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P70281

- SYCP3_MOUSE

UniProt

P70281 - SYCP3_MOUSE

Protein

Synaptonemal complex protein 3

Gene

Sycp3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Required for axial elements (AE) in meiotic cells and for assembly of the synaptonemal complex. May be important for testis development and male fertility. Required for efficient phosphorylation of HORMAD1 and HORMAD2.2 Publications

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. protein heterodimerization activity Source: MGI

    GO - Biological processi

    1. chiasma assembly Source: UniProtKB
    2. female meiosis chromosome segregation Source: UniProtKB
    3. female meiosis chromosome separation Source: UniProtKB
    4. female meiosis sister chromatid cohesion Source: UniProtKB
    5. lateral element assembly Source: MGI
    6. meiotic DNA repair synthesis Source: MGI
    7. meiotic nuclear division Source: MGI
    8. mitotic nuclear division Source: MGI
    9. negative regulation of apoptotic process Source: UniProtKB
    10. photosynthesis Source: UniProtKB-KW
    11. spermatogenesis Source: UniProtKB
    12. sperm chromatin condensation Source: MGI
    13. synapsis Source: MGI
    14. synaptonemal complex assembly Source: UniProtKB

    Keywords - Biological processi

    Cell cycle, Cell division, Meiosis

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_198626. Meiotic synapsis.
    REACT_75800. Meiotic Synapsis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptonemal complex protein 3
    Short name:
    SCP-3
    Gene namesi
    Name:Sycp3
    Synonyms:Scp3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:109542. Sycp3.

    Subcellular locationi

    Nucleus By similarity. Chromosome 1 Publication
    Note: In tripartite segments of synaptonemal complexes, irrespective of whether these are synapsed or unsynapsed.By similarity

    GO - Cellular componenti

    1. chromosome Source: MGI
    2. condensed chromosome Source: MGI
    3. condensed nuclear chromosome Source: MGI
    4. lateral element Source: UniProtKB
    5. male germ cell nucleus Source: MGI
    6. nucleoplasm Source: Reactome
    7. nucleus Source: MGI
    8. synaptonemal complex Source: MGI
    9. transverse filament Source: MGI

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Homozygous males with null mutations were sterile due to massive apoptotic cell death during meiotic prophase. Failed to form axial/lateral elements and SCs, and the chromosomes in the mutant spermatocytes did not synapse. In contrast, females were fertile and generated healthy offspring. However, they exhibited a sharp reduction in litter size that increased with advancing maternal age.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Synaptonemal complex protein 3PRO_0000223044Add
    BLAST

    Post-translational modificationi

    Phosphorylated.1 Publication

    Proteomic databases

    PaxDbiP70281.
    PRIDEiP70281.

    PTM databases

    PhosphoSiteiP70281.

    Expressioni

    Gene expression databases

    CleanExiMM_SYCP3.
    GenevestigatoriP70281.

    Interactioni

    Subunit structurei

    Interacts with SYCP2.By similarity

    Protein-protein interaction databases

    BioGridi203598. 2 interactions.
    IntActiP70281. 3 interactions.
    MINTiMINT-8144355.

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili115 – 252138Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi106 – 1094Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi123 – 250128Gln-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the XLR/SYCP3 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG27405.
    HOGENOMiHOG000236293.
    HOVERGENiHBG100390.
    InParanoidiP70281.
    PhylomeDBiP70281.

    Family and domain databases

    InterProiIPR006888. Cor1/Xlr/Xmr.
    [Graphical view]
    PANTHERiPTHR19368. PTHR19368. 1 hit.
    PfamiPF04803. Cor1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70281-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLRGCGDSDS SPEPLSKHLK MVPGGRKHSG KSGKPPLVDQ PKKAFDFEKD    50
    DKDLSGSEED VADEKAPVID KHGKKRSAGI IEDVGGEVQN MLEKFGADIN 100
    KALLAKRKRI EMYTKASFKA SNQKIEQIWK TQQEEIQKLN NEYSQQFMNV 150
    LQQWELDIQK FEEQGEKLSN LFRQQQKIFQ QSRIVQSQRM FAMKQIHEQF 200
    IKSLEDVEKN NDNLFTGTQS ELKKEMAMLQ KKVMMETQQQ EMANVRKSLQ 250
    SMLF 254
    Length:254
    Mass (Da):29,347
    Last modified:February 1, 1997 - v1
    Checksum:iE0121D58A8DCD2EA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911F → K in BAE20894. (PubMed:16141072)Curated
    Sequence conflicti193 – 1931M → I in BAE20894. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08485 mRNA. Translation: CAA69719.1.
    Y08486 Genomic DNA. Translation: CAA69720.1.
    AF181478
    , AF181473, AF181474, AF181475, AF181476, AF181477 Genomic DNA. Translation: AAG17538.1.
    AK131949 mRNA. Translation: BAE20894.1.
    CCDSiCCDS24111.1.
    RefSeqiNP_035647.2. NM_011517.2.
    UniGeneiMm.297977.

    Genome annotation databases

    GeneIDi20962.
    KEGGimmu:20962.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08485 mRNA. Translation: CAA69719.1 .
    Y08486 Genomic DNA. Translation: CAA69720.1 .
    AF181478
    , AF181473 , AF181474 , AF181475 , AF181476 , AF181477 Genomic DNA. Translation: AAG17538.1 .
    AK131949 mRNA. Translation: BAE20894.1 .
    CCDSi CCDS24111.1.
    RefSeqi NP_035647.2. NM_011517.2.
    UniGenei Mm.297977.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203598. 2 interactions.
    IntActi P70281. 3 interactions.
    MINTi MINT-8144355.

    PTM databases

    PhosphoSitei P70281.

    Proteomic databases

    PaxDbi P70281.
    PRIDEi P70281.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20962.
    KEGGi mmu:20962.

    Organism-specific databases

    CTDi 50511.
    MGIi MGI:109542. Sycp3.

    Phylogenomic databases

    eggNOGi NOG27405.
    HOGENOMi HOG000236293.
    HOVERGENi HBG100390.
    InParanoidi P70281.
    PhylomeDBi P70281.

    Enzyme and pathway databases

    Reactomei REACT_198626. Meiotic synapsis.
    REACT_75800. Meiotic Synapsis.

    Miscellaneous databases

    ChiTaRSi SYCP3. mouse.
    NextBioi 299914.
    PROi P70281.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_SYCP3.
    Genevestigatori P70281.

    Family and domain databases

    InterProi IPR006888. Cor1/Xlr/Xmr.
    [Graphical view ]
    PANTHERi PTHR19368. PTHR19368. 1 hit.
    Pfami PF04803. Cor1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mouse synaptosomal complex protein gene Sycp3 maps to band C of chromosome 10."
      Klink A., Lee M., Cooke H.J.
      Mamm. Genome 8:376-377(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
      Tissue: Liver and Testis.
    2. "The genomic structure of SYCP3, a meiosis-specific gene encoding a protein of the chromosome core."
      Botelho R.J., DiNicolo L., Tsao N., Karaiskakis A., Tarsounas M., Moens P.B., Pearlman R.E.
      Biochim. Biophys. Acta 1518:294-299(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryonic stem cell.
    4. "The murine SCP3 gene is required for synaptonemal complex assembly, chromosome synapsis, and male fertility."
      Yuan L., Liu J.G., Zhao J., Brundell E., Daneholt B., Hoog C.
      Mol. Cell 5:73-83(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    5. "Phosphorylation of chromosome core components may serve as axis marks for the status of chromosomal events during mammalian meiosis."
      Fukuda T., Pratto F., Schimenti J.C., Turner J.M., Camerini-Otero R.D., Hoeoeg C.
      PLoS Genet. 8:E1002485-E1002485(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, PHOSPHORYLATION.

    Entry informationi

    Entry nameiSYCP3_MOUSE
    AccessioniPrimary (citable) accession number: P70281
    Secondary accession number(s): Q3V2A4, Q549A7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3