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Protein

Netrin receptor DCC

Gene

Dcc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior axon guidance Source: MGI
  • apoptotic process Source: UniProtKB-KW
  • axon guidance Source: Reactome
  • dorsal/ventral axon guidance Source: MGI
  • neuron migration Source: MGI
  • regulation of neuron death Source: MGI
  • spinal cord ventral commissure morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-MMU-373752. Netrin-1 signaling.
R-MMU-376172. DSCAM interactions.
R-MMU-418885. DCC mediated attractive signaling.
R-MMU-418886. Netrin mediated repulsion signals.
R-MMU-418889. Ligand-independent caspase activation via DCC.
R-MMU-418890. Role of second messengers in netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor DCC
Alternative name(s):
Tumor suppressor protein DCC
Gene namesi
Name:Dcc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:94869. Dcc.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 1097ExtracellularSequence analysisAdd BLAST1072
Transmembranei1098 – 1122HelicalSequence analysisAdd BLAST25
Topological domaini1123 – 1447CytoplasmicSequence analysisAdd BLAST325

GO - Cellular componenti

  • axon Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001474526 – 1447Netrin receptor DCCAdd BLAST1422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi61 ↔ 117PROSITE-ProRule annotation
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi161 ↔ 212PROSITE-ProRule annotation
Disulfide bondi261 ↔ 310PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi352 ↔ 400PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Glycosylationi628N-linked (GlcNAc...)Sequence analysis1
Glycosylationi702N-linked (GlcNAc...)Sequence analysis1
Modified residuei1178Phosphoserine; by MAPK1By similarity1
Modified residuei1187Phosphothreonine; by MAPK1By similarity1
Modified residuei1267Phosphoserine; by MAPK1By similarity1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP70211.
PaxDbiP70211.
PeptideAtlasiP70211.
PRIDEiP70211.

PTM databases

iPTMnetiP70211.
PhosphoSitePlusiP70211.

Expressioni

Tissue specificityi

In the embryo, expressed at high levels in the developing brain and neural tube. In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo.

Developmental stagei

Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult.

Gene expression databases

BgeeiENSMUSG00000060534.
CleanExiMM_DCC.
GenevisibleiP70211. MM.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with MAPK1. Interacts with NTN1 (By similarity). Interacts with DSCAM. Interacts with PTK2/FAK1. Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DscamQ9ERC84EBI-1798863,EBI-1798601
MAZP562702EBI-1798863,EBI-1809742From a different organism.
MazP566713EBI-1798863,EBI-1809712

Protein-protein interaction databases

BioGridi199064. 6 interactors.
DIPiDIP-46587N.
IntActiP70211. 11 interactors.
MINTiMINT-4996953.
STRINGi10090.ENSMUSP00000110593.

Structurei

Secondary structure

11447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi732 – 736Combined sources5
Beta strandi741 – 745Combined sources5
Beta strandi757 – 766Combined sources10
Beta strandi769 – 773Combined sources5
Beta strandi780 – 783Combined sources4
Beta strandi791 – 800Combined sources10
Beta strandi808 – 813Combined sources6
Beta strandi848 – 854Combined sources7
Beta strandi856 – 865Combined sources10
Beta strandi880 – 887Combined sources8
Beta strandi896 – 908Combined sources13
Beta strandi915 – 924Combined sources10
Beta strandi935 – 938Combined sources4
Helixi1416 – 1421Combined sources6
Helixi1425 – 1443Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PZDX-ray2.50B1410-1445[»]
4PLOX-ray2.90B721-942[»]
ProteinModelPortaliP70211.
SMRiP70211.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 135Ig-like C2-type 1Add BLAST100
Domaini139 – 229Ig-like C2-type 2Add BLAST91
Domaini234 – 326Ig-like C2-type 3Add BLAST93
Domaini331 – 416Ig-like C2-type 4Add BLAST86
Domaini431 – 524Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini530 – 620Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini625 – 718Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini728 – 821Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini846 – 942Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST97
Domaini947 – 1044Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST98

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated
Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000230686.
HOVERGENiHBG005455.
InParanoidiP70211.
KOiK06765.
OMAiWGPGESS.
OrthoDBiEOG091G098C.
TreeFamiTF321506.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR033012. DCC.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
PANTHERiPTHR10489:SF68. PTHR10489:SF68. 1 hit.
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform A (identifier: P70211-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MENSLGCVWV PKLAFVLFGA SLLSAHLQVT GFQIKPFTSL HFVSEPSDAV
60 70 80 90 100
TMRGGNVLLN CSAESDRGVP VIKWKKDGLI LALGMDDRKQ QLPNGSLLIQ
110 120 130 140 150
NILHSRHHKP DEGLYQCEAS LADSGSIISR TAKVTVAGPL RFLSQTESIT
160 170 180 190 200
AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL NPLPGDSRVV VLPSGALQIS
210 220 230 240 250
RLQPGDSGVY RCSARNPASI RTGNEAEVRI LSDPGLHRQL YFLQRPSNVI
260 270 280 290 300
AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV
310 320 330 340 350
TDDDSGTYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF
360 370 380 390 400
ECAVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC
410 420 430 440 450
VAENEAGNAQ SSAQLIVPKP AIPSSSILPS APRDVLPVLV SSRFVRLSWR
460 470 480 490 500
PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF
510 520 530 540 550
RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLHAVSTS PTSILITWEP
560 570 580 590 600
PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYTLRFLA
610 620 630 640 650
YNRYGPGVST DDITVVTLSD VPSAPPQNIS LEVVNSRSIK VSWLPPPSGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT
710 720 730 740 750
VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSGPDV STPMLPPVGV
860 870 880 890 900
QAVALTHEAV RVSWADNSVP KNQKTSDVRL YTVRWRTSFS ASAKYKSEDT
910 920 930 940 950
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD
960 970 980 990 1000
LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI
1010 1020 1030 1040 1050
SGDRLTHQIM DLSLDTMYYF RIQARNVKGV GPLSDPILFR TLKVEHPDKM
1060 1070 1080 1090 1100
ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV
1110 1120 1130 1140 1150
ITVVTVGVLT VLVVVIVAVI CTRRSSAQQR KKRATHSVSK RKGSQKDLRP
1160 1170 1180 1190 1200
PDLWIHHEEM EMKNIEKPTG TDPAGRDSPI QSCQDLTPVS HSQSETQMGS
1210 1220 1230 1240 1250
KSASHSGQDT EDAGSSMSTL ERSLAARRAT RAKLMIPMEA QSSNPAVVSA
1260 1270 1280 1290 1300
IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRTQS
1310 1320 1330 1340 1350
VSEGPTTQQQ PMLPPAQPEH PSSEEAPSRT IPTACVRPTH PLRSFANPLL
1360 1370 1380 1390 1400
PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP
1410 1420 1430 1440
TAPEVSEESH KPTEDPASVY EQDDLSEQMA SLEGLMKQLN AITGSAF
Length:1,447
Mass (Da):158,341
Last modified:October 3, 2012 - v2
Checksum:iF905BE27C991EA42
GO
Isoform C (identifier: P70211-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     819-838: Missing.

Show »
Length:1,427
Mass (Da):156,135
Checksum:iCEF2CE39FE115F9B
GO
Isoform B (identifier: P70211-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Note: Produced by alternative initiation at Met-85 of isoform A.
Show »
Length:1,363
Mass (Da):149,345
Checksum:i0B1075107D6A1DBC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1138V → G in CAA59786 (PubMed:8570174).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0188071 – 84Missing in isoform B. 1 PublicationAdd BLAST84
Alternative sequenceiVSP_002501819 – 838Missing in isoform C. 1 PublicationAdd BLAST20

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85788 mRNA. Translation: CAA59786.1.
AC105957 Genomic DNA. No translation available.
AC107230 Genomic DNA. No translation available.
AC109179 Genomic DNA. No translation available.
AC109499 Genomic DNA. No translation available.
AC121523 Genomic DNA. No translation available.
AC136637 Genomic DNA. No translation available.
AC161177 Genomic DNA. No translation available.
AC163492 Genomic DNA. No translation available.
AC167547 Genomic DNA. No translation available.
AC167548 Genomic DNA. No translation available.
AC167549 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL09563.1.
CCDSiCCDS29336.1. [P70211-1]
RefSeqiNP_031857.2. NM_007831.3. [P70211-1]
XP_006525651.1. XM_006525588.3. [P70211-2]
UniGeneiMm.167882.

Genome annotation databases

EnsembliENSMUST00000073379; ENSMUSP00000073094; ENSMUSG00000060534. [P70211-2]
ENSMUST00000114943; ENSMUSP00000110593; ENSMUSG00000060534. [P70211-1]
GeneIDi13176.
KEGGimmu:13176.
UCSCiuc008fop.1. mouse. [P70211-1]
uc008foq.1. mouse. [P70211-2]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85788 mRNA. Translation: CAA59786.1.
AC105957 Genomic DNA. No translation available.
AC107230 Genomic DNA. No translation available.
AC109179 Genomic DNA. No translation available.
AC109499 Genomic DNA. No translation available.
AC121523 Genomic DNA. No translation available.
AC136637 Genomic DNA. No translation available.
AC161177 Genomic DNA. No translation available.
AC163492 Genomic DNA. No translation available.
AC167547 Genomic DNA. No translation available.
AC167548 Genomic DNA. No translation available.
AC167549 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL09563.1.
CCDSiCCDS29336.1. [P70211-1]
RefSeqiNP_031857.2. NM_007831.3. [P70211-1]
XP_006525651.1. XM_006525588.3. [P70211-2]
UniGeneiMm.167882.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3PZDX-ray2.50B1410-1445[»]
4PLOX-ray2.90B721-942[»]
ProteinModelPortaliP70211.
SMRiP70211.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199064. 6 interactors.
DIPiDIP-46587N.
IntActiP70211. 11 interactors.
MINTiMINT-4996953.
STRINGi10090.ENSMUSP00000110593.

PTM databases

iPTMnetiP70211.
PhosphoSitePlusiP70211.

Proteomic databases

MaxQBiP70211.
PaxDbiP70211.
PeptideAtlasiP70211.
PRIDEiP70211.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000073379; ENSMUSP00000073094; ENSMUSG00000060534. [P70211-2]
ENSMUST00000114943; ENSMUSP00000110593; ENSMUSG00000060534. [P70211-1]
GeneIDi13176.
KEGGimmu:13176.
UCSCiuc008fop.1. mouse. [P70211-1]
uc008foq.1. mouse. [P70211-2]

Organism-specific databases

CTDi1630.
MGIiMGI:94869. Dcc.

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000230686.
HOVERGENiHBG005455.
InParanoidiP70211.
KOiK06765.
OMAiWGPGESS.
OrthoDBiEOG091G098C.
TreeFamiTF321506.

Enzyme and pathway databases

ReactomeiR-MMU-373752. Netrin-1 signaling.
R-MMU-376172. DSCAM interactions.
R-MMU-418885. DCC mediated attractive signaling.
R-MMU-418886. Netrin mediated repulsion signals.
R-MMU-418889. Ligand-independent caspase activation via DCC.
R-MMU-418890. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiDcc. mouse.
PROiP70211.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060534.
CleanExiMM_DCC.
GenevisibleiP70211. MM.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR033012. DCC.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
PANTHERiPTHR10489:SF68. PTHR10489:SF68. 1 hit.
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF13895. Ig_2. 1 hit.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCC_MOUSE
AccessioniPrimary (citable) accession number: P70211
Secondary accession number(s): G3X9X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 161 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.