Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P70211

- DCC_MOUSE

UniProt

P70211 - DCC_MOUSE

Protein

Netrin receptor DCC

Gene

Dcc

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.

    GO - Molecular functioni

    1. netrin receptor activity Source: Ensembl
    2. protein binding Source: IntAct
    3. transcription coactivator activity Source: Ensembl

    GO - Biological processi

    1. anterior/posterior axon guidance Source: MGI
    2. apoptotic process Source: UniProtKB-KW
    3. dorsal/ventral axon guidance Source: MGI
    4. neuron migration Source: MGI
    5. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    6. positive regulation of neuron projection development Source: Ensembl
    7. response to amphetamine Source: Ensembl
    8. spinal cord ventral commissure morphogenesis Source: MGI

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Apoptosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Netrin receptor DCC
    Alternative name(s):
    Tumor suppressor protein DCC
    Gene namesi
    Name:Dcc
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:94869. Dcc.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: MGI
    2. growth cone membrane Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. membrane raft Source: Ensembl
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Keywords - Diseasei

    Tumor suppressor

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 14471422Netrin receptor DCCPRO_0000014745Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi61 ↔ 117PROSITE-ProRule annotation
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi161 ↔ 212PROSITE-ProRule annotation
    Disulfide bondi261 ↔ 310PROSITE-ProRule annotation
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi352 ↔ 400PROSITE-ProRule annotation
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi702 – 7021N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1178 – 11781Phosphoserine; by MAPK1By similarity
    Modified residuei1187 – 11871Phosphothreonine; by MAPK1By similarity
    Modified residuei1267 – 12671Phosphoserine; by MAPK1By similarity

    Post-translational modificationi

    Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP70211.
    PRIDEiP70211.

    PTM databases

    PhosphoSiteiP70211.

    Expressioni

    Tissue specificityi

    In the embryo, expressed at high levels in the developing brain and neural tube. In adult, highly expressed in brain with very low levels found in testis, heart and thymus. Isoform C is expressed only in the embryo.

    Developmental stagei

    Low levels in early gestation. Highest levels expressed during mid gestation. Levels decrease in late gestation and remain at this level in the adult.

    Gene expression databases

    CleanExiMM_DCC.
    GenevestigatoriP70211.

    Interactioni

    Subunit structurei

    Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with MAPK1. Interacts with NTN1 By similarity. Interacts with DSCAM. Interacts with PTK2/FAK1. Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DscamQ9ERC84EBI-1798863,EBI-1798601
    MAZP562702EBI-1798863,EBI-1809742From a different organism.
    MazP566713EBI-1798863,EBI-1809712

    Protein-protein interaction databases

    DIPiDIP-46587N.
    IntActiP70211. 11 interactions.
    MINTiMINT-4996953.
    STRINGi10090.ENSMUSP00000110593.

    Structurei

    Secondary structure

    1
    1447
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1416 – 14216
    Helixi1425 – 144319

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3PZDX-ray2.50B1410-1445[»]
    4PLOX-ray2.90B721-942[»]
    ProteinModelPortaliP70211.
    SMRiP70211. Positions 39-818, 833-1047, 1410-1445.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 10971072ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1123 – 1447325CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1098 – 112225HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini36 – 135100Ig-like C2-type 1Add
    BLAST
    Domaini139 – 22991Ig-like C2-type 2Add
    BLAST
    Domaini234 – 32693Ig-like C2-type 3Add
    BLAST
    Domaini331 – 41686Ig-like C2-type 4Add
    BLAST
    Domaini431 – 52494Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini530 – 62091Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini625 – 71894Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini728 – 82194Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini846 – 94297Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini947 – 104498Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. DCC family.Curated
    Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249790.
    GeneTreeiENSGT00730000110320.
    HOGENOMiHOG000230686.
    HOVERGENiHBG005455.
    InParanoidiP70211.
    KOiK06765.
    OMAiWGPGESS.
    OrthoDBiEOG7RRF65.
    TreeFamiTF321506.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR010560. Neogenin_C.
    [Graphical view]
    PfamiPF00041. fn3. 6 hits.
    PF07679. I-set. 3 hits.
    PF06583. Neogenin_C. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 6 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 3 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 4 hits.
    PROSITEiPS50853. FN3. 6 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing and alternative initiation. Align

    Isoform A (identifier: P70211-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MENSLGCVWV PKLAFVLFGA SLLSAHLQVT GFQIKPFTSL HFVSEPSDAV     50
    TMRGGNVLLN CSAESDRGVP VIKWKKDGLI LALGMDDRKQ QLPNGSLLIQ 100
    NILHSRHHKP DEGLYQCEAS LADSGSIISR TAKVTVAGPL RFLSQTESIT 150
    AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL NPLPGDSRVV VLPSGALQIS 200
    RLQPGDSGVY RCSARNPASI RTGNEAEVRI LSDPGLHRQL YFLQRPSNVI 250
    AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV 300
    TDDDSGTYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF 350
    ECAVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC 400
    VAENEAGNAQ SSAQLIVPKP AIPSSSILPS APRDVLPVLV SSRFVRLSWR 450
    PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF 500
    RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLHAVSTS PTSILITWEP 550
    PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYTLRFLA 600
    YNRYGPGVST DDITVVTLSD VPSAPPQNIS LEVVNSRSIK VSWLPPPSGT 650
    QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT 700
    VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN 750
    PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN 800
    NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSGPDV STPMLPPVGV 850
    QAVALTHEAV RVSWADNSVP KNQKTSDVRL YTVRWRTSFS ASAKYKSEDT 900
    TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD 950
    LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI 1000
    SGDRLTHQIM DLSLDTMYYF RIQARNVKGV GPLSDPILFR TLKVEHPDKM 1050
    ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV 1100
    ITVVTVGVLT VLVVVIVAVI CTRRSSAQQR KKRATHSVSK RKGSQKDLRP 1150
    PDLWIHHEEM EMKNIEKPTG TDPAGRDSPI QSCQDLTPVS HSQSETQMGS 1200
    KSASHSGQDT EDAGSSMSTL ERSLAARRAT RAKLMIPMEA QSSNPAVVSA 1250
    IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRTQS 1300
    VSEGPTTQQQ PMLPPAQPEH PSSEEAPSRT IPTACVRPTH PLRSFANPLL 1350
    PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP 1400
    TAPEVSEESH KPTEDPASVY EQDDLSEQMA SLEGLMKQLN AITGSAF 1447
    Length:1,447
    Mass (Da):158,341
    Last modified:October 3, 2012 - v2
    Checksum:iF905BE27C991EA42
    GO
    Isoform C (identifier: P70211-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         819-838: Missing.

    Show »
    Length:1,427
    Mass (Da):156,135
    Checksum:iCEF2CE39FE115F9B
    GO
    Isoform B (identifier: P70211-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-84: Missing.

    Note: Produced by alternative initiation at Met-85 of isoform A.

    Show »
    Length:1,363
    Mass (Da):149,345
    Checksum:i0B1075107D6A1DBC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1138 – 11381V → G in CAA59786. (PubMed:8570174)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8484Missing in isoform B. 1 PublicationVSP_018807Add
    BLAST
    Alternative sequencei819 – 83820Missing in isoform C. 1 PublicationVSP_002501Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85788 mRNA. Translation: CAA59786.1.
    AC105957 Genomic DNA. No translation available.
    AC107230 Genomic DNA. No translation available.
    AC109179 Genomic DNA. No translation available.
    AC109499 Genomic DNA. No translation available.
    AC121523 Genomic DNA. No translation available.
    AC136637 Genomic DNA. No translation available.
    AC161177 Genomic DNA. No translation available.
    AC163492 Genomic DNA. No translation available.
    AC167547 Genomic DNA. No translation available.
    AC167548 Genomic DNA. No translation available.
    AC167549 Genomic DNA. No translation available.
    CH466528 Genomic DNA. Translation: EDL09563.1.
    CCDSiCCDS29336.1. [P70211-1]
    RefSeqiNP_031857.2. NM_007831.3. [P70211-1]
    XP_006525651.1. XM_006525588.1. [P70211-2]
    UniGeneiMm.167882.

    Genome annotation databases

    EnsembliENSMUST00000073379; ENSMUSP00000073094; ENSMUSG00000060534. [P70211-2]
    ENSMUST00000114943; ENSMUSP00000110593; ENSMUSG00000060534. [P70211-1]
    GeneIDi13176.
    KEGGimmu:13176.
    UCSCiuc008fop.1. mouse.

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X85788 mRNA. Translation: CAA59786.1 .
    AC105957 Genomic DNA. No translation available.
    AC107230 Genomic DNA. No translation available.
    AC109179 Genomic DNA. No translation available.
    AC109499 Genomic DNA. No translation available.
    AC121523 Genomic DNA. No translation available.
    AC136637 Genomic DNA. No translation available.
    AC161177 Genomic DNA. No translation available.
    AC163492 Genomic DNA. No translation available.
    AC167547 Genomic DNA. No translation available.
    AC167548 Genomic DNA. No translation available.
    AC167549 Genomic DNA. No translation available.
    CH466528 Genomic DNA. Translation: EDL09563.1 .
    CCDSi CCDS29336.1. [P70211-1 ]
    RefSeqi NP_031857.2. NM_007831.3. [P70211-1 ]
    XP_006525651.1. XM_006525588.1. [P70211-2 ]
    UniGenei Mm.167882.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3PZD X-ray 2.50 B 1410-1445 [» ]
    4PLO X-ray 2.90 B 721-942 [» ]
    ProteinModelPortali P70211.
    SMRi P70211. Positions 39-818, 833-1047, 1410-1445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-46587N.
    IntActi P70211. 11 interactions.
    MINTi MINT-4996953.
    STRINGi 10090.ENSMUSP00000110593.

    PTM databases

    PhosphoSitei P70211.

    Proteomic databases

    PaxDbi P70211.
    PRIDEi P70211.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073379 ; ENSMUSP00000073094 ; ENSMUSG00000060534 . [P70211-2 ]
    ENSMUST00000114943 ; ENSMUSP00000110593 ; ENSMUSG00000060534 . [P70211-1 ]
    GeneIDi 13176.
    KEGGi mmu:13176.
    UCSCi uc008fop.1. mouse.

    Organism-specific databases

    CTDi 1630.
    MGIi MGI:94869. Dcc.

    Phylogenomic databases

    eggNOGi NOG249790.
    GeneTreei ENSGT00730000110320.
    HOGENOMi HOG000230686.
    HOVERGENi HBG005455.
    InParanoidi P70211.
    KOi K06765.
    OMAi WGPGESS.
    OrthoDBi EOG7RRF65.
    TreeFami TF321506.

    Miscellaneous databases

    NextBioi 283280.
    PROi P70211.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_DCC.
    Genevestigatori P70211.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR010560. Neogenin_C.
    [Graphical view ]
    Pfami PF00041. fn3. 6 hits.
    PF07679. I-set. 3 hits.
    PF06583. Neogenin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 6 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 4 hits.
    PROSITEi PS50853. FN3. 6 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the mouse homologue of the deleted in colorectal cancer gene (mDCC) and its expression in the developing mouse embryo."
      Cooper H.M., Armes P., Britto J., Gad J., Wilks A.F.
      Oncogene 11:2243-2254(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
      Strain: BALB/c.
      Tissue: Brain.
    2. Cooper H.M.
      Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "Activation of FAK and Src are receptor-proximal events required for netrin signaling."
      Li W., Lee J., Vikis H.G., Lee S.H., Liu G., Aurandt J., Shen T.L., Fearon E.R., Guan J.L., Han M., Rao Y., Hong K., Guan K.L.
      Nat. Neurosci. 7:1213-1221(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PTK2/FAK1.
    6. "DSCAM is a netrin receptor that collaborates with DCC in mediating turning responses to netrin-1."
      Ly A., Nikolaev A., Suresh G., Zheng Y., Tessier-Lavigne M., Stein E.
      Cell 133:1241-1254(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DSCAM.
    7. "The Cbln family of proteins interact with multiple signaling pathways."
      Wei P., Pattarini R., Rong Y., Guo H., Bansal P.K., Kusnoor S.V., Deutch A.Y., Parris J., Morgan J.I.
      J. Neurochem. 121:717-729(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CBLN4.
    8. "Cargo recognition mechanism of myosin X revealed by the structure of its tail MyTH4-FERM tandem in complex with the DCC P3 domain."
      Wei Z., Yan J., Lu Q., Pan L., Zhang M.
      Proc. Natl. Acad. Sci. U.S.A. 108:3572-3577(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1410-1445 IN COMPLEX WITH MYO10.

    Entry informationi

    Entry nameiDCC_MOUSE
    AccessioniPrimary (citable) accession number: P70211
    Secondary accession number(s): G3X9X6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 139 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3