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P70210 (TEAD3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional enhancer factor TEF-5
Alternative name(s):
DTEF-1
ETF-related factor 1
Short name=ETFR-1
TEA domain family member 3
Short name=TEAD-3
Gene names
Name:Tead3
Synonyms:Tcf13r2, Tef5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction By similarity.

Subunit structure

Interacts with YAP1 and WWTR1/TAZ By similarity.

Subcellular location

Nucleus.

Tissue specificity

Expressed in embryos as well as in many adult tissues.

Sequence similarities

Contains 1 TEA DNA-binding domain.

Sequence caution

The sequence AAC12263.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.

The sequence BAA13517.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.

The sequence CAA71136.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence CAA71136.1 differs from that shown. Reason: Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 439438Transcriptional enhancer factor TEF-5
PRO_0000205935

Regions

DNA binding30 – 9768TEA
Region173 – 439267Transcriptional activation Potential
Compositional bias146 – 21772Pro-rich
Compositional bias156 – 1594Poly-Ser

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Natural variations

Natural variant871R → G.

Sequences

Sequence LengthMass (Da)Tools
P70210 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: C042B19A113A7A40

FASTA43948,938
        10         20         30         40         50         60 
MASNSWTANS SPGEAREDGS EGLDKGLDND AEGVWSPDIE QSFQEALAIY PPCGRRKIIL 

        70         80         90        100        110        120 
SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK KVREYQVGIK AMNLDQVSKD 

       130        140        150        160        170        180 
KALQSMASMS SAQIVSASVL QNKFSPPSPL PQAVFSSSSR FWSSPPLLGQ QPGPSQDIKP 

       190        200        210        220        230        240 
FAQPAYPIQP PLPPALNSYE SLAPLPPAAA SATASAPAWQ DRTIASSRLR LLEYSAFMEV 

       250        260        270        280        290        300 
QRDPDTYSKH LFVHIGQTNP AFSDPPLEAV DVRQIYDKFP EKKGGLKELY EKGPPNAFFL 

       310        320        330        340        350        360 
VKFWADLNST IQEGPGAFYG VSSQYSSADS MTISVSTKVC SFGKQVVEKV ETEYARLENG 

       370        380        390        400        410        420 
RFVYRIHRSP MCEYMINFIH KLKHLPEKYM MNSVLENFTI LQVVTSRDSQ ETLLVIAFVF 

       430 
EVSTSEHGAQ HHVYKLVKD 

« Hide

References

[1]"A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns."
Yasunami M., Suzuki K., Ohkubo H.
Biochem. Biophys. Res. Commun. 228:365-370(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: FVB/N and ICR X Swiss Webster.
Tissue: Embryo.
[2]Kaneko K.J., DePamphilis M.L.
Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Carcinoma.
[3]"cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the TEA/ATTS family of transcription factors."
Yockey C.E., Shimizu N.
DNA Cell Biol. 17:187-196(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: NIH Swiss.
Tissue: Heart.
[4]"Differential expression of the TEF family of transcription factors in the murine placenta and during differentation of primary human trophoblasts in vitro."
Jacquemin P., Sapin V., Alsat E., Evain-Brion D., Dolle P., Davidson I.
Dev. Dyn. 212:423-436(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87964 mRNA. Translation: BAA13517.1. Sequence problems.
D87963 mRNA. Translation: BAA13516.1.
Y10027 mRNA. Translation: CAA71136.1. Sequence problems.
AF002670 mRNA. Translation: AAC12263.1. Sequence problems.
Y16611 mRNA. Translation: CAA76315.2.
CCDSCCDS28577.3.
RefSeqNP_001091696.2. NM_001098226.3.
NP_001191085.1. NM_001204156.1.
NP_035696.3. NM_011566.4.
UniGeneMm.6655.

3D structure databases

ProteinModelPortalP70210.
SMRP70210. Positions 27-104, 222-438.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204100. 2 interactions.

PTM databases

PhosphoSiteP70210.

Proteomic databases

PRIDEP70210.

Protocols and materials databases

DNASU21678.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID21678.
KEGGmmu:21678.
UCSCuc008bqr.2. mouse.

Organism-specific databases

CTD7005.
MGIMGI:109241. Tead3.

Phylogenomic databases

eggNOGNOG246992.
HOVERGENHBG056905.
KOK09448.

Gene expression databases

CleanExMM_TEAD3.
GenevestigatorP70210.

Family and domain databases

InterProIPR000818. TEA/ATTS.
IPR016361. TEF.
IPR027253. TEF-5.
[Graphical view]
PANTHERPTHR11834. PTHR11834. 1 hit.
PfamPF01285. TEA. 1 hit.
[Graphical view]
PIRSFPIRSF002603. TEF. 1 hit.
PIRSF500720. TEF-5. 1 hit.
PRINTSPR00065. TEADOMAIN.
SMARTSM00426. TEA. 1 hit.
[Graphical view]
PROSITEPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio300976.
PROP70210.
SOURCESearch...

Entry information

Entry nameTEAD3_MOUSE
AccessionPrimary (citable) accession number: P70210
Secondary accession number(s): O08516, O70623, P70209
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot