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P70217

- HXD13_MOUSE

UniProt

P70217 - HXD13_MOUSE

Protein

Homeobox protein Hox-D13

Gene

Hoxd13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 118 (01 Oct 2014)
      Sequence version 2 (05 Sep 2006)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi272 – 33160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding Source: MGI
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. branch elongation of an epithelium Source: MGI
    3. embryonic digit morphogenesis Source: MGI
    4. embryonic hindgut morphogenesis Source: Ensembl
    5. embryonic limb morphogenesis Source: MGI
    6. gland morphogenesis Source: MGI
    7. limb morphogenesis Source: MGI
    8. male genitalia development Source: MGI
    9. morphogenesis of an epithelial fold Source: MGI
    10. pattern specification process Source: MGI
    11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    12. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
    13. regulation of branching involved in prostate gland morphogenesis Source: MGI
    14. regulation of cell proliferation Source: MGI
    15. skeletal system development Source: MGI
    16. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-D13
    Alternative name(s):
    Homeobox protein Hox-4.8
    Gene namesi
    Name:Hoxd13
    Synonyms:Hox-4.8
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 2

    Organism-specific databases

    MGIiMGI:96205. Hoxd13.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Homeobox protein Hox-D13PRO_0000200245Add
    BLAST

    Proteomic databases

    PRIDEiP70217.

    PTM databases

    PhosphoSiteiP70217.

    Expressioni

    Gene expression databases

    BgeeiP70217.
    CleanExiMM_HOXD13.
    GenevestigatoriP70217.

    Interactioni

    Protein-protein interaction databases

    BioGridi200395. 7 interactions.
    IntActiP70217. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP70217.
    SMRiP70217. Positions 272-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi25 – 295Poly-Ser
    Compositional biasi53 – 6715Poly-AlaAdd
    BLAST
    Compositional biasi81 – 888Poly-Ser
    Compositional biasi105 – 11410Poly-Ala

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG251666.
    GeneTreeiENSGT00730000110374.
    HOGENOMiHOG000231176.
    HOVERGENiHBG106958.
    InParanoidiP70217.
    KOiK09298.
    OMAiAKECPAP.
    OrthoDBiEOG7SJD53.
    PhylomeDBiP70217.
    TreeFamiTF330813.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70217-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRSGTWDMD GLRADGGAAG AAPASSSSSV AAPGQCRGFL SAPVFAGTHS    50
    GRAAAAAAAA AAAAAAASSF AYPGTSERTG SSSSSSSSAV IATRPEAPVA 100
    KECPAPAAAA TAAAPPGAPA LGYGYHFGNG YYSCRMSHGV GLQQNALKSS 150
    PHASLGGFPV EKYMDVSGLA SSSVPTNEVP ARAKEVSFYQ GYTSPYQHVP 200
    GYIDMVSTFG SGEPRHEAYI SMEGYQSWTL ANGWNSQVYC AKDQPQGSHF 250
    WKSSFPGDVA LNQPDMCVYR RGRKKRVPYT KLQLKELENE YAINKFINKD 300
    KRRRISAATN LSERQVTIWF QNRRVKDKKI VSKLKDTVS 339
    Length:339
    Mass (Da):35,889
    Last modified:September 5, 2006 - v2
    Checksum:iC1BD2FAF6D56E533
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91M → I in BC109143. (PubMed:15489334)Curated
    Sequence conflicti69 – 691S → T in CAA67675. (PubMed:8978698)Curated
    Sequence conflicti304 – 3041R → T in AAB21366. (PubMed:1685889)Curated
    Sequence conflicti307 – 3071A → R in AAB21366. (PubMed:1685889)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99291 mRNA. Translation: CAA67675.1.
    AL928644 Genomic DNA. Translation: CAM20525.1.
    BC109143 mRNA. No translation available.
    BC109144 mRNA. No translation available.
    S80553 Genomic DNA. Translation: AAB21366.2.
    CCDSiCCDS16139.1.
    PIRiA56563.
    RefSeqiNP_032301.2. NM_008275.3.
    UniGeneiMm.57227.

    Genome annotation databases

    EnsembliENSMUST00000001872; ENSMUSP00000001872; ENSMUSG00000001819.
    GeneIDi15433.
    KEGGimmu:15433.
    UCSCiuc008kdu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X99291 mRNA. Translation: CAA67675.1 .
    AL928644 Genomic DNA. Translation: CAM20525.1 .
    BC109143 mRNA. No translation available.
    BC109144 mRNA. No translation available.
    S80553 Genomic DNA. Translation: AAB21366.2 .
    CCDSi CCDS16139.1.
    PIRi A56563.
    RefSeqi NP_032301.2. NM_008275.3.
    UniGenei Mm.57227.

    3D structure databases

    ProteinModelPortali P70217.
    SMRi P70217. Positions 272-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200395. 7 interactions.
    IntActi P70217. 1 interaction.

    PTM databases

    PhosphoSitei P70217.

    Proteomic databases

    PRIDEi P70217.

    Protocols and materials databases

    DNASUi 15433.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001872 ; ENSMUSP00000001872 ; ENSMUSG00000001819 .
    GeneIDi 15433.
    KEGGi mmu:15433.
    UCSCi uc008kdu.1. mouse.

    Organism-specific databases

    CTDi 3239.
    MGIi MGI:96205. Hoxd13.

    Phylogenomic databases

    eggNOGi NOG251666.
    GeneTreei ENSGT00730000110374.
    HOGENOMi HOG000231176.
    HOVERGENi HBG106958.
    InParanoidi P70217.
    KOi K09298.
    OMAi AKECPAP.
    OrthoDBi EOG7SJD53.
    PhylomeDBi P70217.
    TreeFami TF330813.

    Miscellaneous databases

    NextBioi 288202.
    PROi P70217.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70217.
    CleanExi MM_HOXD13.
    Genevestigatori P70217.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Function of the Evx-2 gene in the morphogenesis of vertebrate limbs."
      Herault Y., Hraba-Reveney S., van der Hoeven F., Duboule D.
      EMBO J. 15:6727-6738(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-339.
    4. "The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development."
      Dolle P., Izpisua-Belmonte J.-C., Boncinelli E., Duboule D.
      Mech. Dev. 36:3-13(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 258-339.

    Entry informationi

    Entry nameiHXD13_MOUSE
    AccessioniPrimary (citable) accession number: P70217
    Secondary accession number(s): A2ASM5
    , Q2VPB0, Q2VPB1, Q64177
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: September 5, 2006
    Last modified: October 1, 2014
    This is version 118 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Caution

    It is uncertain whether Met-1 or Met-9 is the initiator.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3