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P70206

- PLXA1_MOUSE

UniProt

P70206 - PLXA1_MOUSE

Protein

Plexin-A1

Gene

Plxna1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.2 Publications

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. semaphorin receptor activity Source: MGI

    GO - Biological processi

    1. dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
    2. regulation of smooth muscle cell migration Source: MGI
    3. semaphorin-plexin signaling pathway Source: GOC

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Plexin-A1
    Short name:
    Plex 1
    Short name:
    Plexin-1
    Gene namesi
    Name:Plxna1
    Synonyms:Kiaa4053
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:107685. Plxna1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: MGI
    4. nucleus Source: Ensembl
    5. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1266 – 12683KRK → AAA: Loss of interaction with FARP2. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2727Sequence AnalysisAdd
    BLAST
    Chaini28 – 18941867Plexin-A1PRO_0000232746Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi93 ↔ 102PROSITE-ProRule annotation
    Disulfide bondi128 ↔ 136PROSITE-ProRule annotation
    Disulfide bondi284 ↔ 405PROSITE-ProRule annotation
    Disulfide bondi300 ↔ 356PROSITE-ProRule annotation
    Disulfide bondi374 ↔ 393PROSITE-ProRule annotation
    Disulfide bondi513 ↔ 530PROSITE-ProRule annotation
    Disulfide bondi519 ↔ 561PROSITE-ProRule annotation
    Disulfide bondi522 ↔ 539PROSITE-ProRule annotation
    Disulfide bondi533 ↔ 545PROSITE-ProRule annotation
    Disulfide bondi596 ↔ 615PROSITE-ProRule annotation
    Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1041 – 10411N-linked (GlcNAc...)1 Publication
    Glycosylationi1185 – 11851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1210 – 12101N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiP70206.
    PaxDbiP70206.
    PRIDEiP70206.

    PTM databases

    PhosphoSiteiP70206.

    Expressioni

    Tissue specificityi

    Ubiquitous.2 Publications

    Gene expression databases

    ArrayExpressiP70206.
    BgeeiP70206.
    CleanExiMM_PLXNA1.
    GenevestigatoriP70206.

    Interactioni

    Subunit structurei

    Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with WITH CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4.6 Publications

    Protein-protein interaction databases

    BioGridi202261. 4 interactions.
    DIPiDIP-29745N.
    IntActiP70206. 3 interactions.
    MINTiMINT-4106183.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3RYTX-ray3.58A/B1269-1894[»]
    ProteinModelPortaliP70206.
    SMRiP70206. Positions 37-705, 812-923, 1278-1890.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini28 – 12421215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1264 – 1894631CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1243 – 126321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 510483SemaPROSITE-ProRule annotationAdd
    BLAST
    Domaini862 – 95796IPT/TIG 1Add
    BLAST
    Domaini959 – 104385IPT/TIG 2Add
    BLAST
    Domaini1046 – 1145100IPT/TIG 3Add
    BLAST
    Domaini1148 – 123487IPT/TIG 4Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili1262 – 131554Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the plexin family.Curated
    Contains 4 IPT/TIG domains.Curated
    Contains 1 Sema domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG254546.
    GeneTreeiENSGT00750000117292.
    HOGENOMiHOG000231377.
    HOVERGENiHBG105711.
    InParanoidiB2RQP7.
    KOiK06820.
    OMAiIGCEQAG.
    OrthoDBiEOG7Q8CM9.
    PhylomeDBiP70206.
    TreeFamiTF312962.

    Family and domain databases

    Gene3Di2.130.10.10. 1 hit.
    2.60.40.10. 4 hits.
    InterProiIPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view]
    PfamiPF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 3 hits.
    PF01403. Sema. 1 hit.
    PF01833. TIG. 4 hits.
    [Graphical view]
    SMARTiSM00429. IPT. 4 hits.
    SM00423. PSI. 3 hits.
    SM00630. Sema. 1 hit.
    [Graphical view]
    SUPFAMiSSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 2 hits.
    SSF48350. SSF48350. 2 hits.
    SSF81296. SSF81296. 4 hits.
    PROSITEiPS51004. SEMA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70206-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLPPLSSRT LLLLLLLLLR GVWIAISSPP AGLGPQPAFR TFVASDWGLT     50
    HLVVHEQTGE VYVGAVNRIY KLSGNLTLLR AHVTGPVEDN EKCYPPPSVQ 100
    SCPHGLGSTD NVNKLLLLDY AANRLLACGS ASQGICQFLR LDDLFKLGEP 150
    HHRKEHYLSS VREAGSMAGV LIAGPPGQGQ AKLFVGTPID GKSEYFPTLS 200
    SRRLMANEED ADMFGFVYQD EFVSSQLKIP SDTLSKFPAF DIYYVYSFRS 250
    EQFVYYLTLQ LDTQLTSPDA AGEHFFTSKI VRLCVNDPKF YSYVEFPIGC 300
    EQAGVEYRLV QDAYLSRPGQ ALAKQLGLAE DEEVLFTVFA QGQKNRVKPP 350
    KESALCLFTL RAIKEKIKER IQSCYRGEGK LSLPWLLNKE LGCINSPLQI 400
    DDDFCGQDFN QPLGGTVTIE GTPLFVDKED GLTAVAAYDY QGRTVVFAGT 450
    RSGRIRKILV DLANPSGRPA LAYESVVAQE GNPILRDLVL SPNRQYLYAM 500
    TEKQVTQVPV ESCVQYTSCE LCLGSRDPHC GWCVLHSICS RQDACERAEE 550
    PQRFASDLLQ CVQLTVQPRN VSVTMSQVPL VLQAWNVPDL SAGVNCSFED 600
    FTETESILED GRIHCHSPSA REVAPITQGQ GDQRVVKLYL KSKETGKKFA 650
    SVDFVFYNCS VHQSCLACVN GSFPCHWCKY RHVCTNNAAD CAFLEGRVNM 700
    SEDCPQILPS THIYVPVGVV KPITLAARNL PQPQSGQRGY ECLFHIPGSP 750
    ARVTALRFNS SSLQCQNSSY SYEGNDVSDL PVNLSVVWNG NFVIDNPQNI 800
    QAHLYKCPAL RQSCGLCLKA DPRFECGWCV AERRCSLRHH CPADSPASWM 850
    HAHHGSSRCT DPKILKLSPE TGPRQGGTRL TITGENLGLR FEDVRLGVHV 900
    GKVLCSPVES EYISAEQIVC EIGDASTLRA HDALVEVCVR DCSLHYRALS 950
    PKRFTFVTPT FYRVSPSRGP LSGGTWIGIE GSHLNAGSDV AVSIGGRPCS 1000
    FSWRNSREIR CLTPPGHTPG SAPIVININR AQLSNPEVKY NYTEDPTILR 1050
    IDPEWSINSG GTLLTVTGTN LATVREPRIR AKYGGIEREN SCMVYNDTTM 1100
    VCRAPSIDNP KRSPPELGER PDEIGFIMDN VRTLLVLNSS SFLYYPDPVL 1150
    EPLSPTGLLE LKPSSPLILK GRNLLPPAPG NSRLNYTVLI GSTPCILTVS 1200
    ETQLLCEAPN LTGQHKVTVR AGGFEFSPGM LQVYSDSLLT LPAIVGIGGG 1250
    GGLLLLVIVA VLIAYKRKSR DADRTLKRLQ LQMDNLESRV ALECKEAFAE 1300
    LQTDIHELTS DLDGAGIPFL DYRTYAMRVL FPGIEDHPVL KEMEVQANVE 1350
    KSLTLFGQLL TKKHFLLTFI RTLEAQRSFS MRDRGNVASL IMTALQGEME 1400
    YATGVLKQLL SDLIEKNLES KNHPKLLLRR TESVAEKMLT NWFTFLLYKF 1450
    LKECAGEPLF MLYCAIKQQM EKGPIDAITG EARYSLSEDK LIRQQIDYKT 1500
    LTLNCVNPEH ENAPEVPVKG LNCDTVTQVK EKLLDAVYKG VPYSQRPKAG 1550
    DMDLEWRQGR MARIILQDED VTTKIDNDWK RLNTLAHYQV TDGSSVALVP 1600
    KQTSAYNISN SSTFTKSLSR YESMLRTASS PDSLRSRTPM ITPDLESGTK 1650
    LWHLVKNHDH LDQREGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETIF 1700
    STAHRGSALP LAIKYMFDFL DEQADKHQIH DSDVRHTWKS NCLPLRFWVN 1750
    VIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHKLG KDSPSNKLLY 1800
    AKDIPNYKSW VERYYADIAK MPAISDQDMS AYLAEQSRLH LSQFNSMSAL 1850
    HEIYSYIAKY KDEILVALEK DEQARRQRLR SKLEQVVDTM ALSS 1894
    Length:1,894
    Mass (Da):211,099
    Last modified:February 1, 1997 - v1
    Checksum:iA8E6BB29C6824C94
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86948 mRNA. Translation: BAA13188.1.
    BC138023 mRNA. Translation: AAI38024.1.
    AK220460 mRNA. Translation: BAD90489.1.
    CCDSiCCDS20344.1.
    PIRiJC4980.
    RefSeqiNP_032907.1. NM_008881.2.
    UniGeneiMm.3789.

    Genome annotation databases

    EnsembliENSMUST00000049845; ENSMUSP00000063066; ENSMUSG00000030084.
    ENSMUST00000163139; ENSMUSP00000131840; ENSMUSG00000030084.
    GeneIDi18844.
    KEGGimmu:18844.
    UCSCiuc009cwg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86948 mRNA. Translation: BAA13188.1 .
    BC138023 mRNA. Translation: AAI38024.1 .
    AK220460 mRNA. Translation: BAD90489.1 .
    CCDSi CCDS20344.1.
    PIRi JC4980.
    RefSeqi NP_032907.1. NM_008881.2.
    UniGenei Mm.3789.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3RYT X-ray 3.58 A/B 1269-1894 [» ]
    ProteinModelPortali P70206.
    SMRi P70206. Positions 37-705, 812-923, 1278-1890.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 202261. 4 interactions.
    DIPi DIP-29745N.
    IntActi P70206. 3 interactions.
    MINTi MINT-4106183.

    PTM databases

    PhosphoSitei P70206.

    Proteomic databases

    MaxQBi P70206.
    PaxDbi P70206.
    PRIDEi P70206.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049845 ; ENSMUSP00000063066 ; ENSMUSG00000030084 .
    ENSMUST00000163139 ; ENSMUSP00000131840 ; ENSMUSG00000030084 .
    GeneIDi 18844.
    KEGGi mmu:18844.
    UCSCi uc009cwg.2. mouse.

    Organism-specific databases

    CTDi 5361.
    MGIi MGI:107685. Plxna1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG254546.
    GeneTreei ENSGT00750000117292.
    HOGENOMi HOG000231377.
    HOVERGENi HBG105711.
    InParanoidi B2RQP7.
    KOi K06820.
    OMAi IGCEQAG.
    OrthoDBi EOG7Q8CM9.
    PhylomeDBi P70206.
    TreeFami TF312962.

    Miscellaneous databases

    NextBioi 295216.
    PROi P70206.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70206.
    Bgeei P70206.
    CleanExi MM_PLXNA1.
    Genevestigatori P70206.

    Family and domain databases

    Gene3Di 2.130.10.10. 1 hit.
    2.60.40.10. 4 hits.
    InterProi IPR013783. Ig-like_fold.
    IPR014756. Ig_E-set.
    IPR002909. IPT.
    IPR016201. Plexin-like_fold.
    IPR013548. Plexin_cytoplasmic_RasGAP_dom.
    IPR002165. Plexin_repeat.
    IPR008936. Rho_GTPase_activation_prot.
    IPR001627. Semap_dom.
    IPR015943. WD40/YVTN_repeat-like_dom.
    [Graphical view ]
    Pfami PF08337. Plexin_cytopl. 1 hit.
    PF01437. PSI. 3 hits.
    PF01403. Sema. 1 hit.
    PF01833. TIG. 4 hits.
    [Graphical view ]
    SMARTi SM00429. IPT. 4 hits.
    SM00423. PSI. 3 hits.
    SM00630. Sema. 1 hit.
    [Graphical view ]
    SUPFAMi SSF101912. SSF101912. 1 hit.
    SSF103575. SSF103575. 2 hits.
    SSF48350. SSF48350. 2 hits.
    SSF81296. SSF81296. 4 hits.
    PROSITEi PS51004. SEMA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: BALB/c and ICR.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
      Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-1894.
      Tissue: Brain.
    4. "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors."
      Takahashi T., Fournier A., Nakamura F., Wang L.-H., Murakami Y., Kalb R.G., Fujisawa H., Strittmatter S.M.
      Cell 99:59-69(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2; SEMA3A AND SEMA3F.
    5. "Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A."
      Rohm B., Ottemeyer A., Lohrum M., Pueschel A.W.
      Mech. Dev. 93:95-104(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2; SEMA3A AND SEMA3C.
    6. "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains."
      Usui H., Taniguchi M., Yokomizo T., Shimizu T.
      Biochem. Biophys. Res. Commun. 300:927-931(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH PLXNB1, TISSUE SPECIFICITY.
    7. "Structural bases for CRMP function in plexin-dependent semaphorin3A signaling."
      Deo R.C., Schmidt E.F., Elhabazi A., Togashi H., Burley S.K., Strittmatter S.M.
      EMBO J. 23:9-22(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CRMP1; DPYSL2/CRMP2; DPYSL3/CRMP3 AND DPYSL4/CRMP4.
    8. "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2."
      Toyofuku T., Zhang H., Kumanogoh A., Takegahara N., Suto F., Kamei J., Aoki K., Yabuki M., Hori M., Fujisawa H., Kikutani H.
      Genes Dev. 18:435-447(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SEMA6D AND KDR.
    9. Cited for: INTERACTION WITH FARP2 AND RND1, MUTAGENESIS OF 1266-LYS--LYS-1268.
    10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1041.

    Entry informationi

    Entry nameiPLXA1_MOUSE
    AccessioniPrimary (citable) accession number: P70206
    Secondary accession number(s): B2RQP7, Q5DTR0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 18, 2006
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3