast of oocytes and throughout early mouse embryo development. In adult, expression is localized in gonadal germ cells.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily.

Contains 10 fibronectin type-III domains.

Contains 2 tyrosine-protein phosphatase domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 17051687Receptor-type tyrosine-protein phosphatase V
PRO_0000025466

Regions

Topological domain19 – 10771059Extracellular Potential
Transmembrane1078 – 110023Helical; Potential
Topological domain1101 – 1705605Cytoplasmic Potential
Domain34 – 12693Fibronectin type-III 1
Domain128 – 21790Fibronectin type-III 2
Domain218 – 30588Fibronectin type-III 3
Domain306 – 38883Fibronectin type-III 4
Domain393 – 45462Fibronectin type-III 5
Domain473 – 56391Fibronectin type-III 6
Domain565 – 65490Fibronectin type-III 7
Domain655 – 74288Fibronectin type-III 8
Domain744 – 83188Fibronectin type-III 9
Domain833 – 92290Fibronectin type-III 10
Domain1150 – 1409260Tyrosine-protein phosphatase 1
Domain1427 – 1695269Tyrosine-protein phosphatase 2
Region1350 – 13567Substrate binding By similarity

Sites

Active site13501Phosphocysteine intermediate By similarity
Binding site13161Substrate By similarity
Binding site13941Substrate By similarity

Amino acid modifications

Glycosylation741N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Glycosylation1741N-linked (GlcNAc...) Potential
Glycosylation2391N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Glycosylation3451N-linked (GlcNAc...) Potential
Glycosylation4311N-linked (GlcNAc...) Potential
Glycosylation5511N-linked (GlcNAc...) Potential
Glycosylation5701N-linked (GlcNAc...) Potential
Glycosylation6201N-linked (GlcNAc...) Potential
Glycosylation6491N-linked (GlcNAc...) Potential
Glycosylation6631N-linked (GlcNAc...) Potential
Glycosylation7371N-linked (GlcNAc...) Potential
Glycosylation8511N-linked (GlcNAc...) Potential
Glycosylation8821N-linked (GlcNAc...) Potential
Glycosylation9701N-linked (GlcNAc...) Potential
Glycosylation9821N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P70289 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 2783755F15387D5B

FASTA1,705186,796
        10         20         30         40         50         60 
MRPLILLAAL LWLQDSLAQE DVCSSLDGSP DRQGGGPPLS VSVTSRGRPT SLFLSWVAAE 

        70         80         90        100        110        120 
PGGFDYALCL RAMNLSGFPE GQQLQAHTNE SSFEFHGLVP GSRYQLELTV LRPCWQNVTI 

       130        140        150        160        170        180 
TLTARTAPTV VRGLQLHSTG SPASLEASWS DASGDQDSYQ LLLYHPESHT LACNVSVSPD 

       190        200        210        220        230        240 
TLSYNFGDLL PGSQYVLEVI TWAGSLHAKT SILQWTEPVP PDHLRVRALG TSSLQAFWNS 

       250        260        270        280        290        300 
SEGATWFHLI LTDLLEGTNL TKVVRQGIST HTFLRLSPGT PYQLKICAAA GPHQIWGPNA 

       310        320        330        340        350        360 
TEWTYPSYPS DLVLTPLWNE LWASWKAGQG ARDGYVLKLS GPVENTTTLG PEECNAVFPG 

       370        380        390        400        410        420 
PLPPGHYTLG LRVLAGPYDA WVEGSIWLAE SAARPMEVPG ARLWLEGLEA TKQPGRRALL 

       430        440        450        460        470        480 
YSVDAPGLLG NISVSSGATH VTFCGLVPGA HYRVDIASSM GDITQSLTGY TSPLPPQSLE 

       490        500        510        520        530        540 
IISRNSPSDL TIGWAPAPGQ MEGYKVTWHQ DGSQRSPGDL VDLGPDISSL TLKSLVPGSC 

       550        560        570        580        590        600 
YTVSAWAWSG NLSSDSQKIH SCTRPAPPTN LSLGFAHQPA TLRASWCHPP GGRDAFQLRL 

       610        620        630        640        650        660 
YRLRPLTLES EKILSQEAQN FSWAQLPAGY EFQVQLSTLW GSEESGSANT TGWTPPSAPT 

       670        680        690        700        710        720 
LVNVTSEAPT QLHVSWVHAA GDRSSYQVTL YQESTRTATS IVGPKADSTS FWGLTPGTKY 

       730        740        750        760        770        780 
KVEAISWAGP LYTAAANVSA WTYPLTPNEL LASMQAGSAV VNLAWPSGPL GRGTCHAQLS 

       790        800        810        820        830        840 
DAGHLSWEQP LSLGQDLLML RNLIPGHTVS LSVKCRAGPL QASTHPLVLS VEPGPVEDVF 

       850        860        870        880        890        900 
CQPEATYLSL NWTMPTGDVA VCLVEVEQLV PGGSAHFVFQ VNTSEDALLL PNLTPTTSYR 

       910        920        930        940        950        960 
LSLTVLGGNR QWSRAVTLVC TTSAEVWHPP ELAEAPQVEL GTGMGVTVTR GMFGKDDGQI 

       970        980        990       1000       1010       1020 
QWYGIIATIN MTLAQPSQEA INHTWYDHYY RGHDSYLALL FPNPFYPEPW AVPRSWTVPV 

      1030       1040       1050       1060       1070       1080 
GTEDCDNTQE ICNGHLKPGF QYRFSIAAFS RLSSPETILA FSAFSEPQAS ISLVAMPLTV 

      1090       1100       1110       1120       1130       1140 
MMGTVVGCII IVCAVLCLLC RRGLKGPRSE KNGFSQELMP YNLWRTHRPI PSHSFRQSYE 

      1150       1160       1170       1180       1190       1200 
AKSARAHQAF FQEFEELKEV GKDQPRLEAE HPANITKNRY PHVLPYDHSR VRLTQLSGEP 

      1210       1220       1230       1240       1250       1260 
HSDYINANFI PGYSHPQEII ATQGPLKKTV EDFWRLVWEQ QVHVIIMLTV GMENGRVLCE 

      1270       1280       1290       1300       1310       1320 
HYWPVNSTPV THGHITTHLL AEESEDEWTR REFQLQHGAE QKQRRVKQLQ FTTWPDHSVP 

      1330       1340       1350       1360       1370       1380 
EAPSSLLAFV ELVQEEVKAT QGKGPILVHC SAGVGRTGTF VALLPAVRQL EEEQVVDVFN 

      1390       1400       1410       1420       1430       1440 
TVYILRLHRP LMIQTLSQYI FLHSCLLNKI LEGPSDASDS GPIPVMNFAQ ACAKRAANAN 

      1450       1460       1470       1480       1490       1500 
AGFLKEYRLL KQAIKDETGS LLPSPDYNQN SIASCHHSQE QLALVEESPA DNMLAASLFP 

      1510       1520       1530       1540       1550       1560 
GGPSGRDHVV LTGSAGPKEL WEMVWEHGAY VLVSLGLPDT KEKPQDIWPM EMQPIVTDMV 

      1570       1580       1590       1600       1610       1620 
TVHRVAESNT AGWPSTLIRV IHGDSGTERQ VQCLQFPHCE TGSELPANTL LTFLDAVGQC 

      1630       1640       1650       1660       1670       1680 
CSRGNSKKPG TLLSHSSKVT NQLSTFLAME QLLQQAGTER TVDVFSVALK QTQACAVKTP 

      1690       1700 
TLEQYIYLYN CLNSALRNRL PRARK

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References

[1]"Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm."
Lee K., Nichols J., Smith A.
Mech. Dev. 59:153-164(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryonic stem cell.
[2]Erratum
Lee K., Nichols J., Smith A.
Mech. Dev. 61:213-215(1996)
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		U36488 mRNA. Translation: AAC52868.1.
IPIIPI00323957.
UniGeneMm.4450.

3D structure databases

ProteinModelPortalP70289.
SMRP70289. Positions 91-294, 354-379, 434-729, 885-915, 1126-1689.
ModBaseSearch...

Proteomic databases

PRIDEP70289.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:108027. Ptprv.

Phylogenomic databases

HOVERGENHBG053764.

Gene expression databases

CleanExMM_PTPRV.
GenevestigatorP70289.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSPR00700. PRTYPHPHTASE.
SMARTSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 8 hits.
PROSITEPS50853. FN3. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry namePTPRV_MOUSE
AccessionPrimary (citable) accession number: P70289
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: May 1, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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