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P70206

- PLXA1_MOUSE

UniProt

P70206 - PLXA1_MOUSE

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Protein

Plexin-A1

Gene

Plxna1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.2 Publications

GO - Molecular functioni

  1. semaphorin receptor activity Source: MGI

GO - Biological processi

  1. dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
  2. regulation of smooth muscle cell migration Source: MGI
  3. semaphorin-plexin signaling pathway Source: GOC
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_231928. Other semaphorin interactions.
REACT_244852. CRMPs in Sema3A signaling.
REACT_246154. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_254306. Sema3A PAK dependent Axon repulsion.

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A1
Short name:
Plex 1
Short name:
Plexin-1
Gene namesi
Name:Plxna1
Synonyms:Kiaa4053
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:107685. Plxna1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 12421215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1243 – 126321HelicalSequence AnalysisAdd
BLAST
Topological domaini1264 – 1894631CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. membrane Source: MGI
  5. nucleus Source: Ensembl
  6. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1266 – 12683KRK → AAA: Loss of interaction with FARP2. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727Sequence AnalysisAdd
BLAST
Chaini28 – 18941867Plexin-A1PRO_0000232746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi93 ↔ 102PROSITE-ProRule annotation
Disulfide bondi128 ↔ 136PROSITE-ProRule annotation
Disulfide bondi284 ↔ 405PROSITE-ProRule annotation
Disulfide bondi300 ↔ 356PROSITE-ProRule annotation
Disulfide bondi374 ↔ 393PROSITE-ProRule annotation
Disulfide bondi513 ↔ 530PROSITE-ProRule annotation
Disulfide bondi519 ↔ 561PROSITE-ProRule annotation
Disulfide bondi522 ↔ 539PROSITE-ProRule annotation
Disulfide bondi533 ↔ 545PROSITE-ProRule annotation
Disulfide bondi596 ↔ 615PROSITE-ProRule annotation
Glycosylationi658 – 6581N-linked (GlcNAc...)Sequence Analysis
Glycosylationi670 – 6701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1041 – 10411N-linked (GlcNAc...)1 Publication
Glycosylationi1185 – 11851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1210 – 12101N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70206.
PaxDbiP70206.
PRIDEiP70206.

PTM databases

PhosphoSiteiP70206.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

BgeeiP70206.
CleanExiMM_PLXNA1.
ExpressionAtlasiP70206. baseline and differential.
GenevestigatoriP70206.

Interactioni

Subunit structurei

Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with WITH CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4.6 Publications

Protein-protein interaction databases

BioGridi202261. 4 interactions.
DIPiDIP-29745N.
IntActiP70206. 3 interactions.
MINTiMINT-4106183.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RYTX-ray3.58A/B1269-1894[»]
ProteinModelPortaliP70206.
SMRiP70206. Positions 37-705, 812-923, 1278-1890.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 510483SemaPROSITE-ProRule annotationAdd
BLAST
Domaini862 – 95796IPT/TIG 1Add
BLAST
Domaini959 – 104385IPT/TIG 2Add
BLAST
Domaini1046 – 1145100IPT/TIG 3Add
BLAST
Domaini1148 – 123487IPT/TIG 4Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1262 – 131554Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.Curated
Contains 4 IPT/TIG domains.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254546.
GeneTreeiENSGT00760000119048.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiP70206.
KOiK06820.
OMAiIGCEQAG.
OrthoDBiEOG7Q8CM9.
PhylomeDBiP70206.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 2 hits.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70206-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLPPLSSRT LLLLLLLLLR GVWIAISSPP AGLGPQPAFR TFVASDWGLT
60 70 80 90 100
HLVVHEQTGE VYVGAVNRIY KLSGNLTLLR AHVTGPVEDN EKCYPPPSVQ
110 120 130 140 150
SCPHGLGSTD NVNKLLLLDY AANRLLACGS ASQGICQFLR LDDLFKLGEP
160 170 180 190 200
HHRKEHYLSS VREAGSMAGV LIAGPPGQGQ AKLFVGTPID GKSEYFPTLS
210 220 230 240 250
SRRLMANEED ADMFGFVYQD EFVSSQLKIP SDTLSKFPAF DIYYVYSFRS
260 270 280 290 300
EQFVYYLTLQ LDTQLTSPDA AGEHFFTSKI VRLCVNDPKF YSYVEFPIGC
310 320 330 340 350
EQAGVEYRLV QDAYLSRPGQ ALAKQLGLAE DEEVLFTVFA QGQKNRVKPP
360 370 380 390 400
KESALCLFTL RAIKEKIKER IQSCYRGEGK LSLPWLLNKE LGCINSPLQI
410 420 430 440 450
DDDFCGQDFN QPLGGTVTIE GTPLFVDKED GLTAVAAYDY QGRTVVFAGT
460 470 480 490 500
RSGRIRKILV DLANPSGRPA LAYESVVAQE GNPILRDLVL SPNRQYLYAM
510 520 530 540 550
TEKQVTQVPV ESCVQYTSCE LCLGSRDPHC GWCVLHSICS RQDACERAEE
560 570 580 590 600
PQRFASDLLQ CVQLTVQPRN VSVTMSQVPL VLQAWNVPDL SAGVNCSFED
610 620 630 640 650
FTETESILED GRIHCHSPSA REVAPITQGQ GDQRVVKLYL KSKETGKKFA
660 670 680 690 700
SVDFVFYNCS VHQSCLACVN GSFPCHWCKY RHVCTNNAAD CAFLEGRVNM
710 720 730 740 750
SEDCPQILPS THIYVPVGVV KPITLAARNL PQPQSGQRGY ECLFHIPGSP
760 770 780 790 800
ARVTALRFNS SSLQCQNSSY SYEGNDVSDL PVNLSVVWNG NFVIDNPQNI
810 820 830 840 850
QAHLYKCPAL RQSCGLCLKA DPRFECGWCV AERRCSLRHH CPADSPASWM
860 870 880 890 900
HAHHGSSRCT DPKILKLSPE TGPRQGGTRL TITGENLGLR FEDVRLGVHV
910 920 930 940 950
GKVLCSPVES EYISAEQIVC EIGDASTLRA HDALVEVCVR DCSLHYRALS
960 970 980 990 1000
PKRFTFVTPT FYRVSPSRGP LSGGTWIGIE GSHLNAGSDV AVSIGGRPCS
1010 1020 1030 1040 1050
FSWRNSREIR CLTPPGHTPG SAPIVININR AQLSNPEVKY NYTEDPTILR
1060 1070 1080 1090 1100
IDPEWSINSG GTLLTVTGTN LATVREPRIR AKYGGIEREN SCMVYNDTTM
1110 1120 1130 1140 1150
VCRAPSIDNP KRSPPELGER PDEIGFIMDN VRTLLVLNSS SFLYYPDPVL
1160 1170 1180 1190 1200
EPLSPTGLLE LKPSSPLILK GRNLLPPAPG NSRLNYTVLI GSTPCILTVS
1210 1220 1230 1240 1250
ETQLLCEAPN LTGQHKVTVR AGGFEFSPGM LQVYSDSLLT LPAIVGIGGG
1260 1270 1280 1290 1300
GGLLLLVIVA VLIAYKRKSR DADRTLKRLQ LQMDNLESRV ALECKEAFAE
1310 1320 1330 1340 1350
LQTDIHELTS DLDGAGIPFL DYRTYAMRVL FPGIEDHPVL KEMEVQANVE
1360 1370 1380 1390 1400
KSLTLFGQLL TKKHFLLTFI RTLEAQRSFS MRDRGNVASL IMTALQGEME
1410 1420 1430 1440 1450
YATGVLKQLL SDLIEKNLES KNHPKLLLRR TESVAEKMLT NWFTFLLYKF
1460 1470 1480 1490 1500
LKECAGEPLF MLYCAIKQQM EKGPIDAITG EARYSLSEDK LIRQQIDYKT
1510 1520 1530 1540 1550
LTLNCVNPEH ENAPEVPVKG LNCDTVTQVK EKLLDAVYKG VPYSQRPKAG
1560 1570 1580 1590 1600
DMDLEWRQGR MARIILQDED VTTKIDNDWK RLNTLAHYQV TDGSSVALVP
1610 1620 1630 1640 1650
KQTSAYNISN SSTFTKSLSR YESMLRTASS PDSLRSRTPM ITPDLESGTK
1660 1670 1680 1690 1700
LWHLVKNHDH LDQREGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETIF
1710 1720 1730 1740 1750
STAHRGSALP LAIKYMFDFL DEQADKHQIH DSDVRHTWKS NCLPLRFWVN
1760 1770 1780 1790 1800
VIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHKLG KDSPSNKLLY
1810 1820 1830 1840 1850
AKDIPNYKSW VERYYADIAK MPAISDQDMS AYLAEQSRLH LSQFNSMSAL
1860 1870 1880 1890
HEIYSYIAKY KDEILVALEK DEQARRQRLR SKLEQVVDTM ALSS
Length:1,894
Mass (Da):211,099
Last modified:February 1, 1997 - v1
Checksum:iA8E6BB29C6824C94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86948 mRNA. Translation: BAA13188.1.
BC138023 mRNA. Translation: AAI38024.1.
AK220460 mRNA. Translation: BAD90489.1.
CCDSiCCDS20344.1.
PIRiJC4980.
RefSeqiNP_032907.1. NM_008881.2.
UniGeneiMm.3789.

Genome annotation databases

EnsembliENSMUST00000049845; ENSMUSP00000063066; ENSMUSG00000030084.
ENSMUST00000163139; ENSMUSP00000131840; ENSMUSG00000030084.
GeneIDi18844.
KEGGimmu:18844.
UCSCiuc009cwg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86948 mRNA. Translation: BAA13188.1 .
BC138023 mRNA. Translation: AAI38024.1 .
AK220460 mRNA. Translation: BAD90489.1 .
CCDSi CCDS20344.1.
PIRi JC4980.
RefSeqi NP_032907.1. NM_008881.2.
UniGenei Mm.3789.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RYT X-ray 3.58 A/B 1269-1894 [» ]
ProteinModelPortali P70206.
SMRi P70206. Positions 37-705, 812-923, 1278-1890.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202261. 4 interactions.
DIPi DIP-29745N.
IntActi P70206. 3 interactions.
MINTi MINT-4106183.

PTM databases

PhosphoSitei P70206.

Proteomic databases

MaxQBi P70206.
PaxDbi P70206.
PRIDEi P70206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049845 ; ENSMUSP00000063066 ; ENSMUSG00000030084 .
ENSMUST00000163139 ; ENSMUSP00000131840 ; ENSMUSG00000030084 .
GeneIDi 18844.
KEGGi mmu:18844.
UCSCi uc009cwg.2. mouse.

Organism-specific databases

CTDi 5361.
MGIi MGI:107685. Plxna1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG254546.
GeneTreei ENSGT00760000119048.
HOGENOMi HOG000231377.
HOVERGENi HBG105711.
InParanoidi P70206.
KOi K06820.
OMAi IGCEQAG.
OrthoDBi EOG7Q8CM9.
PhylomeDBi P70206.
TreeFami TF312962.

Enzyme and pathway databases

Reactomei REACT_231928. Other semaphorin interactions.
REACT_244852. CRMPs in Sema3A signaling.
REACT_246154. SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion.
REACT_254306. Sema3A PAK dependent Axon repulsion.

Miscellaneous databases

NextBioi 295216.
PROi P70206.
SOURCEi Search...

Gene expression databases

Bgeei P70206.
CleanExi MM_PLXNA1.
ExpressionAtlasi P70206. baseline and differential.
Genevestigatori P70206.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view ]
SMARTi SM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 2 hits.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c and ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-1894.
    Tissue: Brain.
  4. "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors."
    Takahashi T., Fournier A., Nakamura F., Wang L.-H., Murakami Y., Kalb R.G., Fujisawa H., Strittmatter S.M.
    Cell 99:59-69(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2; SEMA3A AND SEMA3F.
  5. "Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A."
    Rohm B., Ottemeyer A., Lohrum M., Pueschel A.W.
    Mech. Dev. 93:95-104(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2; SEMA3A AND SEMA3C.
  6. "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains."
    Usui H., Taniguchi M., Yokomizo T., Shimizu T.
    Biochem. Biophys. Res. Commun. 300:927-931(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXNB1, TISSUE SPECIFICITY.
  7. "Structural bases for CRMP function in plexin-dependent semaphorin3A signaling."
    Deo R.C., Schmidt E.F., Elhabazi A., Togashi H., Burley S.K., Strittmatter S.M.
    EMBO J. 23:9-22(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRMP1; DPYSL2/CRMP2; DPYSL3/CRMP3 AND DPYSL4/CRMP4.
  8. "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2."
    Toyofuku T., Zhang H., Kumanogoh A., Takegahara N., Suto F., Kamei J., Aoki K., Yabuki M., Hori M., Fujisawa H., Kikutani H.
    Genes Dev. 18:435-447(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEMA6D AND KDR.
  9. Cited for: INTERACTION WITH FARP2 AND RND1, MUTAGENESIS OF 1266-LYS--LYS-1268.
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1041.

Entry informationi

Entry nameiPLXA1_MOUSE
AccessioniPrimary (citable) accession number: P70206
Secondary accession number(s): B2RQP7, Q5DTR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3