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P70208

- PLXA3_MOUSE

UniProt

P70208 - PLXA3_MOUSE

Protein

Plexin-A3

Gene

Plxna3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.6 Publications

    GO - Molecular functioni

    1. semaphorin receptor activity Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: MGI
    2. branchiomotor neuron axon guidance Source: ParkinsonsUK-UCL
    3. facial nerve structural organization Source: ParkinsonsUK-UCL
    4. hippocampus development Source: MGI
    5. negative chemotaxis Source: MGI
    6. negative regulation of axon extension involved in axon guidance Source: MGI
    7. positive regulation of cytoskeleton organization Source: UniProtKB
    8. pyramidal neuron development Source: MGI
    9. semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCL
    10. trigeminal nerve structural organization Source: ParkinsonsUK-UCL

    Keywords - Molecular functioni

    Receptor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plexin-A3
    Gene namesi
    Name:Plxna3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:107683. Plxna3.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. intracellular Source: InterPro
    3. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype, but causes subtle changes in the central nervous system. Mice exhibit altered apical dendrite spine morphology in pyramidal neurons. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. The number of neurons in the dorsal root ganglion is higher than normal, probably due to reduced neuronal apoptosis. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro).5 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1279 – 12791L → R: Strongly reduced response to semaphorin. 1 Publication
    Mutagenesisi1300 – 13001Y → A: Almost abolishes response to semaphorin. 1 Publication
    Mutagenesisi1309 – 13091F → A: Almost abolishes response to semaphorin. 1 Publication
    Mutagenesisi1407 – 14082RR → AA: Abolishes response to semaphorin.
    Mutagenesisi1453 – 14531I → R: Abolishes response to semaphorin. 1 Publication
    Mutagenesisi1464 – 14641L → G: Almost abolishes response to semaphorin. 1 Publication
    Mutagenesisi1506 – 15061Q → A: Abolishes response to semaphorin. 1 Publication
    Mutagenesisi1631 – 16322HL → AA: Abolishes response to semaphorin.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 18721853Plexin-A3PRO_0000411104Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi78 ↔ 87PROSITE-ProRule annotation
    Disulfide bondi113 ↔ 121PROSITE-ProRule annotation
    Disulfide bondi267 ↔ 388PROSITE-ProRule annotation
    Disulfide bondi283 ↔ 339PROSITE-ProRule annotation
    Disulfide bondi357 ↔ 376PROSITE-ProRule annotation
    Disulfide bondi492 ↔ 509PROSITE-ProRule annotation
    Disulfide bondi498 ↔ 540PROSITE-ProRule annotation
    Disulfide bondi501 ↔ 518PROSITE-ProRule annotation
    Disulfide bondi512 ↔ 524PROSITE-ProRule annotation
    Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi575 ↔ 595PROSITE-ProRule annotation
    Glycosylationi1163 – 11631N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP70208.

    Expressioni

    Tissue specificityi

    Detected in embryonic hindbrain, spinal cord, dorsal root ganglion, trigeminal ganglion and superior cervical ganglion. In newborns, detected throughout all layers of the hippocampus.3 Publications

    Gene expression databases

    BgeeiP70208.
    GenevestigatoriP70208.

    Interactioni

    Protein-protein interaction databases

    DIPiDIP-48959N.
    STRINGi10090.ENSMUSP00000004326.

    Structurei

    Secondary structure

    1
    1872
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1248 – 128639
    Helixi1300 – 13089
    Helixi1316 – 13183
    Helixi1325 – 133713
    Helixi1341 – 135212
    Helixi1359 – 137214
    Helixi1374 – 13763
    Helixi1377 – 139721
    Turni1403 – 14075
    Helixi1412 – 142413
    Helixi1426 – 14316
    Helixi1434 – 144815
    Turni1455 – 14573
    Helixi1466 – 14683
    Beta strandi1478 – 14847
    Turni1486 – 14883
    Beta strandi1493 – 14997
    Helixi1504 – 151512
    Turni1516 – 15183
    Helixi1521 – 15233
    Helixi1527 – 15293
    Beta strandi1530 – 15367
    Beta strandi1541 – 15444
    Beta strandi1546 – 15483
    Beta strandi1557 – 15593
    Turni1563 – 15675
    Beta strandi1573 – 15786
    Beta strandi1628 – 16325
    Helixi1653 – 167725
    Helixi1682 – 16843
    Helixi1689 – 170315
    Turni1704 – 17063
    Helixi1710 – 172011
    Turni1721 – 17244
    Helixi1725 – 17317
    Helixi1733 – 17353
    Helixi1743 – 175917
    Helixi1773 – 17775
    Turni1778 – 17814
    Helixi1782 – 179817
    Helixi1804 – 181714
    Turni1818 – 18203
    Helixi1824 – 183714
    Helixi1839 – 184810
    Helixi1850 – 18545
    Helixi1857 – 186913

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3IG3X-ray1.99A1247-1872[»]
    ProteinModelPortaliP70208.
    SMRiP70208. Positions 1247-1871.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP70208.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 12201201ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1242 – 1872631CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1221 – 124121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 489470SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini841 – 93494IPT/TIG 1Add
    BLAST
    Domaini936 – 102186IPT/TIG 2Add
    BLAST
    Domaini1024 – 1123100IPT/TIG 3Add
    BLAST
    Domaini1126 – 121287IPT/TIG 4Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1240 – 129455Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the plexin family.Curated
    Contains 4 IPT/TIG domains.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00750000117292.
    HOGENOMiHOG000231377.
    HOVERGENiHBG105711.
    InParanoidiP70208.
    KOiK06820.
    OMAiSHPHECS.
    OrthoDBiEOG7Q8CM9.
    TreeFamiTF312962.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 4 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 3 hits.
    PF01403. Sema. 1 hit.
    PF01833. TIG. 4 hits.
    [Graphical view]
    SMARTiSM00429. IPT. 4 hits.
    SM00423. PSI. 3 hits.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    SSF48350. SSF48350. 2 hits.
    SSF81296. SSF81296. 4 hits.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P70208-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA     50
    VNRVFKLAPN LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL 100
    LLIDYAARRL VACGSIWQGI CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD 150
    SMAGVIVEQV QGPSKLFVGT AVDGKSEYFP TLSSRKLIDD EDSGDMFSLV 200
    YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL TLQLDTQQTL 250
    LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK 300
    PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI 350
    RRRIQSCYRG EGTLALPWLL NKELPCINTP LQINGNFCGL VLNQPLGGLH 400
    VIEGLPLLAD STDGMASVAA YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ 450
    LYETVSVVQG SPILRDLLFS PDHRHIYLLS EKQVSQLPVE TCEQYLSCAA 500
    CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELSKC IQVRVRPNNV 550
    SVTSSGVQLT VAMRNVPDLS VGVSCSFEEV TESEAILLPS GELRCPSPSL 600
    QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG 650
    SPYPCHWCKY RHVCTSHPHE CSFQEGRVHS PEGCPEILPQ GDLLIPVGVM 700
    QPLTLRAKNL PQPQSGQKNY ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY 750
    FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF RALLYKCWAQ RPSCGLCLKA 800
    DPRFNCGWCI SEHRCQLRAH CPAPKSNWMH PSQKGARCSH PRITQIHPLT 850
    GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME 900
    ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTFDR VSPSRGPASG 950
    GTRLTISGIS LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PVSTLGPSQS 1000
    PITLAIDHAN ISNTGVIYTY TQDPTVTHLE PTWSIINGST SITVSGTHLL 1050
    TVQEPRVRAK YRGIETTNTC QVINDTAMLC KAPGIFLGHP QPRAQGEHPD 1100
    EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK PGSHVVLKGK 1150
    NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG 1200
    GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA 1250
    DRTLKRLQLQ MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY 1300
    RTYAVRVLFP GIEAHPVLKE LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT 1350
    LEAQSSFSMR DRGTVASLTM VALQSRLDYA TGLLKQLLAD LIEKNLESKN 1400
    HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL YCAIKQQMEK 1450
    GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN 1500
    CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT 1550
    TKIECDWKRV NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE 1600
    SLLRAASSPD SLRSRAPMLT PDQEAGTKLW HLVRNHDHTD HREGDRGSKM 1650
    VSEIYLTRLL ATKGTLQKFV DDLFETVFST AHRGSALPLA IKYMFDFLDE 1700
    QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH KNSITDACLS 1750
    VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA 1800
    SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA 1850
    SCRKHKLRQK LEQIITLVSS SS 1872
    Length:1,872
    Mass (Da):207,958
    Last modified:July 27, 2011 - v2
    Checksum:i39D57886A0C4830A
    GO
    Isoform 2 (identifier: P70208-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1072-1148: Missing.

    Show »
    Length:1,795
    Mass (Da):199,604
    Checksum:i2E590AF8E22FEBA5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1627 – 16271T → A in BAC33681. (PubMed:16141072)Curated
    Sequence conflicti1861 – 18611L → P in BAA13190. (PubMed:8806646)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1072 – 114877Missing in isoform 2. 1 PublicationVSP_041609Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86950 mRNA. Translation: BAA13190.1.
    BC093482 mRNA. Translation: AAH93482.1.
    AJ748653 mRNA. Translation: CAG38687.1.
    AK049319 mRNA. Translation: BAC33681.1.
    CCDSiCCDS30228.1. [P70208-1]
    PIRiJC4976.
    RefSeqiNP_032909.2. NM_008883.2. [P70208-1]
    XP_006527963.1. XM_006527900.1. [P70208-2]
    UniGeneiMm.1685.

    Genome annotation databases

    EnsembliENSMUST00000004326; ENSMUSP00000004326; ENSMUSG00000031398. [P70208-1]
    GeneIDi18846.
    KEGGimmu:18846.
    UCSCiuc009too.1. mouse. [P70208-1]
    uc012hku.1. mouse. [P70208-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86950 mRNA. Translation: BAA13190.1 .
    BC093482 mRNA. Translation: AAH93482.1 .
    AJ748653 mRNA. Translation: CAG38687.1 .
    AK049319 mRNA. Translation: BAC33681.1 .
    CCDSi CCDS30228.1. [P70208-1 ]
    PIRi JC4976.
    RefSeqi NP_032909.2. NM_008883.2. [P70208-1 ]
    XP_006527963.1. XM_006527900.1. [P70208-2 ]
    UniGenei Mm.1685.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3IG3 X-ray 1.99 A 1247-1872 [» ]
    ProteinModelPortali P70208.
    SMRi P70208. Positions 1247-1871.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-48959N.
    STRINGi 10090.ENSMUSP00000004326.

    Proteomic databases

    PRIDEi P70208.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000004326 ; ENSMUSP00000004326 ; ENSMUSG00000031398 . [P70208-1 ]
    GeneIDi 18846.
    KEGGi mmu:18846.
    UCSCi uc009too.1. mouse. [P70208-1 ]
    uc012hku.1. mouse. [P70208-2 ]

    Organism-specific databases

    CTDi 55558.
    MGIi MGI:107683. Plxna3.

    Phylogenomic databases

    GeneTreei ENSGT00750000117292.
    HOGENOMi HOG000231377.
    HOVERGENi HBG105711.
    InParanoidi P70208.
    KOi K06820.
    OMAi SHPHECS.
    OrthoDBi EOG7Q8CM9.
    TreeFami TF312962.

    Miscellaneous databases

    EvolutionaryTracei P70208.
    NextBioi 295224.
    PROi P70208.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70208.
    Genevestigatori P70208.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 4 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 3 hits.
    PF01403. Sema. 1 hit.
    PF01833. TIG. 4 hits.
    [Graphical view ]
    SMARTi SM00429. IPT. 4 hits.
    SM00423. PSI. 3 hits.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 1 hit.
    SSF48350. SSF48350. 2 hits.
    SSF81296. SSF81296. 4 hits.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Tissue: Embryonic brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    3. "Towards functional annotation of all Xq28 genes: expression and intracellular localization analyses reveal novel candidates for disease genes."
      Kolb-Kokocinski A.A., Mehrle A., Bechtel S., Wellenreuther R., Simpson J., Pepperkok R., Wiemann S., Poustka A.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1116-1560.
      Strain: NMRI.
      Tissue: Embryo.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1138-1872.
      Strain: C57BL/6J.
    5. "Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections."
      Cheng H.J., Bagri A., Yaron A., Stein E., Pleasure S.J., Tessier-Lavigne M.
      Neuron 32:249-263(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
    6. "Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors."
      Waimey K.E., Huang P.H., Chen M., Cheng H.J.
      Dev. Biol. 315:448-458(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    7. "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development."
      Schwarz Q., Waimey K.E., Golding M., Takamatsu H., Kumanogoh A., Fujisawa H., Cheng H.J., Ruhrberg C.
      Dev. Biol. 324:1-9(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
    8. "The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development."
      Ben-Zvi A., Manor O., Schachner M., Yaron A., Tessier-Lavigne M., Behar O.
      J. Neurosci. 28:12427-12432(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    9. "Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS."
      Tran T.S., Rubio M.E., Clem R.L., Johnson D., Case L., Tessier-Lavigne M., Huganir R.L., Ginty D.D., Kolodkin A.L.
      Nature 462:1065-1069(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISRUPTION PHENOTYPE, FUNCTION.
    10. "Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration."
      He H., Yang T., Terman J.R., Zhang X.
      Proc. Natl. Acad. Sci. U.S.A. 106:15610-15615(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 1170-1795, FUNCTION, MUTAGENESIS OF LEU-1279; TYR-1300; PHE-1309; 1407-ARG-ARG-1408; ILE-1453; LEU-1464; GLN-1506 AND 1631-HIS-HIS-1632.

    Entry informationi

    Entry nameiPLXA3_MOUSE
    AccessioniPrimary (citable) accession number: P70208
    Secondary accession number(s): A5D6Q5, Q684J0, Q8BWZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 27, 2011
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3