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P70263 (PD2R_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin D2 receptor

Short name=PGD receptor
Short name=PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene names
Name:Ptgdr
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Tissue specificity

Most abundantly expressed in the ileum, followed by lung, stomach and uterus.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Prostaglandin D2 receptor
PRO_0000070048

Regions

Topological domain1 – 2020Extracellular Potential
Transmembrane21 – 4121Helical; Name=1; Potential
Topological domain42 – 5817Cytoplasmic Potential
Transmembrane59 – 7921Helical; Name=2; Potential
Topological domain80 – 10627Extracellular Potential
Transmembrane107 – 12721Helical; Name=3; Potential
Topological domain128 – 14922Cytoplasmic Potential
Transmembrane150 – 17021Helical; Name=4; Potential
Topological domain171 – 19424Extracellular Potential
Transmembrane195 – 21521Helical; Name=5; Potential
Topological domain216 – 26146Cytoplasmic Potential
Transmembrane262 – 28221Helical; Name=6; Potential
Topological domain283 – 30624Extracellular Potential
Transmembrane307 – 32721Helical; Name=7; Potential
Topological domain328 – 35730Cytoplasmic Potential

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation891N-linked (GlcNAc...) Potential
Disulfide bond104 ↔ 182 By similarity

Experimental info

Sequence conflict751K → N in BAC27895. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P70263 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 91CBFF7A5936EB05

FASTA35740,005
        10         20         30         40         50         60 
MNESYRCQTS TWVERGSSAT MGAVLFGAGL LGNLLALVLL ARSGLGSCRP GPLHPPPSVF 

        70         80         90        100        110        120 
YVLVCGLTVT DLLGKCLISP MVLAAYAQNQ SLKELLPASG NQLCETFAFL MSFFGLASTL 

       130        140        150        160        170        180 
QLLAMAVECW LSLGHPFFYQ RHVTLRRGVL VAPVVAAFCL AFCALPFAGF GKFVQYCPGT 

       190        200        210        220        230        240 
WCFIQMIHKE RSFSVIGFSV LYSSLMALLV LATVVCNLGA MYNLYDMHRR QRHYPHRCSR 

       250        260        270        280        290        300 
DRAQSGSDYR HGSLHPLEEL DHFVLLALMT VLFTMCSLPL IYRAYYGAFK LENKAEGDSE 

       310        320        330        340        350 
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKVFTRPLI YRNWSSHSQQ SNVESTL 

« Hide

References

« Hide 'large scale' references
[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Olfactory bulb.
[2]"Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene."
Hirata M., Kakizuka A., Aizawa M., Ushikubi F., Narumiya S.
Proc. Natl. Acad. Sci. U.S.A. 91:11192-11196(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
Tissue: Lung.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK032488 mRNA. Translation: BAC27895.1.
D29765 Genomic DNA. Translation: BAA06168.1.
BC132297 mRNA. Translation: AAI32298.1.
CCDSCCDS26971.1.
PIRI59269.
I80042.
RefSeqNP_032988.3. NM_008962.4.
UniGeneMm.5105.

3D structure databases

ProteinModelPortalP70263.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000093653.

Chemistry

BindingDBP70263.
ChEMBLCHEMBL3933.
GuidetoPHARMACOLOGY338.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEP70263.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000095959; ENSMUSP00000093653; ENSMUSG00000071489.
GeneID19214.
KEGGmmu:19214.
UCSCuc007ter.1. mouse.

Organism-specific databases

CTD5729.
MGIMGI:102966. Ptgdr.

Phylogenomic databases

eggNOGNOG248831.
GeneTreeENSGT00690000101953.
HOGENOMHOG000115475.
HOVERGENHBG003074.
InParanoidA2RSY4.
KOK04332.
OMAAYYGAFK.
OrthoDBEOG72VH6G.
PhylomeDBP70263.
TreeFamTF324982.

Gene expression databases

BgeeP70263.
CleanExMM_PTGDR.
GenevestigatorP70263.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio295968.
PROP70263.
SOURCESearch...

Entry information

Entry namePD2R_MOUSE
AccessionPrimary (citable) accession number: P70263
Secondary accession number(s): A2RSY4, Q8CCM3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries