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P70289

- PTPRV_MOUSE

UniProt

P70289 - PTPRV_MOUSE

Protein

Receptor-type tyrosine-protein phosphatase V

Gene

Ptprv

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    May play a role in the maintenance of pluripotency. Down-regulated during differentiation.

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei1316 – 13161SubstrateBy similarity
    Active sitei1350 – 13501Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei1394 – 13941SubstrateBy similarity

    GO - Molecular functioni

    1. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular lipid catabolic process Source: MGI
    2. cellular response to insulin stimulus Source: MGI
    3. DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: MGI
    4. glucose homeostasis Source: MGI
    5. mitotic G1 DNA damage checkpoint Source: MGI
    6. negative regulation of cell proliferation Source: MGI
    7. negative regulation of insulin secretion Source: MGI
    8. pancreas development Source: MGI
    9. protein carboxylation Source: MGI
    10. type B pancreatic cell proliferation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase V (EC:3.1.3.48)
    Short name:
    R-PTP-V
    Alternative name(s):
    Embryonic stem cell protein-tyrosine phosphatase
    Short name:
    ES cell phosphatase
    Gene namesi
    Name:Ptprv
    Synonyms:Esp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:108027. Ptprv.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 17051687Receptor-type tyrosine-protein phosphatase VPRO_0000025466Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi239 – 2391N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi259 – 2591N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi345 – 3451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi431 – 4311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi551 – 5511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi570 – 5701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi649 – 6491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi663 – 6631N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi851 – 8511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi882 – 8821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi970 – 9701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi982 – 9821N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP70289.

    Expressioni

    Developmental stagei

    Detectable in the epiblast of oocytes and throughout early mouse embryo development. In adult, expression is localized in gonadal germ cells.

    Gene expression databases

    CleanExiMM_PTPRV.
    GenevestigatoriP70289.

    Structurei

    3D structure databases

    ProteinModelPortaliP70289.
    SMRiP70289. Positions 37-301, 308-382, 396-729, 846-909, 1126-1689.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 10771059ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1101 – 1705605CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1078 – 110023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini37 – 12993Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini130 – 22293Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini218 – 30588Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini306 – 38883Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini393 – 45462Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini475 – 56995Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST
    Domaini565 – 65490Fibronectin type-III 7PROSITE-ProRule annotationAdd
    BLAST
    Domaini655 – 74995Fibronectin type-III 8PROSITE-ProRule annotationAdd
    BLAST
    Domaini744 – 83188Fibronectin type-III 9PROSITE-ProRule annotationAdd
    BLAST
    Domaini832 – 92695Fibronectin type-III 10PROSITE-ProRule annotationAdd
    BLAST
    Domaini1150 – 1409260Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1427 – 1695269Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1350 – 13567Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 10 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    HOVERGENiHBG053764.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 9 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 7 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 5 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70289-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRPLILLAAL LWLQDSLAQE DVCSSLDGSP DRQGGGPPLS VSVTSRGRPT     50
    SLFLSWVAAE PGGFDYALCL RAMNLSGFPE GQQLQAHTNE SSFEFHGLVP 100
    GSRYQLELTV LRPCWQNVTI TLTARTAPTV VRGLQLHSTG SPASLEASWS 150
    DASGDQDSYQ LLLYHPESHT LACNVSVSPD TLSYNFGDLL PGSQYVLEVI 200
    TWAGSLHAKT SILQWTEPVP PDHLRVRALG TSSLQAFWNS SEGATWFHLI 250
    LTDLLEGTNL TKVVRQGIST HTFLRLSPGT PYQLKICAAA GPHQIWGPNA 300
    TEWTYPSYPS DLVLTPLWNE LWASWKAGQG ARDGYVLKLS GPVENTTTLG 350
    PEECNAVFPG PLPPGHYTLG LRVLAGPYDA WVEGSIWLAE SAARPMEVPG 400
    ARLWLEGLEA TKQPGRRALL YSVDAPGLLG NISVSSGATH VTFCGLVPGA 450
    HYRVDIASSM GDITQSLTGY TSPLPPQSLE IISRNSPSDL TIGWAPAPGQ 500
    MEGYKVTWHQ DGSQRSPGDL VDLGPDISSL TLKSLVPGSC YTVSAWAWSG 550
    NLSSDSQKIH SCTRPAPPTN LSLGFAHQPA TLRASWCHPP GGRDAFQLRL 600
    YRLRPLTLES EKILSQEAQN FSWAQLPAGY EFQVQLSTLW GSEESGSANT 650
    TGWTPPSAPT LVNVTSEAPT QLHVSWVHAA GDRSSYQVTL YQESTRTATS 700
    IVGPKADSTS FWGLTPGTKY KVEAISWAGP LYTAAANVSA WTYPLTPNEL 750
    LASMQAGSAV VNLAWPSGPL GRGTCHAQLS DAGHLSWEQP LSLGQDLLML 800
    RNLIPGHTVS LSVKCRAGPL QASTHPLVLS VEPGPVEDVF CQPEATYLSL 850
    NWTMPTGDVA VCLVEVEQLV PGGSAHFVFQ VNTSEDALLL PNLTPTTSYR 900
    LSLTVLGGNR QWSRAVTLVC TTSAEVWHPP ELAEAPQVEL GTGMGVTVTR 950
    GMFGKDDGQI QWYGIIATIN MTLAQPSQEA INHTWYDHYY RGHDSYLALL 1000
    FPNPFYPEPW AVPRSWTVPV GTEDCDNTQE ICNGHLKPGF QYRFSIAAFS 1050
    RLSSPETILA FSAFSEPQAS ISLVAMPLTV MMGTVVGCII IVCAVLCLLC 1100
    RRGLKGPRSE KNGFSQELMP YNLWRTHRPI PSHSFRQSYE AKSARAHQAF 1150
    FQEFEELKEV GKDQPRLEAE HPANITKNRY PHVLPYDHSR VRLTQLSGEP 1200
    HSDYINANFI PGYSHPQEII ATQGPLKKTV EDFWRLVWEQ QVHVIIMLTV 1250
    GMENGRVLCE HYWPVNSTPV THGHITTHLL AEESEDEWTR REFQLQHGAE 1300
    QKQRRVKQLQ FTTWPDHSVP EAPSSLLAFV ELVQEEVKAT QGKGPILVHC 1350
    SAGVGRTGTF VALLPAVRQL EEEQVVDVFN TVYILRLHRP LMIQTLSQYI 1400
    FLHSCLLNKI LEGPSDASDS GPIPVMNFAQ ACAKRAANAN AGFLKEYRLL 1450
    KQAIKDETGS LLPSPDYNQN SIASCHHSQE QLALVEESPA DNMLAASLFP 1500
    GGPSGRDHVV LTGSAGPKEL WEMVWEHGAY VLVSLGLPDT KEKPQDIWPM 1550
    EMQPIVTDMV TVHRVAESNT AGWPSTLIRV IHGDSGTERQ VQCLQFPHCE 1600
    TGSELPANTL LTFLDAVGQC CSRGNSKKPG TLLSHSSKVT NQLSTFLAME 1650
    QLLQQAGTER TVDVFSVALK QTQACAVKTP TLEQYIYLYN CLNSALRNRL 1700
    PRARK 1705
    Length:1,705
    Mass (Da):186,796
    Last modified:February 1, 1997 - v1
    Checksum:i2783755F15387D5B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36488 mRNA. Translation: AAC52868.1.
    UniGeneiMm.4450.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U36488 mRNA. Translation: AAC52868.1 .
    UniGenei Mm.4450.

    3D structure databases

    ProteinModelPortali P70289.
    SMRi P70289. Positions 37-301, 308-382, 396-729, 846-909, 1126-1689.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi P70289.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:108027. Ptprv.

    Phylogenomic databases

    HOVERGENi HBG053764.

    Miscellaneous databases

    PROi P70289.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_PTPRV.
    Genevestigatori P70289.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR013783. Ig-like_fold.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 3 hits.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 9 hits.
    SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 7 hits.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 5 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a developmentally regulated protein tyrosine phosphatase in embryonic stem cells that is a marker of pluripotential epiblast and early mesoderm."
      Lee K., Nichols J., Smith A.
      Mech. Dev. 59:153-164(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryonic stem cell.
    2. Erratum
      Lee K., Nichols J., Smith A.
      Mech. Dev. 61:213-215(1996)

    Entry informationi

    Entry nameiPTPRV_MOUSE
    AccessioniPrimary (citable) accession number: P70289
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3