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P70289

- PTPRV_MOUSE

UniProt

P70289 - PTPRV_MOUSE

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Protein

Receptor-type tyrosine-protein phosphatase V

Gene

Ptprv

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in the maintenance of pluripotency. Down-regulated during differentiation.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1316 – 13161SubstrateBy similarity
Active sitei1350 – 13501Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei1394 – 13941SubstrateBy similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular lipid catabolic process Source: MGI
  2. cellular response to insulin stimulus Source: MGI
  3. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: MGI
  4. glucose homeostasis Source: MGI
  5. mitotic G1 DNA damage checkpoint Source: MGI
  6. negative regulation of cell proliferation Source: MGI
  7. negative regulation of insulin secretion Source: MGI
  8. pancreas development Source: MGI
  9. protein carboxylation Source: MGI
  10. type B pancreatic cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase V (EC:3.1.3.48)
Short name:
R-PTP-V
Alternative name(s):
Embryonic stem cell protein-tyrosine phosphatase
Short name:
ES cell phosphatase
Gene namesi
Name:Ptprv
Synonyms:Esp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:108027. Ptprv.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 17051687Receptor-type tyrosine-protein phosphatase VPRO_0000025466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi551 – 5511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
Glycosylationi663 – 6631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi851 – 8511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi970 – 9701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi982 – 9821N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP70289.

Expressioni

Developmental stagei

Detectable in the epiblast of oocytes and throughout early mouse embryo development. In adult, expression is localized in gonadal germ cells.

Gene expression databases

CleanExiMM_PTPRV.
GenevestigatoriP70289.

Structurei

3D structure databases

ProteinModelPortaliP70289.
SMRiP70289. Positions 91-294, 354-379, 434-730, 880-923, 1126-1689.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 10771059ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1101 – 1705605CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1078 – 110023HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 12993Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini130 – 22293Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini218 – 30588Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini306 – 38883Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini393 – 45462Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini475 – 56995Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST
Domaini565 – 65490Fibronectin type-III 7PROSITE-ProRule annotationAdd
BLAST
Domaini655 – 74995Fibronectin type-III 8PROSITE-ProRule annotationAdd
BLAST
Domaini744 – 83188Fibronectin type-III 9PROSITE-ProRule annotationAdd
BLAST
Domaini832 – 92695Fibronectin type-III 10PROSITE-ProRule annotationAdd
BLAST
Domaini1150 – 1409260Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
BLAST
Domaini1427 – 1695269Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1350 – 13567Substrate bindingBy similarity

Sequence similaritiesi

Contains 10 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053764.
InParanoidiP70289.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 7 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70289-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRPLILLAAL LWLQDSLAQE DVCSSLDGSP DRQGGGPPLS VSVTSRGRPT
60 70 80 90 100
SLFLSWVAAE PGGFDYALCL RAMNLSGFPE GQQLQAHTNE SSFEFHGLVP
110 120 130 140 150
GSRYQLELTV LRPCWQNVTI TLTARTAPTV VRGLQLHSTG SPASLEASWS
160 170 180 190 200
DASGDQDSYQ LLLYHPESHT LACNVSVSPD TLSYNFGDLL PGSQYVLEVI
210 220 230 240 250
TWAGSLHAKT SILQWTEPVP PDHLRVRALG TSSLQAFWNS SEGATWFHLI
260 270 280 290 300
LTDLLEGTNL TKVVRQGIST HTFLRLSPGT PYQLKICAAA GPHQIWGPNA
310 320 330 340 350
TEWTYPSYPS DLVLTPLWNE LWASWKAGQG ARDGYVLKLS GPVENTTTLG
360 370 380 390 400
PEECNAVFPG PLPPGHYTLG LRVLAGPYDA WVEGSIWLAE SAARPMEVPG
410 420 430 440 450
ARLWLEGLEA TKQPGRRALL YSVDAPGLLG NISVSSGATH VTFCGLVPGA
460 470 480 490 500
HYRVDIASSM GDITQSLTGY TSPLPPQSLE IISRNSPSDL TIGWAPAPGQ
510 520 530 540 550
MEGYKVTWHQ DGSQRSPGDL VDLGPDISSL TLKSLVPGSC YTVSAWAWSG
560 570 580 590 600
NLSSDSQKIH SCTRPAPPTN LSLGFAHQPA TLRASWCHPP GGRDAFQLRL
610 620 630 640 650
YRLRPLTLES EKILSQEAQN FSWAQLPAGY EFQVQLSTLW GSEESGSANT
660 670 680 690 700
TGWTPPSAPT LVNVTSEAPT QLHVSWVHAA GDRSSYQVTL YQESTRTATS
710 720 730 740 750
IVGPKADSTS FWGLTPGTKY KVEAISWAGP LYTAAANVSA WTYPLTPNEL
760 770 780 790 800
LASMQAGSAV VNLAWPSGPL GRGTCHAQLS DAGHLSWEQP LSLGQDLLML
810 820 830 840 850
RNLIPGHTVS LSVKCRAGPL QASTHPLVLS VEPGPVEDVF CQPEATYLSL
860 870 880 890 900
NWTMPTGDVA VCLVEVEQLV PGGSAHFVFQ VNTSEDALLL PNLTPTTSYR
910 920 930 940 950
LSLTVLGGNR QWSRAVTLVC TTSAEVWHPP ELAEAPQVEL GTGMGVTVTR
960 970 980 990 1000
GMFGKDDGQI QWYGIIATIN MTLAQPSQEA INHTWYDHYY RGHDSYLALL
1010 1020 1030 1040 1050
FPNPFYPEPW AVPRSWTVPV GTEDCDNTQE ICNGHLKPGF QYRFSIAAFS
1060 1070 1080 1090 1100
RLSSPETILA FSAFSEPQAS ISLVAMPLTV MMGTVVGCII IVCAVLCLLC
1110 1120 1130 1140 1150
RRGLKGPRSE KNGFSQELMP YNLWRTHRPI PSHSFRQSYE AKSARAHQAF
1160 1170 1180 1190 1200
FQEFEELKEV GKDQPRLEAE HPANITKNRY PHVLPYDHSR VRLTQLSGEP
1210 1220 1230 1240 1250
HSDYINANFI PGYSHPQEII ATQGPLKKTV EDFWRLVWEQ QVHVIIMLTV
1260 1270 1280 1290 1300
GMENGRVLCE HYWPVNSTPV THGHITTHLL AEESEDEWTR REFQLQHGAE
1310 1320 1330 1340 1350
QKQRRVKQLQ FTTWPDHSVP EAPSSLLAFV ELVQEEVKAT QGKGPILVHC
1360 1370 1380 1390 1400
SAGVGRTGTF VALLPAVRQL EEEQVVDVFN TVYILRLHRP LMIQTLSQYI
1410 1420 1430 1440 1450
FLHSCLLNKI LEGPSDASDS GPIPVMNFAQ ACAKRAANAN AGFLKEYRLL
1460 1470 1480 1490 1500
KQAIKDETGS LLPSPDYNQN SIASCHHSQE QLALVEESPA DNMLAASLFP
1510 1520 1530 1540 1550
GGPSGRDHVV LTGSAGPKEL WEMVWEHGAY VLVSLGLPDT KEKPQDIWPM
1560 1570 1580 1590 1600
EMQPIVTDMV TVHRVAESNT AGWPSTLIRV IHGDSGTERQ VQCLQFPHCE
1610 1620 1630 1640 1650
TGSELPANTL LTFLDAVGQC CSRGNSKKPG TLLSHSSKVT NQLSTFLAME
1660 1670 1680 1690 1700
QLLQQAGTER TVDVFSVALK QTQACAVKTP TLEQYIYLYN CLNSALRNRL

PRARK
Length:1,705
Mass (Da):186,796
Last modified:February 1, 1997 - v1
Checksum:i2783755F15387D5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36488 mRNA. Translation: AAC52868.1.
UniGeneiMm.4450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36488 mRNA. Translation: AAC52868.1 .
UniGenei Mm.4450.

3D structure databases

ProteinModelPortali P70289.
SMRi P70289. Positions 91-294, 354-379, 434-730, 880-923, 1126-1689.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P70289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:108027. Ptprv.

Phylogenomic databases

HOVERGENi HBG053764.
InParanoidi P70289.

Miscellaneous databases

PROi P70289.
SOURCEi Search...

Gene expression databases

CleanExi MM_PTPRV.
Genevestigatori P70289.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 7 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm."
    Lee K., Nichols J., Smith A.
    Mech. Dev. 59:153-164(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic stem cell.
  2. Erratum
    Lee K., Nichols J., Smith A.
    Mech. Dev. 61:213-215(1996)

Entry informationi

Entry nameiPTPRV_MOUSE
AccessioniPrimary (citable) accession number: P70289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3