P70208 (PLXA3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Plexin-A3

Gene names

Name:

Plxna3

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1872 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Ref.5 Ref.6 Ref.7 Ref.8 Ref.9 Ref.10
Subcellular location	Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Detected in embryonic hindbrain, spinal cord, dorsal root ganglion, trigeminal ganglion and superior cervical ganglion. In newborns, detected throughout all layers of the hippocampus. Ref.1 Ref.5 Ref.7
Disruption phenotype	No visible phenotype, but causes subtle changes in the central nervous system. Mice exhibit altered apical dendrite spine morphology in pyramidal neurons. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. The number of neurons in the dorsal root ganglion is higher than normal, probably due to reduced neuronal apoptosis. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro). Ref.5 Ref.6 Ref.7 Ref.8 Ref.9
Sequence similarities	Belongs to the plexin family. Contains 4 IPT/TIG domains. Contains 1 Sema domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Coiled coil Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	axon guidance Inferred from mutant phenotype Ref.5. Source: MGI hippocampus development Inferred from mutant phenotype Ref.5. Source: MGI negative chemotaxis Inferred from genetic interaction Ref.5. Source: MGI negative regulation of axon extension involved in axon guidance Inferred from genetic interaction Ref.5. Source: MGI positive regulation of cytoskeleton organization Inferred from mutant phenotype Ref.10. Source: UniProtKB pyramidal neuron development Inferred from mutant phenotype Ref.5. Source: MGI
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from electronic annotation. Source: InterPro plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	semaphorin receptor activity Inferred from mutant phenotype Ref.10. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P70208-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P70208-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1148: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Potential

Chain

20 – 1872

1853

Plexin-A3

PRO_0000411104

Regions

Topological domain

20 – 1220

1201

Extracellular Potential

Transmembrane

1221 – 1241

21

Helical; Potential

Topological domain

1242 – 1872

631

Cytoplasmic Potential

Domain

20 – 489

470

Sema

Domain

841 – 934

94

IPT/TIG 1

Domain

936 – 1021

86

IPT/TIG 2

Domain

1024 – 1123

100

IPT/TIG 3

Domain

1126 – 1212

87

IPT/TIG 4

Coiled coil

1240 – 1294

55

Potential

Amino acid modifications

Glycosylation

60

1

N-linked (GlcNAc...) Potential

Glycosylation

549

1

N-linked (GlcNAc...) Potential

Glycosylation

1163

1

N-linked (GlcNAc...) Potential

Disulfide bond

78 ↔ 87

By similarity

Disulfide bond

113 ↔ 121

By similarity

Disulfide bond

267 ↔ 388

By similarity

Disulfide bond

283 ↔ 339

By similarity

Disulfide bond

357 ↔ 376

By similarity

Disulfide bond

492 ↔ 509

By similarity

Disulfide bond

498 ↔ 540

By similarity

Disulfide bond

501 ↔ 518

By similarity

Disulfide bond

512 ↔ 524

By similarity

Disulfide bond

575 ↔ 595

By similarity

Natural variations

Alternative sequence

1072 – 1148

77

Missing in isoform 2.

VSP_041609

Experimental info

Mutagenesis

1279

1

L → R: Strongly reduced response to semaphorin. Ref.10

Mutagenesis

1300

1

Y → A: Almost abolishes response to semaphorin. Ref.10

Mutagenesis

1309

1

F → A: Almost abolishes response to semaphorin. Ref.10

Mutagenesis

1407 – 1408

2

RR → AA: Abolishes response to semaphorin.

Mutagenesis

1453

1

I → R: Abolishes response to semaphorin. Ref.10

Mutagenesis

1464

1

L → G: Almost abolishes response to semaphorin. Ref.10

Mutagenesis

1506

1

Q → A: Abolishes response to semaphorin. Ref.10

Mutagenesis

1631 – 1632

2

HL → AA: Abolishes response to semaphorin.

Sequence conflict

1627

1

T → A in BAC33681. Ref.4

Sequence conflict

1861

1

L → P in BAA13190. Ref.1

Secondary structure

1

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1872

Helix Strand Turn

Details...

Helix

1248 – 1286

39

Helix

1300 – 1308

9

Helix

1316 – 1318

3

Helix

1325 – 1337

13

Helix

1341 – 1352

12

Helix

1359 – 1372

14

Helix

1374 – 1376

3

Helix

1377 – 1397

21

Turn

1403 – 1407

5

Helix

1412 – 1424

13

Helix

1426 – 1431

6

Helix

1434 – 1448

15

Turn

1455 – 1457

3

Helix

1466 – 1468

3

Beta strand

1478 – 1484

7

Turn

1486 – 1488

3

Beta strand

1493 – 1499

7

Helix

1504 – 1515

12

Turn

1516 – 1518

3

Helix

1521 – 1523

3

Helix

1527 – 1529

3

Beta strand

1530 – 1536

7

Beta strand

1541 – 1544

4

Beta strand

1546 – 1548

3

Beta strand

1557 – 1559

3

Turn

1563 – 1567

5

Beta strand

1573 – 1578

6

Beta strand

1628 – 1632

5

Helix

1653 – 1677

25

Helix

1682 – 1684

3

Helix

1689 – 1703

15

Turn

1704 – 1706

3

Helix

1710 – 1720

11

Turn

1721 – 1724

4

Helix

1725 – 1731

7

Helix

1733 – 1735

3

Helix

1743 – 1759

17

Helix

1773 – 1777

5

Turn

1778 – 1781

4

Helix

1782 – 1798

17

Helix

1804 – 1817

14

Turn

1818 – 1820

3

Helix

1824 – 1837

14

Helix

1839 – 1848

10

Helix

1850 – 1854

5

Helix

1857 – 1869

13

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 27, 2011. Version 2. Checksum: 39D57886A0C4830A	FASTA	1,872	207,958
	10 20 30 40 50 60 MPTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA VNRVFKLAPN 70 80 90 100 110 120 LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL LLIDYAARRL VACGSIWQGI 130 140 150 160 170 180 CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD SMAGVIVEQV QGPSKLFVGT AVDGKSEYFP 190 200 210 220 230 240 TLSSRKLIDD EDSGDMFSLV YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL 250 260 270 280 290 300 TLQLDTQQTL LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK 310 320 330 340 350 360 PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI RRRIQSCYRG 370 380 390 400 410 420 EGTLALPWLL NKELPCINTP LQINGNFCGL VLNQPLGGLH VIEGLPLLAD STDGMASVAA 430 440 450 460 470 480 YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ LYETVSVVQG SPILRDLLFS PDHRHIYLLS 490 500 510 520 530 540 EKQVSQLPVE TCEQYLSCAA CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELSKC 550 560 570 580 590 600 IQVRVRPNNV SVTSSGVQLT VAMRNVPDLS VGVSCSFEEV TESEAILLPS GELRCPSPSL 610 620 630 640 650 660 QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG SPYPCHWCKY 670 680 690 700 710 720 RHVCTSHPHE CSFQEGRVHS PEGCPEILPQ GDLLIPVGVM QPLTLRAKNL PQPQSGQKNY 730 740 750 760 770 780 ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF 790 800 810 820 830 840 RALLYKCWAQ RPSCGLCLKA DPRFNCGWCI SEHRCQLRAH CPAPKSNWMH PSQKGARCSH 850 860 870 880 890 900 PRITQIHPLT GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME 910 920 930 940 950 960 ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTFDR VSPSRGPASG GTRLTISGIS 970 980 990 1000 1010 1020 LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PVSTLGPSQS PITLAIDHAN ISNTGVIYTY 1030 1040 1050 1060 1070 1080 TQDPTVTHLE PTWSIINGST SITVSGTHLL TVQEPRVRAK YRGIETTNTC QVINDTAMLC 1090 1100 1110 1120 1130 1140 KAPGIFLGHP QPRAQGEHPD EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK 1150 1160 1170 1180 1190 1200 PGSHVVLKGK NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG 1210 1220 1230 1240 1250 1260 GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA DRTLKRLQLQ 1270 1280 1290 1300 1310 1320 MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY RTYAVRVLFP GIEAHPVLKE 1330 1340 1350 1360 1370 1380 LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT LEAQSSFSMR DRGTVASLTM VALQSRLDYA 1390 1400 1410 1420 1430 1440 TGLLKQLLAD LIEKNLESKN HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL 1450 1460 1470 1480 1490 1500 YCAIKQQMEK GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN 1510 1520 1530 1540 1550 1560 CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT TKIECDWKRV 1570 1580 1590 1600 1610 1620 NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE SLLRAASSPD SLRSRAPMLT 1630 1640 1650 1660 1670 1680 PDQEAGTKLW HLVRNHDHTD HREGDRGSKM VSEIYLTRLL ATKGTLQKFV DDLFETVFST 1690 1700 1710 1720 1730 1740 AHRGSALPLA IKYMFDFLDE QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH 1750 1760 1770 1780 1790 1800 KNSITDACLS VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA 1810 1820 1830 1840 1850 1860 SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA SCRKHKLRQK 1870 LEQIITLVSS SS
	Isoform 2 [UniParc]. Checksum: 2E590AF8E22FEBA5	FASTA	1,795	199,604
	10 20 30 40 50 60 MPTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA VNRVFKLAPN 70 80 90 100 110 120 LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL LLIDYAARRL VACGSIWQGI 130 140 150 160 170 180 CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD SMAGVIVEQV QGPSKLFVGT AVDGKSEYFP 190 200 210 220 230 240 TLSSRKLIDD EDSGDMFSLV YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL 250 260 270 280 290 300 TLQLDTQQTL LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK 310 320 330 340 350 360 PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI RRRIQSCYRG 370 380 390 400 410 420 EGTLALPWLL NKELPCINTP LQINGNFCGL VLNQPLGGLH VIEGLPLLAD STDGMASVAA 430 440 450 460 470 480 YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ LYETVSVVQG SPILRDLLFS PDHRHIYLLS 490 500 510 520 530 540 EKQVSQLPVE TCEQYLSCAA CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELSKC 550 560 570 580 590 600 IQVRVRPNNV SVTSSGVQLT VAMRNVPDLS VGVSCSFEEV TESEAILLPS GELRCPSPSL 610 620 630 640 650 660 QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG SPYPCHWCKY 670 680 690 700 710 720 RHVCTSHPHE CSFQEGRVHS PEGCPEILPQ GDLLIPVGVM QPLTLRAKNL PQPQSGQKNY 730 740 750 760 770 780 ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF 790 800 810 820 830 840 RALLYKCWAQ RPSCGLCLKA DPRFNCGWCI SEHRCQLRAH CPAPKSNWMH PSQKGARCSH 850 860 870 880 890 900 PRITQIHPLT GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME 910 920 930 940 950 960 ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTFDR VSPSRGPASG GTRLTISGIS 970 980 990 1000 1010 1020 LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PVSTLGPSQS PITLAIDHAN ISNTGVIYTY 1030 1040 1050 1060 1070 1080 TQDPTVTHLE PTWSIINGST SITVSGTHLL TVQEPRVRAK YRGIETTNTC QGKNLIPAAA 1090 1100 1110 1120 1130 1140 GSSRLNYTVL IGGQPCALTV SDTQLLCDSP SQTGRQPVMV LVGGLEFWLG TLHITADRAL 1150 1160 1170 1180 1190 1200 TLPAMVGLAA GGGLLLLAIT VVLVAYKRKT QDADRTLKRL QLQMDNLESR VALECKEAFA 1210 1220 1230 1240 1250 1260 ELQTDINELT NHMDGVQIPF LDYRTYAVRV LFPGIEAHPV LKELDTPPNV EKALRLFGQL 1270 1280 1290 1300 1310 1320 LHSRAFLLTF IHTLEAQSSF SMRDRGTVAS LTMVALQSRL DYATGLLKQL LADLIEKNLE 1330 1340 1350 1360 1370 1380 SKNHPKLLLR RTESVAEKML TNWFTFLLHK FLKECAGEPL FLLYCAIKQQ MEKGPIDAIT 1390 1400 1410 1420 1430 1440 GEARYSLSED KLIRQQIDYK TLTLHCVCPE SEGSAQVPVK VLNCDSITQA KDKLLDTVYK 1450 1460 1470 1480 1490 1500 GIPYSQRPKA EDMDLEWRQG RMARIILQDE DITTKIECDW KRVNSLAHYQ VTDGSLVALV 1510 1520 1530 1540 1550 1560 PKQVSAYNMA NSFTFTRSLS RYESLLRAAS SPDSLRSRAP MLTPDQEAGT KLWHLVRNHD 1570 1580 1590 1600 1610 1620 HTDHREGDRG SKMVSEIYLT RLLATKGTLQ KFVDDLFETV FSTAHRGSAL PLAIKYMFDF 1630 1640 1650 1660 1670 1680 LDEQADQRQI SDPDVRHTWK SNCLPLRFWV NVIKNPQFVF DIHKNSITDA CLSVVAQTFM 1690 1700 1710 1720 1730 1740 DSCSTSEHRL GKDSPSNKLL YAKDIPNYKS WVERYYRDIA KMASISDQDM DAYLVEQSRL 1750 1760 1770 1780 1790 HANDFNVLSA LSELYFYVTK YRQEILTSLD RDASCRKHKL RQKLEQIITL VSSSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of plexin family molecules in mice." Kameyama T., Murakami Y., Suto F., Kawakami A., Takagi S., Hirata T., Fujisawa H. Biochem. Biophys. Res. Commun. 226:396-402(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY. Tissue: Embryonic brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6. Tissue: Brain.
[3]	"Towards functional annotation of all Xq28 genes: expression and intracellular localization analyses reveal novel candidates for disease genes." Kolb-Kokocinski A.A., Mehrle A., Bechtel S., Wellenreuther R., Simpson J., Pepperkok R., Wiemann S., Poustka A. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1116-1560. Strain: NMRI. Tissue: Embryo.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1138-1872. Strain: C57BL/6J.
[5]	"Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections." Cheng H.J., Bagri A., Yaron A., Stein E., Pleasure S.J., Tessier-Lavigne M. Neuron 32:249-263(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
[6]	"Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors." Waimey K.E., Huang P.H., Chen M., Cheng H.J. Dev. Biol. 315:448-458(2008) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION.
[7]	"Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development." Schwarz Q., Waimey K.E., Golding M., Takamatsu H., Kumanogoh A., Fujisawa H., Cheng H.J., Ruhrberg C. Dev. Biol. 324:1-9(2008) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
[8]	"The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development." Ben-Zvi A., Manor O., Schachner M., Yaron A., Tessier-Lavigne M., Behar O. J. Neurosci. 28:12427-12432(2008) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION.
[9]	"Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS." Tran T.S., Rubio M.E., Clem R.L., Johnson D., Case L., Tessier-Lavigne M., Huganir R.L., Ginty D.D., Kolodkin A.L. Nature 462:1065-1069(2009) [PubMed] [Europe PMC] [Abstract] Cited for: DISRUPTION PHENOTYPE, FUNCTION.
[10]	"Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration." He H., Yang T., Terman J.R., Zhang X. Proc. Natl. Acad. Sci. U.S.A. 106:15610-15615(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 1170-1795, FUNCTION, MUTAGENESIS OF LEU-1279; TYR-1300; PHE-1309; 1407-ARG-ARG-1408; ILE-1453; LEU-1464; GLN-1506 AND 1631-HIS-HIS-1632.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

D86950 mRNA. Translation: BAA13190.1.
BC093482 mRNA. Translation: AAH93482.1.
AJ748653 mRNA. Translation: CAG38687.1.
AK049319 mRNA. Translation: BAC33681.1.

IPI

IPI00137314.
IPI01023183.

PIR

JC4976.

RefSeq

NP_032909.2. NM_008883.2.

UniGene

Mm.1685.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3IG3	X-ray	1.99	A	1247-1872	[»]

ProteinModelPortal

P70208.

SMR

P70208. Positions 1247-1871.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-48959N.

STRING

10090.ENSMUSP00000004326.

Proteomic databases

PRIDE

P70208.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSMUST00000004326; ENSMUSP00000004326; ENSMUSG00000031398.

GeneID

18846.

KEGG

mmu:18846.

UCSC

uc009too.1. mouse.

Organism-specific databases

CTD

55558.

MGI

MGI:107683. Plxna3.

Phylogenomic databases

GeneTree

ENSGT00560000076899.

HOGENOM

HOG000231377.

HOVERGEN

HBG105711.

InParanoid

P70208.

KO

K06820.

Gene expression databases

ArrayExpress

P70208.

Bgee

P70208.

Genevestigator

P70208.

Family and domain databases

Gene3D

2.130.10.10. 1 hit.
2.60.40.10. 4 hits.

InterPro

IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT_TIG_rcpt.
IPR003659. Plexin-like.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semaphorin/CD100_Ag.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]

Pfam

PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]

SMART

SM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]

SUPFAM

SSF81296. Ig_E-set. 4 hits.
SSF103575. Plexin-like_fold. 1 hit.
SSF48350. Rho_GAP. 1 hit.
SSF101912. Sema. 1 hit.

PROSITE

PS51004. SEMA. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P70208.

NextBio

295224.

SOURCE

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Entry information

Entry name

PLXA3_MOUSE

Accession

Primary (citable) accession number: P70208
Secondary accession number(s): A5D6Q5, Q684J0, Q8BWZ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 27, 2011
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 84 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program