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P70193

- LRIG1_MOUSE

UniProt

P70193 - LRIG1_MOUSE

Protein

Leucine-rich repeats and immunoglobulin-like domains protein 1

Gene

Lrig1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 115 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.By similarity

    GO - Biological processi

    1. innervation Source: MGI
    2. otolith morphogenesis Source: MGI
    3. sensory perception of sound Source: MGI

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich repeats and immunoglobulin-like domains protein 1
    Short name:
    LIG-1
    Gene namesi
    Name:Lrig1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:107935. Lrig1.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 10911057Leucine-rich repeats and immunoglobulin-like domains protein 1PRO_0000014828Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi76 – 761N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi320 – 3201N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi385 – 3851N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi518 ↔ 579PROSITE-ProRule annotation
    Disulfide bondi622 ↔ 674PROSITE-ProRule annotation
    Glycosylationi686 – 6861N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi716 ↔ 765PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP70193.
    PRIDEiP70193.

    PTM databases

    PhosphoSiteiP70193.

    Expressioni

    Tissue specificityi

    Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the skin. Low expression is detected in the thymus and heart. No expression in the kidney, liver, lung or small intestine.2 Publications

    Inductioni

    Down-regulated in the psoriasis epidermis.1 Publication

    Gene expression databases

    BgeeiP70193.
    GenevestigatoriP70193.

    Interactioni

    Subunit structurei

    Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4.By similarity

    Protein-protein interaction databases

    MINTiMINT-4996947.
    STRINGi10090.ENSMUSP00000098686.

    Structurei

    3D structure databases

    ProteinModelPortaliP70193.
    SMRiP70193. Positions 489-598.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini35 – 796762ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini818 – 1091274CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei797 – 81721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 7036LRRNTAdd
    BLAST
    Repeati71 – 9222LRR 1Add
    BLAST
    Repeati95 – 11622LRR 2Add
    BLAST
    Repeati118 – 13922LRR 3Add
    BLAST
    Repeati142 – 16322LRR 4Add
    BLAST
    Repeati166 – 18722LRR 5Add
    BLAST
    Repeati191 – 21222LRR 6Add
    BLAST
    Repeati214 – 23522LRR 7Add
    BLAST
    Repeati238 – 25922LRR 8Add
    BLAST
    Repeati262 – 28322LRR 9Add
    BLAST
    Repeati286 – 30722LRR 10Add
    BLAST
    Repeati310 – 33122LRR 11Add
    BLAST
    Repeati334 – 35522LRR 12Add
    BLAST
    Repeati358 – 38023LRR 13Add
    BLAST
    Repeati385 – 40622LRR 14Add
    BLAST
    Repeati409 – 43022LRR 15Add
    BLAST
    Domaini442 – 49352LRRCTAdd
    BLAST
    Domaini497 – 596100Ig-like C2-type 1Add
    BLAST
    Domaini601 – 69090Ig-like C2-type 2Add
    BLAST
    Domaini695 – 78187Ig-like C2-type 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi522 – 5265Poly-Ser

    Domaini

    The LRRs and the Ig-domains are each sufficient for EGFR binding. This interaction is abolished only when these two domains are deleted By similarity.By similarity

    Sequence similaritiesi

    Contains 15 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00730000110575.
    HOGENOMiHOG000113380.
    HOVERGENiHBG052353.
    InParanoidiP70193.
    OMAiESNGVCP.
    OrthoDBiEOG7DNNTD.
    TreeFamiTF325380.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF07679. I-set. 3 hits.
    PF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 4 hits.
    PF01463. LRRCT. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view]
    SMARTiSM00408. IGc2. 3 hits.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    PS51450. LRR. 14 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P70193-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARPGPGVLG APRLAPRLLL WLLLLLLQWP ESAGAQAGPR APCAAACTCA     50
    GDSLDCSGRG LATLPRDLPS WTRSLNLSYN RLSEIDSAAF EDLTNLQEVY 100
    LNSNELTAIP SLGAASIGVV SLFLQHNKIL SVDGSQLKSY LSLEVLDLSS 150
    NNITEIRSSC FPNGLRIREL NLASNRISIL ESGAFDGLSR SLLTLRLSKN 200
    RITQLPVKAF KLPRLTQLDL NRNRIRLIEG LTFQGLDSLE VLRLQRNNIS 250
    RLTDGAFWGL SKMHVLHLEY NSLVEVNSGS LYGLTALHQL HLSNNSISRI 300
    QRDGWSFCQK LHELILSFNN LTRLDEESLA ELSSLSILRL SHNAISHIAE 350
    GAFKGLKSLR VLDLDHNEIS GTIEDTSGAF TGLDNLSKLT LFGNKIKSVA 400
    KRAFSGLESL EHLNLGENAI RSVQFDAFAK MKNLKELYIS SESFLCDCQL 450
    KWLPPWLMGR MLQAFVTATC AHPESLKGQS IFSVLPDSFV CDDFPKPQII 500
    TQPETTMAVV GKDIRFTCSA ASSSSSPMTF AWKKDNEVLA NADMENFAHV 550
    RAQDGEVMEY TTILHLRHVT FGHEGRYQCI ITNHFGSTYS HKARLTVNVL 600
    PSFTKIPHDI AIRTGTTARL ECAATGHPNP QIAWQKDGGT DFPAARERRM 650
    HVMPDDDVFF ITDVKIDDMG VYSCTAQNSA GSVSANATLT VLETPSLAVP 700
    LEDRVVTVGE TVAFQCKATG SPTPRITWLK GGRPLSLTER HHFTPGNQLL 750
    VVQNVMIDDA GRYTCEMSNP LGTERAHSQL SILPTPGCRK DGTTVGIFTI 800
    AVVCSIVLTS LVWVCIIYQT RKKSEEYSVT NTDETIVPPD VPSYLSSQGT 850
    LSDRQETVVR TEGGHQANGH IESNGVCLRD PSLFPEVDIH STTCRQPKLC 900
    VGYTREPWKV TEKADRTAAP HTTAHSGSAV CSDCSTDTAY HPQPVPRDSG 950
    QPGTASSQEL RQHDREYSPH HPYSGTADGS HTLSGGSLYP SNHDRILPSL 1000
    KNKAASADGN GDSSWTLAKL HEADCIDLKP SPTLASGSPE LMEDAISTEA 1050
    QHLLVSNGHL PKACDSSPES VPLKGQITGK RRGPLLLAPR S 1091
    Length:1,091
    Mass (Da):119,156
    Last modified:July 27, 2011 - v2
    Checksum:i938BF3C154520DC0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti38 – 381G → R in BAA11416. (PubMed:8798419)Curated
    Sequence conflicti52 – 521D → N in BAA11416. (PubMed:8798419)Curated
    Sequence conflicti114 – 1141A → T in BAA11416. (PubMed:8798419)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78572 mRNA. Translation: BAA11416.1.
    AC122272 Genomic DNA. No translation available.
    AC155330 Genomic DNA. No translation available.
    CCDSiCCDS20380.1.
    PIRiA58532.
    RefSeqiNP_032403.2. NM_008377.2.
    UniGeneiMm.245210.

    Genome annotation databases

    EnsembliENSMUST00000032105; ENSMUSP00000032105; ENSMUSG00000030029.
    ENSMUST00000101126; ENSMUSP00000098686; ENSMUSG00000030029.
    GeneIDi16206.
    KEGGimmu:16206.
    UCSCiuc009czu.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D78572 mRNA. Translation: BAA11416.1 .
    AC122272 Genomic DNA. No translation available.
    AC155330 Genomic DNA. No translation available.
    CCDSi CCDS20380.1.
    PIRi A58532.
    RefSeqi NP_032403.2. NM_008377.2.
    UniGenei Mm.245210.

    3D structure databases

    ProteinModelPortali P70193.
    SMRi P70193. Positions 489-598.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996947.
    STRINGi 10090.ENSMUSP00000098686.

    PTM databases

    PhosphoSitei P70193.

    Proteomic databases

    PaxDbi P70193.
    PRIDEi P70193.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032105 ; ENSMUSP00000032105 ; ENSMUSG00000030029 .
    ENSMUST00000101126 ; ENSMUSP00000098686 ; ENSMUSG00000030029 .
    GeneIDi 16206.
    KEGGi mmu:16206.
    UCSCi uc009czu.1. mouse.

    Organism-specific databases

    CTDi 26018.
    MGIi MGI:107935. Lrig1.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00730000110575.
    HOGENOMi HOG000113380.
    HOVERGENi HBG052353.
    InParanoidi P70193.
    OMAi ESNGVCP.
    OrthoDBi EOG7DNNTD.
    TreeFami TF325380.

    Miscellaneous databases

    ChiTaRSi LRIG1. mouse.
    NextBioi 289161.
    PROi P70193.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70193.
    Genevestigatori P70193.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003598. Ig_sub2.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF07679. I-set. 3 hits.
    PF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 4 hits.
    PF01463. LRRCT. 1 hit.
    PF01462. LRRNT. 1 hit.
    [Graphical view ]
    SMARTi SM00408. IGc2. 3 hits.
    SM00369. LRR_TYP. 3 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    PS51450. LRR. 14 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains."
      Suzuki Y., Sato N., Tohyama M., Wanaka A., Takagi T.
      J. Biol. Chem. 271:22522-22527(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia."
      Suzuki Y., Miura H., Tanemura A., Kobayashi K., Kondoh G., Sano S., Ozawa K., Inui S., Nakata A., Takagi T., Tohyama M., Yoshikawa K., Itami S.
      FEBS Lett. 521:67-71(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION.

    Entry informationi

    Entry nameiLRIG1_MOUSE
    AccessioniPrimary (citable) accession number: P70193
    Secondary accession number(s): E9QL89
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 11, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 115 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Knockout of the gene results in psiorasiform epidermal hyperplasia.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3