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P70284

- TGIF1_MOUSE

UniProt

P70284 - TGIF1_MOUSE

Protein

Homeobox protein TGIF1

Gene

Tgif1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 2 (17 Jan 2003)
      Previous versions | rss
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    Functioni

    Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi35 – 9763Homeobox; TALE-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. protein binding Source: MGI
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. determination of left/right symmetry Source: MGI
    2. dorsal/ventral pattern formation Source: MGI
    3. negative regulation of cell proliferation Source: MGI
    4. negative regulation of retinoic acid receptor signaling pathway Source: MGI
    5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    6. neural tube closure Source: MGI
    7. nodal signaling pathway Source: MGI
    8. positive regulation of fibroblast proliferation Source: MGI
    9. positive regulation of neuron differentiation Source: MGI
    10. regulation of gastrulation Source: MGI
    11. retina development in camera-type eye Source: MGI
    12. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein TGIF1
    Alternative name(s):
    5'-TG-3'-interacting factor 1
    Gene namesi
    Name:Tgif1
    Synonyms:Tgif
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1194497. Tgif1.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 272272Homeobox protein TGIF1PRO_0000049320Add
    BLAST

    Proteomic databases

    PRIDEiP70284.

    PTM databases

    PhosphoSiteiP70284.

    Expressioni

    Gene expression databases

    ArrayExpressiP70284.
    BgeeiP70284.
    CleanExiMM_TGIF1.
    GenevestigatoriP70284.

    Interactioni

    Subunit structurei

    Interacts with CTBP, SMAD2, SMAD3 and HDAC1.By similarity

    Protein-protein interaction databases

    BioGridi204166. 5 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP70284.
    SMRiP70284. Positions 42-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi24 – 285CTBP-binding motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi36 – 394Poly-Arg

    Sequence similaritiesi

    Belongs to the TALE/TGIF homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG308174.
    GeneTreeiENSGT00680000099964.
    HOGENOMiHOG000232039.
    HOVERGENiHBG001143.
    InParanoidiP70284.
    OrthoDBiEOG7H7937.
    PhylomeDBiP70284.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF05920. Homeobox_KN. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P70284-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKSKKGLVAA SGSDSEDEDS MDSPLDLSSS AASGKRRRRG NLPKESVQIL    50
    RDWLYEHRYN AYPSEQEKAL LSQQTHLSTL QVCNWFINAR RRLLPDMLRK 100
    DGKDPNQFTI SRRGAKISEA SSIEAAMGIK NFMPTLEESP FHSCVVGPNP 150
    TLGRPVSPKP PSPGSILARP SVICHTTVTA LKDGPFSLCQ PIGVGQSTDV 200
    PQIAPSNFTD TSLVYPEDTC KSGPSPNPQS GLFNTPPPTP PDLNQDFSGF 250
    QLLVDVALKR AAEMELQAKL TA 272
    Length:272
    Mass (Da):29,573
    Last modified:January 17, 2003 - v2
    Checksum:i625528713B4C0C42
    GO
    Isoform 2 (identifier: P70284-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: Missing.

    Show »
    Length:252
    Mass (Da):27,550
    Checksum:i5595D6086BABF19A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti35 – 351K → M in CAA61896. (PubMed:8901052)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020Missing in isoform 2. 1 PublicationVSP_002297Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89749 mRNA. Translation: CAA61896.1.
    BC005724 mRNA. Translation: AAH05724.1.
    BC012700 mRNA. Translation: AAH12700.1.
    CCDSiCCDS37683.1. [P70284-1]
    CCDS50174.1. [P70284-2]
    RefSeqiNP_001157546.1. NM_001164074.1. [P70284-2]
    NP_001157548.1. NM_001164076.1. [P70284-2]
    NP_001157549.1. NM_001164077.1. [P70284-2]
    NP_033398.2. NM_009372.3. [P70284-1]
    XP_006524095.1. XM_006524032.1. [P70284-2]
    UniGeneiMm.101034.

    Genome annotation databases

    EnsembliENSMUST00000059775; ENSMUSP00000060512; ENSMUSG00000047407. [P70284-1]
    ENSMUST00000118283; ENSMUSP00000113192; ENSMUSG00000047407. [P70284-2]
    ENSMUST00000172229; ENSMUSP00000127139; ENSMUSG00000047407. [P70284-2]
    GeneIDi21815.
    KEGGimmu:21815.
    UCSCiuc008dlp.2. mouse. [P70284-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X89749 mRNA. Translation: CAA61896.1 .
    BC005724 mRNA. Translation: AAH05724.1 .
    BC012700 mRNA. Translation: AAH12700.1 .
    CCDSi CCDS37683.1. [P70284-1 ]
    CCDS50174.1. [P70284-2 ]
    RefSeqi NP_001157546.1. NM_001164074.1. [P70284-2 ]
    NP_001157548.1. NM_001164076.1. [P70284-2 ]
    NP_001157549.1. NM_001164077.1. [P70284-2 ]
    NP_033398.2. NM_009372.3. [P70284-1 ]
    XP_006524095.1. XM_006524032.1. [P70284-2 ]
    UniGenei Mm.101034.

    3D structure databases

    ProteinModelPortali P70284.
    SMRi P70284. Positions 42-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204166. 5 interactions.

    PTM databases

    PhosphoSitei P70284.

    Proteomic databases

    PRIDEi P70284.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059775 ; ENSMUSP00000060512 ; ENSMUSG00000047407 . [P70284-1 ]
    ENSMUST00000118283 ; ENSMUSP00000113192 ; ENSMUSG00000047407 . [P70284-2 ]
    ENSMUST00000172229 ; ENSMUSP00000127139 ; ENSMUSG00000047407 . [P70284-2 ]
    GeneIDi 21815.
    KEGGi mmu:21815.
    UCSCi uc008dlp.2. mouse. [P70284-1 ]

    Organism-specific databases

    CTDi 7050.
    MGIi MGI:1194497. Tgif1.

    Phylogenomic databases

    eggNOGi NOG308174.
    GeneTreei ENSGT00680000099964.
    HOGENOMi HOG000232039.
    HOVERGENi HBG001143.
    InParanoidi P70284.
    OrthoDBi EOG7H7937.
    PhylomeDBi P70284.

    Enzyme and pathway databases

    Reactomei REACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.

    Miscellaneous databases

    ChiTaRSi TGIF1. mouse.
    NextBioi 301216.
    PROi P70284.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70284.
    Bgeei P70284.
    CleanExi MM_TGIF1.
    Genevestigatori P70284.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001356. Homeobox_dom.
    IPR008422. Homeobox_KN_domain.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF05920. Homeobox_KN. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation."
      Bertolino E., Wildt S., Richards G., Clerc R.G.
      Dev. Dyn. 205:410-420(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: BALB/c.
      Tissue: Liver.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Mammary fibroblast and Mammary gland.

    Entry informationi

    Entry nameiTGIF1_MOUSE
    AccessioniPrimary (citable) accession number: P70284
    Secondary accession number(s): Q921F9, Q99JS3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: January 17, 2003
    Last modified: October 1, 2014
    This is version 131 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3