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P70211

- DCC_MOUSE

UniProt

P70211 - DCC_MOUSE

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Protein

Netrin receptor DCC

Gene

Dcc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

GO - Molecular functioni

  1. netrin receptor activity Source: Ensembl
  2. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. anterior/posterior axon guidance Source: MGI
  2. apoptotic process Source: UniProtKB-KW
  3. dorsal/ventral axon guidance Source: MGI
  4. neuron migration Source: MGI
  5. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  6. positive regulation of neuron projection development Source: Ensembl
  7. response to amphetamine Source: Ensembl
  8. spinal cord ventral commissure morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor DCC
Alternative name(s):
Tumor suppressor protein DCC
Gene namesi
Name:Dcc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:94869. Dcc.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: MGI
  2. growth cone membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane raft Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 14471422Netrin receptor DCCPRO_0000014745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi61 ↔ 117PROSITE-ProRule annotation
Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi161 ↔ 212PROSITE-ProRule annotation
Disulfide bondi261 ↔ 310PROSITE-ProRule annotation
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi352 ↔ 400PROSITE-ProRule annotation
Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi702 – 7021N-linked (GlcNAc...)Sequence Analysis
Modified residuei1178 – 11781Phosphoserine; by MAPK1By similarity
Modified residuei1187 – 11871Phosphothreonine; by MAPK1By similarity
Modified residuei1267 – 12671Phosphoserine; by MAPK1By similarity

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP70211.
PaxDbiP70211.
PRIDEiP70211.

PTM databases

PhosphoSiteiP70211.

Expressioni

Tissue specificityi

In the embryo, expressed at high levels in the developing brain and neural tube. In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo.

Developmental stagei

Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult.

Gene expression databases

CleanExiMM_DCC.
GenevestigatoriP70211.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with MAPK1. Interacts with NTN1 (By similarity). Interacts with DSCAM. Interacts with PTK2/FAK1. Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DscamQ9ERC84EBI-1798863,EBI-1798601
MAZP562702EBI-1798863,EBI-1809742From a different organism.
MazP566713EBI-1798863,EBI-1809712

Protein-protein interaction databases

DIPiDIP-46587N.
IntActiP70211. 11 interactions.
MINTiMINT-4996953.
STRINGi10090.ENSMUSP00000110593.

Structurei

Secondary structure

1
1447
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1416 – 14216
Helixi1425 – 144319

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PZDX-ray2.50B1410-1445[»]
4PLOX-ray2.90B721-942[»]
ProteinModelPortaliP70211.
SMRiP70211. Positions 24-1047, 1410-1445.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 10971072ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1123 – 1447325CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1098 – 112225HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 135100Ig-like C2-type 1Add
BLAST
Domaini139 – 22991Ig-like C2-type 2Add
BLAST
Domaini234 – 32693Ig-like C2-type 3Add
BLAST
Domaini331 – 41686Ig-like C2-type 4Add
BLAST
Domaini431 – 52494Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini530 – 62091Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini625 – 71894Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini728 – 82194Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini846 – 94297Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST
Domaini947 – 104498Fibronectin type-III 6PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated
Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249790.
GeneTreeiENSGT00760000118886.
HOGENOMiHOG000230686.
HOVERGENiHBG005455.
InParanoidiP70211.
KOiK06765.
OMAiWGPGESS.
OrthoDBiEOG7RRF65.
TreeFamiTF321506.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. Align

Isoform A (identifier: P70211-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENSLGCVWV PKLAFVLFGA SLLSAHLQVT GFQIKPFTSL HFVSEPSDAV
60 70 80 90 100
TMRGGNVLLN CSAESDRGVP VIKWKKDGLI LALGMDDRKQ QLPNGSLLIQ
110 120 130 140 150
NILHSRHHKP DEGLYQCEAS LADSGSIISR TAKVTVAGPL RFLSQTESIT
160 170 180 190 200
AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL NPLPGDSRVV VLPSGALQIS
210 220 230 240 250
RLQPGDSGVY RCSARNPASI RTGNEAEVRI LSDPGLHRQL YFLQRPSNVI
260 270 280 290 300
AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV
310 320 330 340 350
TDDDSGTYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF
360 370 380 390 400
ECAVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC
410 420 430 440 450
VAENEAGNAQ SSAQLIVPKP AIPSSSILPS APRDVLPVLV SSRFVRLSWR
460 470 480 490 500
PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF
510 520 530 540 550
RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLHAVSTS PTSILITWEP
560 570 580 590 600
PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYTLRFLA
610 620 630 640 650
YNRYGPGVST DDITVVTLSD VPSAPPQNIS LEVVNSRSIK VSWLPPPSGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT
710 720 730 740 750
VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSGPDV STPMLPPVGV
860 870 880 890 900
QAVALTHEAV RVSWADNSVP KNQKTSDVRL YTVRWRTSFS ASAKYKSEDT
910 920 930 940 950
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD
960 970 980 990 1000
LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI
1010 1020 1030 1040 1050
SGDRLTHQIM DLSLDTMYYF RIQARNVKGV GPLSDPILFR TLKVEHPDKM
1060 1070 1080 1090 1100
ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV
1110 1120 1130 1140 1150
ITVVTVGVLT VLVVVIVAVI CTRRSSAQQR KKRATHSVSK RKGSQKDLRP
1160 1170 1180 1190 1200
PDLWIHHEEM EMKNIEKPTG TDPAGRDSPI QSCQDLTPVS HSQSETQMGS
1210 1220 1230 1240 1250
KSASHSGQDT EDAGSSMSTL ERSLAARRAT RAKLMIPMEA QSSNPAVVSA
1260 1270 1280 1290 1300
IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRTQS
1310 1320 1330 1340 1350
VSEGPTTQQQ PMLPPAQPEH PSSEEAPSRT IPTACVRPTH PLRSFANPLL
1360 1370 1380 1390 1400
PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP
1410 1420 1430 1440
TAPEVSEESH KPTEDPASVY EQDDLSEQMA SLEGLMKQLN AITGSAF
Length:1,447
Mass (Da):158,341
Last modified:October 3, 2012 - v2
Checksum:iF905BE27C991EA42
GO
Isoform C (identifier: P70211-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     819-838: Missing.

Show »
Length:1,427
Mass (Da):156,135
Checksum:iCEF2CE39FE115F9B
GO
Isoform B (identifier: P70211-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Note: Produced by alternative initiation at Met-85 of isoform A.

Show »
Length:1,363
Mass (Da):149,345
Checksum:i0B1075107D6A1DBC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1138 – 11381V → G in CAA59786. (PubMed:8570174)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform B. 1 PublicationVSP_018807Add
BLAST
Alternative sequencei819 – 83820Missing in isoform C. 1 PublicationVSP_002501Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85788 mRNA. Translation: CAA59786.1.
AC105957 Genomic DNA. No translation available.
AC107230 Genomic DNA. No translation available.
AC109179 Genomic DNA. No translation available.
AC109499 Genomic DNA. No translation available.
AC121523 Genomic DNA. No translation available.
AC136637 Genomic DNA. No translation available.
AC161177 Genomic DNA. No translation available.
AC163492 Genomic DNA. No translation available.
AC167547 Genomic DNA. No translation available.
AC167548 Genomic DNA. No translation available.
AC167549 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL09563.1.
CCDSiCCDS29336.1. [P70211-1]
RefSeqiNP_031857.2. NM_007831.3. [P70211-1]
XP_006525651.1. XM_006525588.1. [P70211-2]
UniGeneiMm.167882.

Genome annotation databases

EnsembliENSMUST00000073379; ENSMUSP00000073094; ENSMUSG00000060534. [P70211-2]
ENSMUST00000114943; ENSMUSP00000110593; ENSMUSG00000060534. [P70211-1]
GeneIDi13176.
KEGGimmu:13176.
UCSCiuc008fop.1. mouse.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85788 mRNA. Translation: CAA59786.1 .
AC105957 Genomic DNA. No translation available.
AC107230 Genomic DNA. No translation available.
AC109179 Genomic DNA. No translation available.
AC109499 Genomic DNA. No translation available.
AC121523 Genomic DNA. No translation available.
AC136637 Genomic DNA. No translation available.
AC161177 Genomic DNA. No translation available.
AC163492 Genomic DNA. No translation available.
AC167547 Genomic DNA. No translation available.
AC167548 Genomic DNA. No translation available.
AC167549 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL09563.1 .
CCDSi CCDS29336.1. [P70211-1 ]
RefSeqi NP_031857.2. NM_007831.3. [P70211-1 ]
XP_006525651.1. XM_006525588.1. [P70211-2 ]
UniGenei Mm.167882.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PZD X-ray 2.50 B 1410-1445 [» ]
4PLO X-ray 2.90 B 721-942 [» ]
ProteinModelPortali P70211.
SMRi P70211. Positions 24-1047, 1410-1445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46587N.
IntActi P70211. 11 interactions.
MINTi MINT-4996953.
STRINGi 10090.ENSMUSP00000110593.

PTM databases

PhosphoSitei P70211.

Proteomic databases

MaxQBi P70211.
PaxDbi P70211.
PRIDEi P70211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073379 ; ENSMUSP00000073094 ; ENSMUSG00000060534 . [P70211-2 ]
ENSMUST00000114943 ; ENSMUSP00000110593 ; ENSMUSG00000060534 . [P70211-1 ]
GeneIDi 13176.
KEGGi mmu:13176.
UCSCi uc008fop.1. mouse.

Organism-specific databases

CTDi 1630.
MGIi MGI:94869. Dcc.

Phylogenomic databases

eggNOGi NOG249790.
GeneTreei ENSGT00760000118886.
HOGENOMi HOG000230686.
HOVERGENi HBG005455.
InParanoidi P70211.
KOi K06765.
OMAi WGPGESS.
OrthoDBi EOG7RRF65.
TreeFami TF321506.

Miscellaneous databases

NextBioi 283280.
PROi P70211.
SOURCEi Search...

Gene expression databases

CleanExi MM_DCC.
Genevestigatori P70211.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view ]
Pfami PF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF06583. Neogenin_C. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 6 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 3 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
PROSITEi PS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo."
    Cooper H.M., Armes P., Britto J., Gad J., Wilks A.F.
    Oncogene 11:2243-2254(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
    Strain: BALB/c.
    Tissue: Brain.
  2. Cooper H.M.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Activation of FAK and Src are receptor-proximal events required for netrin signaling."
    Li W., Lee J., Vikis H.G., Lee S.H., Liu G., Aurandt J., Shen T.L., Fearon E.R., Guan J.L., Han M., Rao Y., Hong K., Guan K.L.
    Nat. Neurosci. 7:1213-1221(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTK2/FAK1.
  6. "DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1."
    Ly A., Nikolaev A., Suresh G., Zheng Y., Tessier-Lavigne M., Stein E.
    Cell 133:1241-1254(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DSCAM.
  7. "The Cbln family of proteins interact with multiple signaling pathways."
    Wei P., Pattarini R., Rong Y., Guo H., Bansal P.K., Kusnoor S.V., Deutch A.Y., Parris J., Morgan J.I.
    J. Neurochem. 121:717-729(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBLN4.
  8. "Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain."
    Wei Z., Yan J., Lu Q., Pan L., Zhang M.
    Proc. Natl. Acad. Sci. U.S.A. 108:3572-3577(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1410-1445 IN COMPLEX WITH MYO10.

Entry informationi

Entry nameiDCC_MOUSE
AccessioniPrimary (citable) accession number: P70211
Secondary accession number(s): G3X9X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: October 29, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3