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Protein

Epiphycan

Gene

Epyc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in bone formation and also in establishing the ordered structure of cartilage through matrix organization.

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Epiphycan
Alternative name(s):
Dermatan sulfate proteoglycan 3
Proteoglycan-Lb
Short name:
PG-Lb
Small chondroitin/dermatan sulfate proteoglycan
Gene namesi
Name:Epyc
Synonyms:Dspg3, Pglb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:107942. Epyc.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000003276920 – 322EpiphycanAdd BLAST303

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi64O-linked (Xyl...) (dermatan sulfate) serineBy similarity1
Glycosylationi96O-linked (GalNAc...) serineBy similarity1
Disulfide bondi118 ↔ 130By similarity
Disulfide bondi279 ↔ 312By similarity
Glycosylationi283N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The O-linked polysaccharide on Ser-96 is probably the mucin type linked to GalNAc. There is one glycosaminoglycan chain, known to be dermatan sulfate, and it is probably the O-glycosylation at Ser-64 (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan

Proteomic databases

PaxDbiP70186.
PRIDEiP70186.

PTM databases

iPTMnetiP70186.
PhosphoSitePlusiP70186.

Expressioni

Tissue specificityi

Confined to the middle zone of embryonic epiphyseal cartilage consisting of flattened chondrocytes and the ossifying region in the limb buds of chick embryos. Has also been detected in testis.1 Publication

Developmental stagei

Expression starts at E12.5 dpc and is restricted to developing cartilage.

Gene expression databases

BgeeiENSMUSG00000019936.
CleanExiMM_EPYC.
GenevisibleiP70186. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000020094.

Structurei

3D structure databases

ProteinModelPortaliP70186.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini106 – 143LRRNTAdd BLAST38
Repeati144 – 165LRR 1Add BLAST22
Repeati168 – 189LRR 2Add BLAST22
Repeati192 – 213LRR 3Add BLAST22
Repeati238 – 258LRR 4Add BLAST21
Repeati259 – 280LRR 5Add BLAST22
Repeati290 – 310LRR 6Add BLAST21

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00730000110781.
HOGENOMiHOG000273909.
HOVERGENiHBG006850.
InParanoidiP70186.
KOiK08127.
OMAiCDDHELD.
OrthoDBiEOG091G0C68.
PhylomeDBiP70186.
TreeFamiTF351924.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiView protein in InterPro
IPR027217. Epiphycan.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PANTHERiPTHR24373:SF219. PTHR24373:SF219. 1 hit.
PfamiView protein in Pfam
PF13855. LRR_8. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 3 hits.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 4 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70186-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMLARVALG LIIIDAVLAA PTTELFNYDS EVYDAILEDT GTFYNYEHIP
60 70 80 90 100
DNHVENEKVS ERLSGNRELL TPGPQLGDNQ DEDKDEESTP RLIDGSSPQE
110 120 130 140 150
PEFPGLLGPH TNEDFPTCLL CTCISTTVYC DDHELDAIPP LPKKTTYFYS
160 170 180 190 200
RFNRIKKINK NDFASLNDLK RIDLTSNLIS EIDEDAFRKL PHLQELVLRD
210 220 230 240 250
NKIKQLPELP NTLTFIDISN NRLGRKGIKQ EAFKDMYDLH HLYITDNSLD
260 270 280 290 300
HIPLPLPESL RALHLQNNDI LEMHEDTFCN VKNLTYVRKA LEDIRLDGNP
310 320
INLSRTPQAY MCLPRLPIGS FI
Length:322
Mass (Da):36,763
Last modified:February 1, 1997 - v1
Checksum:iC9C8CBEBECDAC19A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78274 mRNA. Translation: BAA11337.1.
D87187 Genomic DNA. Translation: BAA28770.1.
BC012695 mRNA. Translation: AAH12695.1.
AK015223 mRNA. Translation: BAB29756.1.
CCDSiCCDS24143.1.
PIRiS72271.
RefSeqiNP_031910.1. NM_007884.2.
UniGeneiMm.148886.

Genome annotation databases

EnsembliENSMUST00000020094; ENSMUSP00000020094; ENSMUSG00000019936.
ENSMUST00000105285; ENSMUSP00000100922; ENSMUSG00000019936.
GeneIDi13516.
KEGGimmu:13516.
UCSCiuc007gxb.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiEPYC_MOUSE
AccessioniPrimary (citable) accession number: P70186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: February 1, 1997
Last modified: May 10, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families