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P70263

- PD2R_MOUSE

UniProt

P70263 - PD2R_MOUSE

Protein

Prostaglandin D2 receptor

Gene

Ptgdr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate By similarity.By similarity

    GO - Molecular functioni

    1. prostaglandin D receptor activity Source: MGI
    2. prostaglandin J receptor activity Source: MGI

    GO - Biological processi

    1. adenosine metabolic process Source: MGI
    2. cellular response to prostaglandin D stimulus Source: MGI
    3. inflammatory response Source: MGI
    4. male sex determination Source: MGI
    5. sleep Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin D2 receptor
    Short name:
    PGD receptor
    Short name:
    PGD2 receptor
    Alternative name(s):
    Prostanoid DP receptor
    Gene namesi
    Name:Ptgdr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:102966. Ptgdr.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 357357Prostaglandin D2 receptorPRO_0000070048Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi2 – 21N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi89 – 891N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi104 ↔ 182PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP70263.

    Expressioni

    Tissue specificityi

    Most abundantly expressed in the ileum, followed by lung, stomach and uterus.

    Gene expression databases

    BgeeiP70263.
    CleanExiMM_PTGDR.
    GenevestigatoriP70263.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000093653.

    Structurei

    3D structure databases

    ProteinModelPortaliP70263.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2020ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini42 – 5817CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini80 – 10627ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini128 – 14922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini171 – 19424ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini216 – 26146CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini283 – 30624ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini328 – 35730CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei21 – 4121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei107 – 12721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei195 – 21521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei262 – 28221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei307 – 32721Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG248831.
    GeneTreeiENSGT00690000101953.
    HOGENOMiHOG000115475.
    HOVERGENiHBG003074.
    InParanoidiA2RSY4.
    KOiK04332.
    OMAiAYYGAFK.
    OrthoDBiEOG72VH6G.
    PhylomeDBiP70263.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000376. Pglndn_D_rcpt.
    IPR008365. Prostanoid_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01788. PROSTANOIDR.
    PR00854. PRSTNOIDDPR.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70263-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNESYRCQTS TWVERGSSAT MGAVLFGAGL LGNLLALVLL ARSGLGSCRP    50
    GPLHPPPSVF YVLVCGLTVT DLLGKCLISP MVLAAYAQNQ SLKELLPASG 100
    NQLCETFAFL MSFFGLASTL QLLAMAVECW LSLGHPFFYQ RHVTLRRGVL 150
    VAPVVAAFCL AFCALPFAGF GKFVQYCPGT WCFIQMIHKE RSFSVIGFSV 200
    LYSSLMALLV LATVVCNLGA MYNLYDMHRR QRHYPHRCSR DRAQSGSDYR 250
    HGSLHPLEEL DHFVLLALMT VLFTMCSLPL IYRAYYGAFK LENKAEGDSE 300
    DLQALRFLSV ISIVDPWIFI IFRTSVFRML FHKVFTRPLI YRNWSSHSQQ 350
    SNVESTL 357
    Length:357
    Mass (Da):40,005
    Last modified:February 1, 1997 - v1
    Checksum:i91CBFF7A5936EB05
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751K → N in BAC27895. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032488 mRNA. Translation: BAC27895.1.
    D29765 Genomic DNA. Translation: BAA06168.1.
    BC132297 mRNA. Translation: AAI32298.1.
    CCDSiCCDS26971.1.
    PIRiI59269.
    I80042.
    RefSeqiNP_032988.3. NM_008962.4.
    UniGeneiMm.5105.

    Genome annotation databases

    EnsembliENSMUST00000095959; ENSMUSP00000093653; ENSMUSG00000071489.
    GeneIDi19214.
    KEGGimmu:19214.
    UCSCiuc007ter.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK032488 mRNA. Translation: BAC27895.1 .
    D29765 Genomic DNA. Translation: BAA06168.1 .
    BC132297 mRNA. Translation: AAI32298.1 .
    CCDSi CCDS26971.1.
    PIRi I59269.
    I80042.
    RefSeqi NP_032988.3. NM_008962.4.
    UniGenei Mm.5105.

    3D structure databases

    ProteinModelPortali P70263.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000093653.

    Chemistry

    BindingDBi P70263.
    ChEMBLi CHEMBL3933.
    GuidetoPHARMACOLOGYi 338.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PRIDEi P70263.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000095959 ; ENSMUSP00000093653 ; ENSMUSG00000071489 .
    GeneIDi 19214.
    KEGGi mmu:19214.
    UCSCi uc007ter.1. mouse.

    Organism-specific databases

    CTDi 5729.
    MGIi MGI:102966. Ptgdr.

    Phylogenomic databases

    eggNOGi NOG248831.
    GeneTreei ENSGT00690000101953.
    HOGENOMi HOG000115475.
    HOVERGENi HBG003074.
    InParanoidi A2RSY4.
    KOi K04332.
    OMAi AYYGAFK.
    OrthoDBi EOG72VH6G.
    PhylomeDBi P70263.
    TreeFami TF324982.

    Miscellaneous databases

    NextBioi 295968.
    PROi P70263.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70263.
    CleanExi MM_PTGDR.
    Genevestigatori P70263.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000376. Pglndn_D_rcpt.
    IPR008365. Prostanoid_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01788. PROSTANOIDR.
    PR00854. PRSTNOIDDPR.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Olfactory bulb.
    2. "Molecular characterization of a mouse prostaglandin D receptor and functional expression of the cloned gene."
      Hirata M., Kakizuka A., Aizawa M., Ushikubi F., Narumiya S.
      Proc. Natl. Acad. Sci. U.S.A. 91:11192-11196(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
      Tissue: Lung.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiPD2R_MOUSE
    AccessioniPrimary (citable) accession number: P70263
    Secondary accession number(s): A2RSY4, Q8CCM3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3