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Protein

Prostaglandin D2 receptor

Gene

Ptgdr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity).By similarity

GO - Molecular functioni

  1. prostaglandin D receptor activity Source: MGI
  2. prostaglandin J receptor activity Source: MGI

GO - Biological processi

  1. adenosine metabolic process Source: MGI
  2. cellular response to prostaglandin D stimulus Source: MGI
  3. inflammatory response Source: MGI
  4. male sex determination Source: MGI
  5. sleep Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_230556. Prostanoid ligand receptors.
REACT_242871. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin D2 receptor
Short name:
PGD receptor
Short name:
PGD2 receptor
Alternative name(s):
Prostanoid DP receptor
Gene namesi
Name:Ptgdr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:102966. Ptgdr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
BLAST
Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini42 – 5817CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini80 – 10627ExtracellularSequence AnalysisAdd
BLAST
Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini128 – 14922CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini171 – 19424ExtracellularSequence AnalysisAdd
BLAST
Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini216 – 26146CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini283 – 30624ExtracellularSequence AnalysisAdd
BLAST
Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini328 – 35730CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 357357Prostaglandin D2 receptorPRO_0000070048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP70263.

Expressioni

Tissue specificityi

Most abundantly expressed in the ileum, followed by lung, stomach and uterus.

Gene expression databases

BgeeiP70263.
CleanExiMM_PTGDR.
GenevestigatoriP70263.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093653.

Structurei

3D structure databases

ProteinModelPortaliP70263.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG248831.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP70263.
KOiK04332.
OMAiAYYGAFK.
OrthoDBiEOG72VH6G.
PhylomeDBiP70263.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70263-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESYRCQTS TWVERGSSAT MGAVLFGAGL LGNLLALVLL ARSGLGSCRP
60 70 80 90 100
GPLHPPPSVF YVLVCGLTVT DLLGKCLISP MVLAAYAQNQ SLKELLPASG
110 120 130 140 150
NQLCETFAFL MSFFGLASTL QLLAMAVECW LSLGHPFFYQ RHVTLRRGVL
160 170 180 190 200
VAPVVAAFCL AFCALPFAGF GKFVQYCPGT WCFIQMIHKE RSFSVIGFSV
210 220 230 240 250
LYSSLMALLV LATVVCNLGA MYNLYDMHRR QRHYPHRCSR DRAQSGSDYR
260 270 280 290 300
HGSLHPLEEL DHFVLLALMT VLFTMCSLPL IYRAYYGAFK LENKAEGDSE
310 320 330 340 350
DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKVFTRPLI YRNWSSHSQQ

SNVESTL
Length:357
Mass (Da):40,005
Last modified:February 1, 1997 - v1
Checksum:i91CBFF7A5936EB05
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751K → N in BAC27895 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032488 mRNA. Translation: BAC27895.1.
D29765 Genomic DNA. Translation: BAA06168.1.
BC132297 mRNA. Translation: AAI32298.1.
CCDSiCCDS26971.1.
PIRiI59269.
I80042.
RefSeqiNP_032988.3. NM_008962.4.
UniGeneiMm.5105.

Genome annotation databases

EnsembliENSMUST00000095959; ENSMUSP00000093653; ENSMUSG00000071489.
GeneIDi19214.
KEGGimmu:19214.
UCSCiuc007ter.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032488 mRNA. Translation: BAC27895.1.
D29765 Genomic DNA. Translation: BAA06168.1.
BC132297 mRNA. Translation: AAI32298.1.
CCDSiCCDS26971.1.
PIRiI59269.
I80042.
RefSeqiNP_032988.3. NM_008962.4.
UniGeneiMm.5105.

3D structure databases

ProteinModelPortaliP70263.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000093653.

Chemistry

BindingDBiP70263.
ChEMBLiCHEMBL3933.
GuidetoPHARMACOLOGYi338.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PRIDEiP70263.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095959; ENSMUSP00000093653; ENSMUSG00000071489.
GeneIDi19214.
KEGGimmu:19214.
UCSCiuc007ter.1. mouse.

Organism-specific databases

CTDi5729.
MGIiMGI:102966. Ptgdr.

Phylogenomic databases

eggNOGiNOG248831.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP70263.
KOiK04332.
OMAiAYYGAFK.
OrthoDBiEOG72VH6G.
PhylomeDBiP70263.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiREACT_230556. Prostanoid ligand receptors.
REACT_242871. G alpha (s) signalling events.

Miscellaneous databases

NextBioi295968.
PROiP70263.
SOURCEiSearch...

Gene expression databases

BgeeiP70263.
CleanExiMM_PTGDR.
GenevestigatoriP70263.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000376. Pglndn_D_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00854. PRSTNOIDDPR.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Olfactory bulb.
  2. "Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene."
    Hirata M., Kakizuka A., Aizawa M., Ushikubi F., Narumiya S.
    Proc. Natl. Acad. Sci. U.S.A. 91:11192-11196(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
    Tissue: Lung.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiPD2R_MOUSE
AccessioniPrimary (citable) accession number: P70263
Secondary accession number(s): A2RSY4, Q8CCM3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 7, 2015
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.