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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 1

Gene

Lrig1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.By similarity

GO - Biological processi

  • innervation Source: MGI
  • otolith morphogenesis Source: MGI
  • sensory perception of sound Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-177929. Signaling by EGFR.
R-MMU-6807004. Negative regulation of MET activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 1
Short name:
LIG-1
Gene namesi
Name:Lrig1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107935. Lrig1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini35 – 796ExtracellularSequence analysisAdd BLAST762
Transmembranei797 – 817HelicalSequence analysisAdd BLAST21
Topological domaini818 – 1091CytoplasmicSequence analysisAdd BLAST274

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001482835 – 1091Leucine-rich repeats and immunoglobulin-like domains protein 1Add BLAST1057

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Glycosylationi248N-linked (GlcNAc...)Sequence analysis1
Glycosylationi294N-linked (GlcNAc...)Sequence analysis1
Glycosylationi320N-linked (GlcNAc...)Sequence analysis1
Glycosylationi385N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi518 ↔ 579PROSITE-ProRule annotation
Disulfide bondi622 ↔ 674PROSITE-ProRule annotation
Glycosylationi686N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi716 ↔ 765PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70193.
PaxDbiP70193.
PRIDEiP70193.

PTM databases

iPTMnetiP70193.
PhosphoSitePlusiP70193.

Expressioni

Tissue specificityi

Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the skin. Low expression is detected in the thymus and heart. No expression in the kidney, liver, lung or small intestine.2 Publications

Inductioni

Down-regulated in the psoriasis epidermis.1 Publication

Gene expression databases

BgeeiENSMUSG00000030029.
GenevisibleiP70193. MM.

Interactioni

Subunit structurei

Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.By similarity

Protein-protein interaction databases

MINTiMINT-4996947.
STRINGi10090.ENSMUSP00000032105.

Structurei

3D structure databases

ProteinModelPortaliP70193.
SMRiP70193.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 70LRRNTAdd BLAST36
Repeati71 – 92LRR 1Add BLAST22
Repeati95 – 116LRR 2Add BLAST22
Repeati118 – 139LRR 3Add BLAST22
Repeati142 – 163LRR 4Add BLAST22
Repeati166 – 187LRR 5Add BLAST22
Repeati191 – 212LRR 6Add BLAST22
Repeati214 – 235LRR 7Add BLAST22
Repeati238 – 259LRR 8Add BLAST22
Repeati262 – 283LRR 9Add BLAST22
Repeati286 – 307LRR 10Add BLAST22
Repeati310 – 331LRR 11Add BLAST22
Repeati334 – 355LRR 12Add BLAST22
Repeati358 – 380LRR 13Add BLAST23
Repeati385 – 406LRR 14Add BLAST22
Repeati409 – 430LRR 15Add BLAST22
Domaini442 – 493LRRCTAdd BLAST52
Domaini497 – 596Ig-like C2-type 1Add BLAST100
Domaini601 – 690Ig-like C2-type 2Add BLAST90
Domaini695 – 781Ig-like C2-type 3Add BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi522 – 526Poly-Ser5

Domaini

The LRRs and the Ig-domains are each sufficient for EGFR binding. This interaction is abolished only when these two domains are deleted (By similarity).By similarity

Sequence similaritiesi

Contains 15 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4194. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiP70193.
OMAiPTPGCRK.
OrthoDBiEOG091G04H0.
TreeFamiTF325380.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70193-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPGPGVLG APRLAPRLLL WLLLLLLQWP ESAGAQAGPR APCAAACTCA
60 70 80 90 100
GDSLDCSGRG LATLPRDLPS WTRSLNLSYN RLSEIDSAAF EDLTNLQEVY
110 120 130 140 150
LNSNELTAIP SLGAASIGVV SLFLQHNKIL SVDGSQLKSY LSLEVLDLSS
160 170 180 190 200
NNITEIRSSC FPNGLRIREL NLASNRISIL ESGAFDGLSR SLLTLRLSKN
210 220 230 240 250
RITQLPVKAF KLPRLTQLDL NRNRIRLIEG LTFQGLDSLE VLRLQRNNIS
260 270 280 290 300
RLTDGAFWGL SKMHVLHLEY NSLVEVNSGS LYGLTALHQL HLSNNSISRI
310 320 330 340 350
QRDGWSFCQK LHELILSFNN LTRLDEESLA ELSSLSILRL SHNAISHIAE
360 370 380 390 400
GAFKGLKSLR VLDLDHNEIS GTIEDTSGAF TGLDNLSKLT LFGNKIKSVA
410 420 430 440 450
KRAFSGLESL EHLNLGENAI RSVQFDAFAK MKNLKELYIS SESFLCDCQL
460 470 480 490 500
KWLPPWLMGR MLQAFVTATC AHPESLKGQS IFSVLPDSFV CDDFPKPQII
510 520 530 540 550
TQPETTMAVV GKDIRFTCSA ASSSSSPMTF AWKKDNEVLA NADMENFAHV
560 570 580 590 600
RAQDGEVMEY TTILHLRHVT FGHEGRYQCI ITNHFGSTYS HKARLTVNVL
610 620 630 640 650
PSFTKIPHDI AIRTGTTARL ECAATGHPNP QIAWQKDGGT DFPAARERRM
660 670 680 690 700
HVMPDDDVFF ITDVKIDDMG VYSCTAQNSA GSVSANATLT VLETPSLAVP
710 720 730 740 750
LEDRVVTVGE TVAFQCKATG SPTPRITWLK GGRPLSLTER HHFTPGNQLL
760 770 780 790 800
VVQNVMIDDA GRYTCEMSNP LGTERAHSQL SILPTPGCRK DGTTVGIFTI
810 820 830 840 850
AVVCSIVLTS LVWVCIIYQT RKKSEEYSVT NTDETIVPPD VPSYLSSQGT
860 870 880 890 900
LSDRQETVVR TEGGHQANGH IESNGVCLRD PSLFPEVDIH STTCRQPKLC
910 920 930 940 950
VGYTREPWKV TEKADRTAAP HTTAHSGSAV CSDCSTDTAY HPQPVPRDSG
960 970 980 990 1000
QPGTASSQEL RQHDREYSPH HPYSGTADGS HTLSGGSLYP SNHDRILPSL
1010 1020 1030 1040 1050
KNKAASADGN GDSSWTLAKL HEADCIDLKP SPTLASGSPE LMEDAISTEA
1060 1070 1080 1090
QHLLVSNGHL PKACDSSPES VPLKGQITGK RRGPLLLAPR S
Length:1,091
Mass (Da):119,156
Last modified:July 27, 2011 - v2
Checksum:i938BF3C154520DC0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38G → R in BAA11416 (PubMed:8798419).Curated1
Sequence conflicti52D → N in BAA11416 (PubMed:8798419).Curated1
Sequence conflicti114A → T in BAA11416 (PubMed:8798419).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78572 mRNA. Translation: BAA11416.1.
AC122272 Genomic DNA. No translation available.
AC155330 Genomic DNA. No translation available.
CCDSiCCDS20380.1.
PIRiA58532.
RefSeqiNP_032403.2. NM_008377.2.
UniGeneiMm.245210.

Genome annotation databases

EnsembliENSMUST00000032105; ENSMUSP00000032105; ENSMUSG00000030029.
ENSMUST00000101126; ENSMUSP00000098686; ENSMUSG00000030029.
ENSMUST00000204645; ENSMUSP00000144963; ENSMUSG00000030029.
GeneIDi16206.
KEGGimmu:16206.
UCSCiuc009czu.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78572 mRNA. Translation: BAA11416.1.
AC122272 Genomic DNA. No translation available.
AC155330 Genomic DNA. No translation available.
CCDSiCCDS20380.1.
PIRiA58532.
RefSeqiNP_032403.2. NM_008377.2.
UniGeneiMm.245210.

3D structure databases

ProteinModelPortaliP70193.
SMRiP70193.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4996947.
STRINGi10090.ENSMUSP00000032105.

PTM databases

iPTMnetiP70193.
PhosphoSitePlusiP70193.

Proteomic databases

MaxQBiP70193.
PaxDbiP70193.
PRIDEiP70193.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032105; ENSMUSP00000032105; ENSMUSG00000030029.
ENSMUST00000101126; ENSMUSP00000098686; ENSMUSG00000030029.
ENSMUST00000204645; ENSMUSP00000144963; ENSMUSG00000030029.
GeneIDi16206.
KEGGimmu:16206.
UCSCiuc009czu.1. mouse.

Organism-specific databases

CTDi26018.
MGIiMGI:107935. Lrig1.

Phylogenomic databases

eggNOGiKOG4194. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000118777.
HOGENOMiHOG000113380.
HOVERGENiHBG052353.
InParanoidiP70193.
OMAiPTPGCRK.
OrthoDBiEOG091G04H0.
TreeFamiTF325380.

Enzyme and pathway databases

ReactomeiR-MMU-177929. Signaling by EGFR.
R-MMU-6807004. Negative regulation of MET activity.

Miscellaneous databases

ChiTaRSiLrig1. mouse.
PROiP70193.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030029.
GenevisibleiP70193. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
[Graphical view]
PfamiPF07679. I-set. 2 hits.
PF13855. LRR_8. 5 hits.
PF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 14 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52058. SSF52058. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRIG1_MOUSE
AccessioniPrimary (citable) accession number: P70193
Secondary accession number(s): E9QL89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Knockout of the gene results in psiorasiform epidermal hyperplasia.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.