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P70193

- LRIG1_MOUSE

UniProt

P70193 - LRIG1_MOUSE

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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 1

Gene

Lrig1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.By similarity

GO - Biological processi

  1. innervation Source: MGI
  2. otolith morphogenesis Source: MGI
  3. sensory perception of sound Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_242976. Signaling by EGFR.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 1
Short name:
LIG-1
Gene namesi
Name:Lrig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:107935. Lrig1.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini35 – 796762ExtracellularSequence AnalysisAdd
BLAST
Transmembranei797 – 81721HelicalSequence AnalysisAdd
BLAST
Topological domaini818 – 1091274CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 10911057Leucine-rich repeats and immunoglobulin-like domains protein 1PRO_0000014828Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi518 ↔ 579PROSITE-ProRule annotation
Disulfide bondi622 ↔ 674PROSITE-ProRule annotation
Glycosylationi686 – 6861N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi716 ↔ 765PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70193.
PaxDbiP70193.
PRIDEiP70193.

PTM databases

PhosphoSiteiP70193.

Expressioni

Tissue specificityi

Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the skin. Low expression is detected in the thymus and heart. No expression in the kidney, liver, lung or small intestine.2 Publications

Inductioni

Down-regulated in the psoriasis epidermis.1 Publication

Gene expression databases

BgeeiP70193.
GenevestigatoriP70193.

Interactioni

Subunit structurei

Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.By similarity

Protein-protein interaction databases

MINTiMINT-4996947.
STRINGi10090.ENSMUSP00000098686.

Structurei

3D structure databases

ProteinModelPortaliP70193.
SMRiP70193. Positions 489-598.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 7036LRRNTAdd
BLAST
Repeati71 – 9222LRR 1Add
BLAST
Repeati95 – 11622LRR 2Add
BLAST
Repeati118 – 13922LRR 3Add
BLAST
Repeati142 – 16322LRR 4Add
BLAST
Repeati166 – 18722LRR 5Add
BLAST
Repeati191 – 21222LRR 6Add
BLAST
Repeati214 – 23522LRR 7Add
BLAST
Repeati238 – 25922LRR 8Add
BLAST
Repeati262 – 28322LRR 9Add
BLAST
Repeati286 – 30722LRR 10Add
BLAST
Repeati310 – 33122LRR 11Add
BLAST
Repeati334 – 35522LRR 12Add
BLAST
Repeati358 – 38023LRR 13Add
BLAST
Repeati385 – 40622LRR 14Add
BLAST
Repeati409 – 43022LRR 15Add
BLAST
Domaini442 – 49352LRRCTAdd
BLAST
Domaini497 – 596100Ig-like C2-type 1Add
BLAST
Domaini601 – 69090Ig-like C2-type 2Add
BLAST
Domaini695 – 78187Ig-like C2-type 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi522 – 5265Poly-Ser

Domaini

The LRRs and the Ig-domains are each sufficient for EGFR binding. This interaction is abolished only when these two domains are deleted (By similarity).By similarity

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiP70193.
OMAiESNGVCP.
OrthoDBiEOG7DNNTD.
TreeFamiTF325380.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF07679. I-set. 3 hits.
PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70193-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARPGPGVLG APRLAPRLLL WLLLLLLQWP ESAGAQAGPR APCAAACTCA
60 70 80 90 100
GDSLDCSGRG LATLPRDLPS WTRSLNLSYN RLSEIDSAAF EDLTNLQEVY
110 120 130 140 150
LNSNELTAIP SLGAASIGVV SLFLQHNKIL SVDGSQLKSY LSLEVLDLSS
160 170 180 190 200
NNITEIRSSC FPNGLRIREL NLASNRISIL ESGAFDGLSR SLLTLRLSKN
210 220 230 240 250
RITQLPVKAF KLPRLTQLDL NRNRIRLIEG LTFQGLDSLE VLRLQRNNIS
260 270 280 290 300
RLTDGAFWGL SKMHVLHLEY NSLVEVNSGS LYGLTALHQL HLSNNSISRI
310 320 330 340 350
QRDGWSFCQK LHELILSFNN LTRLDEESLA ELSSLSILRL SHNAISHIAE
360 370 380 390 400
GAFKGLKSLR VLDLDHNEIS GTIEDTSGAF TGLDNLSKLT LFGNKIKSVA
410 420 430 440 450
KRAFSGLESL EHLNLGENAI RSVQFDAFAK MKNLKELYIS SESFLCDCQL
460 470 480 490 500
KWLPPWLMGR MLQAFVTATC AHPESLKGQS IFSVLPDSFV CDDFPKPQII
510 520 530 540 550
TQPETTMAVV GKDIRFTCSA ASSSSSPMTF AWKKDNEVLA NADMENFAHV
560 570 580 590 600
RAQDGEVMEY TTILHLRHVT FGHEGRYQCI ITNHFGSTYS HKARLTVNVL
610 620 630 640 650
PSFTKIPHDI AIRTGTTARL ECAATGHPNP QIAWQKDGGT DFPAARERRM
660 670 680 690 700
HVMPDDDVFF ITDVKIDDMG VYSCTAQNSA GSVSANATLT VLETPSLAVP
710 720 730 740 750
LEDRVVTVGE TVAFQCKATG SPTPRITWLK GGRPLSLTER HHFTPGNQLL
760 770 780 790 800
VVQNVMIDDA GRYTCEMSNP LGTERAHSQL SILPTPGCRK DGTTVGIFTI
810 820 830 840 850
AVVCSIVLTS LVWVCIIYQT RKKSEEYSVT NTDETIVPPD VPSYLSSQGT
860 870 880 890 900
LSDRQETVVR TEGGHQANGH IESNGVCLRD PSLFPEVDIH STTCRQPKLC
910 920 930 940 950
VGYTREPWKV TEKADRTAAP HTTAHSGSAV CSDCSTDTAY HPQPVPRDSG
960 970 980 990 1000
QPGTASSQEL RQHDREYSPH HPYSGTADGS HTLSGGSLYP SNHDRILPSL
1010 1020 1030 1040 1050
KNKAASADGN GDSSWTLAKL HEADCIDLKP SPTLASGSPE LMEDAISTEA
1060 1070 1080 1090
QHLLVSNGHL PKACDSSPES VPLKGQITGK RRGPLLLAPR S
Length:1,091
Mass (Da):119,156
Last modified:July 27, 2011 - v2
Checksum:i938BF3C154520DC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381G → R in BAA11416. (PubMed:8798419)Curated
Sequence conflicti52 – 521D → N in BAA11416. (PubMed:8798419)Curated
Sequence conflicti114 – 1141A → T in BAA11416. (PubMed:8798419)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78572 mRNA. Translation: BAA11416.1.
AC122272 Genomic DNA. No translation available.
AC155330 Genomic DNA. No translation available.
CCDSiCCDS20380.1.
PIRiA58532.
RefSeqiNP_032403.2. NM_008377.2.
UniGeneiMm.245210.

Genome annotation databases

EnsembliENSMUST00000032105; ENSMUSP00000032105; ENSMUSG00000030029.
ENSMUST00000101126; ENSMUSP00000098686; ENSMUSG00000030029.
GeneIDi16206.
KEGGimmu:16206.
UCSCiuc009czu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78572 mRNA. Translation: BAA11416.1 .
AC122272 Genomic DNA. No translation available.
AC155330 Genomic DNA. No translation available.
CCDSi CCDS20380.1.
PIRi A58532.
RefSeqi NP_032403.2. NM_008377.2.
UniGenei Mm.245210.

3D structure databases

ProteinModelPortali P70193.
SMRi P70193. Positions 489-598.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996947.
STRINGi 10090.ENSMUSP00000098686.

PTM databases

PhosphoSitei P70193.

Proteomic databases

MaxQBi P70193.
PaxDbi P70193.
PRIDEi P70193.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032105 ; ENSMUSP00000032105 ; ENSMUSG00000030029 .
ENSMUST00000101126 ; ENSMUSP00000098686 ; ENSMUSG00000030029 .
GeneIDi 16206.
KEGGi mmu:16206.
UCSCi uc009czu.1. mouse.

Organism-specific databases

CTDi 26018.
MGIi MGI:107935. Lrig1.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00760000118777.
HOGENOMi HOG000113380.
HOVERGENi HBG052353.
InParanoidi P70193.
OMAi ESNGVCP.
OrthoDBi EOG7DNNTD.
TreeFami TF325380.

Enzyme and pathway databases

Reactomei REACT_242976. Signaling by EGFR.

Miscellaneous databases

ChiTaRSi Lrig1. mouse.
NextBioi 289161.
PROi P70193.
SOURCEi Search...

Gene expression databases

Bgeei P70193.
Genevestigatori P70193.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF07679. I-set. 3 hits.
PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 4 hits.
PF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view ]
SMARTi SM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains."
    Suzuki Y., Sato N., Tohyama M., Wanaka A., Takagi T.
    J. Biol. Chem. 271:22522-22527(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia."
    Suzuki Y., Miura H., Tanemura A., Kobayashi K., Kondoh G., Sano S., Ozawa K., Inui S., Nakata A., Takagi T., Tohyama M., Yoshikawa K., Itami S.
    FEBS Lett. 521:67-71(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION.

Entry informationi

Entry nameiLRIG1_MOUSE
AccessioniPrimary (citable) accession number: P70193
Secondary accession number(s): E9QL89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 27, 2011
Last modified: November 26, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Knockout of the gene results in psiorasiform epidermal hyperplasia.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3