Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Surfeit locus protein 6

Gene

Surf6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds to both DNA and RNA in vitro, with a stronger binding capacity for RNA. May represent a nucleolar constitutive protein involved in ribosomal biosynthesis or assembly.1 Publication

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • poly(A) RNA binding Source: MGI
  • RNA binding Source: UniProtKB

GO - Biological processi

  • ribosome assembly Source: UniProtKB
  • ribosome biogenesis Source: MGI
Complete GO annotation...

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 6
Gene namesi
Name:Surf6
Synonyms:Surf-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98447. Surf6.

Subcellular locationi

GO - Cellular componenti

  • granular component Source: UniProtKB
  • nucleolus Source: MGI
  • nucleoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 355355Surfeit locus protein 6PRO_0000220970Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei106 – 1061Citrulline1 Publication
Modified residuei136 – 1361PhosphoserineBy similarity
Modified residuei223 – 2231PhosphothreonineBy similarity

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Citrullination, Phosphoprotein

Proteomic databases

EPDiP70279.
PaxDbiP70279.
PeptideAtlasiP70279.
PRIDEiP70279.

PTM databases

iPTMnetiP70279.
PhosphoSiteiP70279.

Expressioni

Tissue specificityi

Expressed in all tissues tested, including heart, brain, spleen, lung, liver, muscle, kidney and testis.

Gene expression databases

BgeeiENSMUSG00000036160.
CleanExiMM_SURF6.
ExpressionAtlasiP70279. baseline and differential.
GenevisibleiP70279. MM.

Interactioni

Protein-protein interaction databases

BioGridi203584. 1 interaction.
STRINGi10090.ENSMUSP00000048457.

Structurei

3D structure databases

ProteinModelPortaliP70279.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 495Nuclear localization signalSequence analysis
Motifi152 – 1565Nuclear localization signalSequence analysis

Sequence similaritiesi

Belongs to the SURF6 family.Curated

Phylogenomic databases

eggNOGiKOG2885. Eukaryota.
ENOG4111G0Y. LUCA.
HOGENOMiHOG000133097.
HOVERGENiHBG054998.
InParanoidiP70279.
OMAiKFRKREE.
OrthoDBiEOG091G0O75.
PhylomeDBiP70279.
TreeFamiTF321608.

Family and domain databases

InterProiIPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view]
PANTHERiPTHR14369. PTHR14369. 1 hit.
PfamiPF04935. SURF6. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLLAKDTY LQDLAKKICA QPGPERQRST WGVRTKGSEA AGAPKKKRKK
60 70 80 90 100
TQKKSPEQEQ KAMDHKTKAL GKKPPTSSRP KNPMVSKQEK GLSSLGSPKD
110 120 130 140 150
SQGTARESVF ALDFLRQRLH EKIQLARGQG STKELSAATL EKRQRRKQER
160 170 180 190 200
ERKKRKRKER QAKQQVAEAE KKEEPVEVTP KMACKELQES GLIFNKVEVT
210 220 230 240 250
EEEPASKAQR KKEKRQKVKG NLTPLTGRNY RQLLDRLQAR QGRLDELRDQ
260 270 280 290 300
DAAKAQELEA KMKWTNLLYK AEGVKIRDDE RLLQEALKRK EKRRAQRQRK
310 320 330 340 350
WEKRSEHVVE KMQQRQDKRR QNLRKKKAAR AERRLQKAHK KGRVLPQDLE

RAGLS
Length:355
Mass (Da):41,235
Last modified:February 1, 1997 - v1
Checksum:i8C55841EDD8259B8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92842 mRNA. Translation: CAA63428.1.
BC026514 mRNA. Translation: AAH26514.1.
BC037634 mRNA. Translation: AAH37634.1.
AK043984 mRNA. Translation: BAC31725.1.
AK075636 mRNA. Translation: BAC35872.1.
CCDSiCCDS15812.1.
RefSeqiNP_033324.1. NM_009298.3.
UniGeneiMm.245577.
Mm.487749.

Genome annotation databases

EnsembliENSMUST00000047632; ENSMUSP00000048457; ENSMUSG00000036160.
GeneIDi20935.
KEGGimmu:20935.
UCSCiuc008iwc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92842 mRNA. Translation: CAA63428.1.
BC026514 mRNA. Translation: AAH26514.1.
BC037634 mRNA. Translation: AAH37634.1.
AK043984 mRNA. Translation: BAC31725.1.
AK075636 mRNA. Translation: BAC35872.1.
CCDSiCCDS15812.1.
RefSeqiNP_033324.1. NM_009298.3.
UniGeneiMm.245577.
Mm.487749.

3D structure databases

ProteinModelPortaliP70279.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203584. 1 interaction.
STRINGi10090.ENSMUSP00000048457.

PTM databases

iPTMnetiP70279.
PhosphoSiteiP70279.

Proteomic databases

EPDiP70279.
PaxDbiP70279.
PeptideAtlasiP70279.
PRIDEiP70279.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047632; ENSMUSP00000048457; ENSMUSG00000036160.
GeneIDi20935.
KEGGimmu:20935.
UCSCiuc008iwc.1. mouse.

Organism-specific databases

CTDi6838.
MGIiMGI:98447. Surf6.

Phylogenomic databases

eggNOGiKOG2885. Eukaryota.
ENOG4111G0Y. LUCA.
HOGENOMiHOG000133097.
HOVERGENiHBG054998.
InParanoidiP70279.
OMAiKFRKREE.
OrthoDBiEOG091G0O75.
PhylomeDBiP70279.
TreeFamiTF321608.

Miscellaneous databases

PROiP70279.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036160.
CleanExiMM_SURF6.
ExpressionAtlasiP70279. baseline and differential.
GenevisibleiP70279. MM.

Family and domain databases

InterProiIPR029190. Rrp14/SURF6_C.
IPR007019. SURF6.
[Graphical view]
PANTHERiPTHR14369. PTHR14369. 1 hit.
PfamiPF04935. SURF6. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSURF6_MOUSE
AccessioniPrimary (citable) accession number: P70279
Secondary accession number(s): Q8BPI4, Q8BRL7, Q8R0Q7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: September 7, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.