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Protein

Transcriptional enhancer factor TEF-5

Gene

Tead3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 104TEAPROSITE-ProRule annotationAdd BLAST77

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-5
Alternative name(s):
DTEF-1
ETF-related factor 1
Short name:
ETFR-1
TEA domain family member 3
Short name:
TEAD-3
Gene namesi
Name:Tead3
Synonyms:Tcf13r2, Tef5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:109241 Tead3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002059352 – 439Transcriptional enhancer factor TEF-5Add BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei148PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP70210
PaxDbiP70210
PRIDEiP70210

PTM databases

iPTMnetiP70210
PhosphoSitePlusiP70210

Expressioni

Tissue specificityi

Expressed in embryos as well as in many adult tissues.

Gene expression databases

CleanExiMM_TEAD3
ExpressionAtlasiP70210 baseline and differential

Interactioni

Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204100, 2 interactors
CORUMiP70210
STRINGi10090.ENSMUSP00000110447

Structurei

3D structure databases

ProteinModelPortaliP70210
SMRiP70210
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 439Transcriptional activationSequence analysisAdd BLAST267

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi146 – 217Pro-richAdd BLAST72
Compositional biasi156 – 159Poly-Ser4

Phylogenomic databases

eggNOGiKOG3841 Eukaryota
ENOG410XQMP LUCA
GeneTreeiENSGT00390000008670
HOVERGENiHBG056905
InParanoidiP70210
KOiK09448

Family and domain databases

Gene3Di1.10.10.1610, 1 hit
InterProiView protein in InterPro
IPR000818 TEA/ATTS_dom
IPR038096 TEA/ATTS_sf
IPR027253 TEF-5
IPR016361 TEF_metazoa
PfamiView protein in Pfam
PF01285 TEA, 1 hit
PIRSFiPIRSF002603 TEF, 1 hit
PIRSF500720 TEF-5, 1 hit
PRINTSiPR00065 TEADOMAIN
SMARTiView protein in SMART
SM00426 TEA, 1 hit
PROSITEiView protein in PROSITE
PS00554 TEA_1, 1 hit
PS51088 TEA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNSWTANS SPGEAREDGS EGLDKGLDND AEGVWSPDIE QSFQEALAIY
60 70 80 90 100
PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK
110 120 130 140 150
KVREYQVGIK AMNLDQVSKD KALQSMASMS SAQIVSASVL QNKFSPPSPL
160 170 180 190 200
PQAVFSSSSR FWSSPPLLGQ QPGPSQDIKP FAQPAYPIQP PLPPALNSYE
210 220 230 240 250
SLAPLPPAAA SATASAPAWQ DRTIASSRLR LLEYSAFMEV QRDPDTYSKH
260 270 280 290 300
LFVHIGQTNP AFSDPPLEAV DVRQIYDKFP EKKGGLKELY EKGPPNAFFL
310 320 330 340 350
VKFWADLNST IQEGPGAFYG VSSQYSSADS MTISVSTKVC SFGKQVVEKV
360 370 380 390 400
ETEYARLENG RFVYRIHRSP MCEYMINFIH KLKHLPEKYM MNSVLENFTI
410 420 430
LQVVTSRDSQ ETLLVIAFVF EVSTSEHGAQ HHVYKLVKD
Length:439
Mass (Da):48,938
Last modified:November 1, 1997 - v2
Checksum:iC042B19A113A7A40
GO

Sequence cautioni

The sequence AAC12263 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence BAA13517 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence CAA71136 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence CAA71136 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti87R → G. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87964 mRNA Translation: BAA13517.1 Sequence problems.
D87963 mRNA Translation: BAA13516.1
Y10027 mRNA Translation: CAA71136.1 Sequence problems.
AF002670 mRNA Translation: AAC12263.1 Sequence problems.
Y16611 mRNA Translation: CAA76315.2
CCDSiCCDS28577.3
RefSeqiNP_001091696.2, NM_001098226.3
NP_001191085.1, NM_001204156.1
NP_035696.3, NM_011566.4
UniGeneiMm.6655

Genome annotation databases

EnsembliENSMUST00000219703; ENSMUSP00000152030; ENSMUSG00000002249
GeneIDi21678
KEGGimmu:21678
UCSCiuc008bqr.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTEAD3_MOUSE
AccessioniPrimary (citable) accession number: P70210
Secondary accession number(s): O08516, O70623, P70209
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: March 28, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health