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Protein

Synaptonemal complex protein 3

Gene

Sycp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for axial elements (AE) in meiotic cells and for assembly of the synaptonemal complex. May be important for testis development and male fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.2 Publications

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. protein heterodimerization activity Source: MGI

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. chiasma assembly Source: UniProtKB
  3. female meiosis chromosome segregation Source: UniProtKB
  4. female meiosis chromosome separation Source: UniProtKB
  5. female meiosis sister chromatid cohesion Source: UniProtKB
  6. lateral element assembly Source: MGI
  7. meiotic DNA repair synthesis Source: MGI
  8. meiotic nuclear division Source: MGI
  9. mitotic nuclear division Source: MGI
  10. negative regulation of apoptotic process Source: UniProtKB
  11. spermatogenesis Source: UniProtKB
  12. spermatogenesis, exchange of chromosomal proteins Source: MGI
  13. sperm chromatin condensation Source: MGI
  14. synapsis Source: MGI
  15. synaptonemal complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Meiosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_287050. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex protein 3
Short name:
SCP-3
Gene namesi
Name:Sycp3
Synonyms:Scp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109542. Sycp3.

Subcellular locationi

Nucleus By similarity. Chromosome 1 Publication
Note: In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.By similarity

GO - Cellular componenti

  1. chromosome Source: MGI
  2. condensed chromosome Source: MGI
  3. condensed nuclear chromosome Source: MGI
  4. lateral element Source: UniProtKB
  5. male germ cell nucleus Source: MGI
  6. nucleoplasm Source: Reactome
  7. nucleus Source: MGI
  8. synaptonemal complex Source: MGI
  9. transverse filament Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Disruption phenotypei

Homozygous males with null mutations were sterile due to massive apoptotic cell death during meiotic prophase. Failed to form axial/lateral elements and SCs, and the chromosomes in the mutant spermatocytes did not synapse. In contrast, females were fertile and generated healthy offspring. However, they exhibited a sharp reduction in litter size that increased with advancing maternal age.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Synaptonemal complex protein 3PRO_0000223044Add
BLAST

Post-translational modificationi

Phosphorylated.1 Publication

Proteomic databases

PaxDbiP70281.
PRIDEiP70281.

PTM databases

PhosphoSiteiP70281.

Expressioni

Gene expression databases

CleanExiMM_SYCP3.
GenevestigatoriP70281.

Interactioni

Subunit structurei

Interacts with SYCP2.By similarity

Protein-protein interaction databases

BioGridi203598. 2 interactions.
IntActiP70281. 3 interactions.
MINTiMINT-8144355.

Structurei

3D structure databases

ProteinModelPortaliP70281.
SMRiP70281. Positions 99-241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili115 – 252138Sequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi106 – 1094Nuclear localization signalSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi123 – 250128Gln-richAdd
BLAST

Sequence similaritiesi

Belongs to the XLR/SYCP3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG27405.
HOGENOMiHOG000236293.
HOVERGENiHBG100390.
InParanoidiP70281.
PhylomeDBiP70281.

Family and domain databases

InterProiIPR006888. Cor1/Xlr/Xmr.
[Graphical view]
PANTHERiPTHR19368. PTHR19368. 1 hit.
PfamiPF04803. Cor1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70281-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGCGDSDS SPEPLSKHLK MVPGGRKHSG KSGKPPLVDQ PKKAFDFEKD
60 70 80 90 100
DKDLSGSEED VADEKAPVID KHGKKRSAGI IEDVGGEVQN MLEKFGADIN
110 120 130 140 150
KALLAKRKRI EMYTKASFKA SNQKIEQIWK TQQEEIQKLN NEYSQQFMNV
160 170 180 190 200
LQQWELDIQK FEEQGEKLSN LFRQQQKIFQ QSRIVQSQRM FAMKQIHEQF
210 220 230 240 250
IKSLEDVEKN NDNLFTGTQS ELKKEMAMLQ KKVMMETQQQ EMANVRKSLQ

SMLF
Length:254
Mass (Da):29,347
Last modified:January 31, 1997 - v1
Checksum:iE0121D58A8DCD2EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti191 – 1911F → K in BAE20894 (PubMed:16141072).Curated
Sequence conflicti193 – 1931M → I in BAE20894 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08485 mRNA. Translation: CAA69719.1.
Y08486 Genomic DNA. Translation: CAA69720.1.
AF181478
, AF181473, AF181474, AF181475, AF181476, AF181477 Genomic DNA. Translation: AAG17538.1.
AK131949 mRNA. Translation: BAE20894.1.
CCDSiCCDS24111.1.
RefSeqiNP_035647.2. NM_011517.2.
UniGeneiMm.297977.

Genome annotation databases

GeneIDi20962.
KEGGimmu:20962.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08485 mRNA. Translation: CAA69719.1.
Y08486 Genomic DNA. Translation: CAA69720.1.
AF181478
, AF181473, AF181474, AF181475, AF181476, AF181477 Genomic DNA. Translation: AAG17538.1.
AK131949 mRNA. Translation: BAE20894.1.
CCDSiCCDS24111.1.
RefSeqiNP_035647.2. NM_011517.2.
UniGeneiMm.297977.

3D structure databases

ProteinModelPortaliP70281.
SMRiP70281. Positions 99-241.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203598. 2 interactions.
IntActiP70281. 3 interactions.
MINTiMINT-8144355.

PTM databases

PhosphoSiteiP70281.

Proteomic databases

PaxDbiP70281.
PRIDEiP70281.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi20962.
KEGGimmu:20962.

Organism-specific databases

CTDi50511.
MGIiMGI:109542. Sycp3.

Phylogenomic databases

eggNOGiNOG27405.
HOGENOMiHOG000236293.
HOVERGENiHBG100390.
InParanoidiP70281.
PhylomeDBiP70281.

Enzyme and pathway databases

ReactomeiREACT_287050. Meiotic synapsis.
REACT_75800. Meiotic Synapsis.

Miscellaneous databases

ChiTaRSiSycp3. mouse.
NextBioi299914.
PROiP70281.
SOURCEiSearch...

Gene expression databases

CleanExiMM_SYCP3.
GenevestigatoriP70281.

Family and domain databases

InterProiIPR006888. Cor1/Xlr/Xmr.
[Graphical view]
PANTHERiPTHR19368. PTHR19368. 1 hit.
PfamiPF04803. Cor1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The mouse synaptosomal complex protein gene Sycp3 maps to band C of chromosome 10."
    Klink A., Lee M., Cooke H.J.
    Mamm. Genome 8:376-377(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
    Tissue: Liver and Testis.
  2. "The genomic structure of SYCP3, a meiosis-specific gene encoding a protein of the chromosome core."
    Botelho R.J., DiNicolo L., Tsao N., Karaiskakis A., Tarsounas M., Moens P.B., Pearlman R.E.
    Biochim. Biophys. Acta 1518:294-299(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryonic stem cell.
  4. "The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility."
    Yuan L., Liu J.G., Zhao J., Brundell E., Daneholt B., Hoog C.
    Mol. Cell 5:73-83(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  5. "Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis."
    Fukuda T., Pratto F., Schimenti J.C., Turner J.M., Camerini-Otero R.D., Hoeoeg C.
    PLoS Genet. 8:E1002485-E1002485(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.

Entry informationi

Entry nameiSYCP3_MOUSE
AccessioniPrimary (citable) accession number: P70281
Secondary accession number(s): Q3V2A4, Q549A7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 14, 1998
Last sequence update: January 31, 1997
Last modified: March 31, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.