##gff-version 3 P70265 UniProtKB Initiator methionine 1 1 . . . Note=Removed;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60825 P70265 UniProtKB Chain 2 519 . . . ID=PRO_0000179965;Note=6-phosphofructo-2-kinase/fructose-2%2C6-bisphosphatase 2 P70265 UniProtKB Region 1 22 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70265 UniProtKB Region 2 251 . . . Note=6-phosphofructo-2-kinase P70265 UniProtKB Region 252 519 . . . Note=Fructose-2%2C6-bisphosphatase P70265 UniProtKB Region 448 493 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70265 UniProtKB Region 500 519 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70265 UniProtKB Compositional bias 1 21 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70265 UniProtKB Compositional bias 456 484 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite P70265 UniProtKB Active site 131 131 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P70265 UniProtKB Active site 161 161 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 P70265 UniProtKB Active site 260 260 . . . Note=Tele-phosphohistidine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Active site 329 329 . . . Note=Proton donor/acceptor;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 48 56 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 81 81 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 105 105 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 133 133 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 139 139 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 170 175 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 175 175 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 196 196 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 200 200 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 259 259 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 266 266 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 272 272 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 340 340 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 351 354 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953 P70265 UniProtKB Binding site 354 354 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 358 358 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 369 369 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 395 399 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953 P70265 UniProtKB Binding site 395 395 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Binding site 399 399 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P07953 P70265 UniProtKB Binding site 431 431 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Site 259 259 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Site 266 266 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Site 394 394 . . . Note=Transition state stabilizer;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q16875 P70265 UniProtKB Modified residue 2 2 . . . Note=N-acetylserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60825 P70265 UniProtKB Modified residue 32 32 . . . Note=Phosphoserine%3B by PKA;Ontology_term=ECO:0000250;evidence=ECO:0000250 P70265 UniProtKB Modified residue 469 469 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P70265 UniProtKB Modified residue 471 471 . . . Note=Phosphothreonine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60825 P70265 UniProtKB Modified residue 478 478 . . . Note=Phosphothreonine%3B by PKC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:P26285 P70265 UniProtKB Modified residue 486 486 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:21183079;Dbxref=PMID:21183079 P70265 UniProtKB Modified residue 496 496 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:O60825 P70265 UniProtKB Sequence conflict 9 9 . . . Note=T->P;Ontology_term=ECO:0000305;evidence=ECO:0000305 P70265 UniProtKB Sequence conflict 12 12 . . . Note=Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 P70265 UniProtKB Sequence conflict 222 222 . . . Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 P70265 UniProtKB Sequence conflict 496 496 . . . Note=S->K;Ontology_term=ECO:0000305;evidence=ECO:0000305