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Protein

Selenoprotein P

Gene

Sepp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium (By similarity). May supply selenium to tissues such as brain and testis.By similarity

GO - Molecular functioni

  • selenium binding Source: MGI

GO - Biological processi

  • brain development Source: MGI
  • growth Source: MGI
  • locomotory behavior Source: MGI
  • post-embryonic development Source: MGI
  • selenium compound metabolic process Source: MGI
  • sexual reproduction Source: MGI
Complete GO annotation...

Keywords - Ligandi

Selenium

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Protein family/group databases

TCDBi9.B.88.1.1. the selenoprotein p hydrogen selenide uptake protein (selp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein P
Short name:
SeP
Alternative name(s):
Plasma selenoprotein P
Gene namesi
Name:Sepp1
Synonyms:Selp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:894288. Sepp1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 380361Selenoprotein PPRO_0000022314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)By similarity
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence analysis
Modified residuei264 – 2641PhosphoserineBy similarity
Glycosylationi365 – 3651N-linked (GlcNAc...)Sequence analysis
Glycosylationi370 – 3701N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70274.
PaxDbiP70274.
PRIDEiP70274.

PTM databases

PhosphoSiteiP70274.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiP70274.
CleanExiMM_SELP.
MM_SEPP1.
ExpressionAtlasiP70274. baseline and differential.
GenevisibleiP70274. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081004.

Structurei

3D structure databases

ProteinModelPortaliP70274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein P family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXIQ. Eukaryota.
ENOG4111JK7. LUCA.
GeneTreeiENSGT00510000049326.
HOVERGENiHBG108473.
InParanoidiP70274.
OMAiSAITXQC.
PhylomeDBiP70274.
TreeFamiTF333425.

Family and domain databases

InterProiIPR007671. Selenoprotein-P_N.
IPR007672. SelP_C.
[Graphical view]
PfamiPF04593. SelP_C. 1 hit.
PF04592. SelP_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRSLGLALA LCLLPYGGAE SQGQSSACYK APEWYIGDQN PMLNSEGKVT
60 70 80 90 100
VVALLQASUY LCLLQASRLE DLRIKLESQG YFNISYIVVN HQGSPSQLKH
110 120 130 140 150
SHLKKQVSEH IAVYRQEEDG IDVWTLLNGN KDDFLIYDRC GRLVYHLGLP
160 170 180 190 200
YSFLTFPYVE EAIKIAYCEE RCGNCNLTSL EDEDFCKTVT SATANKTAEP
210 220 230 240 250
SEAHSHHKHH NKHGQEHLGS SKPSENQQPG PSETTLPPSG LHHHHRHRGQ
260 270 280 290 300
HRQGHLESUD TTASEGLHLS LAQRKLURRG CINQLLCKLS KESEAAPSSC
310 320 330 340 350
CCHCRHLIFE KSGSAIAUQC AENLPSLCSU QGLFAEEKVT ESCQCRSPPA
360 370 380
AUQNQPMNPM EANPNUSUDN QTRKUKUHSN
Length:380
Mass (Da):42,706
Last modified:February 26, 2008 - v3
Checksum:i0972BF4993CC208D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti184 – 1841D → Y in BAC55264 (PubMed:9687017).Curated
Sequence conflicti188 – 1881T → N in AAD01684 (Ref. 2) Curated
Sequence conflicti188 – 1881T → N in AAH01991 (PubMed:16141072).Curated
Sequence conflicti192 – 1921A → V in AAD01684 (Ref. 2) Curated
Sequence conflicti203 – 2031A → V in AAD01684 (Ref. 2) Curated
Sequence conflicti264 – 2641S → R in BAE34948 (PubMed:9687017).Curated
Sequence conflicti308 – 3081I → V in BAC55264 (PubMed:9687017).Curated
Sequence conflicti321 – 3211A → C in AAH01991 (PubMed:16141072).Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei59 – 591Selenocysteine
Non-standard residuei259 – 2591Selenocysteine
Non-standard residuei277 – 2771Selenocysteine
Non-standard residuei318 – 3181Selenocysteine
Non-standard residuei330 – 3301Selenocysteine
Non-standard residuei352 – 3521Selenocysteine
Non-standard residuei366 – 3661Selenocysteine
Non-standard residuei368 – 3681Selenocysteine
Non-standard residuei375 – 3751Selenocysteine
Non-standard residuei377 – 3771Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99807 mRNA. Translation: CAA68140.2.
AF021345 Genomic DNA. Translation: AAD01684.1.
AK002450 mRNA. Translation: BAC55246.3.
AK077265 mRNA. Translation: BAC55264.3.
AK146774 mRNA. Translation: BAE27423.1.
AK148623 mRNA. Translation: BAE28626.1.
AK159269 mRNA. Translation: BAE34948.1.
AK159524 mRNA. Translation: BAE35153.1.
AK159894 mRNA. Translation: BAE35460.1.
AK159911 mRNA. Translation: BAE35474.1.
AK159935 mRNA. Translation: BAE35495.1.
AK167611 mRNA. Translation: BAE39664.1.
AK168463 mRNA. Translation: BAE40359.1.
AK168583 mRNA. Translation: BAE40452.1.
AK168631 mRNA. Translation: BAE40491.1.
AK168747 mRNA. Translation: BAE40587.1.
AK168926 mRNA. Translation: BAE40739.1.
AK169011 mRNA. Translation: BAE40808.1.
AK169158 mRNA. Translation: BAE40937.1.
AK169362 mRNA. Translation: BAE41111.1.
BC001991 mRNA. Translation: AAH01991.2.
CCDSiCCDS27357.1.
PIRiT10442.
RefSeqiNP_001036078.1. NM_001042613.1.
NP_001036079.1. NM_001042614.1.
NP_033181.3. NM_009155.3.
UniGeneiMm.392203.

Genome annotation databases

EnsembliENSMUST00000082424; ENSMUSP00000081004; ENSMUSG00000064373.
ENSMUST00000159216; ENSMUSP00000124305; ENSMUSG00000064373.
GeneIDi20363.
KEGGimmu:20363.
UCSCiuc007vby.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99807 mRNA. Translation: CAA68140.2.
AF021345 Genomic DNA. Translation: AAD01684.1.
AK002450 mRNA. Translation: BAC55246.3.
AK077265 mRNA. Translation: BAC55264.3.
AK146774 mRNA. Translation: BAE27423.1.
AK148623 mRNA. Translation: BAE28626.1.
AK159269 mRNA. Translation: BAE34948.1.
AK159524 mRNA. Translation: BAE35153.1.
AK159894 mRNA. Translation: BAE35460.1.
AK159911 mRNA. Translation: BAE35474.1.
AK159935 mRNA. Translation: BAE35495.1.
AK167611 mRNA. Translation: BAE39664.1.
AK168463 mRNA. Translation: BAE40359.1.
AK168583 mRNA. Translation: BAE40452.1.
AK168631 mRNA. Translation: BAE40491.1.
AK168747 mRNA. Translation: BAE40587.1.
AK168926 mRNA. Translation: BAE40739.1.
AK169011 mRNA. Translation: BAE40808.1.
AK169158 mRNA. Translation: BAE40937.1.
AK169362 mRNA. Translation: BAE41111.1.
BC001991 mRNA. Translation: AAH01991.2.
CCDSiCCDS27357.1.
PIRiT10442.
RefSeqiNP_001036078.1. NM_001042613.1.
NP_001036079.1. NM_001042614.1.
NP_033181.3. NM_009155.3.
UniGeneiMm.392203.

3D structure databases

ProteinModelPortaliP70274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081004.

Protein family/group databases

TCDBi9.B.88.1.1. the selenoprotein p hydrogen selenide uptake protein (selp) family.

PTM databases

PhosphoSiteiP70274.

Proteomic databases

MaxQBiP70274.
PaxDbiP70274.
PRIDEiP70274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082424; ENSMUSP00000081004; ENSMUSG00000064373.
ENSMUST00000159216; ENSMUSP00000124305; ENSMUSG00000064373.
GeneIDi20363.
KEGGimmu:20363.
UCSCiuc007vby.1. mouse.

Organism-specific databases

CTDi6414.
MGIiMGI:894288. Sepp1.

Phylogenomic databases

eggNOGiENOG410IXIQ. Eukaryota.
ENOG4111JK7. LUCA.
GeneTreeiENSGT00510000049326.
HOVERGENiHBG108473.
InParanoidiP70274.
OMAiSAITXQC.
PhylomeDBiP70274.
TreeFamiTF333425.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

PROiP70274.
SOURCEiSearch...

Gene expression databases

BgeeiP70274.
CleanExiMM_SELP.
MM_SEPP1.
ExpressionAtlasiP70274. baseline and differential.
GenevisibleiP70274. MM.

Family and domain databases

InterProiIPR007671. Selenoprotein-P_N.
IPR007672. SelP_C.
[Graphical view]
PfamiPF04593. SelP_C. 1 hit.
PF04592. SelP_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA and deduced polypeptide sequence of a mouse selenoprotein P."
    Steinert P., Ahrens M., Gross G., Flohe L.
    BioFactors 6:311-319(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  2. Steinert P.
    Submitted (DEC-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 59; 259; 277; 318; 330; 352; 366; 368; 375 AND 377.
  3. "Analysis of the mouse selenoprotein P gene."
    Steinert P., Bachner D., Flohe L.
    Biol. Chem. 379:683-691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Amnion, Kidney and Placenta.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary tumor.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung, Spleen and Testis.

Entry informationi

Entry nameiSEPP1_MOUSE
AccessioniPrimary (citable) accession number: P70274
Secondary accession number(s): Q3TJ31
, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: June 8, 2016
This is version 109 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.