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Protein

Atrial natriuretic peptide receptor 3

Gene

Npr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP (PubMed:10377427, PubMed:17951249). May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects (PubMed:10377427, PubMed:17951249). May regulate diuresis, blood pressure and skeletal development (PubMed:10377427). Does not have guanylate cyclase activity (PubMed:10377427).2 Publications

Miscellaneous

Has low affinity for peptide hormones in the absence of bound chloride.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei101ChlorideBy similarity1
Binding sitei130Chloride; via amide nitrogenBy similarity1
Binding sitei131Chloride; via amide nitrogenBy similarity1

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Ensembl
  • negative regulation of adenylate cyclase activity Source: Ensembl
  • negative regulation of smooth muscle cell proliferation Source: Ensembl
  • osteoclast proliferation Source: UniProtKB
  • pancreatic juice secretion Source: Ensembl
  • phosphatidylinositol-mediated signaling Source: Ensembl
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: Ensembl
  • positive regulation of nitric-oxide synthase activity Source: Ensembl
  • positive regulation of urine volume Source: UniProtKB
  • regulation of blood pressure Source: UniProtKB
  • regulation of osteoblast proliferation Source: UniProtKB
  • skeletal system development Source: HGNC

Keywordsi

Molecular functionReceptor
LigandChloride

Names & Taxonomyi

Protein namesi
Recommended name:
Atrial natriuretic peptide receptor 3
Alternative name(s):
Atrial natriuretic peptide clearance receptor
Atrial natriuretic peptide receptor type C
Short name:
ANP-C
Short name:
ANPR-C
Short name:
NPR-C
EF-2
Gene namesi
Name:Npr3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:97373 Npr3

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini41 – 478ExtracellularSequence analysisAdd BLAST438
Transmembranei479 – 499HelicalSequence analysisAdd BLAST21
Topological domaini500 – 536CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Npr3 are the cause of a number of skeletal-overgrowth phenotypes, Longjohn (Lgj), Longjohn-2J (Lgj-2J) and Strigosus (Stri). These are all recessive conditions characterized by an elongated body, thoracic kyphosis, arachnodactyly, and sacral and/or tail kinks, but no significant changes in craniofacial structures (PubMed:10468599).1 Publication

Disruption phenotypei

Half of the mice dies before weaning. They display reduced ability to concentrate urine, a lower blood pressure, and skeletal abnormalities. Despite a reduced half-life of NPPA in the circulation, the plasma levels of NPPA AND NPPB are not affected.1 Publication

Keywords - Diseasei

Disease mutation

Chemistry databases

ChEMBLiCHEMBL4711

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000001237127 – 40Sequence analysisAdd BLAST14
ChainiPRO_000001237241 – 536Atrial natriuretic peptide receptor 3Add BLAST496

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi103 ↔ 131By similarity
Disulfide bondi208 ↔ 256By similarity
Glycosylationi288N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi389N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi468InterchainBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP70180
PaxDbiP70180
PRIDEiP70180

PTM databases

iPTMnetiP70180
PhosphoSitePlusiP70180

Expressioni

Gene expression databases

BgeeiENSMUSG00000022206
CleanExiMM_NPR3
ExpressionAtlasiP70180 baseline and differential
GenevisibleiP70180 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked (By similarity). Interacts with OSTN (PubMed:17951249).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-46248N
IntActiP70180, 3 interactors
MINTiP70180
STRINGi10090.ENSMUSP00000066737

Chemistry databases

BindingDBiP70180

Structurei

3D structure databases

ProteinModelPortaliP70180
SMRiP70180
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ANF receptor family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1023 Eukaryota
COG2114 LUCA
GeneTreeiENSGT00440000033872
HOGENOMiHOG000236252
HOVERGENiHBG060145
InParanoidiP70180
KOiK12325
OMAiYSHLTRV
OrthoDBiEOG091G04YV
TreeFamiTF106339

Family and domain databases

InterProiView protein in InterPro
IPR001828 ANF_lig-bd_rcpt
IPR001170 ANPR/GUC
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF01094 ANF_receptor, 1 hit
PRINTSiPR00255 NATPEPTIDER
SUPFAMiSSF53822 SSF53822, 1 hit
PROSITEiView protein in PROSITE
PS00458 ANF_RECEPTORS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P70180-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSLLLFTFS ACVLLARVLL AGGASSGAGD TRPGSRRRAR EALAAQKIEV
60 70 80 90 100
LVLLPRDDSY LFSLARVRPA IEYALRSVEG NGTGRKLLPP GTRFQVAYED
110 120 130 140 150
SDCGNRALFS LVDRVAAARG AKPDLILGPV CEYAAAPVAR LASHWDLPML
160 170 180 190 200
SAGALAAGFQ HKDTEYSHLT RVAPAYAKMG EMMLALFRHH HWSRAALVYS
210 220 230 240 250
DDKLERNCYF TLEGVHEVFQ EEGLHTSAYN FDETKDLDLD DIVRYIQGSE
260 270 280 290 300
RVVIMCASGD TIRRIMLAVH RHGMTSGDYA FFNIELFNSS SYGDGSWRRG
310 320 330 340 350
DKHDSEAKQA YSSLQTVTLL RTVKPEFEKF SMEVKSSVEK QGLNEEDYVN
360 370 380 390 400
MFVEGFHDAI LLYVLALHEV LRAGYSKKDG GKIIQQTWNR TFEGIAGQVS
410 420 430 440 450
IDANGDRYGD FSVVAMTDTE AGTQEVIGDY FGKEGRFQMR SNVKYPWGPL
460 470 480 490 500
KLRLDETRIV EHTNSSPCKS SGGLEESAVT GIVVGALLGA GLLMAFYFFR
510 520 530
KKYRITIERR NQQEESNIGK HRELREDSIR SHFSVA
Length:536
Mass (Da):59,808
Last modified:October 3, 2012 - v3
Checksum:i78E14B5C4711411E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4L → F in BAA11241 (PubMed:8620881).Curated1
Sequence conflicti4L → F in AAF00104 (PubMed:10468599).Curated1
Sequence conflicti4L → F in AAF00105 (PubMed:10468599).Curated1
Sequence conflicti4L → F in AAF00107 (PubMed:10468599).Curated1
Sequence conflicti58 – 59DS → IT in BAA11241 (PubMed:8620881).Curated2
Sequence conflicti132E → G in BAA11241 (PubMed:8620881).Curated1
Sequence conflicti293G → V in AAB51036 (PubMed:9032278).Curated1
Sequence conflicti348Y → C in AAB51036 (PubMed:9032278).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti66 – 77Missing in Lgj-2J. 1 PublicationAdd BLAST12
Natural varianti168H → N in Lgj. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78175 mRNA Translation: BAA11241.1
AF131861 Genomic DNA Translation: AAF00104.1
AF131862 Genomic DNA Translation: AAF00105.1
AF131864 Genomic DNA Translation: AAF00107.1
AC134793 Genomic DNA No translation available.
CH466581 Genomic DNA Translation: EDL03281.1
U72676 mRNA Translation: AAB51036.1
CCDSiCCDS27386.1
PIRiS71332
RefSeqiNP_032754.2, NM_008728.2
UniGeneiMm.25259

Genome annotation databases

EnsembliENSMUST00000066529; ENSMUSP00000066737; ENSMUSG00000022206
GeneIDi18162
KEGGimmu:18162
UCSCiuc007vhf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiANPRC_MOUSE
AccessioniPrimary (citable) accession number: P70180
Secondary accession number(s): G3X9E5
, P97804, Q9R025, Q9R027, Q9R028
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 141 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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