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P70208

- PLXA3_MOUSE

UniProt

P70208 - PLXA3_MOUSE

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Protein

Plexin-A3

Gene

Plxna3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.6 Publications

GO - Molecular functioni

  1. semaphorin receptor activity Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: MGI
  2. branchiomotor neuron axon guidance Source: ParkinsonsUK-UCL
  3. facial nerve structural organization Source: ParkinsonsUK-UCL
  4. hippocampus development Source: MGI
  5. negative chemotaxis Source: MGI
  6. negative regulation of axon extension involved in axon guidance Source: MGI
  7. positive regulation of cytoskeleton organization Source: UniProtKB
  8. pyramidal neuron development Source: MGI
  9. semaphorin-plexin signaling pathway involved in axon guidance Source: ParkinsonsUK-UCL
  10. trigeminal nerve structural organization Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A3
Gene namesi
Name:Plxna3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:107683. Plxna3.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. intracellular Source: InterPro
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype, but causes subtle changes in the central nervous system. Mice exhibit altered apical dendrite spine morphology in pyramidal neurons. Mice exhibit defasciculation of the facial branchiomotor nerve and of the ophthalmic branch of the trigeminus, with variable severity. The number of neurons in the dorsal root ganglion is higher than normal, probably due to reduced neuronal apoptosis. In mice lacking both Plxna3 and Plxna4, migrating neurons do not show the normal response to Sema3A and Sema3F and do not migrate away from these semaphorins (in vitro).5 Publications

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1279 – 12791L → R: Strongly reduced response to semaphorin. 1 Publication
Mutagenesisi1300 – 13001Y → A: Almost abolishes response to semaphorin. 1 Publication
Mutagenesisi1309 – 13091F → A: Almost abolishes response to semaphorin. 1 Publication
Mutagenesisi1407 – 14082RR → AA: Abolishes response to semaphorin. 1 Publication
Mutagenesisi1453 – 14531I → R: Abolishes response to semaphorin. 1 Publication
Mutagenesisi1464 – 14641L → G: Almost abolishes response to semaphorin. 1 Publication
Mutagenesisi1506 – 15061Q → A: Abolishes response to semaphorin. 1 Publication
Mutagenesisi1631 – 16322HL → AA: Abolishes response to semaphorin. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 18721853Plexin-A3PRO_0000411104Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi78 ↔ 87PROSITE-ProRule annotation
Disulfide bondi113 ↔ 121PROSITE-ProRule annotation
Disulfide bondi267 ↔ 388PROSITE-ProRule annotation
Disulfide bondi283 ↔ 339PROSITE-ProRule annotation
Disulfide bondi357 ↔ 376PROSITE-ProRule annotation
Disulfide bondi492 ↔ 509PROSITE-ProRule annotation
Disulfide bondi498 ↔ 540PROSITE-ProRule annotation
Disulfide bondi501 ↔ 518PROSITE-ProRule annotation
Disulfide bondi512 ↔ 524PROSITE-ProRule annotation
Glycosylationi549 – 5491N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi575 ↔ 595PROSITE-ProRule annotation
Glycosylationi1163 – 11631N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70208.
PRIDEiP70208.

Expressioni

Tissue specificityi

Detected in embryonic hindbrain, spinal cord, dorsal root ganglion, trigeminal ganglion and superior cervical ganglion. In newborns, detected throughout all layers of the hippocampus.3 Publications

Gene expression databases

BgeeiP70208.
ExpressionAtlasiP70208. baseline and differential.
GenevestigatoriP70208.

Interactioni

Protein-protein interaction databases

DIPiDIP-48959N.
STRINGi10090.ENSMUSP00000004326.

Structurei

Secondary structure

1
1872
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1248 – 128639
Helixi1300 – 13089
Helixi1316 – 13183
Helixi1325 – 133713
Helixi1341 – 135212
Helixi1359 – 137214
Helixi1374 – 13763
Helixi1377 – 139721
Turni1403 – 14075
Helixi1412 – 142413
Helixi1426 – 14316
Helixi1434 – 144815
Turni1455 – 14573
Helixi1466 – 14683
Beta strandi1478 – 14847
Turni1486 – 14883
Beta strandi1493 – 14997
Helixi1504 – 151512
Turni1516 – 15183
Helixi1521 – 15233
Helixi1527 – 15293
Beta strandi1530 – 15367
Beta strandi1541 – 15444
Beta strandi1546 – 15483
Beta strandi1557 – 15593
Turni1563 – 15675
Beta strandi1573 – 15786
Beta strandi1628 – 16325
Helixi1653 – 167725
Helixi1682 – 16843
Helixi1689 – 170315
Turni1704 – 17063
Helixi1710 – 172011
Turni1721 – 17244
Helixi1725 – 17317
Helixi1733 – 17353
Helixi1743 – 175917
Helixi1773 – 17775
Turni1778 – 17814
Helixi1782 – 179817
Helixi1804 – 181714
Turni1818 – 18203
Helixi1824 – 183714
Helixi1839 – 184810
Helixi1850 – 18545
Helixi1857 – 186913

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IG3X-ray1.99A1247-1872[»]
ProteinModelPortaliP70208.
SMRiP70208. Positions 1247-1871.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP70208.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 12201201ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1242 – 1872631CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1221 – 124121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 489470SemaPROSITE-ProRule annotationAdd
BLAST
Domaini841 – 93494IPT/TIG 1Add
BLAST
Domaini936 – 102186IPT/TIG 2Add
BLAST
Domaini1024 – 1123100IPT/TIG 3Add
BLAST
Domaini1126 – 121287IPT/TIG 4Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1240 – 129455Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 4 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiP70208.
KOiK06820.
OMAiSHPHECS.
OrthoDBiEOG7Q8CM9.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P70208-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTVCLLPLL FFTIGGCLGS SRPFRTFVVT DTTLTHLAVH RVTGEVFVGA
60 70 80 90 100
VNRVFKLAPN LTELRAHVTG PIEDNARCYP PPSMRVCSHR LVPVDNVNKL
110 120 130 140 150
LLIDYAARRL VACGSIWQGI CQFLRLDDLF KLGEPHHRKE HYLSGAQEPD
160 170 180 190 200
SMAGVIVEQV QGPSKLFVGT AVDGKSEYFP TLSSRKLIDD EDSGDMFSLV
210 220 230 240 250
YQDEFVSSQI KIPSDTLSLY PAFDIYYIYG FVSASFVYFL TLQLDTQQTL
260 270 280 290 300
LDTAGEKFFT SKIVRMCAGD SEFYSYVEFP IGCSWRGVEY RLVQSAHLAK
310 320 330 340 350
PGLLLAQALG VPADEDVLFT IFSQGQKNRA NPPRQTILCL FTLSSINAHI
360 370 380 390 400
RRRIQSCYRG EGTLALPWLL NKELPCINTP LQINGNFCGL VLNQPLGGLH
410 420 430 440 450
VIEGLPLLAD STDGMASVAA YTYHQHSVVF IGTRSGNLKK VRVDGSQDAQ
460 470 480 490 500
LYETVSVVQG SPILRDLLFS PDHRHIYLLS EKQVSQLPVE TCEQYLSCAA
510 520 530 540 550
CLGSGDPHCG WCVLQHRCCR EGACPGASAP HGFAEELSKC IQVRVRPNNV
560 570 580 590 600
SVTSSGVQLT VAMRNVPDLS VGVSCSFEEV TESEAILLPS GELRCPSPSL
610 620 630 640 650
QELQTLTRGH GATHTVRLQL LSMETGVRFA GVDFVFYNCS ALQSCMSCVG
660 670 680 690 700
SPYPCHWCKY RHVCTSHPHE CSFQEGRVHS PEGCPEILPQ GDLLIPVGVM
710 720 730 740 750
QPLTLRAKNL PQPQSGQKNY ECVVRVQGRQ HRVPAVRFNS SSVQCQNASY
760 770 780 790 800
FYEGDEFGDT ELDFSVVWDG DFPIDKPPSF RALLYKCWAQ RPSCGLCLKA
810 820 830 840 850
DPRFNCGWCI SEHRCQLRAH CPAPKSNWMH PSQKGARCSH PRITQIHPLT
860 870 880 890 900
GPKEGGTRVT IVGENLGLTS REVGLRVAGV RCNSIPTEYV SAERIVCEME
910 920 930 940 950
ESLVPSPPPG PAELCVGDCS ADFRTQSQQL YSFVTPTFDR VSPSRGPASG
960 970 980 990 1000
GTRLTISGIS LDAGSRVTVI IRDGECQFVR RDAEAIVCIS PVSTLGPSQS
1010 1020 1030 1040 1050
PITLAIDHAN ISNTGVIYTY TQDPTVTHLE PTWSIINGST SITVSGTHLL
1060 1070 1080 1090 1100
TVQEPRVRAK YRGIETTNTC QVINDTAMLC KAPGIFLGHP QPRAQGEHPD
1110 1120 1130 1140 1150
EFGFLLDHVQ AARSLNRSSF TYYPDPSFEP LGPSGVLDVK PGSHVVLKGK
1160 1170 1180 1190 1200
NLIPAAAGSS RLNYTVLIGG QPCALTVSDT QLLCDSPSQT GRQPVMVLVG
1210 1220 1230 1240 1250
GLEFWLGTLH ITADRALTLP AMVGLAAGGG LLLLAITVVL VAYKRKTQDA
1260 1270 1280 1290 1300
DRTLKRLQLQ MDNLESRVAL ECKEAFAELQ TDINELTNHM DGVQIPFLDY
1310 1320 1330 1340 1350
RTYAVRVLFP GIEAHPVLKE LDTPPNVEKA LRLFGQLLHS RAFLLTFIHT
1360 1370 1380 1390 1400
LEAQSSFSMR DRGTVASLTM VALQSRLDYA TGLLKQLLAD LIEKNLESKN
1410 1420 1430 1440 1450
HPKLLLRRTE SVAEKMLTNW FTFLLHKFLK ECAGEPLFLL YCAIKQQMEK
1460 1470 1480 1490 1500
GPIDAITGEA RYSLSEDKLI RQQIDYKTLT LHCVCPESEG SAQVPVKVLN
1510 1520 1530 1540 1550
CDSITQAKDK LLDTVYKGIP YSQRPKAEDM DLEWRQGRMA RIILQDEDIT
1560 1570 1580 1590 1600
TKIECDWKRV NSLAHYQVTD GSLVALVPKQ VSAYNMANSF TFTRSLSRYE
1610 1620 1630 1640 1650
SLLRAASSPD SLRSRAPMLT PDQEAGTKLW HLVRNHDHTD HREGDRGSKM
1660 1670 1680 1690 1700
VSEIYLTRLL ATKGTLQKFV DDLFETVFST AHRGSALPLA IKYMFDFLDE
1710 1720 1730 1740 1750
QADQRQISDP DVRHTWKSNC LPLRFWVNVI KNPQFVFDIH KNSITDACLS
1760 1770 1780 1790 1800
VVAQTFMDSC STSEHRLGKD SPSNKLLYAK DIPNYKSWVE RYYRDIAKMA
1810 1820 1830 1840 1850
SISDQDMDAY LVEQSRLHAN DFNVLSALSE LYFYVTKYRQ EILTSLDRDA
1860 1870
SCRKHKLRQK LEQIITLVSS SS
Length:1,872
Mass (Da):207,958
Last modified:July 27, 2011 - v2
Checksum:i39D57886A0C4830A
GO
Isoform 2 (identifier: P70208-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1072-1148: Missing.

Show »
Length:1,795
Mass (Da):199,604
Checksum:i2E590AF8E22FEBA5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1627 – 16271T → A in BAC33681. (PubMed:16141072)Curated
Sequence conflicti1861 – 18611L → P in BAA13190. (PubMed:8806646)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1072 – 114877Missing in isoform 2. 1 PublicationVSP_041609Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86950 mRNA. Translation: BAA13190.1.
BC093482 mRNA. Translation: AAH93482.1.
AJ748653 mRNA. Translation: CAG38687.1.
AK049319 mRNA. Translation: BAC33681.1.
CCDSiCCDS30228.1. [P70208-1]
PIRiJC4976.
RefSeqiNP_032909.2. NM_008883.2. [P70208-1]
XP_006527963.1. XM_006527900.1. [P70208-2]
UniGeneiMm.1685.

Genome annotation databases

EnsembliENSMUST00000004326; ENSMUSP00000004326; ENSMUSG00000031398. [P70208-1]
GeneIDi18846.
KEGGimmu:18846.
UCSCiuc009too.1. mouse. [P70208-1]
uc012hku.1. mouse. [P70208-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86950 mRNA. Translation: BAA13190.1 .
BC093482 mRNA. Translation: AAH93482.1 .
AJ748653 mRNA. Translation: CAG38687.1 .
AK049319 mRNA. Translation: BAC33681.1 .
CCDSi CCDS30228.1. [P70208-1 ]
PIRi JC4976.
RefSeqi NP_032909.2. NM_008883.2. [P70208-1 ]
XP_006527963.1. XM_006527900.1. [P70208-2 ]
UniGenei Mm.1685.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IG3 X-ray 1.99 A 1247-1872 [» ]
ProteinModelPortali P70208.
SMRi P70208. Positions 1247-1871.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-48959N.
STRINGi 10090.ENSMUSP00000004326.

Proteomic databases

MaxQBi P70208.
PRIDEi P70208.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000004326 ; ENSMUSP00000004326 ; ENSMUSG00000031398 . [P70208-1 ]
GeneIDi 18846.
KEGGi mmu:18846.
UCSCi uc009too.1. mouse. [P70208-1 ]
uc012hku.1. mouse. [P70208-2 ]

Organism-specific databases

CTDi 55558.
MGIi MGI:107683. Plxna3.

Phylogenomic databases

GeneTreei ENSGT00760000119048.
HOGENOMi HOG000231377.
HOVERGENi HBG105711.
InParanoidi P70208.
KOi K06820.
OMAi SHPHECS.
OrthoDBi EOG7Q8CM9.
TreeFami TF312962.

Miscellaneous databases

EvolutionaryTracei P70208.
NextBioi 295224.
PROi P70208.
SOURCEi Search...

Gene expression databases

Bgeei P70208.
ExpressionAtlasi P70208. baseline and differential.
Genevestigatori P70208.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view ]
SMARTi SM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
    Tissue: Embryonic brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  3. "Towards functional annotation of all Xq28 genes: expression and intracellular localization analyses reveal novel candidates for disease genes."
    Kolb-Kokocinski A.A., Mehrle A., Bechtel S., Wellenreuther R., Simpson J., Pepperkok R., Wiemann S., Poustka A.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1116-1560.
    Strain: NMRI.
    Tissue: Embryo.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1138-1872.
    Strain: C57BL/6J.
  5. "Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections."
    Cheng H.J., Bagri A., Yaron A., Stein E., Pleasure S.J., Tessier-Lavigne M.
    Neuron 32:249-263(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.
  6. "Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors."
    Waimey K.E., Huang P.H., Chen M., Cheng H.J.
    Dev. Biol. 315:448-458(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  7. "Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development."
    Schwarz Q., Waimey K.E., Golding M., Takamatsu H., Kumanogoh A., Fujisawa H., Cheng H.J., Ruhrberg C.
    Dev. Biol. 324:1-9(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION, TISSUE SPECIFICITY.
  8. "The Semaphorin receptor PlexinA3 mediates neuronal apoptosis during dorsal root ganglia development."
    Ben-Zvi A., Manor O., Schachner M., Yaron A., Tessier-Lavigne M., Behar O.
    J. Neurosci. 28:12427-12432(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  9. "Secreted semaphorins control spine distribution and morphogenesis in the postnatal CNS."
    Tran T.S., Rubio M.E., Clem R.L., Johnson D., Case L., Tessier-Lavigne M., Huganir R.L., Ginty D.D., Kolodkin A.L.
    Nature 462:1065-1069(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  10. "Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration."
    He H., Yang T., Terman J.R., Zhang X.
    Proc. Natl. Acad. Sci. U.S.A. 106:15610-15615(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.99 ANGSTROMS) OF 1170-1795, FUNCTION, MUTAGENESIS OF LEU-1279; TYR-1300; PHE-1309; 1407-ARG-ARG-1408; ILE-1453; LEU-1464; GLN-1506 AND 1631-HIS-HIS-1632.

Entry informationi

Entry nameiPLXA3_MOUSE
AccessioniPrimary (citable) accession number: P70208
Secondary accession number(s): A5D6Q5, Q684J0, Q8BWZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 27, 2011
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 97 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3