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P70217 (HXD13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-D13
Alternative name(s):
Homeobox protein Hox-4.8
Gene names
Name:Hoxd13
Synonyms:Hox-4.8
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length339 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Caution

It is uncertain whether Met-1 or Met-9 is the initiator.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from mutant phenotype PubMed 8106170. Source: MGI

branch elongation of an epithelium

Inferred from mutant phenotype PubMed 9097018. Source: MGI

embryonic digit morphogenesis

Inferred from genetic interaction PubMed 17714700PubMed 8900279PubMed 9342042. Source: MGI

embryonic hindgut morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic limb morphogenesis

Inferred from mutant phenotype PubMed 11850178. Source: MGI

gland morphogenesis

Inferred from mutant phenotype PubMed 9097018. Source: MGI

limb morphogenesis

Inferred from mutant phenotype PubMed 11543619. Source: MGI

male genitalia development

Inferred from mutant phenotype PubMed 8106170. Source: MGI

morphogenesis of an epithelial fold

Inferred from mutant phenotype PubMed 9097018. Source: MGI

pattern specification process

Inferred from mutant phenotype PubMed 11850178PubMed 8106170. Source: MGI

positive regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 16314414PubMed 16672333PubMed 19168674. Source: MGI

prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis

Inferred from genetic interaction PubMed 12668621. Source: MGI

regulation of branching involved in prostate gland morphogenesis

Inferred from mutant phenotype PubMed 9097018. Source: MGI

regulation of cell proliferation

Inferred from mutant phenotype PubMed 11850178. Source: MGI

skeletal system development

Inferred from mutant phenotype PubMed 8106170PubMed 8620844. Source: MGI

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay PubMed 15617687. Source: MGI

   Molecular_functionDNA binding

Inferred from direct assay PubMed 19168674. Source: MGI

chromatin binding

Inferred from direct assay PubMed 16672333. Source: MGI

sequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from direct assay PubMed 16314414. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 339339Homeobox protein Hox-D13
PRO_0000200245

Regions

DNA binding272 – 33160Homeobox
Compositional bias25 – 295Poly-Ser
Compositional bias53 – 6715Poly-Ala
Compositional bias81 – 888Poly-Ser
Compositional bias105 – 11410Poly-Ala

Experimental info

Sequence conflict91M → I in BC109143. Ref.3
Sequence conflict691S → T in CAA67675. Ref.1
Sequence conflict3041R → T in AAB21366. Ref.4
Sequence conflict3071A → R in AAB21366. Ref.4

Sequences

Sequence LengthMass (Da)Tools
P70217 [UniParc].

Last modified September 5, 2006. Version 2.
Checksum: C1BD2FAF6D56E533

FASTA33935,889
        10         20         30         40         50         60 
MSRSGTWDMD GLRADGGAAG AAPASSSSSV AAPGQCRGFL SAPVFAGTHS GRAAAAAAAA 

        70         80         90        100        110        120 
AAAAAAASSF AYPGTSERTG SSSSSSSSAV IATRPEAPVA KECPAPAAAA TAAAPPGAPA 

       130        140        150        160        170        180 
LGYGYHFGNG YYSCRMSHGV GLQQNALKSS PHASLGGFPV EKYMDVSGLA SSSVPTNEVP 

       190        200        210        220        230        240 
ARAKEVSFYQ GYTSPYQHVP GYIDMVSTFG SGEPRHEAYI SMEGYQSWTL ANGWNSQVYC 

       250        260        270        280        290        300 
AKDQPQGSHF WKSSFPGDVA LNQPDMCVYR RGRKKRVPYT KLQLKELENE YAINKFINKD 

       310        320        330 
KRRRISAATN LSERQVTIWF QNRRVKDKKI VSKLKDTVS 

« Hide

References

« Hide 'large scale' references
[1]"Function of the Evx-2 gene in the morphogenesis of vertebrate limbs."
Herault Y., Hraba-Reveney S., van der Hoeven F., Duboule D.
EMBO J. 15:6727-6738(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-339.
[4]"The Hox-4.8 gene is localized at the 5' extremity of the Hox-4 complex and is expressed in the most posterior parts of the body during development."
Dolle P., Izpisua-Belmonte J.-C., Boncinelli E., Duboule D.
Mech. Dev. 36:3-13(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 258-339.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X99291 mRNA. Translation: CAA67675.1.
AL928644 Genomic DNA. Translation: CAM20525.1.
BC109143 mRNA. No translation available.
BC109144 mRNA. No translation available.
S80553 Genomic DNA. Translation: AAB21366.2.
CCDSCCDS16139.1.
PIRA56563.
RefSeqNP_032301.2. NM_008275.3.
UniGeneMm.57227.

3D structure databases

ProteinModelPortalP70217.
SMRP70217. Positions 272-337.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200395. 7 interactions.
IntActP70217. 1 interaction.

PTM databases

PhosphoSiteP70217.

Proteomic databases

PRIDEP70217.

Protocols and materials databases

DNASU15433.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001872; ENSMUSP00000001872; ENSMUSG00000001819.
GeneID15433.
KEGGmmu:15433.
UCSCuc008kdu.1. mouse.

Organism-specific databases

CTD3239.
MGIMGI:96205. Hoxd13.

Phylogenomic databases

eggNOGNOG251666.
GeneTreeENSGT00730000110374.
HOGENOMHOG000231176.
HOVERGENHBG106958.
InParanoidP70217.
KOK09298.
OMAAKECPAP.
OrthoDBEOG7SJD53.
PhylomeDBP70217.
TreeFamTF330813.

Gene expression databases

BgeeP70217.
CleanExMM_HOXD13.
GenevestigatorP70217.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288202.
PROP70217.
SOURCESearch...

Entry information

Entry nameHXD13_MOUSE
AccessionPrimary (citable) accession number: P70217
Secondary accession number(s): A2ASM5 expand/collapse secondary AC list , Q2VPB0, Q2VPB1, Q64177
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries