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Protein

Nuclear factor 1 C-type

Gene

Nfic

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 195CTF/NF-IPROSITE-ProRule annotationAdd BLAST195

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: UniProtKB-KW
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDNA replication, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 1 C-type
Short name:
NF1-C
Short name:
Nuclear factor 1/C
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CTF
Nuclear factor I/C
Short name:
NF-I/C
Short name:
NFI-C
TGGCA-binding protein
Gene namesi
Name:Nfic
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109591 Nfic

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001002001 – 439Nuclear factor 1 C-typeAdd BLAST439

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei194PhosphoserineBy similarity1
Modified residuei284PhosphoserineBy similarity1
Modified residuei294PhosphoserineBy similarity1
Modified residuei300PhosphotyrosineCombined sources1
Modified residuei302PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei345Asymmetric dimethylarginineBy similarity1
Modified residuei365Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei365Omega-N-methylarginine; alternateBy similarity1
Modified residuei395Asymmetric dimethylarginineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP70255
PaxDbiP70255
PeptideAtlasiP70255
PRIDEiP70255

PTM databases

iPTMnetiP70255
PhosphoSitePlusiP70255

Expressioni

Tissue specificityi

Highest levels in skeletal muscle. Lower levels in heart, liver, kidney, lung and brain. Very low levels in testis and spleen.

Gene expression databases

BgeeiENSMUSG00000055053
CleanExiMM_NFIC
ExpressionAtlasiP70255 baseline and differential
GenevisibleiP70255 MM

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

BioGridi201748, 2 interactors
IntActiP70255, 1 interactor
MINTiP70255
STRINGi10090.ENSMUSP00000020461

Structurei

3D structure databases

ProteinModelPortaliP70255
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTF/NF-I family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3663 Eukaryota
ENOG410Y16G LUCA
GeneTreeiENSGT00390000009905
HOVERGENiHBG006561
InParanoidiP70255
KOiK09170
OMAiACDPANQ
OrthoDBiEOG091G0HVY
PhylomeDBiP70255
TreeFamiTF313889

Family and domain databases

InterProiView protein in InterPro
IPR000647 CTF/NFI
IPR020604 CTF/NFI_DNA-bd-dom
IPR019739 CTF/NFI_DNA-bd_CS
IPR019548 CTF/NFI_DNA-bd_N
IPR003619 MAD_homology1_Dwarfin-type
PANTHERiPTHR11492 PTHR11492, 1 hit
PfamiView protein in Pfam
PF00859 CTF_NFI, 1 hit
PF03165 MH1, 1 hit
PF10524 NfI_DNAbd_pre-N, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
PROSITEiView protein in PROSITE
PS00349 CTF_NFI_1, 1 hit
PS51080 CTF_NFI_2, 1 hit

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P70255-1) [UniParc]FASTAAdd to basket
Also known as: C1A, C2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS
60 70 80 90 100
KDEERAVKDE LLGEKAEVKQ KWASRLLAKL RKDIRPECRE DFVLAVTGKK
110 120 130 140 150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER
160 170 180 190 200
LVKAAACAHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSSSPRTGVG
210 220 230 240 250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG
260 270 280 290 300
ELQGHLAYDL NPASAGMRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY
310 320 330 340 350
TSPNSPTSSS RNWTEDIEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT
360 370 380 390 400
QHHRPVIAVH SGIARSPHPT SALHFPATPI LPQTASTYFP HTAIRYPPHL
410 420 430
NPQDPLKDLV SLACDPATQQ PGPPALRPTR PLQTVPLWD
Length:439
Mass (Da):48,768
Last modified:February 1, 1997 - v1
Checksum:iF794131A7A1B686A
GO
Isoform 2 (identifier: P70255-2) [UniParc]FASTAAdd to basket
Also known as: C1B

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M

Show »
Length:430
Mass (Da):47,775
Checksum:i348C76F604357548
GO
Isoform 3 (identifier: P70255-3) [UniParc]FASTAAdd to basket
Also known as: C5

The sequence of this isoform differs from the canonical sequence as follows:
     424-439: PALRPTRPLQTVPLWD → SWYLG

Show »
Length:428
Mass (Da):47,533
Checksum:i6B9FD2D21C7AC136
GO
Isoform 4 (identifier: P70255-4) [UniParc]FASTAAdd to basket
Also known as: C8

The sequence of this isoform differs from the canonical sequence as follows:
     320-361: Missing.

Show »
Length:397
Mass (Da):44,171
Checksum:iE66D569D32A5AD99
GO
Isoform 5 (identifier: P70255-5) [UniParc]FASTAAdd to basket
Also known as: C9

The sequence of this isoform differs from the canonical sequence as follows:
     362-423: Missing.

Show »
Length:377
Mass (Da):42,137
Checksum:iD6812CA58974C641
GO
Isoform 6 (identifier: P70255-6) [UniParc]FASTAAdd to basket
Also known as: C10

The sequence of this isoform differs from the canonical sequence as follows:
     247-374: Missing.

Show »
Length:311
Mass (Da):35,067
Checksum:i546844CFEB48DABF
GO
Isoform 7 (identifier: P70255-7) [UniParc]FASTAAdd to basket
Also known as: C11

The sequence of this isoform differs from the canonical sequence as follows:
     247-374: Missing.
     424-439: PALRPTRPLQTVPLWD → SWYLG

Show »
Length:300
Mass (Da):33,832
Checksum:i86D75E67C14D2ECF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0035571 – 10MYSSPLCLTQ → M in isoform 2. 1 Publication10
Alternative sequenceiVSP_007556247 – 374Missing in isoform 6 and isoform 7. CuratedAdd BLAST128
Alternative sequenceiVSP_007557320 – 361Missing in isoform 4. CuratedAdd BLAST42
Alternative sequenceiVSP_007558362 – 423Missing in isoform 5. CuratedAdd BLAST62
Alternative sequenceiVSP_007559424 – 439PALRP…VPLWD → SWYLG in isoform 3 and isoform 7. CuratedAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07692 mRNA Translation: CAA68956.1
Y07693 mRNA Translation: CAA68957.1
U57635 mRNA Translation: AAB49930.1
AK087539 mRNA Translation: BAC39918.1
AK155258 mRNA Translation: BAE33151.1
AF358455 mRNA Translation: AAK21331.1
AF358456 mRNA Translation: AAK21332.1
AF358457 mRNA Translation: AAK21333.1
AF358458 mRNA Translation: AAK21334.1
AF358459 mRNA Translation: AAK21335.1
AF358460 mRNA Translation: AAK21336.1
AF111265 Genomic DNA Translation: AAD39100.1
CCDSiCCDS24058.1 [P70255-1]
CCDS35999.1 [P70255-3]
RefSeqiNP_032714.1, NM_008688.3 [P70255-1]
XP_006513398.1, XM_006513335.3 [P70255-2]
UniGeneiMm.426936
Mm.453078

Genome annotation databases

EnsembliENSMUST00000020461; ENSMUSP00000020461; ENSMUSG00000055053 [P70255-1]
ENSMUST00000078185; ENSMUSP00000077317; ENSMUSG00000055053 [P70255-4]
ENSMUST00000105321; ENSMUSP00000100958; ENSMUSG00000055053 [P70255-3]
ENSMUST00000117966; ENSMUSP00000113046; ENSMUSG00000055053 [P70255-2]
GeneIDi18029
KEGGimmu:18029
UCSCiuc007ghx.1 mouse [P70255-4]
uc007ghy.1 mouse [P70255-1]
uc007gia.1 mouse [P70255-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiNFIC_MOUSE
AccessioniPrimary (citable) accession number: P70255
Secondary accession number(s): O09072
, P70256, Q3U2I9, Q99MA3, Q99MA4, Q99MA5, Q99MA6, Q99MA7, Q99MA8, Q9R1G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health