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P70193 (LRIG1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 1

Short name=LIG-1
Gene names
Name:Lrig1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1091 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation By similarity.

Subunit structure

Interacts with EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Tissue specificity

Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the skin. Low expression is detected in the thymus and heart. No expression in the kidney, liver, lung or small intestine. Ref.1 Ref.3

Induction

Down-regulated in the psoriasis epidermis. Ref.3

Domain

The LRRs and the Ig-domains are each sufficient for EGFR binding. This interaction is abolished only when these two domains are deleted By similarity.

Miscellaneous

Knockout of the gene results in psiorasiform epidermal hyperplasia.

Sequence similarities

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 15 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 10911057Leucine-rich repeats and immunoglobulin-like domains protein 1
PRO_0000014828

Regions

Topological domain35 – 796762Extracellular Potential
Transmembrane797 – 81721Helical; Potential
Topological domain818 – 1091274Cytoplasmic Potential
Domain35 – 7036LRRNT
Repeat71 – 9222LRR 1
Repeat95 – 11622LRR 2
Repeat118 – 13922LRR 3
Repeat142 – 16322LRR 4
Repeat166 – 18722LRR 5
Repeat191 – 21222LRR 6
Repeat214 – 23522LRR 7
Repeat238 – 25922LRR 8
Repeat262 – 28322LRR 9
Repeat286 – 30722LRR 10
Repeat310 – 33122LRR 11
Repeat334 – 35522LRR 12
Repeat358 – 38023LRR 13
Repeat385 – 40622LRR 14
Repeat409 – 43022LRR 15
Domain442 – 49352LRRCT
Domain497 – 596100Ig-like C2-type 1
Domain601 – 69090Ig-like C2-type 2
Domain695 – 78187Ig-like C2-type 3
Compositional bias522 – 5265Poly-Ser

Amino acid modifications

Glycosylation761N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation2481N-linked (GlcNAc...) Potential
Glycosylation2941N-linked (GlcNAc...) Potential
Glycosylation3201N-linked (GlcNAc...) Potential
Glycosylation3851N-linked (GlcNAc...) Potential
Glycosylation6861N-linked (GlcNAc...) Potential
Disulfide bond518 ↔ 579 By similarity
Disulfide bond622 ↔ 674 By similarity
Disulfide bond716 ↔ 765 By similarity

Experimental info

Sequence conflict381G → R in BAA11416. Ref.1
Sequence conflict521D → N in BAA11416. Ref.1
Sequence conflict1141A → T in BAA11416. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P70193 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 938BF3C154520DC0

FASTA1,091119,156
        10         20         30         40         50         60 
MARPGPGVLG APRLAPRLLL WLLLLLLQWP ESAGAQAGPR APCAAACTCA GDSLDCSGRG 

        70         80         90        100        110        120 
LATLPRDLPS WTRSLNLSYN RLSEIDSAAF EDLTNLQEVY LNSNELTAIP SLGAASIGVV 

       130        140        150        160        170        180 
SLFLQHNKIL SVDGSQLKSY LSLEVLDLSS NNITEIRSSC FPNGLRIREL NLASNRISIL 

       190        200        210        220        230        240 
ESGAFDGLSR SLLTLRLSKN RITQLPVKAF KLPRLTQLDL NRNRIRLIEG LTFQGLDSLE 

       250        260        270        280        290        300 
VLRLQRNNIS RLTDGAFWGL SKMHVLHLEY NSLVEVNSGS LYGLTALHQL HLSNNSISRI 

       310        320        330        340        350        360 
QRDGWSFCQK LHELILSFNN LTRLDEESLA ELSSLSILRL SHNAISHIAE GAFKGLKSLR 

       370        380        390        400        410        420 
VLDLDHNEIS GTIEDTSGAF TGLDNLSKLT LFGNKIKSVA KRAFSGLESL EHLNLGENAI 

       430        440        450        460        470        480 
RSVQFDAFAK MKNLKELYIS SESFLCDCQL KWLPPWLMGR MLQAFVTATC AHPESLKGQS 

       490        500        510        520        530        540 
IFSVLPDSFV CDDFPKPQII TQPETTMAVV GKDIRFTCSA ASSSSSPMTF AWKKDNEVLA 

       550        560        570        580        590        600 
NADMENFAHV RAQDGEVMEY TTILHLRHVT FGHEGRYQCI ITNHFGSTYS HKARLTVNVL 

       610        620        630        640        650        660 
PSFTKIPHDI AIRTGTTARL ECAATGHPNP QIAWQKDGGT DFPAARERRM HVMPDDDVFF 

       670        680        690        700        710        720 
ITDVKIDDMG VYSCTAQNSA GSVSANATLT VLETPSLAVP LEDRVVTVGE TVAFQCKATG 

       730        740        750        760        770        780 
SPTPRITWLK GGRPLSLTER HHFTPGNQLL VVQNVMIDDA GRYTCEMSNP LGTERAHSQL 

       790        800        810        820        830        840 
SILPTPGCRK DGTTVGIFTI AVVCSIVLTS LVWVCIIYQT RKKSEEYSVT NTDETIVPPD 

       850        860        870        880        890        900 
VPSYLSSQGT LSDRQETVVR TEGGHQANGH IESNGVCLRD PSLFPEVDIH STTCRQPKLC 

       910        920        930        940        950        960 
VGYTREPWKV TEKADRTAAP HTTAHSGSAV CSDCSTDTAY HPQPVPRDSG QPGTASSQEL 

       970        980        990       1000       1010       1020 
RQHDREYSPH HPYSGTADGS HTLSGGSLYP SNHDRILPSL KNKAASADGN GDSSWTLAKL 

      1030       1040       1050       1060       1070       1080 
HEADCIDLKP SPTLASGSPE LMEDAISTEA QHLLVSNGHL PKACDSSPES VPLKGQITGK 

      1090 
RRGPLLLAPR S 

« Hide

References

« Hide 'large scale' references
[1]"cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains."
Suzuki Y., Sato N., Tohyama M., Wanaka A., Takagi T.
J. Biol. Chem. 271:22522-22527(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia."
Suzuki Y., Miura H., Tanemura A., Kobayashi K., Kondoh G., Sano S., Ozawa K., Inui S., Nakata A., Takagi T., Tohyama M., Yoshikawa K., Itami S.
FEBS Lett. 521:67-71(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D78572 mRNA. Translation: BAA11416.1.
AC122272 Genomic DNA. No translation available.
AC155330 Genomic DNA. No translation available.
PIRA58532.
RefSeqNP_032403.2. NM_008377.2.
UniGeneMm.245210.

3D structure databases

ProteinModelPortalP70193.
SMRP70193. Positions 489-598.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4996947.
STRING10090.ENSMUSP00000098686.

PTM databases

PhosphoSiteP70193.

Proteomic databases

PaxDbP70193.
PRIDEP70193.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000032105; ENSMUSP00000032105; ENSMUSG00000030029.
ENSMUST00000101126; ENSMUSP00000098686; ENSMUSG00000030029.
GeneID16206.
KEGGmmu:16206.
UCSCuc009czu.1. mouse.

Organism-specific databases

CTD26018.
MGIMGI:107935. Lrig1.

Phylogenomic databases

eggNOGCOG4886.
GeneTreeENSGT00730000110575.
HOGENOMHOG000113380.
HOVERGENHBG052353.
InParanoidP70193.
OMAESNGVCP.
OrthoDBEOG7DNNTD.
TreeFamTF325380.

Gene expression databases

BgeeP70193.
GenevestigatorP70193.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR000483. Cys-rich_flank_reg_C.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003598. Ig_sub2.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF07679. I-set. 3 hits.
PF00560. LRR_1. 1 hit.
PF01463. LRRCT. 1 hit.
PF01462. LRRNT. 1 hit.
[Graphical view]
SMARTSM00408. IGc2. 3 hits.
SM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS51450. LRR. 14 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSLRIG1. mouse.
NextBio289161.
PROP70193.
SOURCESearch...

Entry information

Entry nameLRIG1_MOUSE
AccessionPrimary (citable) accession number: P70193
Secondary accession number(s): E9QL89
Entry history
Integrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: July 27, 2011
Last modified: February 19, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot