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P70206

- PLXA1_MOUSE

UniProt

P70206 - PLXA1_MOUSE

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Protein

Plexin-A1

Gene
Plxna1, Kiaa4053
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.2 Publications

GO - Molecular functioni

  1. protein binding Source: MGI
  2. semaphorin receptor activity Source: MGI

GO - Biological processi

  1. dichotomous subdivision of terminal units involved in salivary gland branching Source: MGI
  2. regulation of smooth muscle cell migration Source: MGI
  3. semaphorin-plexin signaling pathway Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A1
Short name:
Plex 1
Short name:
Plexin-1
Gene namesi
Name:Plxna1
Synonyms:Kiaa4053
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:107685. Plxna1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini28 – 12421215Extracellular Reviewed predictionAdd
BLAST
Transmembranei1243 – 126321Helical; Reviewed predictionAdd
BLAST
Topological domaini1264 – 1894631Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. membrane Source: MGI
  4. nucleus Source: Ensembl
  5. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi1266 – 12683KRK → AAA: Loss of interaction with FARP2. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727 Reviewed predictionAdd
BLAST
Chaini28 – 18941867Plexin-A1PRO_0000232746Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi93 ↔ 102 By similarity
Disulfide bondi128 ↔ 136 By similarity
Disulfide bondi284 ↔ 405 By similarity
Disulfide bondi300 ↔ 356 By similarity
Disulfide bondi374 ↔ 393 By similarity
Disulfide bondi513 ↔ 530 By similarity
Disulfide bondi519 ↔ 561 By similarity
Disulfide bondi522 ↔ 539 By similarity
Disulfide bondi533 ↔ 545 By similarity
Disulfide bondi596 ↔ 615 By similarity
Glycosylationi658 – 6581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi670 – 6701N-linked (GlcNAc...) Reviewed prediction
Glycosylationi699 – 6991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1041 – 10411N-linked (GlcNAc...)1 Publication
Glycosylationi1185 – 11851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1210 – 12101N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70206.
PaxDbiP70206.
PRIDEiP70206.

PTM databases

PhosphoSiteiP70206.

Expressioni

Tissue specificityi

Ubiquitous.2 Publications

Gene expression databases

ArrayExpressiP70206.
BgeeiP70206.
CleanExiMM_PLXNA1.
GenevestigatoriP70206.

Interactioni

Subunit structurei

Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Interacts with WITH CRMP1, DPYSL2/CRMP2, DPYSL3/CRMP3 and DPYSL4/CRMP4.6 Publications

Protein-protein interaction databases

BioGridi202261. 4 interactions.
DIPiDIP-29745N.
IntActiP70206. 3 interactions.
MINTiMINT-4106183.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RYTX-ray3.58A/B1269-1894[»]
ProteinModelPortaliP70206.
SMRiP70206. Positions 37-705, 812-923, 1278-1890.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 510483SemaAdd
BLAST
Domaini862 – 95796IPT/TIG 1Add
BLAST
Domaini959 – 104385IPT/TIG 2Add
BLAST
Domaini1046 – 1145100IPT/TIG 3Add
BLAST
Domaini1148 – 123487IPT/TIG 4Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili1262 – 131554 Reviewed predictionAdd
BLAST

Sequence similaritiesi

Belongs to the plexin family.
Contains 4 IPT/TIG domains.
Contains 1 Sema domain.

Keywords - Domaini

Coiled coil, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG254546.
GeneTreeiENSGT00750000117292.
HOGENOMiHOG000231377.
HOVERGENiHBG105711.
InParanoidiB2RQP7.
KOiK06820.
OMAiIGCEQAG.
OrthoDBiEOG7Q8CM9.
PhylomeDBiP70206.
TreeFamiTF312962.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProiIPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PfamiPF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view]
SMARTiSM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 2 hits.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEiPS51004. SEMA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70206-1 [UniParc]FASTAAdd to Basket

« Hide

MPLPPLSSRT LLLLLLLLLR GVWIAISSPP AGLGPQPAFR TFVASDWGLT     50
HLVVHEQTGE VYVGAVNRIY KLSGNLTLLR AHVTGPVEDN EKCYPPPSVQ 100
SCPHGLGSTD NVNKLLLLDY AANRLLACGS ASQGICQFLR LDDLFKLGEP 150
HHRKEHYLSS VREAGSMAGV LIAGPPGQGQ AKLFVGTPID GKSEYFPTLS 200
SRRLMANEED ADMFGFVYQD EFVSSQLKIP SDTLSKFPAF DIYYVYSFRS 250
EQFVYYLTLQ LDTQLTSPDA AGEHFFTSKI VRLCVNDPKF YSYVEFPIGC 300
EQAGVEYRLV QDAYLSRPGQ ALAKQLGLAE DEEVLFTVFA QGQKNRVKPP 350
KESALCLFTL RAIKEKIKER IQSCYRGEGK LSLPWLLNKE LGCINSPLQI 400
DDDFCGQDFN QPLGGTVTIE GTPLFVDKED GLTAVAAYDY QGRTVVFAGT 450
RSGRIRKILV DLANPSGRPA LAYESVVAQE GNPILRDLVL SPNRQYLYAM 500
TEKQVTQVPV ESCVQYTSCE LCLGSRDPHC GWCVLHSICS RQDACERAEE 550
PQRFASDLLQ CVQLTVQPRN VSVTMSQVPL VLQAWNVPDL SAGVNCSFED 600
FTETESILED GRIHCHSPSA REVAPITQGQ GDQRVVKLYL KSKETGKKFA 650
SVDFVFYNCS VHQSCLACVN GSFPCHWCKY RHVCTNNAAD CAFLEGRVNM 700
SEDCPQILPS THIYVPVGVV KPITLAARNL PQPQSGQRGY ECLFHIPGSP 750
ARVTALRFNS SSLQCQNSSY SYEGNDVSDL PVNLSVVWNG NFVIDNPQNI 800
QAHLYKCPAL RQSCGLCLKA DPRFECGWCV AERRCSLRHH CPADSPASWM 850
HAHHGSSRCT DPKILKLSPE TGPRQGGTRL TITGENLGLR FEDVRLGVHV 900
GKVLCSPVES EYISAEQIVC EIGDASTLRA HDALVEVCVR DCSLHYRALS 950
PKRFTFVTPT FYRVSPSRGP LSGGTWIGIE GSHLNAGSDV AVSIGGRPCS 1000
FSWRNSREIR CLTPPGHTPG SAPIVININR AQLSNPEVKY NYTEDPTILR 1050
IDPEWSINSG GTLLTVTGTN LATVREPRIR AKYGGIEREN SCMVYNDTTM 1100
VCRAPSIDNP KRSPPELGER PDEIGFIMDN VRTLLVLNSS SFLYYPDPVL 1150
EPLSPTGLLE LKPSSPLILK GRNLLPPAPG NSRLNYTVLI GSTPCILTVS 1200
ETQLLCEAPN LTGQHKVTVR AGGFEFSPGM LQVYSDSLLT LPAIVGIGGG 1250
GGLLLLVIVA VLIAYKRKSR DADRTLKRLQ LQMDNLESRV ALECKEAFAE 1300
LQTDIHELTS DLDGAGIPFL DYRTYAMRVL FPGIEDHPVL KEMEVQANVE 1350
KSLTLFGQLL TKKHFLLTFI RTLEAQRSFS MRDRGNVASL IMTALQGEME 1400
YATGVLKQLL SDLIEKNLES KNHPKLLLRR TESVAEKMLT NWFTFLLYKF 1450
LKECAGEPLF MLYCAIKQQM EKGPIDAITG EARYSLSEDK LIRQQIDYKT 1500
LTLNCVNPEH ENAPEVPVKG LNCDTVTQVK EKLLDAVYKG VPYSQRPKAG 1550
DMDLEWRQGR MARIILQDED VTTKIDNDWK RLNTLAHYQV TDGSSVALVP 1600
KQTSAYNISN SSTFTKSLSR YESMLRTASS PDSLRSRTPM ITPDLESGTK 1650
LWHLVKNHDH LDQREGDRGS KMVSEIYLTR LLATKGTLQK FVDDLFETIF 1700
STAHRGSALP LAIKYMFDFL DEQADKHQIH DSDVRHTWKS NCLPLRFWVN 1750
VIKNPQFVFD IHKNSITDAC LSVVAQTFMD SCSTSEHKLG KDSPSNKLLY 1800
AKDIPNYKSW VERYYADIAK MPAISDQDMS AYLAEQSRLH LSQFNSMSAL 1850
HEIYSYIAKY KDEILVALEK DEQARRQRLR SKLEQVVDTM ALSS 1894
Length:1,894
Mass (Da):211,099
Last modified:February 1, 1997 - v1
Checksum:iA8E6BB29C6824C94
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86948 mRNA. Translation: BAA13188.1.
BC138023 mRNA. Translation: AAI38024.1.
AK220460 mRNA. Translation: BAD90489.1.
CCDSiCCDS20344.1.
PIRiJC4980.
RefSeqiNP_032907.1. NM_008881.2.
UniGeneiMm.3789.

Genome annotation databases

EnsembliENSMUST00000049845; ENSMUSP00000063066; ENSMUSG00000030084.
ENSMUST00000163139; ENSMUSP00000131840; ENSMUSG00000030084.
GeneIDi18844.
KEGGimmu:18844.
UCSCiuc009cwg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86948 mRNA. Translation: BAA13188.1 .
BC138023 mRNA. Translation: AAI38024.1 .
AK220460 mRNA. Translation: BAD90489.1 .
CCDSi CCDS20344.1.
PIRi JC4980.
RefSeqi NP_032907.1. NM_008881.2.
UniGenei Mm.3789.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RYT X-ray 3.58 A/B 1269-1894 [» ]
ProteinModelPortali P70206.
SMRi P70206. Positions 37-705, 812-923, 1278-1890.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 202261. 4 interactions.
DIPi DIP-29745N.
IntActi P70206. 3 interactions.
MINTi MINT-4106183.

PTM databases

PhosphoSitei P70206.

Proteomic databases

MaxQBi P70206.
PaxDbi P70206.
PRIDEi P70206.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049845 ; ENSMUSP00000063066 ; ENSMUSG00000030084 .
ENSMUST00000163139 ; ENSMUSP00000131840 ; ENSMUSG00000030084 .
GeneIDi 18844.
KEGGi mmu:18844.
UCSCi uc009cwg.2. mouse.

Organism-specific databases

CTDi 5361.
MGIi MGI:107685. Plxna1.
Rougei Search...

Phylogenomic databases

eggNOGi NOG254546.
GeneTreei ENSGT00750000117292.
HOGENOMi HOG000231377.
HOVERGENi HBG105711.
InParanoidi B2RQP7.
KOi K06820.
OMAi IGCEQAG.
OrthoDBi EOG7Q8CM9.
PhylomeDBi P70206.
TreeFami TF312962.

Miscellaneous databases

NextBioi 295216.
PROi P70206.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70206.
Bgeei P70206.
CleanExi MM_PLXNA1.
Genevestigatori P70206.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
2.60.40.10. 4 hits.
InterProi IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR016201. Plexin-like_fold.
IPR013548. Plexin_cytoplasmic_RasGAP_dom.
IPR002165. Plexin_repeat.
IPR008936. Rho_GTPase_activation_prot.
IPR001627. Semap_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view ]
Pfami PF08337. Plexin_cytopl. 1 hit.
PF01437. PSI. 3 hits.
PF01403. Sema. 1 hit.
PF01833. TIG. 4 hits.
[Graphical view ]
SMARTi SM00429. IPT. 4 hits.
SM00423. PSI. 3 hits.
SM00630. Sema. 1 hit.
[Graphical view ]
SUPFAMi SSF101912. SSF101912. 1 hit.
SSF103575. SSF103575. 2 hits.
SSF48350. SSF48350. 2 hits.
SSF81296. SSF81296. 4 hits.
PROSITEi PS51004. SEMA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: BALB/c and ICR.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O., Koga H.
    Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 495-1894.
    Tissue: Brain.
  4. "Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors."
    Takahashi T., Fournier A., Nakamura F., Wang L.-H., Murakami Y., Kalb R.G., Fujisawa H., Strittmatter S.M.
    Cell 99:59-69(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2; SEMA3A AND SEMA3F.
  5. "Plexin/neuropilin complexes mediate repulsion by the axonal guidance signal semaphorin 3A."
    Rohm B., Ottemeyer A., Lohrum M., Pueschel A.W.
    Mech. Dev. 93:95-104(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH NRP1; NRP2; SEMA3A AND SEMA3C.
  6. "Plexin-A1 and plexin-B1 specifically interact at their cytoplasmic domains."
    Usui H., Taniguchi M., Yokomizo T., Shimizu T.
    Biochem. Biophys. Res. Commun. 300:927-931(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PLXNB1, TISSUE SPECIFICITY.
  7. "Structural bases for CRMP function in plexin-dependent semaphorin3A signaling."
    Deo R.C., Schmidt E.F., Elhabazi A., Togashi H., Burley S.K., Strittmatter S.M.
    EMBO J. 23:9-22(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CRMP1; DPYSL2/CRMP2; DPYSL3/CRMP3 AND DPYSL4/CRMP4.
  8. "Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2."
    Toyofuku T., Zhang H., Kumanogoh A., Takegahara N., Suto F., Kamei J., Aoki K., Yabuki M., Hori M., Fujisawa H., Kikutani H.
    Genes Dev. 18:435-447(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SEMA6D AND KDR.
  9. Cited for: INTERACTION WITH FARP2 AND RND1, MUTAGENESIS OF 1266-LYS--LYS-1268.
  10. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1041.

Entry informationi

Entry nameiPLXA1_MOUSE
AccessioniPrimary (citable) accession number: P70206
Secondary accession number(s): B2RQP7, Q5DTR0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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