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Protein

Selenoprotein P

Gene

Sepp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium (By similarity). May supply selenium to tissues such as brain and testis.By similarity

GO - Molecular functioni

  • selenium binding Source: MGI

GO - Biological processi

  • brain development Source: MGI
  • growth Source: MGI
  • locomotory behavior Source: MGI
  • post-embryonic development Source: MGI
  • selenium compound metabolic process Source: MGI
  • sexual reproduction Source: MGI
Complete GO annotation...

Keywords - Ligandi

Selenium

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Protein family/group databases

TCDBi9.B.88.1.1. the selenoprotein p hydrogen selenide uptake protein (selp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Selenoprotein P
Short name:
SeP
Alternative name(s):
Plasma selenoprotein P
Gene namesi
Name:Sepp1
Synonyms:Selp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:894288. Sepp1.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: MGI
  • extracellular region Source: MGI
  • extracellular space Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002231420 – 380Selenoprotein PAdd BLAST361

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi83N-linked (GlcNAc...)By similarity1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi195N-linked (GlcNAc...)Sequence analysis1
Modified residuei264PhosphoserineBy similarity1
Glycosylationi365N-linked (GlcNAc...)Sequence analysis1
Glycosylationi370N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Phosphorylation sites are present in the extracellular medium.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP70274.
PaxDbiP70274.
PeptideAtlasiP70274.
PRIDEiP70274.

PTM databases

PhosphoSitePlusiP70274.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Gene expression databases

BgeeiENSMUSG00000064373.
CleanExiMM_SELP.
MM_SEPP1.
ExpressionAtlasiP70274. baseline and differential.
GenevisibleiP70274. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081004.

Structurei

3D structure databases

ProteinModelPortaliP70274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the selenoprotein P family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXIQ. Eukaryota.
ENOG4111JK7. LUCA.
GeneTreeiENSGT00510000049326.
HOVERGENiHBG108473.
InParanoidiP70274.
OMAiSAITXQC.
OrthoDBiEOG091G18QW.
PhylomeDBiP70274.
TreeFamiTF333425.

Family and domain databases

InterProiIPR007671. Selenoprotein-P_N.
IPR007672. SelP_C.
[Graphical view]
PfamiPF04593. SelP_C. 1 hit.
PF04592. SelP_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70274-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MWRSLGLALA LCLLPYGGAE SQGQSSACYK APEWYIGDQN PMLNSEGKVT
60 70 80 90 100
VVALLQASUY LCLLQASRLE DLRIKLESQG YFNISYIVVN HQGSPSQLKH
110 120 130 140 150
SHLKKQVSEH IAVYRQEEDG IDVWTLLNGN KDDFLIYDRC GRLVYHLGLP
160 170 180 190 200
YSFLTFPYVE EAIKIAYCEE RCGNCNLTSL EDEDFCKTVT SATANKTAEP
210 220 230 240 250
SEAHSHHKHH NKHGQEHLGS SKPSENQQPG PSETTLPPSG LHHHHRHRGQ
260 270 280 290 300
HRQGHLESUD TTASEGLHLS LAQRKLURRG CINQLLCKLS KESEAAPSSC
310 320 330 340 350
CCHCRHLIFE KSGSAIAUQC AENLPSLCSU QGLFAEEKVT ESCQCRSPPA
360 370 380
AUQNQPMNPM EANPNUSUDN QTRKUKUHSN
Length:380
Mass (Da):42,706
Last modified:February 26, 2008 - v3
Checksum:i0972BF4993CC208D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti184D → Y in BAC55264 (PubMed:9687017).Curated1
Sequence conflicti188T → N in AAD01684 (Ref. 2) Curated1
Sequence conflicti188T → N in AAH01991 (PubMed:16141072).Curated1
Sequence conflicti192A → V in AAD01684 (Ref. 2) Curated1
Sequence conflicti203A → V in AAD01684 (Ref. 2) Curated1
Sequence conflicti264S → R in BAE34948 (PubMed:9687017).Curated1
Sequence conflicti308I → V in BAC55264 (PubMed:9687017).Curated1
Sequence conflicti321A → C in AAH01991 (PubMed:16141072).Curated1

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei59Selenocysteine1
Non-standard residuei259Selenocysteine1
Non-standard residuei277Selenocysteine1
Non-standard residuei318Selenocysteine1
Non-standard residuei330Selenocysteine1
Non-standard residuei352Selenocysteine1
Non-standard residuei366Selenocysteine1
Non-standard residuei368Selenocysteine1
Non-standard residuei375Selenocysteine1
Non-standard residuei377Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99807 mRNA. Translation: CAA68140.2.
AF021345 Genomic DNA. Translation: AAD01684.1.
AK002450 mRNA. Translation: BAC55246.3.
AK077265 mRNA. Translation: BAC55264.3.
AK146774 mRNA. Translation: BAE27423.1.
AK148623 mRNA. Translation: BAE28626.1.
AK159269 mRNA. Translation: BAE34948.1.
AK159524 mRNA. Translation: BAE35153.1.
AK159894 mRNA. Translation: BAE35460.1.
AK159911 mRNA. Translation: BAE35474.1.
AK159935 mRNA. Translation: BAE35495.1.
AK167611 mRNA. Translation: BAE39664.1.
AK168463 mRNA. Translation: BAE40359.1.
AK168583 mRNA. Translation: BAE40452.1.
AK168631 mRNA. Translation: BAE40491.1.
AK168747 mRNA. Translation: BAE40587.1.
AK168926 mRNA. Translation: BAE40739.1.
AK169011 mRNA. Translation: BAE40808.1.
AK169158 mRNA. Translation: BAE40937.1.
AK169362 mRNA. Translation: BAE41111.1.
BC001991 mRNA. Translation: AAH01991.2.
CCDSiCCDS27357.1.
PIRiT10442.
RefSeqiNP_001036078.1. NM_001042613.1.
NP_001036079.1. NM_001042614.1.
NP_033181.3. NM_009155.3.
UniGeneiMm.392203.

Genome annotation databases

EnsembliENSMUST00000082424; ENSMUSP00000081004; ENSMUSG00000064373.
ENSMUST00000159216; ENSMUSP00000124305; ENSMUSG00000064373.
GeneIDi20363.
KEGGimmu:20363.
UCSCiuc007vby.1. mouse.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99807 mRNA. Translation: CAA68140.2.
AF021345 Genomic DNA. Translation: AAD01684.1.
AK002450 mRNA. Translation: BAC55246.3.
AK077265 mRNA. Translation: BAC55264.3.
AK146774 mRNA. Translation: BAE27423.1.
AK148623 mRNA. Translation: BAE28626.1.
AK159269 mRNA. Translation: BAE34948.1.
AK159524 mRNA. Translation: BAE35153.1.
AK159894 mRNA. Translation: BAE35460.1.
AK159911 mRNA. Translation: BAE35474.1.
AK159935 mRNA. Translation: BAE35495.1.
AK167611 mRNA. Translation: BAE39664.1.
AK168463 mRNA. Translation: BAE40359.1.
AK168583 mRNA. Translation: BAE40452.1.
AK168631 mRNA. Translation: BAE40491.1.
AK168747 mRNA. Translation: BAE40587.1.
AK168926 mRNA. Translation: BAE40739.1.
AK169011 mRNA. Translation: BAE40808.1.
AK169158 mRNA. Translation: BAE40937.1.
AK169362 mRNA. Translation: BAE41111.1.
BC001991 mRNA. Translation: AAH01991.2.
CCDSiCCDS27357.1.
PIRiT10442.
RefSeqiNP_001036078.1. NM_001042613.1.
NP_001036079.1. NM_001042614.1.
NP_033181.3. NM_009155.3.
UniGeneiMm.392203.

3D structure databases

ProteinModelPortaliP70274.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000081004.

Protein family/group databases

TCDBi9.B.88.1.1. the selenoprotein p hydrogen selenide uptake protein (selp) family.

PTM databases

PhosphoSitePlusiP70274.

Proteomic databases

MaxQBiP70274.
PaxDbiP70274.
PeptideAtlasiP70274.
PRIDEiP70274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000082424; ENSMUSP00000081004; ENSMUSG00000064373.
ENSMUST00000159216; ENSMUSP00000124305; ENSMUSG00000064373.
GeneIDi20363.
KEGGimmu:20363.
UCSCiuc007vby.1. mouse.

Organism-specific databases

CTDi6414.
MGIiMGI:894288. Sepp1.

Phylogenomic databases

eggNOGiENOG410IXIQ. Eukaryota.
ENOG4111JK7. LUCA.
GeneTreeiENSGT00510000049326.
HOVERGENiHBG108473.
InParanoidiP70274.
OMAiSAITXQC.
OrthoDBiEOG091G18QW.
PhylomeDBiP70274.
TreeFamiTF333425.

Enzyme and pathway databases

ReactomeiR-MMU-114608. Platelet degranulation.

Miscellaneous databases

PROiP70274.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064373.
CleanExiMM_SELP.
MM_SEPP1.
ExpressionAtlasiP70274. baseline and differential.
GenevisibleiP70274. MM.

Family and domain databases

InterProiIPR007671. Selenoprotein-P_N.
IPR007672. SelP_C.
[Graphical view]
PfamiPF04593. SelP_C. 1 hit.
PF04592. SelP_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEPP1_MOUSE
AccessioniPrimary (citable) accession number: P70274
Secondary accession number(s): Q3TJ31
, Q3TXG8, Q6PKE7, Q80T08, Q80UF3, Q9Z2T7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 26, 2008
Last modified: November 2, 2016
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.