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P70217

- HXD13_MOUSE

UniProt

P70217 - HXD13_MOUSE

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Protein

Homeobox protein Hox-D13

Gene
Hoxd13, Hox-4.8
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi272 – 33160HomeoboxAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding Source: MGI
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. branch elongation of an epithelium Source: MGI
  3. embryonic digit morphogenesis Source: MGI
  4. embryonic hindgut morphogenesis Source: Ensembl
  5. embryonic limb morphogenesis Source: MGI
  6. gland morphogenesis Source: MGI
  7. limb morphogenesis Source: MGI
  8. male genitalia development Source: MGI
  9. morphogenesis of an epithelial fold Source: MGI
  10. pattern specification process Source: MGI
  11. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  12. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: MGI
  13. regulation of branching involved in prostate gland morphogenesis Source: MGI
  14. regulation of cell proliferation Source: MGI
  15. skeletal system development Source: MGI
  16. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-D13
Alternative name(s):
Homeobox protein Hox-4.8
Gene namesi
Name:Hoxd13
Synonyms:Hox-4.8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 2

Organism-specific databases

MGIiMGI:96205. Hoxd13.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Homeobox protein Hox-D13PRO_0000200245Add
BLAST

Proteomic databases

PRIDEiP70217.

PTM databases

PhosphoSiteiP70217.

Expressioni

Gene expression databases

BgeeiP70217.
CleanExiMM_HOXD13.
GenevestigatoriP70217.

Interactioni

Protein-protein interaction databases

BioGridi200395. 7 interactions.
IntActiP70217. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP70217.
SMRiP70217. Positions 272-337.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi25 – 295Poly-Ser
Compositional biasi53 – 6715Poly-AlaAdd
BLAST
Compositional biasi81 – 888Poly-Ser
Compositional biasi105 – 11410Poly-Ala

Sequence similaritiesi

Belongs to the Abd-B homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG251666.
GeneTreeiENSGT00730000110374.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiP70217.
KOiK09298.
OMAiAKECPAP.
OrthoDBiEOG7SJD53.
PhylomeDBiP70217.
TreeFamiTF330813.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70217-1 [UniParc]FASTAAdd to Basket

« Hide

MSRSGTWDMD GLRADGGAAG AAPASSSSSV AAPGQCRGFL SAPVFAGTHS    50
GRAAAAAAAA AAAAAAASSF AYPGTSERTG SSSSSSSSAV IATRPEAPVA 100
KECPAPAAAA TAAAPPGAPA LGYGYHFGNG YYSCRMSHGV GLQQNALKSS 150
PHASLGGFPV EKYMDVSGLA SSSVPTNEVP ARAKEVSFYQ GYTSPYQHVP 200
GYIDMVSTFG SGEPRHEAYI SMEGYQSWTL ANGWNSQVYC AKDQPQGSHF 250
WKSSFPGDVA LNQPDMCVYR RGRKKRVPYT KLQLKELENE YAINKFINKD 300
KRRRISAATN LSERQVTIWF QNRRVKDKKI VSKLKDTVS 339
Length:339
Mass (Da):35,889
Last modified:September 5, 2006 - v2
Checksum:iC1BD2FAF6D56E533
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91M → I in BC109143. 1 Publication
Sequence conflicti69 – 691S → T in CAA67675. 1 Publication
Sequence conflicti304 – 3041R → T in AAB21366. 1 Publication
Sequence conflicti307 – 3071A → R in AAB21366. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99291 mRNA. Translation: CAA67675.1.
AL928644 Genomic DNA. Translation: CAM20525.1.
BC109143 mRNA. No translation available.
BC109144 mRNA. No translation available.
S80553 Genomic DNA. Translation: AAB21366.2.
CCDSiCCDS16139.1.
PIRiA56563.
RefSeqiNP_032301.2. NM_008275.3.
UniGeneiMm.57227.

Genome annotation databases

EnsembliENSMUST00000001872; ENSMUSP00000001872; ENSMUSG00000001819.
GeneIDi15433.
KEGGimmu:15433.
UCSCiuc008kdu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X99291 mRNA. Translation: CAA67675.1 .
AL928644 Genomic DNA. Translation: CAM20525.1 .
BC109143 mRNA. No translation available.
BC109144 mRNA. No translation available.
S80553 Genomic DNA. Translation: AAB21366.2 .
CCDSi CCDS16139.1.
PIRi A56563.
RefSeqi NP_032301.2. NM_008275.3.
UniGenei Mm.57227.

3D structure databases

ProteinModelPortali P70217.
SMRi P70217. Positions 272-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200395. 7 interactions.
IntActi P70217. 1 interaction.

PTM databases

PhosphoSitei P70217.

Proteomic databases

PRIDEi P70217.

Protocols and materials databases

DNASUi 15433.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001872 ; ENSMUSP00000001872 ; ENSMUSG00000001819 .
GeneIDi 15433.
KEGGi mmu:15433.
UCSCi uc008kdu.1. mouse.

Organism-specific databases

CTDi 3239.
MGIi MGI:96205. Hoxd13.

Phylogenomic databases

eggNOGi NOG251666.
GeneTreei ENSGT00730000110374.
HOGENOMi HOG000231176.
HOVERGENi HBG106958.
InParanoidi P70217.
KOi K09298.
OMAi AKECPAP.
OrthoDBi EOG7SJD53.
PhylomeDBi P70217.
TreeFami TF330813.

Miscellaneous databases

NextBioi 288202.
PROi P70217.
SOURCEi Search...

Gene expression databases

Bgeei P70217.
CleanExi MM_HOXD13.
Genevestigatori P70217.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Function of the Evx-2 gene in the morphogenesis of vertebrate limbs."
    Herault Y., Hraba-Reveney S., van der Hoeven F., Duboule D.
    EMBO J. 15:6727-6738(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-339.
  4. "The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development."
    Dolle P., Izpisua-Belmonte J.-C., Boncinelli E., Duboule D.
    Mech. Dev. 36:3-13(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 258-339.

Entry informationi

Entry nameiHXD13_MOUSE
AccessioniPrimary (citable) accession number: P70217
Secondary accession number(s): A2ASM5
, Q2VPB0, Q2VPB1, Q64177
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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