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P70205

- PACR_MOUSE

UniProt

P70205 - PACR_MOUSE

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Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

Adcyap1r1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. neuropeptide binding Source: Ensembl
  3. vasoactive intestinal polypeptide receptor activity Source: MGI

GO - Biological processi

  1. activation of phospholipase C activity Source: Ensembl
  2. cAMP-mediated signaling Source: Ensembl
  3. cell differentiation Source: UniProtKB-KW
  4. development of primary female sexual characteristics Source: Ensembl
  5. G-protein coupled receptor signaling pathway Source: MGI
  6. multicellular organismal response to stress Source: Ensembl
  7. negative regulation of cell death Source: Ensembl
  8. positive regulation of calcium ion transport into cytosol Source: Ensembl
  9. positive regulation of cAMP biosynthetic process Source: Ensembl
  10. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
  11. response to drug Source: Ensembl
  12. response to estradiol Source: Ensembl
  13. response to ethanol Source: Ensembl
  14. spermatogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Differentiation, Spermatogenesis

Enzyme and pathway databases

ReactomeiREACT_209347. NGF-independant TRKA activation.
REACT_231304. Glucagon-type ligand receptors.
REACT_242871. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor
Short name:
PACAP type I receptor
Short name:
PACAP-R-1
Short name:
PACAP-R1
Gene namesi
Name:Adcyap1r1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:108449. Adcyap1r1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 155135ExtracellularSequence AnalysisAdd
BLAST
Transmembranei156 – 17823Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini179 – 1868CytoplasmicSequence Analysis
Transmembranei187 – 20519Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini206 – 22722ExtracellularSequence AnalysisAdd
BLAST
Transmembranei228 – 25326Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini254 – 26815CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei269 – 29123Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini292 – 30918ExtracellularSequence AnalysisAdd
BLAST
Transmembranei310 – 33223Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini333 – 37846CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei379 – 39921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini400 – 41314ExtracellularSequence AnalysisAdd
BLAST
Transmembranei414 – 43320Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini434 – 49663CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. cell surface Source: Ensembl
  3. endosome Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. neuron projection Source: Ensembl
  6. receptor complex Source: MGI
  7. rough endoplasmic reticulum Source: Ensembl
  8. tight junction Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Chaini21 – 496476Pituitary adenylate cyclase-activating polypeptide type I receptorPRO_0000012842Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 63By similarity
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi54 ↔ 118By similarity
Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi77 ↔ 134By similarity
Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70205.
PaxDbiP70205.
PRIDEiP70205.

PTM databases

PhosphoSiteiP70205.

Expressioni

Gene expression databases

BgeeiP70205.
ExpressionAtlasiP70205. baseline and differential.
GenevestigatoriP70205.

Interactioni

Subunit structurei

Interacts (via N-terminal extracellular domain) with ADCYAP1.By similarity

Protein-protein interaction databases

IntActiP70205. 1 interaction.
MINTiMINT-4544489.

Structurei

3D structure databases

ProteinModelPortaliP70205.
SMRiP70205. Positions 26-140, 150-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni125 – 13915Important for ligand binding and specificityBy similarityAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG330024.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP70205.
KOiK04587.
OrthoDBiEOG7TF78W.
PhylomeDBiP70205.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70205-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARTLQLSLT ALLLLPMAIA MHSDCIFKKE QAMCLERIQR ANDLMGLNES
60 70 80 90 100
SPGCPGMWDN ITCWKPAQIG EMVLVSCPEV FRIFNPDQVW MTETIGDSGF
110 120 130 140 150
ADSNSLEITD MGVVGRNCTE DGWSEPFPHY FDACGFDDYE PESGDQDYYY
160 170 180 190 200
LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA
210 220 230 240 250
ISVFIKDWIL YAEQDSSHCF VSTVECKAVM VFFHYCVVSN YFWLFIEGLY
260 270 280 290 300
LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWAVLRLY FDDAGCWDMN
310 320 330 340 350
DSTALWWVIK GPVVGSIMVN FVLFIGIIII LVQKLQSPDM GGNESSIYFS
360 370 380 390 400
CVQKCYCKPQ RAQQHSCKMS ELSTITLRLA RSTLLLIPLF GIHYTVFAFS
410 420 430 440 450
PENVSKRERL VFELGLGSFQ GFVVAVLYCF LNGEVQAEIK RKWRSWKVNR
460 470 480 490
YFTMDFKHRH PSLASSGVNG GTQLSILSKS SSQLRMSSLP ADNLAT
Length:496
Mass (Da):56,640
Last modified:February 1, 1997 - v1
Checksum:i47B5D51D4209060A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82935 mRNA. Translation: BAA11639.1.
CCDSiCCDS20167.1.
RefSeqiNP_031433.3. NM_007407.4.
UniGeneiMm.44245.

Genome annotation databases

EnsembliENSMUST00000070736; ENSMUSP00000063784; ENSMUSG00000029778.
GeneIDi11517.
KEGGimmu:11517.
UCSCiuc009cat.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D82935 mRNA. Translation: BAA11639.1 .
CCDSi CCDS20167.1.
RefSeqi NP_031433.3. NM_007407.4.
UniGenei Mm.44245.

3D structure databases

ProteinModelPortali P70205.
SMRi P70205. Positions 26-140, 150-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P70205. 1 interaction.
MINTi MINT-4544489.

Chemistry

GuidetoPHARMACOLOGYi 370.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P70205.

Proteomic databases

MaxQBi P70205.
PaxDbi P70205.
PRIDEi P70205.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000070736 ; ENSMUSP00000063784 ; ENSMUSG00000029778 .
GeneIDi 11517.
KEGGi mmu:11517.
UCSCi uc009cat.1. mouse.

Organism-specific databases

CTDi 117.
MGIi MGI:108449. Adcyap1r1.

Phylogenomic databases

eggNOGi NOG330024.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000008249.
HOVERGENi HBG008318.
InParanoidi P70205.
KOi K04587.
OrthoDBi EOG7TF78W.
PhylomeDBi P70205.
TreeFami TF315710.

Enzyme and pathway databases

Reactomei REACT_209347. NGF-independant TRKA activation.
REACT_231304. Glucagon-type ligand receptors.
REACT_242871. G alpha (s) signalling events.

Miscellaneous databases

ChiTaRSi Adcyap1r1. mouse.
NextBioi 278938.
PROi P70205.
SOURCEi Search...

Gene expression databases

Bgeei P70205.
ExpressionAtlasi P70205. baseline and differential.
Genevestigatori P70205.

Family and domain databases

InterProi IPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA cloning of a mouse pituitary adenylate cyclase-activating polypeptide receptor."
    Hashimoto H., Yamamoto K., Hagigara N., Ogawa N., Nishino A., Aino H., Nogi H., Imanishi K., Matsuda T., Baba A.
    Biochim. Biophys. Acta 1281:129-133(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiPACR_MOUSE
AccessioniPrimary (citable) accession number: P70205
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3