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Protein

Homeobox protein SIX5

Gene

Six5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • lens development in camera-type eye Source: MGI
  • negative regulation of cell proliferation Source: MGI
  • negative regulation of skeletal muscle satellite cell proliferation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • spermatid development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SIX5
Alternative name(s):
DM locus-associated homeodomain protein homolog
Sine oculis homeobox homolog 5
Gene namesi
Name:Six5
Synonyms:Dmahp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:106220. Six5.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Homeobox protein SIX5PRO_0000049306Add
BLAST

Proteomic databases

PRIDEiP70178.

PTM databases

PhosphoSiteiP70178.

Expressioni

Gene expression databases

BgeeiP70178.
GenevisibleiP70178. MM.

Interactioni

Subunit structurei

Probably binds DNA dimer. Interacts with EYA3, and probably EYA1 and EYA2.2 Publications

Protein-protein interaction databases

IntActiP70178. 2 interactions.
MINTiMINT-1739334.
STRINGi10090.ENSMUSP00000045973.

Structurei

3D structure databases

ProteinModelPortaliP70178.
SMRiP70178. Positions 79-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SIX/Sine oculis homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG244874.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000154329.
HOVERGENiHBG050139.
InParanoidiP70178.
OMAiAAQGSIF.
OrthoDBiEOG7C5M8Z.
PhylomeDBiP70178.
TreeFamiTF315545.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSPAEPSA GPAARGEAAA ATEEQEEEAR QLLQTLQAAE GEAAAAGAGD
60 70 80 90 100
AAAAADSGSP SGPGSPRETV TEVPTGLRFS PEQVACVCEA LLQAGHAGRL
110 120 130 140 150
SRFLGALPPA ERLRGSDPVL RARALVAFQR GEYAELYQLL ESRPFPAAHH
160 170 180 190 200
AFLQDLYLRA RYHEAERARG RALGAVDKYR LRKKFPLPKT IWDGEETVYC
210 220 230 240 250
FKERSRAALK ACYRGNRYPT PDEKRRLATL TGLSLTQVSN WFKNRRQRDR
260 270 280 290 300
TGTGGGAPCK SESDGNPTTE DESSRSPEDL ERGVASMAAE APAQSSIFLA
310 320 330 340 350
GATSPATCPA SSSILVNGSF LAASSPPAVL LNGSPVIINS LALGENSSLG
360 370 380 390 400
PLLLTGGSAP QPQPSLQGVS EAKNSLVLDP QTGEVRLDEA QSEAPETKGV
410 420 430 440 450
HGTTGEEIPG ALPQVVPGPP PASTFPLTPG AVPAVAAPQV VPLSPSSGYP
460 470 480 490 500
TGLSPTSPRL NLPQVVPTSQ VVTLPQAVGP LQLLAAGPGS PVKVAAAAGP
510 520 530 540 550
TNVHLINSSV GVTALQLPSS TAPGNFLLAN PVSGSPIVTG VAVQQGKIIL
560 570 580 590 600
TATFPTSMLV SQVLPPAPSL ALPLKQEPAI TVPEGALPVG PSPTLPEGHT
610 620 630 640 650
LGPISTQPLP PASVVTSGTS LPFSPDSSGL LSSFSAPLPE GLMLSPAAVP
660 670 680 690 700
VWPAGLELST GVEGLGTQAT HTVLRLPDPD PQGLLLGATT GTEVDEGLEA
710
EAKVLTQLQS VPVEEPLEL
Length:719
Mass (Da):73,717
Last modified:April 13, 2004 - v2
Checksum:iB559618D3C831CD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145199 Genomic DNA. No translation available.
D83146 mRNA. Translation: BAA11824.1.
CCDSiCCDS20889.1.
PIRiS74254.
RefSeqiNP_035513.1. NM_011383.1.
UniGeneiMm.3410.

Genome annotation databases

EnsembliENSMUST00000049454; ENSMUSP00000045973; ENSMUSG00000040841.
GeneIDi20475.
KEGGimmu:20475.
UCSCiuc009fkr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145199 Genomic DNA. No translation available.
D83146 mRNA. Translation: BAA11824.1.
CCDSiCCDS20889.1.
PIRiS74254.
RefSeqiNP_035513.1. NM_011383.1.
UniGeneiMm.3410.

3D structure databases

ProteinModelPortaliP70178.
SMRiP70178. Positions 79-252.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP70178. 2 interactions.
MINTiMINT-1739334.
STRINGi10090.ENSMUSP00000045973.

PTM databases

PhosphoSiteiP70178.

Proteomic databases

PRIDEiP70178.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049454; ENSMUSP00000045973; ENSMUSG00000040841.
GeneIDi20475.
KEGGimmu:20475.
UCSCiuc009fkr.1. mouse.

Organism-specific databases

CTDi147912.
MGIiMGI:106220. Six5.

Phylogenomic databases

eggNOGiNOG244874.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000154329.
HOVERGENiHBG050139.
InParanoidiP70178.
OMAiAAQGSIF.
OrthoDBiEOG7C5M8Z.
PhylomeDBiP70178.
TreeFamiTF315545.

Miscellaneous databases

NextBioi298595.
PROiP70178.
SOURCEiSearch...

Gene expression databases

BgeeiP70178.
GenevisibleiP70178. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Identification and expression of Six family genes in mouse retina."
    Kawakami K., Ohto H., Takizawa T., Saito T.
    FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-719, DNA-BINDING.
    Strain: BALB/c.
    Tissue: Retina.
  3. "Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
    Ohto H., Kamada S., Tago K., Tominaga S., Ozaki H., Sato S., Kawakami K.
    Mol. Cell. Biol. 19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EYA1; EYA2 AND EYA3.
  4. "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1."
    Sato S., Nakamura M., Cho D.H., Tapscott S.J., Ozaki H., Kawakami K.
    Hum. Mol. Genet. 11:1045-1058(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  5. "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein."
    Ikeda K., Watanabe Y., Ohto H., Kawakami K.
    Mol. Cell. Biol. 22:6759-6766(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EYA3.

Entry informationi

Entry nameiSIX5_MOUSE
AccessioniPrimary (citable) accession number: P70178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 13, 2004
Last modified: June 24, 2015
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.