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P70289

- PTPRV_MOUSE

UniProt

P70289 - PTPRV_MOUSE

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Protein
Receptor-type tyrosine-protein phosphatase V
Gene
Ptprv, Esp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in the maintenance of pluripotency. Down-regulated during differentiation.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei1316 – 13161Substrate By similarity
Active sitei1350 – 13501Phosphocysteine intermediate By similarity
Binding sitei1394 – 13941Substrate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: MGI
  2. cellular lipid catabolic process Source: MGI
  3. cellular response to insulin stimulus Source: MGI
  4. glucose homeostasis Source: MGI
  5. mitotic G1 DNA damage checkpoint Source: MGI
  6. negative regulation of cell proliferation Source: MGI
  7. negative regulation of insulin secretion Source: MGI
  8. pancreas development Source: MGI
  9. protein carboxylation Source: MGI
  10. type B pancreatic cell proliferation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase V (EC:3.1.3.48)
Short name:
R-PTP-V
Alternative name(s):
Embryonic stem cell protein-tyrosine phosphatase
Short name:
ES cell phosphatase
Gene namesi
Name:Ptprv
Synonyms:Esp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:108027. Ptprv.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 10771059Extracellular Reviewed prediction
Add
BLAST
Transmembranei1078 – 110023Helical; Reviewed prediction
Add
BLAST
Topological domaini1101 – 1705605Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 17051687Receptor-type tyrosine-protein phosphatase V
PRO_0000025466Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi74 – 741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction
Glycosylationi117 – 1171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi174 – 1741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi239 – 2391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi345 – 3451N-linked (GlcNAc...) Reviewed prediction
Glycosylationi431 – 4311N-linked (GlcNAc...) Reviewed prediction
Glycosylationi551 – 5511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi570 – 5701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi620 – 6201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi649 – 6491N-linked (GlcNAc...) Reviewed prediction
Glycosylationi663 – 6631N-linked (GlcNAc...) Reviewed prediction
Glycosylationi737 – 7371N-linked (GlcNAc...) Reviewed prediction
Glycosylationi851 – 8511N-linked (GlcNAc...) Reviewed prediction
Glycosylationi882 – 8821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi970 – 9701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi982 – 9821N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP70289.

Expressioni

Developmental stagei

Detectable in the epiblast of oocytes and throughout early mouse embryo development. In adult, expression is localized in gonadal germ cells.

Gene expression databases

CleanExiMM_PTPRV.
GenevestigatoriP70289.

Structurei

3D structure databases

ProteinModelPortaliP70289.
SMRiP70289. Positions 37-301, 308-382, 396-729, 846-909, 1126-1689.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini37 – 12993Fibronectin type-III 1
Add
BLAST
Domaini130 – 22293Fibronectin type-III 2
Add
BLAST
Domaini218 – 30588Fibronectin type-III 3
Add
BLAST
Domaini306 – 38883Fibronectin type-III 4
Add
BLAST
Domaini393 – 45462Fibronectin type-III 5
Add
BLAST
Domaini475 – 56995Fibronectin type-III 6
Add
BLAST
Domaini565 – 65490Fibronectin type-III 7
Add
BLAST
Domaini655 – 74995Fibronectin type-III 8
Add
BLAST
Domaini744 – 83188Fibronectin type-III 9
Add
BLAST
Domaini832 – 92695Fibronectin type-III 10
Add
BLAST
Domaini1150 – 1409260Tyrosine-protein phosphatase 1
Add
BLAST
Domaini1427 – 1695269Tyrosine-protein phosphatase 2
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1350 – 13567Substrate binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG053764.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]
PfamiPF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 7 hits.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70289-1 [UniParc]FASTAAdd to Basket

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MRPLILLAAL LWLQDSLAQE DVCSSLDGSP DRQGGGPPLS VSVTSRGRPT     50
SLFLSWVAAE PGGFDYALCL RAMNLSGFPE GQQLQAHTNE SSFEFHGLVP 100
GSRYQLELTV LRPCWQNVTI TLTARTAPTV VRGLQLHSTG SPASLEASWS 150
DASGDQDSYQ LLLYHPESHT LACNVSVSPD TLSYNFGDLL PGSQYVLEVI 200
TWAGSLHAKT SILQWTEPVP PDHLRVRALG TSSLQAFWNS SEGATWFHLI 250
LTDLLEGTNL TKVVRQGIST HTFLRLSPGT PYQLKICAAA GPHQIWGPNA 300
TEWTYPSYPS DLVLTPLWNE LWASWKAGQG ARDGYVLKLS GPVENTTTLG 350
PEECNAVFPG PLPPGHYTLG LRVLAGPYDA WVEGSIWLAE SAARPMEVPG 400
ARLWLEGLEA TKQPGRRALL YSVDAPGLLG NISVSSGATH VTFCGLVPGA 450
HYRVDIASSM GDITQSLTGY TSPLPPQSLE IISRNSPSDL TIGWAPAPGQ 500
MEGYKVTWHQ DGSQRSPGDL VDLGPDISSL TLKSLVPGSC YTVSAWAWSG 550
NLSSDSQKIH SCTRPAPPTN LSLGFAHQPA TLRASWCHPP GGRDAFQLRL 600
YRLRPLTLES EKILSQEAQN FSWAQLPAGY EFQVQLSTLW GSEESGSANT 650
TGWTPPSAPT LVNVTSEAPT QLHVSWVHAA GDRSSYQVTL YQESTRTATS 700
IVGPKADSTS FWGLTPGTKY KVEAISWAGP LYTAAANVSA WTYPLTPNEL 750
LASMQAGSAV VNLAWPSGPL GRGTCHAQLS DAGHLSWEQP LSLGQDLLML 800
RNLIPGHTVS LSVKCRAGPL QASTHPLVLS VEPGPVEDVF CQPEATYLSL 850
NWTMPTGDVA VCLVEVEQLV PGGSAHFVFQ VNTSEDALLL PNLTPTTSYR 900
LSLTVLGGNR QWSRAVTLVC TTSAEVWHPP ELAEAPQVEL GTGMGVTVTR 950
GMFGKDDGQI QWYGIIATIN MTLAQPSQEA INHTWYDHYY RGHDSYLALL 1000
FPNPFYPEPW AVPRSWTVPV GTEDCDNTQE ICNGHLKPGF QYRFSIAAFS 1050
RLSSPETILA FSAFSEPQAS ISLVAMPLTV MMGTVVGCII IVCAVLCLLC 1100
RRGLKGPRSE KNGFSQELMP YNLWRTHRPI PSHSFRQSYE AKSARAHQAF 1150
FQEFEELKEV GKDQPRLEAE HPANITKNRY PHVLPYDHSR VRLTQLSGEP 1200
HSDYINANFI PGYSHPQEII ATQGPLKKTV EDFWRLVWEQ QVHVIIMLTV 1250
GMENGRVLCE HYWPVNSTPV THGHITTHLL AEESEDEWTR REFQLQHGAE 1300
QKQRRVKQLQ FTTWPDHSVP EAPSSLLAFV ELVQEEVKAT QGKGPILVHC 1350
SAGVGRTGTF VALLPAVRQL EEEQVVDVFN TVYILRLHRP LMIQTLSQYI 1400
FLHSCLLNKI LEGPSDASDS GPIPVMNFAQ ACAKRAANAN AGFLKEYRLL 1450
KQAIKDETGS LLPSPDYNQN SIASCHHSQE QLALVEESPA DNMLAASLFP 1500
GGPSGRDHVV LTGSAGPKEL WEMVWEHGAY VLVSLGLPDT KEKPQDIWPM 1550
EMQPIVTDMV TVHRVAESNT AGWPSTLIRV IHGDSGTERQ VQCLQFPHCE 1600
TGSELPANTL LTFLDAVGQC CSRGNSKKPG TLLSHSSKVT NQLSTFLAME 1650
QLLQQAGTER TVDVFSVALK QTQACAVKTP TLEQYIYLYN CLNSALRNRL 1700
PRARK 1705
Length:1,705
Mass (Da):186,796
Last modified:February 1, 1997 - v1
Checksum:i2783755F15387D5B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36488 mRNA. Translation: AAC52868.1.
UniGeneiMm.4450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U36488 mRNA. Translation: AAC52868.1 .
UniGenei Mm.4450.

3D structure databases

ProteinModelPortali P70289.
SMRi P70289. Positions 37-301, 308-382, 396-729, 846-909, 1126-1689.
ModBasei Search...

Proteomic databases

PRIDEi P70289.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:108027. Ptprv.

Phylogenomic databases

HOVERGENi HBG053764.

Miscellaneous databases

PROi P70289.
SOURCEi Search...

Gene expression databases

CleanExi MM_PTPRV.
Genevestigatori P70289.

Family and domain databases

Gene3Di 2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProi IPR003961. Fibronectin_type3.
IPR013783. Ig-like_fold.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view ]
Pfami PF00041. fn3. 3 hits.
PF00102. Y_phosphatase. 2 hits.
[Graphical view ]
PRINTSi PR00700. PRTYPHPHTASE.
SMARTi SM00060. FN3. 9 hits.
SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 7 hits.
SSF52799. SSF52799. 2 hits.
PROSITEi PS50853. FN3. 5 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm."
    Lee K., Nichols J., Smith A.
    Mech. Dev. 59:153-164(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryonic stem cell.
  2. Erratum
    Lee K., Nichols J., Smith A.
    Mech. Dev. 61:213-215(1996)

Entry informationi

Entry nameiPTPRV_MOUSE
AccessioniPrimary (citable) accession number: P70289
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi