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P70207

- PLXA2_MOUSE

UniProt

P70207 - PLXA2_MOUSE

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Protein

Plexin-A2

Gene
Plxna2, Kiaa0463
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.3 Publications

GO - Molecular functioni

  1. semaphorin receptor activity Source: UniProtKB

GO - Biological processi

  1. cell surface receptor signaling pathway Source: MGI
  2. centrosome localization Source: MGI
  3. cerebellar granule cell precursor tangential migration Source: MGI
  4. limb bud formation Source: BHF-UCL
  5. neural tube development Source: BHF-UCL
  6. pharyngeal system development Source: BHF-UCL
  7. regulation of cell migration Source: UniProtKB
  8. semaphorin-plexin signaling pathway Source: UniProtKB
  9. somitogenesis Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A2
Short name:
Plex 2
Short name:
Plexin-2
Gene namesi
Name:Plxna2
Synonyms:Kiaa0463
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:107684. Plxna2.

Subcellular locationi

Cell membrane; Single-pass type I membrane protein 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 12371203Extracellular Reviewed predictionAdd
BLAST
Transmembranei1238 – 125821Helical; Reviewed predictionAdd
BLAST
Topological domaini1259 – 1894636Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. intracellular Source: InterPro
  3. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi193 – 1931D → K: Abolishes interaction with SEMA6A. 1 Publication
Mutagenesisi221 – 2211F → A or R: Abolishes interaction with SEMA6A. 2 Publications
Mutagenesisi396 – 3961A → E: Abolishes interaction with SEMA6A. 2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed predictionAdd
BLAST
Chaini35 – 18941860Plexin-A2PRO_0000232748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi76 – 761N-linked (GlcNAc...)2 Publications
Disulfide bondi94 ↔ 1032 Publications
Disulfide bondi129 ↔ 1372 Publications
Glycosylationi163 – 1631N-linked (GlcNAc...)1 Publication
Disulfide bondi284 ↔ 4052 Publications
Disulfide bondi300 ↔ 3562 Publications
Glycosylationi327 – 3271N-linked (GlcNAc...)1 Publication
Disulfide bondi374 ↔ 3932 Publications
Disulfide bondi511 ↔ 5282 Publications
Disulfide bondi517 ↔ 5592 Publications
Disulfide bondi520 ↔ 5372 Publications
Disulfide bondi531 ↔ 5432 Publications
Disulfide bondi594 ↔ 6132 Publications
Glycosylationi598 – 5981N-linked (GlcNAc...)1 Publication
Glycosylationi696 – 6961N-linked (GlcNAc...) Reviewed prediction
Glycosylationi756 – 7561N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1180 – 11801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1205 – 12051N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70207.
PaxDbiP70207.
PRIDEiP70207.

PTM databases

PhosphoSiteiP70207.

Expressioni

Gene expression databases

ArrayExpressiP70207.
BgeeiP70207.
CleanExiMM_PLXNA2.
GenevestigatoriP70207.

Interactioni

Subunit structurei

Homodimer. Interacts with RND1 By similarity. Interacts directly with NRP1 and NRP2. The PLXNA2 homodimer interacts with a SEMA6A homodimer, giving rise to a heterotetramer.4 Publications

Protein-protein interaction databases

BioGridi202262. 1 interaction.
DIPiDIP-32252N.
IntActiP70207. 1 interaction.

Structurei

Secondary structure

1
1894
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi40 – 423
Beta strandi44 – 485
Beta strandi50 – 556
Turni57 – 593
Beta strandi62 – 665
Beta strandi69 – 735
Beta strandi79 – 846
Beta strandi88 – 903
Turni98 – 1003
Beta strandi108 – 1103
Beta strandi114 – 1207
Helixi121 – 1233
Beta strandi125 – 1328
Turni133 – 1353
Beta strandi137 – 1415
Turni142 – 1443
Beta strandi147 – 1493
Helixi155 – 1573
Beta strandi165 – 1739
Beta strandi176 – 1783
Beta strandi180 – 1867
Turni192 – 1943
Beta strandi197 – 2037
Turni210 – 2134
Beta strandi215 – 2184
Beta strandi223 – 2264
Helixi230 – 2356
Beta strandi242 – 2498
Beta strandi252 – 2609
Beta strandi275 – 28612
Beta strandi294 – 3029
Beta strandi305 – 31612
Helixi320 – 3267
Beta strandi334 – 34411
Beta strandi346 – 3483
Beta strandi353 – 3597
Helixi360 – 37516
Helixi384 – 3874
Beta strandi408 – 4103
Beta strandi422 – 4309
Beta strandi432 – 4409
Beta strandi443 – 4508
Beta strandi453 – 46210
Turni463 – 4653
Beta strandi466 – 4749
Beta strandi492 – 4987
Beta strandi500 – 5089
Helixi511 – 5133
Helixi517 – 5204
Beta strandi529 – 5313
Turni532 – 5354
Beta strandi536 – 5383
Helixi540 – 5423
Turni544 – 5474
Beta strandi551 – 5533
Helixi557 – 5615
Beta strandi577 – 5837
Beta strandi592 – 5965
Turni597 – 5993
Beta strandi600 – 6034
Beta strandi605 – 6073
Beta strandi610 – 6145
Turni618 – 6203
Beta strandi630 – 63910
Turni640 – 6423
Beta strandi645 – 65410
Helixi656 – 6583
Helixi662 – 6665
Beta strandi673 – 6753
Turni676 – 6794
Beta strandi680 – 6834
Helixi685 – 6873
Beta strandi688 – 6903
Helixi691 – 6933
Helixi698 – 7003

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3AL8X-ray3.60B31-561[»]
3AL9X-ray2.10A/B31-561[»]
3OKTX-ray2.30A35-703[»]
3OKYX-ray2.20A35-703[»]
4GZAX-ray7.00A/B/C/D/E/F33-703[»]
ProteinModelPortaliP70207.
SMRiP70207. Positions 36-702, 809-1040, 1273-1890.

Miscellaneous databases

EvolutionaryTraceiP70207.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 508474SemaAdd
BLAST
Domaini858 – 95194IPT/TIG 1Add
BLAST
Domaini954 – 103784IPT/TIG 2Add
BLAST
Domaini1041 – 113999IPT/TIG 3Add
BLAST
Domaini1143 – 122886IPT/TIG 4Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1261 – 131050 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254546.
GeneTreeiENSGT00750000117292.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiP70207.
KOiK06820.
OMAiCKDDPKF.
OrthoDBiEOG7Q8CM9.
PhylomeDBiP70207.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 2 hits.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70207-1 [UniParc]FASTAAdd to Basket

« Hide

MEQRRFYLRA MQADNLSVVL LSVAWLLLAR GTTGMPQYST FHSENRDWTF     50
NHLTVHRRTG AVYVGAINRV YKLTGNLTIQ VAHKTGPEED NKACYPPLIV 100
QPCSEVLTLT NNVNKLLIID YSENRLLACG SLYQGVCKLL RLDDLFILVE 150
PSHKKEHYLS SVNKTGTMYG VIVRSEGEDG KLFIGTAVDG KQDYFPTLSS 200
RKLPRDPESS AMLDYELHSD FVSSLIKIPS DTLALVSHFD IFYIYGFASG 250
GFVYFLTVQP ETPDGMAINS AGDLFYTSRI VRLCKDDPKF HSYVSLPFGC 300
TRAGVEYRLL QAAYLAKPGE ALAQAFNISS DEDVLFAIFS KGQKQYHHPP 350
DDSALCAFPI RAINLQIKER LQSCYHGEGN LELNWLLGKD VQCTKAPVPI 400
DDNFCGLDIN QPLGGSTPVE GLTLYTTSRD RLTSVASYVY NGYSVVFVGT 450
KSGKLKKIRA DGPPHGGVQY EMVSVFKDGS PILRDMAFSI NQLYLYVMSE 500
RQVTRVPVES CEQYTTCGEC LSSGDPHCGW CALHNMCSRR DKCQRAWEAN 550
RFAASISQCM SLEVHPNSIS VSDHSRLLSL VVNDAPNLSE GIACAFGNLT 600
EVEGQVSGSQ VICISPGPKD VPVIPLDQDW FGLELQLRSK ETGKIFVSTE 650
FKFYNCSAHQ LCLSCVNSAF RCHWCKYRNL CTHDPTTCSF QEGRINVSED 700
CPQLVPTEEI LIPVGEVKPI TLKARNLPQP QSGQRGYECV LSIQGAVHRV 750
PALRFNSSSV QCQNSSYQYD GMDISNLAVD FAVVWNGNFI IDNPQDLKVH 800
LYKCAAQRES CGLCLKADHK FECGWCSGER RCTLHQHCPS TSSPWLDWSS 850
HNVKCSNPQI TEILTVSGPP EGGTRVTIHG VNLGLDFSEI AHHVQVAGVP 900
CTPIPGEYII AEQIVCEMGH AVIGTTSGPV RLCIGECKPE FMTKSHQQYT 950
FVNPSVLSLS PIRGPESGGT MVTITGHYLG AGSSVAVYLG NQTCEFYGRS 1000
MNEIVCVSPP SSNGLGPVPV SVSVDRARVD SSLQFEYIDD PRVQRIEPEW 1050
SITSGHTPLT ITGFNLDVIQ EPRVRVKFNG KESVNVCTVV NTTTLTCLAP 1100
SLTSDYRPGL DTVERPDEFG FLFNNVQSLL IYNDTKFIYY PNPTFELLSP 1150
TGILDQKPGS PIILKGKNLC PPASGGAKLN YTVMIGETPC TVTVSETQLL 1200
CEPPNLTGQH KVMVHVGGMV FSPGSVSVIS DSLLTLPAII SIAAGGSLLL 1250
IIVIIVLIAY KRKSRENDLT LKRLQMQMDN LESRVALECK EAFAELQTDI 1300
NELTSDLDRS GIPYLDYRTY AMRVLFPGIE DHPVLRELEV QGNGQQHVEK 1350
ALKLFAQLIN NKVFLLTFIR TLELQRSFSM RDRGNVASLI MTGLQGRLEY 1400
ATDVLKQLLS DLIDKNLENK NHPKLLLRRT ESVAEKMLTN WFAFLLHKFL 1450
KECAGEPLFM LYCAIKQQME KGPIDAITGE ARYSLSEDKL IRQQIEYKTL 1500
ILNCVNPDNE NSPEIPVKVL NCDTITQVKE KILDAVYKNV PYSQRPRAVD 1550
MDLEWRQGRI ARVVLQDEDI TTKIEGDWKR LNTLMHYQVS DRSVVALVPK 1600
QTSSYNIPAS ASISRTSISR YDSSFRYTGS PDSLRSRVPM ITPDLESGVK 1650
VWHLVKNHDH GDQKEGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETLF 1700
STVHRGSALP LAIKYMFDFL DEQADRHSIH DTDVRHTWKS NCLPLRFWVN 1750
VIKNPQFVFD IHKGSITDAC LSVVAQTFMD SCSTSEHRLG KDSPSNKLLY 1800
AKDIPSYKNW VERYYADIAK LPAISDQDMN AYLAEQSRLH ATEFNMLSAL 1850
NEIYSYVSKY SEELIGALEQ DEQARRQRLA YKVEHLINAM SIES 1894
Length:1,894
Mass (Da):211,535
Last modified:July 7, 2009 - v2
Checksum:i9F6C34F48BC29CEE
GO

Sequence cautioni

The sequence AAH68155.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence BAA13189.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti211 – 2111A → P in AAH68155. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86949 mRNA. Translation: BAA13189.1. Different initiation.
BC024509 mRNA. Translation: AAH24509.1.
BC056475 mRNA. Translation: AAH56475.1.
BC068155 mRNA. Translation: AAH68155.1. Different initiation.
AK122289 mRNA. Translation: BAC65571.1.
CCDSiCCDS35827.1.
PIRiJC4975.
RefSeqiNP_032908.2. NM_008882.2.
UniGeneiMm.2251.

Genome annotation databases

EnsembliENSMUST00000027952; ENSMUSP00000027952; ENSMUSG00000026640.
GeneIDi18845.
KEGGimmu:18845.
UCSCiuc007een.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86949 mRNA. Translation: BAA13189.1 . Different initiation.
BC024509 mRNA. Translation: AAH24509.1 .
BC056475 mRNA. Translation: AAH56475.1 .
BC068155 mRNA. Translation: AAH68155.1 . Different initiation.
AK122289 mRNA. Translation: BAC65571.1 .
CCDSi CCDS35827.1.
PIRi JC4975.
RefSeqi NP_032908.2. NM_008882.2.
UniGenei Mm.2251.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3AL8 X-ray 3.60 B 31-561 [» ]
3AL9 X-ray 2.10 A/B 31-561 [» ]
3OKT X-ray 2.30 A 35-703 [» ]
3OKY X-ray 2.20 A 35-703 [» ]
4GZA X-ray 7.00 A/B/C/D/E/F 33-703 [» ]
ProteinModelPortali P70207.
SMRi P70207. Positions 36-702, 809-1040, 1273-1890.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202262. 1 interaction.
DIPi DIP-32252N.
IntActi P70207. 1 interaction.

PTM databases

PhosphoSitei P70207.

Proteomic databases

MaxQBi P70207.
PaxDbi P70207.
PRIDEi P70207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027952 ; ENSMUSP00000027952 ; ENSMUSG00000026640 .
GeneIDi 18845.
KEGGi mmu:18845.
UCSCi uc007een.1. mouse.

Organism-specific databases

CTDi 5362.
MGIi MGI:107684. Plxna2.
Rougei Search...

Phylogenomic databases

eggNOGi NOG254546.
GeneTreei ENSGT00750000117292.
HOGENOMi HOG000231377.
HOVERGENi HBG105711.
InParanoidi P70207.
KOi K06820.
OMAi CKDDPKF.
OrthoDBi EOG7Q8CM9.
PhylomeDBi P70207.
TreeFami TF312962.

Miscellaneous databases

ChiTaRSi PLXNA2. mouse.
EvolutionaryTracei P70207.
NextBioi 295220.
PROi P70207.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70207.
Bgeei P70207.
CleanExi MM_PLXNA2.
Genevestigatori P70207.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view ]
SMARTi SM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 2 hits.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain and Colon.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 366-1894.
    Tissue: Brain.
  4. "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors."
    Takahashi T., Fournier A., Nakamura F., Wang L.-H., Murakami Y., Kalb R.G., Fujisawa H., Strittmatter S.M.
    Cell 99:59-69(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NRP1 AND SEMA3A.
  5. "Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A."
    Rohm B., Ottemeyer A., Lohrum M., Pueschel A.W.
    Mech. Dev. 93:95-104(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2 AND SEMA3A.
  6. Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 35-701 IN COMPLEX WITH SEMA6A, INTERACTION WITH SEMA6A, FUNCTION, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-76; ASN-163; ASN-327 AND ASN-598, MUTAGENESIS OF PHE-221 AND ALA-396, DISULFIDE BONDS.
  7. Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 31-561 IN COMPLEX WITH SEMA6A, INTERACTION WITH SEMA6A, SUBUNIT, SUBCELLULAR LOCATION, GLYCOSYLATION AT ASN-76, MUTAGENESIS OF ASP-193; PHE-221 AND ALA-396, DISULFIDE BONDS.

Entry informationi

Entry nameiPLXA2_MOUSE
AccessioniPrimary (citable) accession number: P70207
Secondary accession number(s): Q6NVE6
, Q6PHN4, Q80TZ7, Q8R1I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: July 7, 2009
Last modified: September 3, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi