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P70191 (TRAF5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
TNF receptor-associated factor 5
Gene names
Name:Traf5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length558 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. Ref.4

Subunit structure

Homotrimer Probable. Heterotrimer with TRAF3 By similarity. Associates with TNFRSF5/CD40 through interaction with TRAF3 By similarity. Associates with LTBR/TNFRSF3, TNFRSF4, TNFRSF8/CD30, TNFRSF11A/RANK, TNFRSF13B/TACI, TNFRSF14, TNFRSF17, TNFRSF19/TROY, RIPK2, MAP3K14, MAP3K5, and TRAF and TNF receptor associated protein TDP2 By similarity. Interacts (via C-terminus) with EIF2AK2/PKR (via the kinase catalytic domain) By similarity. Ref.1 Ref.2

Subcellular location

Cytoplasm By similarity. Cytoplasmcytosol.

Domain

The MATH/TRAF domain binds to receptor cytoplasmic domains.

Sequence similarities

Belongs to the TNF receptor-associated factor family. A subfamily.

Contains 1 MATH domain.

Contains 1 RING-type zinc finger.

Contains 2 TRAF-type zinc fingers.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

COG7P834362EBI-523899,EBI-389534From a different organism.
Srsf1Q6PDM22EBI-523899,EBI-2550360
TRAF2Q129332EBI-523899,EBI-355744From a different organism.
Traf3ip2Q8N7N63EBI-523899,EBI-646165

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 558558TNF receptor-associated factor 5
PRO_0000056406

Regions

Domain403 – 550148MATH
Zinc finger45 – 8541RING-type
Zinc finger127 – 18155TRAF-type 1
Zinc finger182 – 23958TRAF-type 2
Region345 – 558214Interaction with EIF2AK2/PKR By similarity
Coiled coil252 – 30251 Potential
Coiled coil340 – 40061 Potential

Experimental info

Sequence conflict3281Q → H in BAA11218. Ref.1

Secondary structure

................................ 558
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P70191 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 48F64FB83BD587E5

FASTA55864,145
        10         20         30         40         50         60 
MAHSEEQAAV PCAFIRQNSG NSISLDFEPD TEYQFVEQLE ERYKCAFCHS VLHNPHQTGC 

        70         80         90        100        110        120 
GHRFCQQCIR SLRELNSVPI CPVDKEVIKP QEVFKDNCCK REVLNLHVYC KNAPGCNARI 

       130        140        150        160        170        180 
ILGRFQDHLQ HCSFQAVPCP NESCREAMLR KDVKEHLSAY CRFREEKCLY CKRDIVVTNL 

       190        200        210        220        230        240 
QDHEENSCPA YPVSCPNRCV QTIPRARVNE HLTVCPEAEQ DCPFKHYGCT VKGKRGNLLE 

       250        260        270        280        290        300 
HERAALQDHM LLVLEKNYQL EQRISDLYQS LEQKESKIQQ LAETVKKFEK ELKQFTQMFG 

       310        320        330        340        350        360 
RNGTFLSNVQ ALTSHTDKSA WLEAQVRQLL QIVNQQPSRL DLRSLVDAVD SVKQRITQLE 

       370        380        390        400        410        420 
ASDQRLVLLE GETSKHDAHI NIHKAQLNKN EERFKQLEGA CYSGKLIWKV TDYRVKKREA 

       430        440        450        460        470        480 
VEGHTVSVFS QPFYTSRCGY RLCARAYLNG DGSGKGTHLS LYFVVMRGEF DSLLQWPFRQ 

       490        500        510        520        530        540 
RVTLMLLDQS GKKNHIVETF KADPNSSSFK RPDGEMNIAS GCPRFVSHST LENSKNTYIK 

       550 
DDTLFLKVAV DLTDLEDL 

« Hide

References

« Hide 'large scale' references
[1]"TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor."
Nakano H., Oshima H., Chung W., Williams-Abbott L., Ware C.F., Yagita H., Okumura K.
J. Biol. Chem. 271:14661-14664(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH LTBR.
Strain: BALB/c.
[2]"TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling."
Ishida T., Tojo T., Aoki T., Kobayashi N., Ohishi T., Watanabe T., Yamamoto T., Inoue J.
Proc. Natl. Acad. Sci. U.S.A. 93:9437-9442(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH TNFRSF5.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Colon.
[4]"TRAF family proteins link PKR with NF-kappa B activation."
Gil J., Garcia M.A., Gomez-Puertas P., Guerra S., Rullas J., Nakano H., Alcami J., Esteban M.
Mol. Cell. Biol. 24:4502-4512(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D78141 mRNA. Translation: BAA11218.1.
D83528 mRNA. Translation: BAA11942.1.
BC012702 mRNA. Translation: AAH12702.1.
RefSeqNP_035763.2. NM_011633.2.
UniGeneMm.380491.
Mm.389227.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4GJHX-ray2.80A/B/C381-558[»]
ProteinModelPortalP70191.
SMRP70191. Positions 32-189, 347-557.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204306. 4 interactions.
IntActP70191. 13 interactions.

PTM databases

PhosphoSiteP70191.

Proteomic databases

PRIDEP70191.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID22033.
KEGGmmu:22033.
UCSCuc029qvg.1. mouse.

Organism-specific databases

CTD7188.
MGIMGI:107548. Traf5.

Phylogenomic databases

eggNOGNOG239194.
HOGENOMHOG000231557.
HOVERGENHBG058222.
InParanoidP70191.
KOK09849.
PhylomeDBP70191.

Gene expression databases

CleanExMM_TRAF5.
GenevestigatorP70191.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
3.90.890.10. 2 hits.
InterProIPR002083. MATH.
IPR013323. SIAH-type.
IPR012227. TNF_rcpt--assoc_TRAF.
IPR008974. TRAF-like.
IPR027130. TRAF5.
IPR018957. Znf_C3HC4_RING-type.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
IPR001293. Znf_TRAF.
[Graphical view]
PANTHERPTHR10131:SF66. PTHR10131:SF66. 1 hit.
PfamPF00917. MATH. 1 hit.
PF00097. zf-C3HC4. 1 hit.
[Graphical view]
PIRSFPIRSF015614. TRAF. 1 hit.
SMARTSM00061. MATH. 1 hit.
SM00184. RING. 1 hit.
[Graphical view]
SUPFAMSSF49599. SSF49599. 3 hits.
PROSITEPS50144. MATH. 1 hit.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
PS50145. ZF_TRAF. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio301794.
PROP70191.
SOURCESearch...

Entry information

Entry nameTRAF5_MOUSE
AccessionPrimary (citable) accession number: P70191
Secondary accession number(s): Q61480
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: February 1, 1997
Last modified: June 11, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot