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Protein

Plexin-A1

Gene

Plxna1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.2 Publications

GO - Molecular functioni

  • semaphorin receptor activity Source: MGI

GO - Biological processi

  • branchiomotor neuron axon guidance Source: GO_Central
  • dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
  • neuron projection extension Source: MGI
  • neuron projection guidance Source: MGI
  • regulation of axon extension involved in axon guidance Source: GO_Central
  • regulation of smooth muscle cell migration Source: MGI
  • semaphorin-plexin signaling pathway involved in axon guidance Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-399954. Sema3A PAK dependent Axon repulsion.
R-MMU-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-MMU-399956. CRMPs in Sema3A signaling.
R-MMU-416700. Other semaphorin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A1
Short name:
Plex 1
Short name:
Plexin-1
Gene namesi
Name:Plxna1
Synonyms:Kiaa4053
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107685. Plxna1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 1242ExtracellularSequence analysisAdd BLAST1215
Transmembranei1243 – 1263HelicalSequence analysisAdd BLAST21
Topological domaini1264 – 1894CytoplasmicSequence analysisAdd BLAST631

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1266 – 1268KRK → AAA: Loss of interaction with FARP2. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000023274628 – 1894Plexin-A1Add BLAST1867

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi93 ↔ 102PROSITE-ProRule annotation
Disulfide bondi128 ↔ 136PROSITE-ProRule annotation
Disulfide bondi284 ↔ 405PROSITE-ProRule annotation
Disulfide bondi300 ↔ 356PROSITE-ProRule annotation
Disulfide bondi374 ↔ 393PROSITE-ProRule annotation
Disulfide bondi513 ↔ 530PROSITE-ProRule annotation
Disulfide bondi519 ↔ 561PROSITE-ProRule annotation
Disulfide bondi522 ↔ 539PROSITE-ProRule annotation
Disulfide bondi533 ↔ 545PROSITE-ProRule annotation
Disulfide bondi596 ↔ 615PROSITE-ProRule annotation
Glycosylationi658N-linked (GlcNAc...)Sequence analysis1
Glycosylationi670N-linked (GlcNAc...)Sequence analysis1
Glycosylationi699N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1041N-linked (GlcNAc...)1 Publication1
Glycosylationi1185N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1210N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70206.
PaxDbiP70206.
PeptideAtlasiP70206.
PRIDEiP70206.

PTM databases

iPTMnetiP70206.
PhosphoSitePlusiP70206.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiENSMUSG00000030084.
CleanExiMM_PLXNA1.
ExpressionAtlasiP70206. baseline and differential.
GenevisibleiP70206. MM.

Interactioni

Subunit structurei

Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with WITH CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4.6 Publications

Protein-protein interaction databases

BioGridi202261. 4 interactors.
DIPiDIP-29745N.
IntActiP70206. 3 interactors.
MINTiMINT-4106183.
STRINGi10090.ENSMUSP00000063066.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RYTX-ray3.58A/B1269-1894[»]
5L56X-ray4.00A37-1236[»]
5L59X-ray6.00A/B37-1236[»]
5L5CX-ray6.00A37-1236[»]
ProteinModelPortaliP70206.
SMRiP70206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 510SemaPROSITE-ProRule annotationAdd BLAST483
Domaini862 – 957IPT/TIG 1Add BLAST96
Domaini959 – 1043IPT/TIG 2Add BLAST85
Domaini1046 – 1145IPT/TIG 3Add BLAST100
Domaini1148 – 1234IPT/TIG 4Add BLAST87

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili1262 – 1315Sequence analysisAdd BLAST54

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 4 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiP70206.
KOiK06820.
OMAiIGCEQAG.
OrthoDBiEOG091G00EK.
PhylomeDBiP70206.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70206-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPPLSSRT LLLLLLLLLR GVWIAISSPP AGLGPQPAFR TFVASDWGLT
60 70 80 90 100
HLVVHEQTGE VYVGAVNRIY KLSGNLTLLR AHVTGPVEDN EKCYPPPSVQ
110 120 130 140 150
SCPHGLGSTD NVNKLLLLDY AANRLLACGS ASQGICQFLR LDDLFKLGEP
160 170 180 190 200
HHRKEHYLSS VREAGSMAGV LIAGPPGQGQ AKLFVGTPID GKSEYFPTLS
210 220 230 240 250
SRRLMANEED ADMFGFVYQD EFVSSQLKIP SDTLSKFPAF DIYYVYSFRS
260 270 280 290 300
EQFVYYLTLQ LDTQLTSPDA AGEHFFTSKI VRLCVNDPKF YSYVEFPIGC
310 320 330 340 350
EQAGVEYRLV QDAYLSRPGQ ALAKQLGLAE DEEVLFTVFA QGQKNRVKPP
360 370 380 390 400
KESALCLFTL RAIKEKIKER IQSCYRGEGK LSLPWLLNKE LGCINSPLQI
410 420 430 440 450
DDDFCGQDFN QPLGGTVTIE GTPLFVDKED GLTAVAAYDY QGRTVVFAGT
460 470 480 490 500
RSGRIRKILV DLANPSGRPA LAYESVVAQE GNPILRDLVL SPNRQYLYAM
510 520 530 540 550
TEKQVTQVPV ESCVQYTSCE LCLGSRDPHC GWCVLHSICS RQDACERAEE
560 570 580 590 600
PQRFASDLLQ CVQLTVQPRN VSVTMSQVPL VLQAWNVPDL SAGVNCSFED
610 620 630 640 650
FTETESILED GRIHCHSPSA REVAPITQGQ GDQRVVKLYL KSKETGKKFA
660 670 680 690 700
SVDFVFYNCS VHQSCLACVN GSFPCHWCKY RHVCTNNAAD CAFLEGRVNM
710 720 730 740 750
SEDCPQILPS THIYVPVGVV KPITLAARNL PQPQSGQRGY ECLFHIPGSP
760 770 780 790 800
ARVTALRFNS SSLQCQNSSY SYEGNDVSDL PVNLSVVWNG NFVIDNPQNI
810 820 830 840 850
QAHLYKCPAL RQSCGLCLKA DPRFECGWCV AERRCSLRHH CPADSPASWM
860 870 880 890 900
HAHHGSSRCT DPKILKLSPE TGPRQGGTRL TITGENLGLR FEDVRLGVHV
910 920 930 940 950
GKVLCSPVES EYISAEQIVC EIGDASTLRA HDALVEVCVR DCSLHYRALS
960 970 980 990 1000
PKRFTFVTPT FYRVSPSRGP LSGGTWIGIE GSHLNAGSDV AVSIGGRPCS
1010 1020 1030 1040 1050
FSWRNSREIR CLTPPGHTPG SAPIVININR AQLSNPEVKY NYTEDPTILR
1060 1070 1080 1090 1100
IDPEWSINSG GTLLTVTGTN LATVREPRIR AKYGGIEREN SCMVYNDTTM
1110 1120 1130 1140 1150
VCRAPSIDNP KRSPPELGER PDEIGFIMDN VRTLLVLNSS SFLYYPDPVL
1160 1170 1180 1190 1200
EPLSPTGLLE LKPSSPLILK GRNLLPPAPG NSRLNYTVLI GSTPCILTVS
1210 1220 1230 1240 1250
ETQLLCEAPN LTGQHKVTVR AGGFEFSPGM LQVYSDSLLT LPAIVGIGGG
1260 1270 1280 1290 1300
GGLLLLVIVA VLIAYKRKSR DADRTLKRLQ LQMDNLESRV ALECKEAFAE
1310 1320 1330 1340 1350
LQTDIHELTS DLDGAGIPFL DYRTYAMRVL FPGIEDHPVL KEMEVQANVE
1360 1370 1380 1390 1400
KSLTLFGQLL TKKHFLLTFI RTLEAQRSFS MRDRGNVASL IMTALQGEME
1410 1420 1430 1440 1450
YATGVLKQLL SDLIEKNLES KNHPKLLLRR TESVAEKMLT NWFTFLLYKF
1460 1470 1480 1490 1500
LKECAGEPLF MLYCAIKQQM EKGPIDAITG EARYSLSEDK LIRQQIDYKT
1510 1520 1530 1540 1550
LTLNCVNPEH ENAPEVPVKG LNCDTVTQVK EKLLDAVYKG VPYSQRPKAG
1560 1570 1580 1590 1600
DMDLEWRQGR MARIILQDED VTTKIDNDWK RLNTLAHYQV TDGSSVALVP
1610 1620 1630 1640 1650
KQTSAYNISN SSTFTKSLSR YESMLRTASS PDSLRSRTPM ITPDLESGTK
1660 1670 1680 1690 1700
LWHLVKNHDH LDQREGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETIF
1710 1720 1730 1740 1750
STAHRGSALP LAIKYMFDFL DEQADKHQIH DSDVRHTWKS NCLPLRFWVN
1760 1770 1780 1790 1800
VIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHKLG KDSPSNKLLY
1810 1820 1830 1840 1850
AKDIPNYKSW VERYYADIAK MPAISDQDMS AYLAEQSRLH LSQFNSMSAL
1860 1870 1880 1890
HEIYSYIAKY KDEILVALEK DEQARRQRLR SKLEQVVDTM ALSS
Length:1,894
Mass (Da):211,099
Last modified:February 1, 1997 - v1
Checksum:iA8E6BB29C6824C94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86948 mRNA. Translation: BAA13188.1.
BC138023 mRNA. Translation: AAI38024.1.
AK220460 mRNA. Translation: BAD90489.1.
CCDSiCCDS20344.1.
PIRiJC4980.
RefSeqiNP_032907.1. NM_008881.2.
UniGeneiMm.3789.

Genome annotation databases

EnsembliENSMUST00000049845; ENSMUSP00000063066; ENSMUSG00000030084.
ENSMUST00000163139; ENSMUSP00000131840; ENSMUSG00000030084.
GeneIDi18844.
KEGGimmu:18844.
UCSCiuc009cwg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86948 mRNA. Translation: BAA13188.1.
BC138023 mRNA. Translation: AAI38024.1.
AK220460 mRNA. Translation: BAD90489.1.
CCDSiCCDS20344.1.
PIRiJC4980.
RefSeqiNP_032907.1. NM_008881.2.
UniGeneiMm.3789.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RYTX-ray3.58A/B1269-1894[»]
5L56X-ray4.00A37-1236[»]
5L59X-ray6.00A/B37-1236[»]
5L5CX-ray6.00A37-1236[»]
ProteinModelPortaliP70206.
SMRiP70206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202261. 4 interactors.
DIPiDIP-29745N.
IntActiP70206. 3 interactors.
MINTiMINT-4106183.
STRINGi10090.ENSMUSP00000063066.

PTM databases

iPTMnetiP70206.
PhosphoSitePlusiP70206.

Proteomic databases

MaxQBiP70206.
PaxDbiP70206.
PeptideAtlasiP70206.
PRIDEiP70206.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049845; ENSMUSP00000063066; ENSMUSG00000030084.
ENSMUST00000163139; ENSMUSP00000131840; ENSMUSG00000030084.
GeneIDi18844.
KEGGimmu:18844.
UCSCiuc009cwg.2. mouse.

Organism-specific databases

CTDi5361.
MGIiMGI:107685. Plxna1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG3610. Eukaryota.
ENOG410XR88. LUCA.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiP70206.
KOiK06820.
OMAiIGCEQAG.
OrthoDBiEOG091G00EK.
PhylomeDBiP70206.
TreeFamiTF312962.

Enzyme and pathway databases

ReactomeiR-MMU-399954. Sema3A PAK dependent Axon repulsion.
R-MMU-399955. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
R-MMU-399956. CRMPs in Sema3A signaling.
R-MMU-416700. Other semaphorin interactions.

Miscellaneous databases

PROiP70206.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030084.
CleanExiMM_PLXNA1.
ExpressionAtlasiP70206. baseline and differential.
GenevisibleiP70206. MM.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR031148. Plexin.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR22625. PTHR22625. 1 hit.
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 2 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLXA1_MOUSE
AccessioniPrimary (citable) accession number: P70206
Secondary accession number(s): B2RQP7, Q5DTR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.