P70217 (HXD13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-D13

Alternative name(s):
Homeobox protein Hox-4.8

Gene names

Name:	Hoxd13
Synonyms:	Hox-4.8

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	339 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.
Caution	It is uncertain whether Met-1 or Met-9 is the initiator.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from mutant phenotype PubMed 8106170. Source: MGI branch elongation of an epithelium Inferred from mutant phenotype PubMed 9097018. Source: MGI embryonic digit morphogenesis Inferred from genetic interaction PubMed 17714700PubMed 8900279PubMed 9342042. Source: MGI embryonic hindgut morphogenesis Inferred from electronic annotation. Source: Compara male genitalia development Inferred from mutant phenotype PubMed 8106170. Source: MGI morphogenesis of an epithelial fold Inferred from mutant phenotype PubMed 9097018. Source: MGI positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 16314414PubMed 16672333PubMed 19168674. Source: MGI prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Inferred from genetic interaction PubMed 12668621. Source: MGI regulation of branching involved in prostate gland morphogenesis Inferred from mutant phenotype PubMed 9097018. Source: MGI regulation of cell proliferation Inferred from mutant phenotype PubMed 11850178. Source: MGI skeletal system development Inferred from mutant phenotype PubMed 8106170PubMed 8620844. Source: MGI transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from direct assay PubMed 15617687. Source: MGI
Molecular_function	DNA binding Inferred from direct assay PubMed 19168674. Source: MGI chromatin binding Inferred from direct assay PubMed 16672333. Source: MGI sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 16314414. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 339	339	Homeobox protein Hox-D13		PRO_0000200245
Regions
	DNA binding	272 – 331	60	Homeobox
	Compositional bias	25 – 29	5	Poly-Ser
	Compositional bias	53 – 67	15	Poly-Ala
	Compositional bias	81 – 88	8	Poly-Ser
	Compositional bias	105 – 114	10	Poly-Ala
Experimental info
	Sequence conflict	9	1	M → I in BC109143. Ref.3
	Sequence conflict	69	1	S → T in CAA67675. Ref.1
	Sequence conflict	304	1	R → T in AAB21366. Ref.4
	Sequence conflict	307	1	A → R in AAB21366. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	P70217 [UniParc]. Last modified September 5, 2006. Version 2. Checksum: C1BD2FAF6D56E533	FASTA	339	35,889
	10 20 30 40 50 60 MSRSGTWDMD GLRADGGAAG AAPASSSSSV AAPGQCRGFL SAPVFAGTHS GRAAAAAAAA 70 80 90 100 110 120 AAAAAAASSF AYPGTSERTG SSSSSSSSAV IATRPEAPVA KECPAPAAAA TAAAPPGAPA 130 140 150 160 170 180 LGYGYHFGNG YYSCRMSHGV GLQQNALKSS PHASLGGFPV EKYMDVSGLA SSSVPTNEVP 190 200 210 220 230 240 ARAKEVSFYQ GYTSPYQHVP GYIDMVSTFG SGEPRHEAYI SMEGYQSWTL ANGWNSQVYC 250 260 270 280 290 300 AKDQPQGSHF WKSSFPGDVA LNQPDMCVYR RGRKKRVPYT KLQLKELENE YAINKFINKD 310 320 330 KRRRISAATN LSERQVTIWF QNRRVKDKKI VSKLKDTVS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Function of the Evx-2 gene in the morphogenesis of vertebrate limbs." Herault Y., Hraba-Reveney S., van der Hoeven F., Duboule D. EMBO J. 15:6727-6738(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-339.
[4]	"The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development." Dolle P., Izpisua-Belmonte J.-C., Boncinelli E., Duboule D. Mech. Dev. 36:3-13(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 258-339.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X99291 mRNA. Translation: CAA67675.1. AL928644 Genomic DNA. Translation: CAM20525.1. BC109143 mRNA. No translation available. BC109144 mRNA. No translation available. S80553 Genomic DNA. Translation: AAB21366.2.
IPI	IPI00137359.
PIR	A56563.
RefSeq	NP_032301.2. NM_008275.3.
UniGene	Mm.57227.
3D structure databases
ProteinModelPortal	P70217.
SMR	P70217. Positions 272-337.
ModBase	Search...
Protein-protein interaction databases
IntAct	P70217. 1 interaction.
PTM databases
PhosphoSite	P70217.
Proteomic databases
PRIDE	P70217.
Protocols and materials databases
DNASU	15433.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000001872; ENSMUSP00000001872; ENSMUSG00000001819.
GeneID	15433.
KEGG	mmu:15433.
UCSC	uc008kdu.1. mouse.
Organism-specific databases
CTD	3239.
MGI	MGI:96205. Hoxd13.
Phylogenomic databases
eggNOG	NOG251666.
GeneTree	ENSGT00670000097683.
HOGENOM	HOG000231176.
HOVERGEN	HBG106958.
InParanoid	P70217.
KO	K09298.
OMA	GFAYPGT.
OrthoDB	EOG4X3H26.
Gene expression databases
Bgee	P70217.
CleanEx	MM_HOXD13.
Genevestigator	P70217.
GermOnline	ENSMUSG00000001819. Mus musculus.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR001356. Homeodomain. IPR009057. Homeodomain-like. IPR022067. HoxA13_N. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. PF12284. HoxA13_N. 1 hit. [Graphical view]
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288202.
SOURCE	Search...

Entry information

Entry name

HXD13_MOUSE

Accession

Primary (citable) accession number: P70217
Secondary accession number(s): A2ASM5 , Q2VPB0, Q2VPB1, Q64177

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	September 5, 2006
Last modified:	April 3, 2013
This is version 109 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program