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Protein

Homeobox protein Hox-D13

Gene

Hoxd13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi272 – 33160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • chromatin binding Source: MGI
  • DNA binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: NTNU_SB
  • sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  • anterior/posterior pattern specification Source: MGI
  • branch elongation of an epithelium Source: MGI
  • embryonic digit morphogenesis Source: MGI
  • embryonic hindgut morphogenesis Source: Ensembl
  • embryonic limb morphogenesis Source: MGI
  • gland morphogenesis Source: MGI
  • limb morphogenesis Source: MGI
  • male genitalia development Source: MGI
  • morphogenesis of an epithelial fold Source: MGI
  • pattern specification process Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  • regulation of branching involved in prostate gland morphogenesis Source: MGI
  • regulation of cell proliferation Source: MGI
  • skeletal system development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D13
Alternative name(s):
Homeobox protein Hox-4.8
Gene namesi
Name:Hoxd13
Synonyms:Hox-4.8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:96205. Hoxd13.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Homeobox protein Hox-D13PRO_0000200245Add
BLAST

Proteomic databases

MaxQBiP70217.
PRIDEiP70217.

PTM databases

PhosphoSiteiP70217.

Expressioni

Gene expression databases

BgeeiP70217.
CleanExiMM_HOXD13.
GenevisibleiP70217. MM.

Interactioni

Protein-protein interaction databases

BioGridi200395. 7 interactions.
IntActiP70217. 1 interaction.
STRINGi10090.ENSMUSP00000001872.

Structurei

3D structure databases

ProteinModelPortaliP70217.
SMRiP70217. Positions 272-337.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 295Poly-Ser
Compositional biasi53 – 6715Poly-AlaAdd
BLAST
Compositional biasi81 – 888Poly-Ser
Compositional biasi105 – 11410Poly-Ala

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG251666.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP70217.
KOiK09298.
OMAiAKECPAP.
OrthoDBiEOG7SJD53.
PhylomeDBiP70217.
TreeFamiTF330813.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70217-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRSGTWDMD GLRADGGAAG AAPASSSSSV AAPGQCRGFL SAPVFAGTHS
60 70 80 90 100
GRAAAAAAAA AAAAAAASSF AYPGTSERTG SSSSSSSSAV IATRPEAPVA
110 120 130 140 150
KECPAPAAAA TAAAPPGAPA LGYGYHFGNG YYSCRMSHGV GLQQNALKSS
160 170 180 190 200
PHASLGGFPV EKYMDVSGLA SSSVPTNEVP ARAKEVSFYQ GYTSPYQHVP
210 220 230 240 250
GYIDMVSTFG SGEPRHEAYI SMEGYQSWTL ANGWNSQVYC AKDQPQGSHF
260 270 280 290 300
WKSSFPGDVA LNQPDMCVYR RGRKKRVPYT KLQLKELENE YAINKFINKD
310 320 330
KRRRISAATN LSERQVTIWF QNRRVKDKKI VSKLKDTVS
Length:339
Mass (Da):35,889
Last modified:September 5, 2006 - v2
Checksum:iC1BD2FAF6D56E533
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91M → I in BC109143 (PubMed:15489334).Curated
Sequence conflicti69 – 691S → T in CAA67675 (PubMed:8978698).Curated
Sequence conflicti304 – 3041R → T in AAB21366 (PubMed:1685889).Curated
Sequence conflicti307 – 3071A → R in AAB21366 (PubMed:1685889).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99291 mRNA. Translation: CAA67675.1.
AL928644 Genomic DNA. Translation: CAM20525.1.
BC109143 mRNA. No translation available.
BC109144 mRNA. No translation available.
S80553 Genomic DNA. Translation: AAB21366.2.
CCDSiCCDS16139.1.
PIRiA56563.
RefSeqiNP_032301.2. NM_008275.3.
UniGeneiMm.57227.

Genome annotation databases

EnsembliENSMUST00000001872; ENSMUSP00000001872; ENSMUSG00000001819.
GeneIDi15433.
KEGGimmu:15433.
UCSCiuc008kdu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X99291 mRNA. Translation: CAA67675.1.
AL928644 Genomic DNA. Translation: CAM20525.1.
BC109143 mRNA. No translation available.
BC109144 mRNA. No translation available.
S80553 Genomic DNA. Translation: AAB21366.2.
CCDSiCCDS16139.1.
PIRiA56563.
RefSeqiNP_032301.2. NM_008275.3.
UniGeneiMm.57227.

3D structure databases

ProteinModelPortaliP70217.
SMRiP70217. Positions 272-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200395. 7 interactions.
IntActiP70217. 1 interaction.
STRINGi10090.ENSMUSP00000001872.

PTM databases

PhosphoSiteiP70217.

Proteomic databases

MaxQBiP70217.
PRIDEiP70217.

Protocols and materials databases

DNASUi15433.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001872; ENSMUSP00000001872; ENSMUSG00000001819.
GeneIDi15433.
KEGGimmu:15433.
UCSCiuc008kdu.1. mouse.

Organism-specific databases

CTDi3239.
MGIiMGI:96205. Hoxd13.

Phylogenomic databases

eggNOGiNOG251666.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP70217.
KOiK09298.
OMAiAKECPAP.
OrthoDBiEOG7SJD53.
PhylomeDBiP70217.
TreeFamiTF330813.

Miscellaneous databases

NextBioi288202.
PROiP70217.
SOURCEiSearch...

Gene expression databases

BgeeiP70217.
CleanExiMM_HOXD13.
GenevisibleiP70217. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Function of the Evx-2 gene in the morphogenesis of vertebrate limbs."
    Herault Y., Hraba-Reveney S., van der Hoeven F., Duboule D.
    EMBO J. 15:6727-6738(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-339.
  4. "The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development."
    Dolle P., Izpisua-Belmonte J.-C., Boncinelli E., Duboule D.
    Mech. Dev. 36:3-13(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 258-339.

Entry informationi

Entry nameiHXD13_MOUSE
AccessioniPrimary (citable) accession number: P70217
Secondary accession number(s): A2ASM5
, Q2VPB0, Q2VPB1, Q64177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 5, 2006
Last modified: June 24, 2015
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.