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Protein

Homeobox protein TGIF1

Gene

Tgif1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi35 – 97Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

  • determination of left/right symmetry Source: MGI
  • dorsal/ventral pattern formation Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of retinoic acid receptor signaling pathway Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neural tube closure Source: MGI
  • nodal signaling pathway Source: MGI
  • positive regulation of fibroblast proliferation Source: MGI
  • positive regulation of neuron differentiation Source: MGI
  • regulation of gastrulation Source: MGI
  • retina development in camera-type eye Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF1
Alternative name(s):
5'-TG-3'-interacting factor 1
Gene namesi
Name:Tgif1
Synonyms:Tgif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1194497 Tgif1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493201 – 272Homeobox protein TGIF1Add BLAST272

Proteomic databases

MaxQBiP70284
PaxDbiP70284
PRIDEiP70284

PTM databases

iPTMnetiP70284
PhosphoSitePlusiP70284

Expressioni

Gene expression databases

BgeeiENSMUSG00000047407
CleanExiMM_TGIF1
ExpressionAtlasiP70284 baseline and differential
GenevisibleiP70284 MM

Interactioni

Subunit structurei

Interacts with CTBP, SMAD2, SMAD3 and HDAC1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204166, 5 interactors
STRINGi10090.ENSMUSP00000130930

Structurei

3D structure databases

ProteinModelPortaliP70284
SMRiP70284
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi24 – 28CTBP-binding motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi36 – 39Poly-Arg4

Sequence similaritiesi

Belongs to the TALE/TGIF homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0773 Eukaryota
ENOG410XPMQ LUCA
GeneTreeiENSGT00550000074260
HOGENOMiHOG000232039
HOVERGENiHBG001143
InParanoidiP70284
KOiK19383
PhylomeDBiP70284

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS50071 HOMEOBOX_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70284-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKSKKGLVAA SGSDSEDEDS MDSPLDLSSS AASGKRRRRG NLPKESVQIL
60 70 80 90 100
RDWLYEHRYN AYPSEQEKAL LSQQTHLSTL QVCNWFINAR RRLLPDMLRK
110 120 130 140 150
DGKDPNQFTI SRRGAKISEA SSIEAAMGIK NFMPTLEESP FHSCVVGPNP
160 170 180 190 200
TLGRPVSPKP PSPGSILARP SVICHTTVTA LKDGPFSLCQ PIGVGQSTDV
210 220 230 240 250
PQIAPSNFTD TSLVYPEDTC KSGPSPNPQS GLFNTPPPTP PDLNQDFSGF
260 270
QLLVDVALKR AAEMELQAKL TA
Length:272
Mass (Da):29,573
Last modified:January 17, 2003 - v2
Checksum:i625528713B4C0C42
GO
Isoform 2 (identifier: P70284-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:252
Mass (Da):27,550
Checksum:i5595D6086BABF19A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35K → M in CAA61896 (PubMed:8901052).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0022971 – 20Missing in isoform 2. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89749 mRNA Translation: CAA61896.1
BC005724 mRNA Translation: AAH05724.1
BC012700 mRNA Translation: AAH12700.1
CCDSiCCDS37683.1 [P70284-1]
CCDS50174.1 [P70284-2]
RefSeqiNP_001157546.1, NM_001164074.1 [P70284-2]
NP_001157548.1, NM_001164076.1 [P70284-2]
NP_001157549.1, NM_001164077.1 [P70284-2]
NP_033398.2, NM_009372.3 [P70284-1]
XP_006524095.1, XM_006524032.2 [P70284-2]
UniGeneiMm.101034

Genome annotation databases

EnsembliENSMUST00000059775; ENSMUSP00000060512; ENSMUSG00000047407 [P70284-1]
ENSMUST00000118283; ENSMUSP00000113192; ENSMUSG00000047407 [P70284-2]
ENSMUST00000172229; ENSMUSP00000127139; ENSMUSG00000047407 [P70284-2]
GeneIDi21815
KEGGimmu:21815
UCSCiuc008dlp.2 mouse [P70284-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTGIF1_MOUSE
AccessioniPrimary (citable) accession number: P70284
Secondary accession number(s): Q921F9, Q99JS3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 17, 2003
Last modified: March 28, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health