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P70205

- PACR_MOUSE

UniProt

P70205 - PACR_MOUSE

Protein

Pituitary adenylate cyclase-activating polypeptide type I receptor

Gene

Adcyap1r1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: MGI
    2. neuropeptide binding Source: Ensembl
    3. protein binding Source: MGI
    4. vasoactive intestinal polypeptide receptor activity Source: MGI

    GO - Biological processi

    1. activation of phospholipase C activity Source: Ensembl
    2. cAMP-mediated signaling Source: Ensembl
    3. cell differentiation Source: UniProtKB-KW
    4. development of primary female sexual characteristics Source: Ensembl
    5. G-protein coupled receptor signaling pathway Source: MGI
    6. multicellular organismal response to stress Source: Ensembl
    7. negative regulation of cell death Source: Ensembl
    8. positive regulation of calcium ion transport into cytosol Source: Ensembl
    9. positive regulation of cAMP biosynthetic process Source: Ensembl
    10. positive regulation of inositol phosphate biosynthetic process Source: Ensembl
    11. response to drug Source: Ensembl
    12. response to estradiol Source: Ensembl
    13. response to ethanol Source: Ensembl
    14. spermatogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Differentiation, Spermatogenesis

    Enzyme and pathway databases

    ReactomeiREACT_209347. NGF-independant TRKA activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pituitary adenylate cyclase-activating polypeptide type I receptor
    Short name:
    PACAP type I receptor
    Short name:
    PACAP-R-1
    Short name:
    PACAP-R1
    Gene namesi
    Name:Adcyap1r1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:108449. Adcyap1r1.

    Subcellular locationi

    GO - Cellular componenti

    1. caveola Source: Ensembl
    2. cell surface Source: Ensembl
    3. endosome Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. neuron projection Source: Ensembl
    6. receptor complex Source: MGI
    7. rough endoplasmic reticulum Source: Ensembl
    8. tight junction Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 496476Pituitary adenylate cyclase-activating polypeptide type I receptorPRO_0000012842Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi34 ↔ 63By similarity
    Glycosylationi48 – 481N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi54 ↔ 118By similarity
    Glycosylationi60 – 601N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi77 ↔ 134By similarity
    Glycosylationi117 – 1171N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP70205.
    PRIDEiP70205.

    PTM databases

    PhosphoSiteiP70205.

    Expressioni

    Gene expression databases

    ArrayExpressiP70205.
    BgeeiP70205.
    GenevestigatoriP70205.

    Interactioni

    Subunit structurei

    Interacts (via N-terminal extracellular domain) with ADCYAP1.By similarity

    Protein-protein interaction databases

    IntActiP70205. 1 interaction.
    MINTiMINT-4544489.

    Structurei

    3D structure databases

    ProteinModelPortaliP70205.
    SMRiP70205. Positions 26-140, 150-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini21 – 155135ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini179 – 1868CytoplasmicSequence Analysis
    Topological domaini206 – 22722ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini254 – 26815CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini292 – 30918ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini333 – 37846CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini400 – 41314ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini434 – 49663CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei156 – 17823Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20519Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei228 – 25326Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei269 – 29123Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei310 – 33223Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei414 – 43320Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni125 – 13915Important for ligand binding and specificityBy similarityAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG330024.
    GeneTreeiENSGT00620000087538.
    HOGENOMiHOG000008249.
    HOVERGENiHBG008318.
    InParanoidiP70205.
    KOiK04587.
    OrthoDBiEOG7TF78W.
    PhylomeDBiP70205.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002285. GPCR_2_PACAP_1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00249. GPCRSECRETIN.
    PR01156. PACAPRECEPTR.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70205-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARTLQLSLT ALLLLPMAIA MHSDCIFKKE QAMCLERIQR ANDLMGLNES    50
    SPGCPGMWDN ITCWKPAQIG EMVLVSCPEV FRIFNPDQVW MTETIGDSGF 100
    ADSNSLEITD MGVVGRNCTE DGWSEPFPHY FDACGFDDYE PESGDQDYYY 150
    LSVKALYTVG YSTSLVTLTT AMVILCRFRK LHCTRNFIHM NLFVSFMLRA 200
    ISVFIKDWIL YAEQDSSHCF VSTVECKAVM VFFHYCVVSN YFWLFIEGLY 250
    LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWAVLRLY FDDAGCWDMN 300
    DSTALWWVIK GPVVGSIMVN FVLFIGIIII LVQKLQSPDM GGNESSIYFS 350
    CVQKCYCKPQ RAQQHSCKMS ELSTITLRLA RSTLLLIPLF GIHYTVFAFS 400
    PENVSKRERL VFELGLGSFQ GFVVAVLYCF LNGEVQAEIK RKWRSWKVNR 450
    YFTMDFKHRH PSLASSGVNG GTQLSILSKS SSQLRMSSLP ADNLAT 496
    Length:496
    Mass (Da):56,640
    Last modified:February 1, 1997 - v1
    Checksum:i47B5D51D4209060A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82935 mRNA. Translation: BAA11639.1.
    CCDSiCCDS20167.1.
    RefSeqiNP_031433.3. NM_007407.4.
    UniGeneiMm.44245.

    Genome annotation databases

    EnsembliENSMUST00000070736; ENSMUSP00000063784; ENSMUSG00000029778.
    GeneIDi11517.
    KEGGimmu:11517.
    UCSCiuc009cat.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D82935 mRNA. Translation: BAA11639.1 .
    CCDSi CCDS20167.1.
    RefSeqi NP_031433.3. NM_007407.4.
    UniGenei Mm.44245.

    3D structure databases

    ProteinModelPortali P70205.
    SMRi P70205. Positions 26-140, 150-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P70205. 1 interaction.
    MINTi MINT-4544489.

    Chemistry

    GuidetoPHARMACOLOGYi 370.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P70205.

    Proteomic databases

    PaxDbi P70205.
    PRIDEi P70205.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000070736 ; ENSMUSP00000063784 ; ENSMUSG00000029778 .
    GeneIDi 11517.
    KEGGi mmu:11517.
    UCSCi uc009cat.1. mouse.

    Organism-specific databases

    CTDi 117.
    MGIi MGI:108449. Adcyap1r1.

    Phylogenomic databases

    eggNOGi NOG330024.
    GeneTreei ENSGT00620000087538.
    HOGENOMi HOG000008249.
    HOVERGENi HBG008318.
    InParanoidi P70205.
    KOi K04587.
    OrthoDBi EOG7TF78W.
    PhylomeDBi P70205.
    TreeFami TF315710.

    Enzyme and pathway databases

    Reactomei REACT_209347. NGF-independant TRKA activation.

    Miscellaneous databases

    NextBioi 278938.
    PROi P70205.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70205.
    Bgeei P70205.
    Genevestigatori P70205.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR002285. GPCR_2_PACAP_1_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00249. GPCRSECRETIN.
    PR01156. PACAPRECEPTR.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a mouse pituitary adenylate cyclase-activating polypeptide receptor."
      Hashimoto H., Yamamoto K., Hagigara N., Ogawa N., Nishino A., Aino H., Nogi H., Imanishi K., Matsuda T., Baba A.
      Biochim. Biophys. Acta 1281:129-133(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiPACR_MOUSE
    AccessioniPrimary (citable) accession number: P70205
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3