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P70178

- SIX5_MOUSE

UniProt

P70178 - SIX5_MOUSE

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Protein

Homeobox protein SIX5

Gene

Six5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter (By similarity). Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: MGI

GO - Biological processi

  1. lens development in camera-type eye Source: MGI
  2. negative regulation of cell proliferation Source: MGI
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
  4. spermatid development Source: MGI
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SIX5
Alternative name(s):
DM locus-associated homeodomain protein homolog
Sine oculis homeobox homolog 5
Gene namesi
Name:Six5
Synonyms:Dmahp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:106220. Six5.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Homeobox protein SIX5PRO_0000049306Add
BLAST

Proteomic databases

PRIDEiP70178.

PTM databases

PhosphoSiteiP70178.

Expressioni

Gene expression databases

BgeeiP70178.
GenevestigatoriP70178.

Interactioni

Subunit structurei

Probably binds DNA dimer. Interacts with EYA3, and probably EYA1 and EYA2.2 Publications

Protein-protein interaction databases

IntActiP70178. 2 interactions.
MINTiMINT-1739334.
STRINGi10090.ENSMUSP00000045973.

Structurei

3D structure databases

ProteinModelPortaliP70178.
SMRiP70178. Positions 79-252.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SIX/Sine oculis homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG244874.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000154329.
HOVERGENiHBG050139.
InParanoidiP70178.
OMAiAFQRGEY.
OrthoDBiEOG7C5M8Z.
PhylomeDBiP70178.
TreeFamiTF315545.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70178-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MATSPAEPSA GPAARGEAAA ATEEQEEEAR QLLQTLQAAE GEAAAAGAGD
60 70 80 90 100
AAAAADSGSP SGPGSPRETV TEVPTGLRFS PEQVACVCEA LLQAGHAGRL
110 120 130 140 150
SRFLGALPPA ERLRGSDPVL RARALVAFQR GEYAELYQLL ESRPFPAAHH
160 170 180 190 200
AFLQDLYLRA RYHEAERARG RALGAVDKYR LRKKFPLPKT IWDGEETVYC
210 220 230 240 250
FKERSRAALK ACYRGNRYPT PDEKRRLATL TGLSLTQVSN WFKNRRQRDR
260 270 280 290 300
TGTGGGAPCK SESDGNPTTE DESSRSPEDL ERGVASMAAE APAQSSIFLA
310 320 330 340 350
GATSPATCPA SSSILVNGSF LAASSPPAVL LNGSPVIINS LALGENSSLG
360 370 380 390 400
PLLLTGGSAP QPQPSLQGVS EAKNSLVLDP QTGEVRLDEA QSEAPETKGV
410 420 430 440 450
HGTTGEEIPG ALPQVVPGPP PASTFPLTPG AVPAVAAPQV VPLSPSSGYP
460 470 480 490 500
TGLSPTSPRL NLPQVVPTSQ VVTLPQAVGP LQLLAAGPGS PVKVAAAAGP
510 520 530 540 550
TNVHLINSSV GVTALQLPSS TAPGNFLLAN PVSGSPIVTG VAVQQGKIIL
560 570 580 590 600
TATFPTSMLV SQVLPPAPSL ALPLKQEPAI TVPEGALPVG PSPTLPEGHT
610 620 630 640 650
LGPISTQPLP PASVVTSGTS LPFSPDSSGL LSSFSAPLPE GLMLSPAAVP
660 670 680 690 700
VWPAGLELST GVEGLGTQAT HTVLRLPDPD PQGLLLGATT GTEVDEGLEA
710
EAKVLTQLQS VPVEEPLEL
Length:719
Mass (Da):73,717
Last modified:April 13, 2004 - v2
Checksum:iB559618D3C831CD6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145199 Genomic DNA. No translation available.
D83146 mRNA. Translation: BAA11824.1.
CCDSiCCDS20889.1.
PIRiS74254.
RefSeqiNP_035513.1. NM_011383.1.
UniGeneiMm.3410.

Genome annotation databases

EnsembliENSMUST00000049454; ENSMUSP00000045973; ENSMUSG00000040841.
GeneIDi20475.
KEGGimmu:20475.
UCSCiuc009fkr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC145199 Genomic DNA. No translation available.
D83146 mRNA. Translation: BAA11824.1 .
CCDSi CCDS20889.1.
PIRi S74254.
RefSeqi NP_035513.1. NM_011383.1.
UniGenei Mm.3410.

3D structure databases

ProteinModelPortali P70178.
SMRi P70178. Positions 79-252.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P70178. 2 interactions.
MINTi MINT-1739334.
STRINGi 10090.ENSMUSP00000045973.

PTM databases

PhosphoSitei P70178.

Proteomic databases

PRIDEi P70178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049454 ; ENSMUSP00000045973 ; ENSMUSG00000040841 .
GeneIDi 20475.
KEGGi mmu:20475.
UCSCi uc009fkr.1. mouse.

Organism-specific databases

CTDi 147912.
MGIi MGI:106220. Six5.

Phylogenomic databases

eggNOGi NOG244874.
GeneTreei ENSGT00540000070251.
HOGENOMi HOG000154329.
HOVERGENi HBG050139.
InParanoidi P70178.
OMAi AFQRGEY.
OrthoDBi EOG7C5M8Z.
PhylomeDBi P70178.
TreeFami TF315545.

Miscellaneous databases

NextBioi 298595.
PROi P70178.
SOURCEi Search...

Gene expression databases

Bgeei P70178.
Genevestigatori P70178.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Identification and expression of Six family genes in mouse retina."
    Kawakami K., Ohto H., Takizawa T., Saito T.
    FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-719, DNA-BINDING.
    Strain: BALB/c.
    Tissue: Retina.
  3. "Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
    Ohto H., Kamada S., Tago K., Tominaga S., Ozaki H., Sato S., Kawakami K.
    Mol. Cell. Biol. 19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EYA1; EYA2 AND EYA3.
  4. "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1."
    Sato S., Nakamura M., Cho D.H., Tapscott S.J., Ozaki H., Kawakami K.
    Hum. Mol. Genet. 11:1045-1058(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  5. "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein."
    Ikeda K., Watanabe Y., Ohto H., Kawakami K.
    Mol. Cell. Biol. 22:6759-6766(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EYA3.

Entry informationi

Entry nameiSIX5_MOUSE
AccessioniPrimary (citable) accession number: P70178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 13, 2004
Last modified: October 29, 2014
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3