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P70284

- TGIF1_MOUSE

UniProt

P70284 - TGIF1_MOUSE

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Protein
Homeobox protein TGIF1
Gene
Tgif1, Tgif
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi35 – 9763Homeobox; TALE-type
Add
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. protein binding Source: MGI
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. determination of left/right symmetry Source: MGI
  2. dorsal/ventral pattern formation Source: MGI
  3. negative regulation of cell proliferation Source: MGI
  4. negative regulation of retinoic acid receptor signaling pathway Source: MGI
  5. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  6. neural tube closure Source: MGI
  7. nodal signaling pathway Source: MGI
  8. positive regulation of fibroblast proliferation Source: MGI
  9. positive regulation of neuron differentiation Source: MGI
  10. regulation of gastrulation Source: MGI
  11. retina development in camera-type eye Source: MGI
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein TGIF1
Alternative name(s):
5'-TG-3'-interacting factor 1
Gene namesi
Name:Tgif1
Synonyms:Tgif
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1194497. Tgif1.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 272272Homeobox protein TGIF1
PRO_0000049320Add
BLAST

Proteomic databases

PRIDEiP70284.

PTM databases

PhosphoSiteiP70284.

Expressioni

Gene expression databases

ArrayExpressiP70284.
BgeeiP70284.
CleanExiMM_TGIF1.
GenevestigatoriP70284.

Interactioni

Subunit structurei

Interacts with CTBP, SMAD2, SMAD3 and HDAC1 By similarity.

Protein-protein interaction databases

BioGridi204166. 5 interactions.

Structurei

3D structure databases

ProteinModelPortaliP70284.
SMRiP70284. Positions 42-119.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi24 – 285CTBP-binding motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi36 – 394Poly-Arg

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG308174.
GeneTreeiENSGT00680000099964.
HOGENOMiHOG000232039.
HOVERGENiHBG001143.
InParanoidiP70284.
OrthoDBiEOG7H7937.
PhylomeDBiP70284.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF05920. Homeobox_KN. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P70284-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKSKKGLVAA SGSDSEDEDS MDSPLDLSSS AASGKRRRRG NLPKESVQIL    50
RDWLYEHRYN AYPSEQEKAL LSQQTHLSTL QVCNWFINAR RRLLPDMLRK 100
DGKDPNQFTI SRRGAKISEA SSIEAAMGIK NFMPTLEESP FHSCVVGPNP 150
TLGRPVSPKP PSPGSILARP SVICHTTVTA LKDGPFSLCQ PIGVGQSTDV 200
PQIAPSNFTD TSLVYPEDTC KSGPSPNPQS GLFNTPPPTP PDLNQDFSGF 250
QLLVDVALKR AAEMELQAKL TA 272
Length:272
Mass (Da):29,573
Last modified:January 17, 2003 - v2
Checksum:i625528713B4C0C42
GO
Isoform 2 (identifier: P70284-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.

Show »
Length:252
Mass (Da):27,550
Checksum:i5595D6086BABF19A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2020Missing in isoform 2.
VSP_002297Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti35 – 351K → M in CAA61896. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89749 mRNA. Translation: CAA61896.1.
BC005724 mRNA. Translation: AAH05724.1.
BC012700 mRNA. Translation: AAH12700.1.
CCDSiCCDS37683.1. [P70284-1]
CCDS50174.1. [P70284-2]
RefSeqiNP_001157546.1. NM_001164074.1. [P70284-2]
NP_001157548.1. NM_001164076.1. [P70284-2]
NP_001157549.1. NM_001164077.1. [P70284-2]
NP_033398.2. NM_009372.3. [P70284-1]
XP_006524095.1. XM_006524032.1. [P70284-2]
UniGeneiMm.101034.

Genome annotation databases

EnsembliENSMUST00000059775; ENSMUSP00000060512; ENSMUSG00000047407. [P70284-1]
ENSMUST00000118283; ENSMUSP00000113192; ENSMUSG00000047407. [P70284-2]
ENSMUST00000172229; ENSMUSP00000127139; ENSMUSG00000047407. [P70284-2]
GeneIDi21815.
KEGGimmu:21815.
UCSCiuc008dlp.2. mouse. [P70284-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X89749 mRNA. Translation: CAA61896.1 .
BC005724 mRNA. Translation: AAH05724.1 .
BC012700 mRNA. Translation: AAH12700.1 .
CCDSi CCDS37683.1. [P70284-1 ]
CCDS50174.1. [P70284-2 ]
RefSeqi NP_001157546.1. NM_001164074.1. [P70284-2 ]
NP_001157548.1. NM_001164076.1. [P70284-2 ]
NP_001157549.1. NM_001164077.1. [P70284-2 ]
NP_033398.2. NM_009372.3. [P70284-1 ]
XP_006524095.1. XM_006524032.1. [P70284-2 ]
UniGenei Mm.101034.

3D structure databases

ProteinModelPortali P70284.
SMRi P70284. Positions 42-119.
ModBasei Search...

Protein-protein interaction databases

BioGridi 204166. 5 interactions.

PTM databases

PhosphoSitei P70284.

Proteomic databases

PRIDEi P70284.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059775 ; ENSMUSP00000060512 ; ENSMUSG00000047407 . [P70284-1 ]
ENSMUST00000118283 ; ENSMUSP00000113192 ; ENSMUSG00000047407 . [P70284-2 ]
ENSMUST00000172229 ; ENSMUSP00000127139 ; ENSMUSG00000047407 . [P70284-2 ]
GeneIDi 21815.
KEGGi mmu:21815.
UCSCi uc008dlp.2. mouse. [P70284-1 ]

Organism-specific databases

CTDi 7050.
MGIi MGI:1194497. Tgif1.

Phylogenomic databases

eggNOGi NOG308174.
GeneTreei ENSGT00680000099964.
HOGENOMi HOG000232039.
HOVERGENi HBG001143.
InParanoidi P70284.
OrthoDBi EOG7H7937.
PhylomeDBi P70284.

Enzyme and pathway databases

Reactomei REACT_220566. Downregulation of SMAD2/3:SMAD4 transcriptional activity.

Miscellaneous databases

ChiTaRSi TGIF1. mouse.
NextBioi 301216.
PROi P70284.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70284.
Bgeei P70284.
CleanExi MM_TGIF1.
Genevestigatori P70284.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001356. Homeobox_dom.
IPR008422. Homeobox_KN_domain.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF05920. Homeobox_KN. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation."
    Bertolino E., Wildt S., Richards G., Clerc R.G.
    Dev. Dyn. 205:410-420(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: BALB/c.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Mammary fibroblast and Mammary gland.

Entry informationi

Entry nameiTGIF1_MOUSE
AccessioniPrimary (citable) accession number: P70284
Secondary accession number(s): Q921F9, Q99JS3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 17, 2003
Last modified: September 3, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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