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Protein

Transcriptional enhancer factor TEF-5

Gene

Tead3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi30 – 9768TEAPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • hippo signaling Source: MGI
  • positive regulation of stem cell maintenance Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional enhancer factor TEF-5
Alternative name(s):
DTEF-1
ETF-related factor 1
Short name:
ETFR-1
TEA domain family member 3
Short name:
TEAD-3
Gene namesi
Name:Tead3
Synonyms:Tcf13r2, Tef5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109241. Tead3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB-SubCell
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 439438Transcriptional enhancer factor TEF-5PRO_0000205935Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiP70210.

PTM databases

PhosphoSiteiP70210.

Expressioni

Tissue specificityi

Expressed in embryos as well as in many adult tissues.

Gene expression databases

CleanExiMM_TEAD3.
GenevisibleiP70210. MM.

Interactioni

Subunit structurei

Interacts with YAP1 and WWTR1/TAZ.By similarity

Protein-protein interaction databases

BioGridi204100. 2 interactions.
STRINGi10090.ENSMUSP00000110447.

Structurei

3D structure databases

ProteinModelPortaliP70210.
SMRiP70210. Positions 27-104, 222-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni173 – 439267Transcriptional activationSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi146 – 21772Pro-richAdd
BLAST
Compositional biasi156 – 1594Poly-Ser

Sequence similaritiesi

Contains 1 TEA DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG246992.
HOVERGENiHBG056905.
InParanoidiP70210.
KOiK09448.

Family and domain databases

InterProiIPR000818. TEA/ATTS.
IPR027253. TEF-5.
IPR016361. TEF_metazoa.
[Graphical view]
PANTHERiPTHR11834. PTHR11834. 1 hit.
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PIRSFiPIRSF002603. TEF. 1 hit.
PIRSF500720. TEF-5. 1 hit.
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70210-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASNSWTANS SPGEAREDGS EGLDKGLDND AEGVWSPDIE QSFQEALAIY
60 70 80 90 100
PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV SSHIQVLARK
110 120 130 140 150
KVREYQVGIK AMNLDQVSKD KALQSMASMS SAQIVSASVL QNKFSPPSPL
160 170 180 190 200
PQAVFSSSSR FWSSPPLLGQ QPGPSQDIKP FAQPAYPIQP PLPPALNSYE
210 220 230 240 250
SLAPLPPAAA SATASAPAWQ DRTIASSRLR LLEYSAFMEV QRDPDTYSKH
260 270 280 290 300
LFVHIGQTNP AFSDPPLEAV DVRQIYDKFP EKKGGLKELY EKGPPNAFFL
310 320 330 340 350
VKFWADLNST IQEGPGAFYG VSSQYSSADS MTISVSTKVC SFGKQVVEKV
360 370 380 390 400
ETEYARLENG RFVYRIHRSP MCEYMINFIH KLKHLPEKYM MNSVLENFTI
410 420 430
LQVVTSRDSQ ETLLVIAFVF EVSTSEHGAQ HHVYKLVKD
Length:439
Mass (Da):48,938
Last modified:November 1, 1997 - v2
Checksum:iC042B19A113A7A40
GO

Sequence cautioni

The sequence AAC12263.1 differs from that shown.Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence BAA13517.1 differs from that shown.Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence CAA71136.1 differs from that shown.Unusual initiator. The initiator methionine is coded by a non-canonical ATA isoleucine codon.Curated
The sequence CAA71136.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti87 – 871R → G.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87964 mRNA. Translation: BAA13517.1. Sequence problems.
D87963 mRNA. Translation: BAA13516.1.
Y10027 mRNA. Translation: CAA71136.1. Sequence problems.
AF002670 mRNA. Translation: AAC12263.1. Sequence problems.
Y16611 mRNA. Translation: CAA76315.2.
CCDSiCCDS28577.3.
RefSeqiNP_001091696.2. NM_001098226.3.
NP_001191085.1. NM_001204156.1.
NP_035696.3. NM_011566.4.
UniGeneiMm.6655.

Genome annotation databases

GeneIDi21678.
KEGGimmu:21678.
UCSCiuc008bqr.2. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87964 mRNA. Translation: BAA13517.1. Sequence problems.
D87963 mRNA. Translation: BAA13516.1.
Y10027 mRNA. Translation: CAA71136.1. Sequence problems.
AF002670 mRNA. Translation: AAC12263.1. Sequence problems.
Y16611 mRNA. Translation: CAA76315.2.
CCDSiCCDS28577.3.
RefSeqiNP_001091696.2. NM_001098226.3.
NP_001191085.1. NM_001204156.1.
NP_035696.3. NM_011566.4.
UniGeneiMm.6655.

3D structure databases

ProteinModelPortaliP70210.
SMRiP70210. Positions 27-104, 222-438.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204100. 2 interactions.
STRINGi10090.ENSMUSP00000110447.

PTM databases

PhosphoSiteiP70210.

Proteomic databases

PRIDEiP70210.

Protocols and materials databases

DNASUi21678.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi21678.
KEGGimmu:21678.
UCSCiuc008bqr.2. mouse.

Organism-specific databases

CTDi7005.
MGIiMGI:109241. Tead3.

Phylogenomic databases

eggNOGiNOG246992.
HOVERGENiHBG056905.
InParanoidiP70210.
KOiK09448.

Miscellaneous databases

ChiTaRSiTead3. mouse.
NextBioi300976.
PROiP70210.
SOURCEiSearch...

Gene expression databases

CleanExiMM_TEAD3.
GenevisibleiP70210. MM.

Family and domain databases

InterProiIPR000818. TEA/ATTS.
IPR027253. TEF-5.
IPR016361. TEF_metazoa.
[Graphical view]
PANTHERiPTHR11834. PTHR11834. 1 hit.
PfamiPF01285. TEA. 1 hit.
[Graphical view]
PIRSFiPIRSF002603. TEF. 1 hit.
PIRSF500720. TEF-5. 1 hit.
PRINTSiPR00065. TEADOMAIN.
SMARTiSM00426. TEA. 1 hit.
[Graphical view]
PROSITEiPS00554. TEA_1. 1 hit.
PS51088. TEA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel family of TEA domain-containing transcription factors with distinct spatiotemporal expression patterns."
    Yasunami M., Suzuki K., Ohkubo H.
    Biochem. Biophys. Res. Commun. 228:365-370(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: FVB/N and ICR X Swiss Webster.
    Tissue: Embryo.
  2. Kaneko K.J., DePamphilis M.L.
    Submitted (DEC-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Carcinoma.
  3. "cDNA cloning and characterization of mouse DTEF-1 and ETF, members of the TEA/ATTS family of transcription factors."
    Yockey C.E., Shimizu N.
    DNA Cell Biol. 17:187-196(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: NIH Swiss.
    Tissue: Heart.
  4. "Differential expression of the TEF family of transcription factors in the murine placenta and during differentation of primary human trophoblasts in vitro."
    Jacquemin P., Sapin V., Alsat E., Evain-Brion D., Dolle P., Davidson I.
    Dev. Dyn. 212:423-436(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.

Entry informationi

Entry nameiTEAD3_MOUSE
AccessioniPrimary (citable) accession number: P70210
Secondary accession number(s): O08516, O70623, P70209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: June 24, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.