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Reviewed, UniProtKB/Swiss-Prot P70206 (PLXA1_MOUSE)

Last modified May 5, 2009. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Plexin-A1
      Short name=Plexin-1
      Short name=Plex 1
Gene names
Name: Plxna1
Synonyms: Kiaa4053
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length1894 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. Ref.3 Ref.4

Subunit structure

Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with WITH CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4. Ref.3 Ref.4 Ref.5 Ref.6 Ref.7 Ref.8

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.5 Ref.1

Sequence similarities

Belongs to the plexin family.

Contains 4 IPT/TIG domains.

Contains 1 Sema domain.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 Potential
Chain28 – 18941867Plexin-A1
PRO_0000232746

Regions

Topological domain28 – 12421215Extracellular Potential
Transmembrane1243 – 126321 Potential
Topological domain1264 – 1894631Cytoplasmic Potential
Domain28 – 510483Sema
Domain862 – 95796IPT/TIG 1
Domain959 – 104385IPT/TIG 2
Domain1046 – 1145100IPT/TIG 3
Domain1148 – 123487IPT/TIG 4
Coiled coil1262 – 131554 Potential

Amino acid modifications

Modified residue1201Phosphotyrosine Ref.9
Glycosylation751N-linked (GlcNAc...) Potential
Glycosylation6581N-linked (GlcNAc...) Potential
Glycosylation6701N-linked (GlcNAc...) Potential
Glycosylation6991N-linked (GlcNAc...) Potential
Glycosylation10411N-linked (GlcNAc...) Potential
Glycosylation11851N-linked (GlcNAc...) Potential
Glycosylation12101N-linked (GlcNAc...) Potential

Experimental info

Mutagenesis1266 – 12683KRK → AAA: Loss of interaction with FARP2. Ref.8

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Sequences

Sequence LengthMass (Da)Tools
P70206-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: A8E6BB29C6824C94

FASTA1,894211,099
        10         20         30         40         50         60 
MPLPPLSSRT LLLLLLLLLR GVWIAISSPP AGLGPQPAFR TFVASDWGLT HLVVHEQTGE 

        70         80         90        100        110        120 
VYVGAVNRIY KLSGNLTLLR AHVTGPVEDN EKCYPPPSVQ SCPHGLGSTD NVNKLLLLDY 

       130        140        150        160        170        180 
AANRLLACGS ASQGICQFLR LDDLFKLGEP HHRKEHYLSS VREAGSMAGV LIAGPPGQGQ 

       190        200        210        220        230        240 
AKLFVGTPID GKSEYFPTLS SRRLMANEED ADMFGFVYQD EFVSSQLKIP SDTLSKFPAF 

       250        260        270        280        290        300 
DIYYVYSFRS EQFVYYLTLQ LDTQLTSPDA AGEHFFTSKI VRLCVNDPKF YSYVEFPIGC 

       310        320        330        340        350        360 
EQAGVEYRLV QDAYLSRPGQ ALAKQLGLAE DEEVLFTVFA QGQKNRVKPP KESALCLFTL 

       370        380        390        400        410        420 
RAIKEKIKER IQSCYRGEGK LSLPWLLNKE LGCINSPLQI DDDFCGQDFN QPLGGTVTIE 

       430        440        450        460        470        480 
GTPLFVDKED GLTAVAAYDY QGRTVVFAGT RSGRIRKILV DLANPSGRPA LAYESVVAQE 

       490        500        510        520        530        540 
GNPILRDLVL SPNRQYLYAM TEKQVTQVPV ESCVQYTSCE LCLGSRDPHC GWCVLHSICS 

       550        560        570        580        590        600 
RQDACERAEE PQRFASDLLQ CVQLTVQPRN VSVTMSQVPL VLQAWNVPDL SAGVNCSFED 

       610        620        630        640        650        660 
FTETESILED GRIHCHSPSA REVAPITQGQ GDQRVVKLYL KSKETGKKFA SVDFVFYNCS 

       670        680        690        700        710        720 
VHQSCLACVN GSFPCHWCKY RHVCTNNAAD CAFLEGRVNM SEDCPQILPS THIYVPVGVV 

       730        740        750        760        770        780 
KPITLAARNL PQPQSGQRGY ECLFHIPGSP ARVTALRFNS SSLQCQNSSY SYEGNDVSDL 

       790        800        810        820        830        840 
PVNLSVVWNG NFVIDNPQNI QAHLYKCPAL RQSCGLCLKA DPRFECGWCV AERRCSLRHH 

       850        860        870        880        890        900 
CPADSPASWM HAHHGSSRCT DPKILKLSPE TGPRQGGTRL TITGENLGLR FEDVRLGVHV 

       910        920        930        940        950        960 
GKVLCSPVES EYISAEQIVC EIGDASTLRA HDALVEVCVR DCSLHYRALS PKRFTFVTPT 

       970        980        990       1000       1010       1020 
FYRVSPSRGP LSGGTWIGIE GSHLNAGSDV AVSIGGRPCS FSWRNSREIR CLTPPGHTPG 

      1030       1040       1050       1060       1070       1080 
SAPIVININR AQLSNPEVKY NYTEDPTILR IDPEWSINSG GTLLTVTGTN LATVREPRIR 

      1090       1100       1110       1120       1130       1140 
AKYGGIEREN SCMVYNDTTM VCRAPSIDNP KRSPPELGER PDEIGFIMDN VRTLLVLNSS 

      1150       1160       1170       1180       1190       1200 
SFLYYPDPVL EPLSPTGLLE LKPSSPLILK GRNLLPPAPG NSRLNYTVLI GSTPCILTVS 

      1210       1220       1230       1240       1250       1260 
ETQLLCEAPN LTGQHKVTVR AGGFEFSPGM LQVYSDSLLT LPAIVGIGGG GGLLLLVIVA 

      1270       1280       1290       1300       1310       1320 
VLIAYKRKSR DADRTLKRLQ LQMDNLESRV ALECKEAFAE LQTDIHELTS DLDGAGIPFL 

      1330       1340       1350       1360       1370       1380 
DYRTYAMRVL FPGIEDHPVL KEMEVQANVE KSLTLFGQLL TKKHFLLTFI RTLEAQRSFS 

      1390       1400       1410       1420       1430       1440 
MRDRGNVASL IMTALQGEME YATGVLKQLL SDLIEKNLES KNHPKLLLRR TESVAEKMLT 

      1450       1460       1470       1480       1490       1500 
NWFTFLLYKF LKECAGEPLF MLYCAIKQQM EKGPIDAITG EARYSLSEDK LIRQQIDYKT 

      1510       1520       1530       1540       1550       1560 
LTLNCVNPEH ENAPEVPVKG LNCDTVTQVK EKLLDAVYKG VPYSQRPKAG DMDLEWRQGR 

      1570       1580       1590       1600       1610       1620 
MARIILQDED VTTKIDNDWK RLNTLAHYQV TDGSSVALVP KQTSAYNISN SSTFTKSLSR 

      1630       1640       1650       1660       1670       1680 
YESMLRTASS PDSLRSRTPM ITPDLESGTK LWHLVKNHDH LDQREGDRGS KMVSEIYLTR 

      1690       1700       1710       1720       1730       1740 
LLATKGTLQK FVDDLFETIF STAHRGSALP LAIKYMFDFL DEQADKHQIH DSDVRHTWKS 

      1750       1760       1770       1780       1790       1800 
NCLPLRFWVN VIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHKLG KDSPSNKLLY 

      1810       1820       1830       1840       1850       1860 
AKDIPNYKSW VERYYADIAK MPAISDQDMS AYLAEQSRLH LSQFNSMSAL HEIYSYIAKY 

      1870       1880       1890 
KDEILVALEK DEQARRQRLR SKLEQVVDTM ALSS

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References

« Hide 'large scale' references
[1]"Identification of a neuronal cell surface molecule, plexin, in mice."
Kameyama T., Murakami Y., Suto F., Kawakami A., Takagi S., Hirata T., Fujisawa H.
Biochem. Biophys. Res. Commun. 226:524-529(1996) [PubMed: 8806667] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c and ICR.
Tissue: Brain.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-1894.
Tissue: Brain.
[3]"Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors."
Takahashi T., Fournier A., Nakamura F., Wang L.-H., Murakami Y., Kalb R.G., Fujisawa H., Strittmatter S.M.
Cell 99:59-69(1999) [PubMed: 10520994] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2; SEMA3A AND SEMA3F.
[4]"Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A."
Rohm B., Ottemeyer A., Lohrum M., Pueschel A.W.
Mech. Dev. 93:95-104(2000) [PubMed: 10781943] [Abstract]
Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2; SEMA3A AND SEMA3C.
[5]"Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains."
Usui H., Taniguchi M., Yokomizo T., Shimizu T.
Biochem. Biophys. Res. Commun. 300:927-931(2003) [PubMed: 12559962] [Abstract]
Cited for: INTERACTION WITH PLXNB1, TISSUE SPECIFICITY.
[6]"Structural bases for CRMP function in plexin-dependent semaphorin3A signaling."
Deo R.C., Schmidt E.F., Elhabazi A., Togashi H., Burley S.K., Strittmatter S.M.
EMBO J. 23:9-22(2004) [PubMed: 14685275] [Abstract]
Cited for: INTERACTION WITH CRMP1; DPYSL2/CRMP2; DPYSL3/CRMP3 AND DPYSL4/CRMP4.
[7]"Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2."
Toyofuku T., Zhang H., Kumanogoh A., Takegahara N., Suto F., Kamei J., Aoki K., Yabuki M., Hori M., Fujisawa H., Kikutani H.
Genes Dev. 18:435-447(2004) [PubMed: 14977921] [Abstract]
Cited for: INTERACTION WITH SEMA6D AND KDR.
[8]"FARP2 triggers signals for Sema3A-mediated axonal repulsion."
Toyofuku T., Yoshida J., Sugimoto T., Zhang H., Kumanogoh A., Hori M., Kikutani H.
Nat. Neurosci. 8:1712-1719(2005) [PubMed: 16286926] [Abstract]
Cited for: INTERACTION WITH FARP2 AND RND1, MUTAGENESIS OF 1266-LYS--LYS-1268.
[9]"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry."
Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R.
J. Proteome Res. 6:250-262(2007) [PubMed: 17203969] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-120, MASS SPECTROMETRY.
Tissue: Liver.
+Additional computationally mapped references.

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Cross-references

Sequence databases

D86948 mRNA. Translation: BAA13188.1.
AK220460 mRNA. Translation: BAD90489.1.
IPIIPI00137311.
PIRJC4980.
RefSeqNP_032907.1.
UniGeneMm.3789

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteP70206.

Proteomic databases

PRIDEP70206.

Genome annotation databases

EnsemblENSMUSG00000030084. Mus musculus. [Contig view]
GeneID18844.
KEGGmmu:18844.

Organism-specific databases

MGIMGI:107685. Plxna1.
RougeSearch...

Phylogenomic databases

HOGENOMP70206.
HOVERGENP70206.
OMAP70206. CELCLGS.

Gene expression databases

ArrayExpressP70206.
BgeeP70206.
CleanExMM_PLXNA1.
GermOnlineENSMUSG00000030084. Mus musculus.

Family and domain databases

InterProIPR002909. IPT_TIG_rcpt.
IPR003659. Plexin-like.
IPR013548. Plexin_cytopl.
IPR002165. Plexin_repeat.
IPR001627. Semaphorin/CD100_Ag.
IPR015943. WD40/YVTN_repeat-like.
[Graphical view]
Gene3DG3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
PfamPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
PROSITEPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio295216.
SOURCESearch...

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Entry information

Entry namePLXA1_MOUSE
AccessionPrimary (citable) accession number: P70206
Secondary accession number(s): Q5DTR0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: February 1, 1997
Last modified: May 5, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents