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P70211

- DCC_MOUSE

UniProt

P70211 - DCC_MOUSE

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Protein
Netrin receptor DCC
Gene
Dcc
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

GO - Molecular functioni

  1. netrin receptor activity Source: Ensembl
  2. protein binding Source: IntAct
  3. transcription coactivator activity Source: Ensembl

GO - Biological processi

  1. anterior/posterior axon guidance Source: MGI
  2. apoptotic process Source: UniProtKB-KW
  3. dorsal/ventral axon guidance Source: MGI
  4. neuron migration Source: MGI
  5. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  6. positive regulation of neuron projection development Source: Ensembl
  7. response to amphetamine Source: Ensembl
  8. spinal cord ventral commissure morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor DCC
Alternative name(s):
Tumor suppressor protein DCC
Gene namesi
Name:Dcc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:94869. Dcc.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini26 – 10971072Extracellular Reviewed prediction
Add
BLAST
Transmembranei1098 – 112225Helical; Reviewed prediction
Add
BLAST
Topological domaini1123 – 1447325Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. growth cone membrane Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane raft Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525 Reviewed prediction
Add
BLAST
Chaini26 – 14471422Netrin receptor DCC
PRO_0000014745Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi61 ↔ 117 By similarity
Glycosylationi94 – 941N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi161 ↔ 212 By similarity
Disulfide bondi261 ↔ 310 By similarity
Glycosylationi299 – 2991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi318 – 3181N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi352 ↔ 400 By similarity
Glycosylationi478 – 4781N-linked (GlcNAc...) Reviewed prediction
Glycosylationi628 – 6281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi702 – 7021N-linked (GlcNAc...) Reviewed prediction
Modified residuei1178 – 11781Phosphoserine; by MAPK1 By similarity
Modified residuei1187 – 11871Phosphothreonine; by MAPK1 By similarity
Modified residuei1267 – 12671Phosphoserine; by MAPK1 By similarity

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP70211.
PRIDEiP70211.

PTM databases

PhosphoSiteiP70211.

Expressioni

Tissue specificityi

In the embryo, expressed at high levels in the developing brain and neural tube. In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo.

Developmental stagei

Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult.

Gene expression databases

CleanExiMM_DCC.
GenevestigatoriP70211.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with MAPK1. Interacts with NTN1 By similarity. Interacts with DSCAM. Interacts with PTK2/FAK1. Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DscamQ9ERC84EBI-1798863,EBI-1798601
MAZP562702EBI-1798863,EBI-1809742From a different organism.
MazP566713EBI-1798863,EBI-1809712

Protein-protein interaction databases

DIPiDIP-46587N.
IntActiP70211. 11 interactions.
MINTiMINT-4996953.
STRINGi10090.ENSMUSP00000110593.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1416 – 14216
Helixi1425 – 144319

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PZDX-ray2.50B1410-1445[»]
4PLOX-ray2.90B721-942[»]
ProteinModelPortaliP70211.
SMRiP70211. Positions 39-818, 833-1047, 1410-1445.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 135100Ig-like C2-type 1
Add
BLAST
Domaini139 – 22991Ig-like C2-type 2
Add
BLAST
Domaini234 – 32693Ig-like C2-type 3
Add
BLAST
Domaini331 – 41686Ig-like C2-type 4
Add
BLAST
Domaini431 – 52494Fibronectin type-III 1
Add
BLAST
Domaini530 – 62091Fibronectin type-III 2
Add
BLAST
Domaini625 – 71894Fibronectin type-III 3
Add
BLAST
Domaini728 – 82194Fibronectin type-III 4
Add
BLAST
Domaini846 – 94297Fibronectin type-III 5
Add
BLAST
Domaini947 – 104498Fibronectin type-III 6
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249790.
GeneTreeiENSGT00730000110320.
HOGENOMiHOG000230686.
HOVERGENiHBG005455.
InParanoidiP70211.
KOiK06765.
OMAiWGPGESS.
OrthoDBiEOG7RRF65.
TreeFamiTF321506.

Family and domain databases

Gene3Di2.60.40.10. 10 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. Align

Isoform A (identifier: P70211-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MENSLGCVWV PKLAFVLFGA SLLSAHLQVT GFQIKPFTSL HFVSEPSDAV     50
TMRGGNVLLN CSAESDRGVP VIKWKKDGLI LALGMDDRKQ QLPNGSLLIQ 100
NILHSRHHKP DEGLYQCEAS LADSGSIISR TAKVTVAGPL RFLSQTESIT 150
AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL NPLPGDSRVV VLPSGALQIS 200
RLQPGDSGVY RCSARNPASI RTGNEAEVRI LSDPGLHRQL YFLQRPSNVI 250
AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV 300
TDDDSGTYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF 350
ECAVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC 400
VAENEAGNAQ SSAQLIVPKP AIPSSSILPS APRDVLPVLV SSRFVRLSWR 450
PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF 500
RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLHAVSTS PTSILITWEP 550
PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYTLRFLA 600
YNRYGPGVST DDITVVTLSD VPSAPPQNIS LEVVNSRSIK VSWLPPPSGT 650
QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT 700
VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN 750
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN 800
NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSGPDV STPMLPPVGV 850
QAVALTHEAV RVSWADNSVP KNQKTSDVRL YTVRWRTSFS ASAKYKSEDT 900
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD 950
LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI 1000
SGDRLTHQIM DLSLDTMYYF RIQARNVKGV GPLSDPILFR TLKVEHPDKM 1050
ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV 1100
ITVVTVGVLT VLVVVIVAVI CTRRSSAQQR KKRATHSVSK RKGSQKDLRP 1150
PDLWIHHEEM EMKNIEKPTG TDPAGRDSPI QSCQDLTPVS HSQSETQMGS 1200
KSASHSGQDT EDAGSSMSTL ERSLAARRAT RAKLMIPMEA QSSNPAVVSA 1250
IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRTQS 1300
VSEGPTTQQQ PMLPPAQPEH PSSEEAPSRT IPTACVRPTH PLRSFANPLL 1350
PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP 1400
TAPEVSEESH KPTEDPASVY EQDDLSEQMA SLEGLMKQLN AITGSAF 1447
Length:1,447
Mass (Da):158,341
Last modified:October 3, 2012 - v2
Checksum:iF905BE27C991EA42
GO
Isoform C (identifier: P70211-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     819-838: Missing.

Show »
Length:1,427
Mass (Da):156,135
Checksum:iCEF2CE39FE115F9B
GO
Isoform B (identifier: P70211-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.

Note: Produced by alternative initiation at Met-85 of isoform A.

Show »
Length:1,363
Mass (Da):149,345
Checksum:i0B1075107D6A1DBC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8484Missing in isoform B.
VSP_018807Add
BLAST
Alternative sequencei819 – 83820Missing in isoform C.
VSP_002501Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1138 – 11381V → G in CAA59786. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85788 mRNA. Translation: CAA59786.1.
AC105957 Genomic DNA. No translation available.
AC107230 Genomic DNA. No translation available.
AC109179 Genomic DNA. No translation available.
AC109499 Genomic DNA. No translation available.
AC121523 Genomic DNA. No translation available.
AC136637 Genomic DNA. No translation available.
AC161177 Genomic DNA. No translation available.
AC163492 Genomic DNA. No translation available.
AC167547 Genomic DNA. No translation available.
AC167548 Genomic DNA. No translation available.
AC167549 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL09563.1.
CCDSiCCDS29336.1. [P70211-1]
RefSeqiNP_031857.2. NM_007831.3. [P70211-1]
XP_006525651.1. XM_006525588.1. [P70211-2]
UniGeneiMm.167882.

Genome annotation databases

EnsembliENSMUST00000073379; ENSMUSP00000073094; ENSMUSG00000060534. [P70211-2]
ENSMUST00000114943; ENSMUSP00000110593; ENSMUSG00000060534. [P70211-1]
GeneIDi13176.
KEGGimmu:13176.
UCSCiuc008fop.1. mouse.

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X85788 mRNA. Translation: CAA59786.1 .
AC105957 Genomic DNA. No translation available.
AC107230 Genomic DNA. No translation available.
AC109179 Genomic DNA. No translation available.
AC109499 Genomic DNA. No translation available.
AC121523 Genomic DNA. No translation available.
AC136637 Genomic DNA. No translation available.
AC161177 Genomic DNA. No translation available.
AC163492 Genomic DNA. No translation available.
AC167547 Genomic DNA. No translation available.
AC167548 Genomic DNA. No translation available.
AC167549 Genomic DNA. No translation available.
CH466528 Genomic DNA. Translation: EDL09563.1 .
CCDSi CCDS29336.1. [P70211-1 ]
RefSeqi NP_031857.2. NM_007831.3. [P70211-1 ]
XP_006525651.1. XM_006525588.1. [P70211-2 ]
UniGenei Mm.167882.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PZD X-ray 2.50 B 1410-1445 [» ]
4PLO X-ray 2.90 B 721-942 [» ]
ProteinModelPortali P70211.
SMRi P70211. Positions 39-818, 833-1047, 1410-1445.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-46587N.
IntActi P70211. 11 interactions.
MINTi MINT-4996953.
STRINGi 10090.ENSMUSP00000110593.

PTM databases

PhosphoSitei P70211.

Proteomic databases

PaxDbi P70211.
PRIDEi P70211.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073379 ; ENSMUSP00000073094 ; ENSMUSG00000060534 . [P70211-2 ]
ENSMUST00000114943 ; ENSMUSP00000110593 ; ENSMUSG00000060534 . [P70211-1 ]
GeneIDi 13176.
KEGGi mmu:13176.
UCSCi uc008fop.1. mouse.

Organism-specific databases

CTDi 1630.
MGIi MGI:94869. Dcc.

Phylogenomic databases

eggNOGi NOG249790.
GeneTreei ENSGT00730000110320.
HOGENOMi HOG000230686.
HOVERGENi HBG005455.
InParanoidi P70211.
KOi K06765.
OMAi WGPGESS.
OrthoDBi EOG7RRF65.
TreeFami TF321506.

Miscellaneous databases

NextBioi 283280.
PROi P70211.
SOURCEi Search...

Gene expression databases

CleanExi MM_DCC.
Genevestigatori P70211.

Family and domain databases

Gene3Di 2.60.40.10. 10 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view ]
Pfami PF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF06583. Neogenin_C. 1 hit.
[Graphical view ]
SMARTi SM00060. FN3. 6 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 3 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 4 hits.
PROSITEi PS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo."
    Cooper H.M., Armes P., Britto J., Gad J., Wilks A.F.
    Oncogene 11:2243-2254(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
    Strain: BALB/c.
    Tissue: Brain.
  2. Cooper H.M.
    Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Activation of FAK and Src are receptor-proximal events required for netrin signaling."
    Li W., Lee J., Vikis H.G., Lee S.H., Liu G., Aurandt J., Shen T.L., Fearon E.R., Guan J.L., Han M., Rao Y., Hong K., Guan K.L.
    Nat. Neurosci. 7:1213-1221(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTK2/FAK1.
  6. "DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1."
    Ly A., Nikolaev A., Suresh G., Zheng Y., Tessier-Lavigne M., Stein E.
    Cell 133:1241-1254(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DSCAM.
  7. "The Cbln family of proteins interact with multiple signaling pathways."
    Wei P., Pattarini R., Rong Y., Guo H., Bansal P.K., Kusnoor S.V., Deutch A.Y., Parris J., Morgan J.I.
    J. Neurochem. 121:717-729(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CBLN4.
  8. "Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain."
    Wei Z., Yan J., Lu Q., Pan L., Zhang M.
    Proc. Natl. Acad. Sci. U.S.A. 108:3572-3577(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1410-1445 IN COMPLEX WITH MYO10.

Entry informationi

Entry nameiDCC_MOUSE
AccessioniPrimary (citable) accession number: P70211
Secondary accession number(s): G3X9X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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