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P70211 (DCC_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 112. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Netrin receptor DCC
Alternative name(s):
Tumor suppressor protein DCC
Gene names
Name:Dcc
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length1447 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

Subunit structure

Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D By similarity. Interacts with DSCAM. Interacts with PTK2/FAK1. Ref.3 Ref.4

Subcellular location

Membrane; Single-pass type I membrane protein.

Tissue specificity

In the embryo, expressed at high levels in the developing brain and neural tube. In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo.

Developmental stage

Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult.

Post-translational modification

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation By similarity.

Sequence similarities

Belongs to the immunoglobulin superfamily. DCC family.

Contains 6 fibronectin type-III domains.

Contains 4 Ig-like C2-type (immunoglobulin-like) domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

DscamQ9ERC84EBI-1798863,EBI-1798601
MAZP562702EBI-1798863,EBI-1809742From a different organism.
MazP566713EBI-1798863,EBI-1809712

Alternative products

This entry describes 3 isoforms produced by alternative splicing and alternative initiation. [Align] [Select]
Isoform A (identifier: P70211-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform C (identifier: P70211-2)

The sequence of this isoform differs from the canonical sequence as follows:
     819-838: Missing.
Isoform B (identifier: P70211-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-84: Missing.
Note: Produced by alternative initiation at Met-85 of isoform A.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 14471422Netrin receptor DCC
PRO_0000014745

Regions

Topological domain26 – 10971072Extracellular Potential
Transmembrane1098 – 112225Helical; Potential
Topological domain1123 – 1447325Cytoplasmic Potential
Domain36 – 135100Ig-like C2-type 1
Domain139 – 22991Ig-like C2-type 2
Domain234 – 32693Ig-like C2-type 3
Domain331 – 41686Ig-like C2-type 4
Domain429 – 52092Fibronectin type-III 1
Domain528 – 61689Fibronectin type-III 2
Domain622 – 71493Fibronectin type-III 3
Domain726 – 81489Fibronectin type-III 4
Domain843 – 93997Fibronectin type-III 5
Domain944 – 104198Fibronectin type-III 6

Amino acid modifications

Modified residue8681Phosphoserine By similarity
Modified residue10731Phosphoserine By similarity
Modified residue10741Phosphothreonine By similarity
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation941N-linked (GlcNAc...) Potential
Glycosylation2991N-linked (GlcNAc...) Potential
Glycosylation3181N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Glycosylation6281N-linked (GlcNAc...) Potential
Glycosylation7021N-linked (GlcNAc...) Potential
Disulfide bond61 ↔ 117 By similarity
Disulfide bond161 ↔ 212 By similarity
Disulfide bond261 ↔ 310 By similarity
Disulfide bond352 ↔ 400 By similarity

Natural variations

Alternative sequence1 – 8484Missing in isoform B.
VSP_018807
Alternative sequence819 – 83820Missing in isoform C.
VSP_002501

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 0D1F1097C22D5B9F

FASTA1,447158,299
        10         20         30         40         50         60 
MENSLGCVWV PKLAFVLFGA SLLSAHLQVT GFQIKPFTSL HFVSEPSDAV TMRGGNVLLN 

        70         80         90        100        110        120 
CSAESDRGVP VIKWKKDGLI LALGMDDRKQ QLPNGSLLIQ NILHSRHHKP DEGLYQCEAS 

       130        140        150        160        170        180 
LADSGSIISR TAKVTVAGPL RFLSQTESIT AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL 

       190        200        210        220        230        240 
NPLPGDSRVV VLPSGALQIS RLQPGDSGVY RCSARNPASI RTGNEAEVRI LSDPGLHRQL 

       250        260        270        280        290        300 
YFLQRPSNVI AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV 

       310        320        330        340        350        360 
TDDDSGTYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF ECAVSGKPVP 

       370        380        390        400        410        420 
TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC VAENEAGNAQ SSAQLIVPKP 

       430        440        450        460        470        480 
AIPSSSILPS APRDVLPVLV SSRFVRLSWR PPAEAKGNIQ TFTVFFSREG DNRERALNTT 

       490        500        510        520        530        540 
QPGSLQLTVG NLKPEAMYTF RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLHAVSTS 

       550        560        570        580        590        600 
PTSILITWEP PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYTLRFLA 

       610        620        630        640        650        660 
YNRYGPGVST DDITVVTLSD VPSAPPQNIS LEVVNSRSIK VSWLPPPSGT QNGFITGYKI 

       670        680        690        700        710        720 
RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT VNGTGPPSNW YTAETPENDL 

       730        740        750        760        770        780 
DESQVPDQPS SLHVRPQTNC IIMSWTPPLN PNIVVRGYII GYGVGSPYAE TVRVDSKQRY 

       790        800        810        820        830        840 
YSIERLESSS HYVISLKAFN NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSGPDV 

       850        860        870        880        890        900 
STPMLPPVGV QAVALTHEAV RVSWADNSVP KNQKTSDVRL YTVRWRTSFS ASAKYKSEDT 

       910        920        930        940        950        960 
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD LTVITREGKP 

       970        980        990       1000       1010       1020 
RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI SGDRLTHQIM DLSLDTMYYF 

      1030       1040       1050       1060       1070       1080 
RIQARNVKGV GPLSDPILFR TLKVEHPDKM ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI 

      1090       1100       1110       1120       1130       1140 
GQMHPPHGSV TPQKNSNLLV ITVVTVGVLT VLVVVIVAVI CTRRSSAQQR KKRATHSGSK 

      1150       1160       1170       1180       1190       1200 
RKGSQKDLRP PDLWIHHEEM EMKNIEKPTG TDPAGRDSPI QSCQDLTPVS HSQSETQMGS 

      1210       1220       1230       1240       1250       1260 
KSASHSGQDT EDAGSSMSTL ERSLAARRAT RAKLMIPMEA QSSNPAVVSA IPVPTLESAQ 

      1270       1280       1290       1300       1310       1320 
YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRTQS VSEGPTTQQQ PMLPPAQPEH 

      1330       1340       1350       1360       1370       1380 
PSSEEAPSRT IPTACVRPTH PLRSFANPLL PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK 

      1390       1400       1410       1420       1430       1440 
TASLGLAGKA RSPLLPVSVP TAPEVSEESH KPTEDPASVY EQDDLSEQMA SLEGLMKQLN 


AITGSAF

« Hide

Isoform C [UniParc].

Checksum: 3AE86089F5ADEE46
Show »

FASTA1,427156,093
Isoform B [UniParc].

Checksum: FF0ADBA076D6AC61
Show »

FASTA1,363149,303

References

[1]"Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo."
Cooper H.M., Armes P., Britto J., Gad J., Wilks A.F.
Oncogene 11:2243-2254(1995) [PubMed: 8570174] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
Strain: BALB/c.
Tissue: Brain.
[2]Cooper H.M.
Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Activation of FAK and Src are receptor-proximal events required for netrin signaling."
Li W., Lee J., Vikis H.G., Lee S.H., Liu G., Aurandt J., Shen T.L., Fearon E.R., Guan J.L., Han M., Rao Y., Hong K., Guan K.L.
Nat. Neurosci. 7:1213-1221(2004) [PubMed: 15494734] [Abstract]
Cited for: INTERACTION WITH PTK2/FAK1.
[4]"DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1."
Ly A., Nikolaev A., Suresh G., Zheng Y., Tessier-Lavigne M., Stein E.
Cell 133:1241-1254(2008) [PubMed: 18585357] [Abstract]
Cited for: INTERACTION WITH DSCAM.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X85788 mRNA. Translation: CAA59786.1.
IPIIPI00137347.
IPI00225034.
IPI00759859.
UniGeneMm.167882.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3PZDX-ray2.50B1410-1445[»]
ProteinModelPortalP70211.
SMRP70211. Positions 38-1047, 1410-1445.
ModBaseSearch...

Protein-protein interaction databases

IntActP70211. 10 interactions.
STRINGP70211.

PTM databases

PhosphoSiteP70211.

Proteomic databases

PRIDEP70211.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc008fop.1. mouse.
uc008foq.1. mouse.

Organism-specific databases

MGIMGI:94869. Dcc.

Phylogenomic databases

eggNOGroNOG04119.
GeneTreeENSGT00590000082947.
HOGENOMHBG358293.
HOVERGENHBG005455.
InParanoidP70211.
OrthoDBEOG4WM4SV.

Enzyme and pathway databases

ReactomeREACT_112933. Cell-Cell communication.
REACT_115492. Developmental Biology.

Gene expression databases

ArrayExpressP70211.
BgeeP70211.
CleanExMM_DCC.
GenevestigatorP70211.
GermOnlineENSMUSG00000060534. Mus musculus.

Family and domain databases

InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 10 hits.
PfamPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTSM00060. FN3. 6 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 6 hits.
PROSITEPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameDCC_MOUSE
AccessionPrimary (citable) accession number: P70211
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: January 25, 2012
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents