ID GP143_MOUSE Reviewed; 405 AA. AC P70259; O89031; DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 27-MAR-2024, entry version 147. DE RecName: Full=G-protein coupled receptor 143; DE AltName: Full=MOA1; DE AltName: Full=Ocular albinism type 1 protein homolog; GN Name=Gpr143; Synonyms=Oa1; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; TISSUE=Retina; RX PubMed=8889556; DOI=10.1101/gr.6.9.880; RA Bassi M.T., Incerti B., Easty D.J., Sviderskaya E.V., Ballabio A.; RT "Cloning of the murine homolog of the ocular albinism type 1 (OA1) gene: RT sequence, genomic structure, and expression analysis in pigment cells."; RL Genome Res. 6:880-885(1996). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RX PubMed=8921399; DOI=10.1006/geno.1996.0545; RA Newton J.M., Orlow S.J., Barsh G.S.; RT "Isolation and characterization of a mouse homolog of the X-linked ocular RT albinism (OA1) gene."; RL Genomics 37:219-225(1996). RN [3] RP FUNCTION. RX PubMed=18697795; DOI=10.1093/hmg/ddn241; RA Palmisano I., Bagnato P., Palmigiano A., Innamorati G., Rotondo G., RA Altimare D., Venturi C., Sviderskaya E.V., Piccirillo R., Coppola M., RA Marigo V., Incerti B., Ballabio A., Surace E.M., Tacchetti C., RA Bennett D.C., Schiaffino M.V.; RT "The ocular albinism type 1 protein, an intracellular G protein-coupled RT receptor, regulates melanosome transport in pigment cells."; RL Hum. Mol. Genet. 17:3487-3501(2008). CC -!- FUNCTION: Receptor for tyrosine, L-DOPA and dopamine. After binding to CC L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases CC secretion of the neurotrophic factor SERPINF1 and relocalizes beta CC arrestin at the plasma membrane; this ligand-dependent signaling occurs CC through a G(q)-mediated pathway in melanocytic cells. Its activity is CC mediated by G proteins which activate the phosphoinositide signaling CC pathway. Also plays a role as an intracellular G protein-coupled CC receptor involved in melanosome biogenesis, organization and transport. CC {ECO:0000269|PubMed:18697795}. CC -!- SUBUNIT: Interacts with heterotrimeric G(i) proteins. Interacts with CC ARRB1 and ARRB2. Interacts with MLANA (By similarity). {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Melanosome membrane CC {ECO:0000250|UniProtKB:P51810}; Multi-pass membrane protein CC {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P51810}; Multi- CC pass membrane protein {ECO:0000255}. Apical cell membrane CC {ECO:0000250|UniProtKB:P51810}; Multi-pass membrane protein CC {ECO:0000255}. Note=Distributed throughout the endo-melanosomal system CC but most of endogenous protein is localized in unpigmented stage II CC melanosomes. Its expression on the apical cell membrane is sensitive to CC tyrosine. {ECO:0000250|UniProtKB:P51810}. CC -!- DOMAIN: The cytoplasmic domain 3 and the C-terminus tail domain contain CC the lysosomal sorting signals and are necessary and sufficient for CC intracellular retention and delivery to lysosomal and melanosomal, CC respectively in melanocytic and non-melanocytic cells. {ECO:0000250}. CC -!- PTM: Glycosylated. {ECO:0000250}. CC -!- PTM: Phosphorylated. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor OA family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X98352; CAA66996.1; -; Genomic_DNA. DR EMBL; U63918; AAC52890.1; -; mRNA. DR CCDS; CCDS30476.1; -. DR RefSeq; NP_035081.3; NM_010951.3. DR AlphaFoldDB; P70259; -. DR SMR; P70259; -. DR STRING; 10090.ENSMUSP00000026383; -. DR GlyCosmos; P70259; 2 sites, No reported glycans. DR GlyGen; P70259; 2 sites. DR iPTMnet; P70259; -. DR PhosphoSitePlus; P70259; -. DR PaxDb; 10090-ENSMUSP00000026383; -. DR ProteomicsDB; 267747; -. DR Antibodypedia; 8143; 191 antibodies from 28 providers. DR DNASU; 18241; -. DR Ensembl; ENSMUST00000026383.4; ENSMUSP00000026383.4; ENSMUSG00000025333.11. DR GeneID; 18241; -. DR KEGG; mmu:18241; -. DR UCSC; uc009uqo.1; mouse. DR AGR; MGI:107193; -. DR CTD; 4935; -. DR MGI; MGI:107193; Gpr143. DR VEuPathDB; HostDB:ENSMUSG00000025333; -. DR eggNOG; ENOG502QQII; Eukaryota. DR GeneTree; ENSGT00390000016722; -. DR HOGENOM; CLU_053538_1_1_1; -. DR InParanoid; P70259; -. DR OMA; TFCCHNR; -. DR OrthoDB; 2957018at2759; -. DR PhylomeDB; P70259; -. DR TreeFam; TF324849; -. DR Reactome; R-MMU-375280; Amine ligand-binding receptors. DR Reactome; R-MMU-416476; G alpha (q) signalling events. DR BioGRID-ORCS; 18241; 2 hits in 79 CRISPR screens. DR PRO; PR:P70259; -. DR Proteomes; UP000000589; Chromosome X. DR RNAct; P70259; Protein. DR Bgee; ENSMUSG00000025333; Expressed in iris and 25 other cell types or tissues. DR ExpressionAtlas; P70259; baseline and differential. DR GO; GO:0016324; C:apical plasma membrane; ISS:UniProtKB. DR GO; GO:0005794; C:Golgi apparatus; ISS:UniProtKB. DR GO; GO:0005765; C:lysosomal membrane; ISS:UniProtKB. DR GO; GO:0042470; C:melanosome; ISS:UniProtKB. DR GO; GO:0033162; C:melanosome membrane; ISS:UniProtKB. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0035240; F:dopamine binding; ISS:UniProtKB. DR GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB. DR GO; GO:0072544; F:L-DOPA binding; ISS:UniProtKB. DR GO; GO:0035643; F:L-DOPA receptor activity; ISS:UniProtKB. DR GO; GO:0072545; F:tyrosine binding; ISS:UniProtKB. DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; ISS:UniProtKB. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB. DR GO; GO:0032400; P:melanosome localization; ISO:MGI. DR GO; GO:0032438; P:melanosome organization; ISS:UniProtKB. DR GO; GO:0032402; P:melanosome transport; ISO:MGI. DR GO; GO:0007200; P:phospholipase C-activating G protein-coupled receptor signaling pathway; ISO:MGI. DR GO; GO:0050848; P:regulation of calcium-mediated signaling; ISS:UniProtKB. DR GO; GO:1903056; P:regulation of melanosome organization; IMP:UniProtKB. DR GO; GO:1902908; P:regulation of melanosome transport; IMP:UniProtKB. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR001414; GPR143. DR PANTHER; PTHR15177; G-PROTEIN COUPLED RECEPTOR 143; 1. DR PANTHER; PTHR15177:SF2; G-PROTEIN COUPLED RECEPTOR 143; 1. DR Pfam; PF02101; Ocular_alb; 1. DR PRINTS; PR00965; OCULARALBNSM. DR Genevisible; P70259; MM. PE 2: Evidence at transcript level; KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lysosome; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..405 FT /note="G-protein coupled receptor 143" FT /id="PRO_0000195087" FT TOPO_DOM 1..27 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 28..48 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 49..78 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 79..99 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 100..124 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 125..145 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 146..153 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 154..174 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 175..191 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 192..212 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 213..248 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 249..269 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 270..292 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 293..313 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 314..405 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 221..238 FT /note="Necessary for its G protein-activation ability and FT normal distribution of melanosomes" FT /evidence="ECO:0000250" FT MOTIF 222..231 FT /note="lysosomal/melanosomal membrane localization signal" FT /evidence="ECO:0000250" FT MOTIF 329..330 FT /note="lysosomal/melanosomal membrane localization signal" FT /evidence="ECO:0000250" FT CARBOHYD 101 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 106 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CONFLICT 175 FT /note="M -> S (in Ref. 2; AAC52890)" FT /evidence="ECO:0000305" FT CONFLICT 213 FT /note="F -> L (in Ref. 2; AAC52890)" FT /evidence="ECO:0000305" FT CONFLICT 285 FT /note="Q -> L (in Ref. 2; AAC52890)" FT /evidence="ECO:0000305" SQ SEQUENCE 405 AA; 44564 MW; 716405A6512ED312 CRC64; MASPRLGIFC CPTWDAATQL VLSFQPRVFH ALCLGSGTLR LVLGLLQLLS GRRSVGHRAP ATSPAASVHI LRAATACDLL GCLGIVIRST VWIAYPEFIE NISNVNATDI WPATFCVGSA MWIQLLYSAC FWWLFCYAVD VYLVIRRSAG RSTILLYHIM AWGLAVLLCV EGAVMLYYPS VSRCERGLDH AIPHYVTTYL PLLLVLVANP ILFHKTVTSV ASLLKGRKGV YTENERLMGA VIKTRFFKIM LVLIACWLSN IINESLLFYL EMQPDIHGGS LKRIQNAART TWFIMGILNP AQGLLLSLAF YGWTGCSLDV HPPKMVIQWE TMTASAAEGT YQTPVRSCVP HQNPRKVVCV GGHTSDEVLS ILSEDSDAST VEIHTATGSC NIKEVDSISQ AQGEL //