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P70210

- TEAD3_MOUSE

UniProt

P70210 - TEAD3_MOUSE

Protein

Transcriptional enhancer factor TEF-5

Gene

Tead3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi30 – 9768TEAPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. hippo signaling Source: InterPro
    2. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional enhancer factor TEF-5
    Alternative name(s):
    DTEF-1
    ETF-related factor 1
    Short name:
    ETFR-1
    TEA domain family member 3
    Short name:
    TEAD-3
    Gene namesi
    Name:Tead3
    Synonyms:Tcf13r2, Tef5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:109241. Tead3.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 439438Transcriptional enhancer factor TEF-5PRO_0000205935Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiP70210.

    PTM databases

    PhosphoSiteiP70210.

    Expressioni

    Tissue specificityi

    Expressed in embryos as well as in many adult tissues.

    Gene expression databases

    CleanExiMM_TEAD3.
    GenevestigatoriP70210.

    Interactioni

    Subunit structurei

    Interacts with YAP1 and WWTR1/TAZ.By similarity

    Protein-protein interaction databases

    BioGridi204100. 2 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliP70210.
    SMRiP70210. Positions 27-104, 222-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni173 – 439267Transcriptional activationSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi146 – 21772Pro-richAdd
    BLAST
    Compositional biasi156 – 1594Poly-Ser

    Sequence similaritiesi

    Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG246992.
    HOVERGENiHBG056905.
    KOiK09448.

    Family and domain databases

    InterProiIPR000818. TEA/ATTS.
    IPR016361. TEF.
    IPR027253. TEF-5.
    [Graphical view]
    PANTHERiPTHR11834. PTHR11834. 1 hit.
    PfamiPF01285. TEA. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002603. TEF. 1 hit.
    PIRSF500720. TEF-5. 1 hit.
    PRINTSiPR00065. TEADOMAIN.
    SMARTiSM00426. TEA. 1 hit.
    [Graphical view]
    PROSITEiPS00554. TEA_1. 1 hit.
    PS51088. TEA_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70210-1 [UniParc]FASTAAdd to Basket

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    MASNSWTANS SPGEAREDGS EGLDKGLDND AEGVWSPDIE QSFQEALAIY    50
    PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK 100
    KVREYQVGIK AMNLDQVSKD KALQSMASMS SAQIVSASVL QNKFSPPSPL 150
    PQAVFSSSSR FWSSPPLLGQ QPGPSQDIKP FAQPAYPIQP PLPPALNSYE 200
    SLAPLPPAAA SATASAPAWQ DRTIASSRLR LLEYSAFMEV QRDPDTYSKH 250
    LFVHIGQTNP AFSDPPLEAV DVRQIYDKFP EKKGGLKELY EKGPPNAFFL 300
    VKFWADLNST IQEGPGAFYG VSSQYSSADS MTISVSTKVC SFGKQVVEKV 350
    ETEYARLENG RFVYRIHRSP MCEYMINFIH KLKHLPEKYM MNSVLENFTI 400
    LQVVTSRDSQ ETLLVIAFVF EVSTSEHGAQ HHVYKLVKD 439
    Length:439
    Mass (Da):48,938
    Last modified:November 1, 1997 - v2
    Checksum:iC042B19A113A7A40
    GO

    Sequence cautioni

    The sequence AAC12263.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.
    The sequence BAA13517.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.
    The sequence CAA71136.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.
    The sequence CAA71136.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti87 – 871R → G.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87964 mRNA. Translation: BAA13517.1. Sequence problems.
    D87963 mRNA. Translation: BAA13516.1.
    Y10027 mRNA. Translation: CAA71136.1. Sequence problems.
    AF002670 mRNA. Translation: AAC12263.1. Sequence problems.
    Y16611 mRNA. Translation: CAA76315.2.
    CCDSiCCDS28577.3.
    RefSeqiNP_001091696.2. NM_001098226.3.
    NP_001191085.1. NM_001204156.1.
    NP_035696.3. NM_011566.4.
    UniGeneiMm.6655.

    Genome annotation databases

    GeneIDi21678.
    KEGGimmu:21678.
    UCSCiuc008bqr.2. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87964 mRNA. Translation: BAA13517.1 . Sequence problems.
    D87963 mRNA. Translation: BAA13516.1 .
    Y10027 mRNA. Translation: CAA71136.1 . Sequence problems.
    AF002670 mRNA. Translation: AAC12263.1 . Sequence problems.
    Y16611 mRNA. Translation: CAA76315.2 .
    CCDSi CCDS28577.3.
    RefSeqi NP_001091696.2. NM_001098226.3.
    NP_001191085.1. NM_001204156.1.
    NP_035696.3. NM_011566.4.
    UniGenei Mm.6655.

    3D structure databases

    ProteinModelPortali P70210.
    SMRi P70210. Positions 27-104, 222-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204100. 2 interactions.

    PTM databases

    PhosphoSitei P70210.

    Proteomic databases

    PRIDEi P70210.

    Protocols and materials databases

    DNASUi 21678.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 21678.
    KEGGi mmu:21678.
    UCSCi uc008bqr.2. mouse.

    Organism-specific databases

    CTDi 7005.
    MGIi MGI:109241. Tead3.

    Phylogenomic databases

    eggNOGi NOG246992.
    HOVERGENi HBG056905.
    KOi K09448.

    Miscellaneous databases

    NextBioi 300976.
    PROi P70210.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_TEAD3.
    Genevestigatori P70210.

    Family and domain databases

    InterProi IPR000818. TEA/ATTS.
    IPR016361. TEF.
    IPR027253. TEF-5.
    [Graphical view ]
    PANTHERi PTHR11834. PTHR11834. 1 hit.
    Pfami PF01285. TEA. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002603. TEF. 1 hit.
    PIRSF500720. TEF-5. 1 hit.
    PRINTSi PR00065. TEADOMAIN.
    SMARTi SM00426. TEA. 1 hit.
    [Graphical view ]
    PROSITEi PS00554. TEA_1. 1 hit.
    PS51088. TEA_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns."
      Yasunami M., Suzuki K., Ohkubo H.
      Biochem. Biophys. Res. Commun. 228:365-370(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: FVB/N and ICR X Swiss Webster.
      Tissue: Embryo.
    2. Kaneko K.J., DePamphilis M.L.
      Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Carcinoma.
    3. "cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the TEA/ATTS family of transcription factors."
      Yockey C.E., Shimizu N.
      DNA Cell Biol. 17:187-196(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: NIH Swiss.
      Tissue: Heart.
    4. "Differential expression of the TEF family of transcription factors in the murine placenta and during differentation of primary human trophoblasts in vitro."
      Jacquemin P., Sapin V., Alsat E., Evain-Brion D., Dolle P., Davidson I.
      Dev. Dyn. 212:423-436(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.

    Entry informationi

    Entry nameiTEAD3_MOUSE
    AccessioniPrimary (citable) accession number: P70210
    Secondary accession number(s): O08516, O70623, P70209
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3