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Protein

C-type lectin domain family 4 member F

Gene

Clec4f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor with an affinity for galactose and fucose. Could be involved in endocytosis.

GO - Molecular functioni

  • galactose binding Source: MGI
  • glycolipid binding Source: MGI

GO - Biological processi

  • endocytosis Source: UniProtKB-KW
  • NK T cell activation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 4 member F
Alternative name(s):
C-type lectin superfamily member 13
Short name:
C-type lectin 13
Kupffer cell receptor
Gene namesi
Name:Clec4f
Synonyms:Clecsf13, Kclr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1859834. Clec4f.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4242CytoplasmicSequence analysisAdd
BLAST
Transmembranei43 – 6927Helical; Signal-anchor for type II membrane proteinSequence analysisAdd
BLAST
Topological domaini70 – 548479ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 548548C-type lectin domain family 4 member FPRO_0000046623Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi86 – 861N-linked (GlcNAc...)Sequence analysis
Glycosylationi92 – 921N-linked (GlcNAc...)Sequence analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis
Glycosylationi209 – 2091N-linked (GlcNAc...)Sequence analysis
Glycosylationi255 – 2551N-linked (GlcNAc...)Sequence analysis
Disulfide bondi440 ↔ 536PROSITE-ProRule annotation
Disulfide bondi516 ↔ 528PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP70194.
MaxQBiP70194.
PaxDbiP70194.
PRIDEiP70194.

PTM databases

iPTMnetiP70194.
PhosphoSiteiP70194.

Expressioni

Tissue specificityi

Kupffer cells.

Gene expression databases

BgeeiP70194.
CleanExiMM_CLEC4F.

Interactioni

Protein-protein interaction databases

MINTiMINT-1864469.
STRINGi10090.ENSMUSP00000014686.

Structurei

3D structure databases

ProteinModelPortaliP70194.
SMRiP70194. Positions 387-538.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini438 – 538101C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IS3X. Eukaryota.
ENOG41123NI. LUCA.
HOGENOMiHOG000264252.
HOVERGENiHBG081248.
InParanoidiP70194.
KOiK10060.
OrthoDBiEOG7HXCVB.
PhylomeDBiP70194.
TreeFamiTF333341.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70194-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKEAELNRDM ARYCTDNQCV SLQPQGLGPK SAALMAPRTL RHVQVILALM
60 70 80 90 100
VVTVIFSLLA LFVVASQPWR PEWNKEPPSL LLRGSNNSGH DNHSQFVRET
110 120 130 140 150
EMQVAIQRLR DYEENSSSCH KEVQILKYQM DNVSSLVQLL GSHLEDVNAD
160 170 180 190 200
ILQTKDVLKE SGALALETQA LRSSLEVASA DIHSLRGDLE KANAMTSQTR
210 220 230 240 250
GLLKSSTENT SAELHVLGRG LEEAQSEIQA LRGSLQSAND LSSQTQGFLQ
260 270 280 290 300
HSMDNISAQI QTVRDGMERA GEKMNSLKKE LETLTAQTQK ANGHLEQTDA
310 320 330 340 350
QIQGLKAELK STSSLNSRIE VVNGQMKDAS RELQTLRRDL SDVSALKSNV
360 370 380 390 400
QMLQSNLQRA KTEMQTLKAD LQATKALTAK IQGEQNRLGA LQEAVAAQKQ
410 420 430 440 450
EQKTQNQVLQ LIAQNWKYFN GNFYYFSRDK KPWREAEKFC TSQGAHLASV
460 470 480 490 500
TSQEEQAFLV QTTSSGDHWI GLTDQGTEGI WRWVDGTPFN NAQSKGFWGK
510 520 530 540
NQPDNWRHRN GEREDCVHVR QQWNDMACGS SYPWVCKKST GWSAARVG
Length:548
Mass (Da):61,269
Last modified:February 1, 1997 - v1
Checksum:i6F6495E820E73BD9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti366 – 3661T → S in BAC30671 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88577 mRNA. Translation: BAA13647.1.
AK040696 mRNA. Translation: BAC30671.1.
BC013647 mRNA. Translation: AAH13647.1.
CCDSiCCDS20281.1.
RefSeqiNP_058031.2. NM_016751.3.
UniGeneiMm.3115.

Genome annotation databases

GeneIDi51811.
KEGGimmu:51811.
UCSCiuc009cnv.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Kupffer cell receptor

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88577 mRNA. Translation: BAA13647.1.
AK040696 mRNA. Translation: BAC30671.1.
BC013647 mRNA. Translation: AAH13647.1.
CCDSiCCDS20281.1.
RefSeqiNP_058031.2. NM_016751.3.
UniGeneiMm.3115.

3D structure databases

ProteinModelPortaliP70194.
SMRiP70194. Positions 387-538.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-1864469.
STRINGi10090.ENSMUSP00000014686.

PTM databases

iPTMnetiP70194.
PhosphoSiteiP70194.

Proteomic databases

EPDiP70194.
MaxQBiP70194.
PaxDbiP70194.
PRIDEiP70194.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi51811.
KEGGimmu:51811.
UCSCiuc009cnv.1. mouse.

Organism-specific databases

CTDi165530.
MGIiMGI:1859834. Clec4f.

Phylogenomic databases

eggNOGiENOG410IS3X. Eukaryota.
ENOG41123NI. LUCA.
HOGENOMiHOG000264252.
HOVERGENiHBG081248.
InParanoidiP70194.
KOiK10060.
OrthoDBiEOG7HXCVB.
PhylomeDBiP70194.
TreeFamiTF333341.

Miscellaneous databases

NextBioi308064.
PROiP70194.
SOURCEiSearch...

Gene expression databases

BgeeiP70194.
CleanExiMM_CLEC4F.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Takezawa R., Wagatsuma H., Nomoto C., Watanabe Y., Akaike T.
    Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Liver.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiCLC4F_MOUSE
AccessioniPrimary (citable) accession number: P70194
Secondary accession number(s): Q8BLZ8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: March 16, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.