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Protein

Unconventional myosin-If

Gene

Myo1f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi110 – 1178ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

  • defense response to Gram-positive bacterium Source: MGI
  • negative regulation of cell adhesion Source: MGI
  • neutrophil degranulation Source: MGI
  • neutrophil mediated immunity Source: MGI
  • positive regulation of cell migration Source: MGI
  • regulation of actin cytoskeleton organization Source: MGI
  • regulation of innate immune response Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-If
Gene namesi
Name:Myo1f
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:107711. Myo1f.

Subcellular locationi

GO - Cellular componenti

  • cortical actin cytoskeleton Source: MGI
  • filamentous actin Source: MGI
  • myosin complex Source: UniProtKB-KW
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10991099Unconventional myosin-IfPRO_0000123453Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1025 – 10251PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP70248.
MaxQBiP70248.
PeptideAtlasiP70248.
PRIDEiP70248.

PTM databases

iPTMnetiP70248.
PhosphoSiteiP70248.

Expressioni

Tissue specificityi

Expressed in liver, kidney, spleen, eye, brain, lung, small intestine, testis and cochlea. Barely detectable in heart.1 Publication

Gene expression databases

CleanExiMM_MYO1F.

Interactioni

Protein-protein interaction databases

IntActiP70248. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP70248.
SMRiP70248. Positions 1045-1099.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 690674Myosin motorAdd
BLAST
Domaini693 – 72230IQPROSITE-ProRule annotationAdd
BLAST
Domaini728 – 917190TH1PROSITE-ProRule annotationAdd
BLAST
Domaini1042 – 109958SH3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni579 – 58911Actin-bindingSequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 SH3 domain.PROSITE-ProRule annotation
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

HOGENOMiHOG000260265.
HOVERGENiHBG100702.
InParanoidiP70248.
PhylomeDBiP70248.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
PR00452. SH3DOMAIN.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70248-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSKERFHWQ SHNVKQSGVD DMVLLSQITE DAIVRNLHKR FMDDYIFTYI
60 70 80 90 100
GSVLISVNPF KQMPYFTDRE IDLYQGAVQY EEPPHIYALT DNMYRNMLID
110 120 130 140 150
CENQCVIISG ESGAGKTVAA KYIMGYISKV SGGGDKVQHV KDIILQSNPL
160 170 180 190 200
LEAFGNAKTV RNNNSSRFGK YFEIQFSRGG EPDGGKISNF LLEKSRVVMQ
210 220 230 240 250
NENERNFHIY YQLLEGASQE QQQNLGIMSQ DYYYYLNQSD TYKVEGTDDR
260 270 280 290 300
SDFSETLSAM QVMGFRQACQ QLVLQLVAGI LHLGNISFCE EGNYARVESV
310 320 330 340 350
DSLAFPAYLL GIDSGRLQEK LTSRKMDSKW GGRSESIDVT LNVEQAAYTR
360 370 380 390 400
DALAKGLYAR LFDFLVEAIN RAMQKPQEEY SIGVLDIYGF EIFQKNGFEQ
410 420 430 440 450
FCINFVNEKL QQIFIELTLK AEQEEYVQEG IRWTPIEYFN NKIVCDLIEN
460 470 480 490 500
KLSPPGIMSV LDDVCATMHA TGGGADQTLL QKLQAAVGTH EHFNSWSAGF
510 520 530 540 550
VIHHYAGKVS YDVSGFCERN RDVLFSDLIE LMQSSDQDFL RMLFPEKLNI
560 570 580 590 600
DKKGRPSTAG SKIKKQANDL VSTLKKCTPH YIRCIKPNET KRPRDWEESR
610 620 630 640 650
VKHQVEYLGL RENIRVRRAG FAYRRQFSKF LQRYAILTPE TWPRWRGDER
660 670 680 690 700
QGVQHLLRAV NMEPDQYQMG STKVFVKNPE SLFLLEEMRE RKFDGFARTI
710 720 730 740 750
QKAWRRHVAV RKYEEMREEA SNILLNKKER RRNSINRNFV GNYLGLEERP
760 770 780 790 800
ELRQFLAKRE RVDFADSVTK YDRRFKPIKR DLILTPKCVY VIGTEKVKRG
810 820 830 840 850
PEKGLVREVL KKKLDIQALR GVSLSTRQDD FFILQEEAAD TFLESIFKTE
860 870 880 890 900
FVSLLCKRFE EAARRPLPLT FQDILQFRVK KKGWGGGGTR NVTFSAGQVN
910 920 930 940 950
LAVLKAGGKT LTISLGDGLP KNSKPTRKGL AQGKPRRSAQ APTRAVPWAS
960 970 980 990 1000
QGLNRNGATL FPRGEGPYTL EIYIWPQEFP EASTAIHLQP QDASRRPRAR
1010 1020 1030 1040 1050
PPSEHSTEFL NVPDQGVAGM QRKRSIGQRP VPASRPKPQP RTHGPRCRAL
1060 1070 1080 1090
YQYIGQDVDE LSFNVNEVIE ILIEDSSGWW KGRLHGQEGL FPGNYVEKI
Length:1,099
Mass (Da):125,947
Last modified:February 1, 1997 - v1
Checksum:i7D11592310C0C8F0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97650 mRNA. Translation: CAA66251.1.
PIRiA59300.
UniGeneiMm.42019.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97650 mRNA. Translation: CAA66251.1.
PIRiA59300.
UniGeneiMm.42019.

3D structure databases

ProteinModelPortaliP70248.
SMRiP70248. Positions 1045-1099.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70248. 1 interaction.

PTM databases

iPTMnetiP70248.
PhosphoSiteiP70248.

Proteomic databases

EPDiP70248.
MaxQBiP70248.
PeptideAtlasiP70248.
PRIDEiP70248.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:107711. Myo1f.

Phylogenomic databases

HOGENOMiHOG000260265.
HOVERGENiHBG100702.
InParanoidiP70248.
PhylomeDBiP70248.

Miscellaneous databases

PROiP70248.
SOURCEiSearch...

Gene expression databases

CleanExiMM_MYO1F.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
PF14604. SH3_9. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
PR00452. SH3DOMAIN.
SMARTiSM00242. MYSc. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
PS51456. MYOSIN_MOTOR. 1 hit.
PS50002. SH3. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1F_MOUSE
AccessioniPrimary (citable) accession number: P70248
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: February 1, 1997
Last modified: July 6, 2016
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.