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P70205 (PACR_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pituitary adenylate cyclase-activating polypeptide type I receptor

Short name=PACAP type I receptor
Short name=PACAP-R-1
Short name=PACAP-R1
Gene names
Name:Adcyap1r1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length496 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.

Subunit structure

Interacts (via N-terminal extracellular domain) with ADCYAP1 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 2 family.

Ontologies

Keywords
   Biological processDifferentiation
Spermatogenesis
   Cellular componentCell membrane
Membrane
   DomainSignal
Transmembrane
Transmembrane helix
   Molecular functionDevelopmental protein
G-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Traceable author statement PubMed 9729410. Source: MGI

activation of phospholipase C activity

Inferred from electronic annotation. Source: Ensembl

cAMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

cell differentiation

Inferred from electronic annotation. Source: UniProtKB-KW

development of primary female sexual characteristics

Inferred from electronic annotation. Source: Ensembl

multicellular organismal response to stress

Inferred from electronic annotation. Source: Ensembl

negative regulation of cell death

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion transport into cytosol

Inferred from electronic annotation. Source: Ensembl

positive regulation of inositol phosphate biosynthetic process

Inferred from electronic annotation. Source: Ensembl

response to drug

Inferred from electronic annotation. Source: Ensembl

response to estradiol

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcaveola

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from electronic annotation. Source: Ensembl

endosome

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

neuron projection

Inferred from electronic annotation. Source: Ensembl

receptor complex

Inferred from sequence orthology PubMed 23382219. Source: MGI

rough endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

tight junction

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionG-protein coupled receptor activity

Traceable author statement PubMed 9729410. Source: MGI

neuropeptide binding

Inferred from electronic annotation. Source: Ensembl

vasoactive intestinal polypeptide receptor activity

Traceable author statement PubMed 9729410. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 496476Pituitary adenylate cyclase-activating polypeptide type I receptor
PRO_0000012842

Regions

Topological domain21 – 155135Extracellular Potential
Transmembrane156 – 17823Helical; Name=1; Potential
Topological domain179 – 1868Cytoplasmic Potential
Transmembrane187 – 20519Helical; Name=2; Potential
Topological domain206 – 22722Extracellular Potential
Transmembrane228 – 25326Helical; Name=3; Potential
Topological domain254 – 26815Cytoplasmic Potential
Transmembrane269 – 29123Helical; Name=4; Potential
Topological domain292 – 30918Extracellular Potential
Transmembrane310 – 33223Helical; Name=5; Potential
Topological domain333 – 37846Cytoplasmic Potential
Transmembrane379 – 39921Helical; Name=6; Potential
Topological domain400 – 41314Extracellular Potential
Transmembrane414 – 43320Helical; Name=7; Potential
Topological domain434 – 49663Cytoplasmic Potential
Region125 – 13915Important for ligand binding and specificity By similarity

Amino acid modifications

Glycosylation481N-linked (GlcNAc...) Potential
Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation1171N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 63 By similarity
Disulfide bond54 ↔ 118 By similarity
Disulfide bond77 ↔ 134 By similarity

Sequences

Sequence LengthMass (Da)Tools
P70205 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 47B5D51D4209060A

FASTA49656,640
        10         20         30         40         50         60 
MARTLQLSLT ALLLLPMAIA MHSDCIFKKE QAMCLERIQR ANDLMGLNES SPGCPGMWDN 

        70         80         90        100        110        120 
ITCWKPAQIG EMVLVSCPEV FRIFNPDQVW MTETIGDSGF ADSNSLEITD MGVVGRNCTE 

       130        140        150        160        170        180 
DGWSEPFPHY FDACGFDDYE PESGDQDYYY LSVKALYTVG YSTSLVTLTT AMVILCRFRK 

       190        200        210        220        230        240 
LHCTRNFIHM NLFVSFMLRA ISVFIKDWIL YAEQDSSHCF VSTVECKAVM VFFHYCVVSN 

       250        260        270        280        290        300 
YFWLFIEGLY LFTLLVETFF PERRYFYWYT IIGWGTPTVC VTVWAVLRLY FDDAGCWDMN 

       310        320        330        340        350        360 
DSTALWWVIK GPVVGSIMVN FVLFIGIIII LVQKLQSPDM GGNESSIYFS CVQKCYCKPQ 

       370        380        390        400        410        420 
RAQQHSCKMS ELSTITLRLA RSTLLLIPLF GIHYTVFAFS PENVSKRERL VFELGLGSFQ 

       430        440        450        460        470        480 
GFVVAVLYCF LNGEVQAEIK RKWRSWKVNR YFTMDFKHRH PSLASSGVNG GTQLSILSKS 

       490 
SSQLRMSSLP ADNLAT 

« Hide

References

[1]"cDNA cloning of a mouse pituitary adenylate cyclase-activating polypeptide receptor."
Hashimoto H., Yamamoto K., Hagigara N., Ogawa N., Nishino A., Aino H., Nogi H., Imanishi K., Matsuda T., Baba A.
Biochim. Biophys. Acta 1281:129-133(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D82935 mRNA. Translation: BAA11639.1.
RefSeqNP_031433.3. NM_007407.4.
UniGeneMm.44245.

3D structure databases

ProteinModelPortalP70205.
SMRP70205. Positions 26-140, 150-438.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP70205. 1 interaction.
MINTMINT-4544489.

Chemistry

GuidetoPHARMACOLOGY370.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP70205.

Proteomic databases

PaxDbP70205.
PRIDEP70205.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000070736; ENSMUSP00000063784; ENSMUSG00000029778.
GeneID11517.
KEGGmmu:11517.
UCSCuc009cat.1. mouse.

Organism-specific databases

CTD117.
MGIMGI:108449. Adcyap1r1.

Phylogenomic databases

eggNOGNOG330024.
GeneTreeENSGT00620000087538.
HOGENOMHOG000008249.
HOVERGENHBG008318.
InParanoidP70205.
KOK04587.
OrthoDBEOG7TF78W.
PhylomeDBP70205.
TreeFamTF315710.

Gene expression databases

ArrayExpressP70205.
BgeeP70205.
GenevestigatorP70205.

Family and domain databases

InterProIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR002285. GPCR_2_PACAP_1_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PANTHERPTHR12011:SF30. PTHR12011:SF30. 1 hit.
PfamPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSPR00249. GPCRSECRETIN.
PR01156. PACAPRECEPTR.
SMARTSM00008. HormR. 1 hit.
[Graphical view]
PROSITEPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio278938.
PROP70205.
SOURCESearch...

Entry information

Entry namePACR_MOUSE
AccessionPrimary (citable) accession number: P70205
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries