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P70178 (SIX5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein SIX5
Alternative name(s):
DM locus-associated homeodomain protein homolog
Sine oculis homeobox homolog 5
Gene names
Name:Six5
Synonyms:Dmahp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length719 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter By similarity. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3. Ref.3

Subunit structure

Probably binds DNA dimer. Interacts with EYA3, and probably EYA1 and EYA2. Ref.3 Ref.5

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SIX/Sine oculis homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 719719Homeobox protein SIX5
PRO_0000049306

Regions

DNA binding194 – 25360Homeobox Ref.2 Ref.4

Sequences

Sequence LengthMass (Da)Tools
P70178 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: B559618D3C831CD6

FASTA71973,717
        10         20         30         40         50         60 
MATSPAEPSA GPAARGEAAA ATEEQEEEAR QLLQTLQAAE GEAAAAGAGD AAAAADSGSP 

        70         80         90        100        110        120 
SGPGSPRETV TEVPTGLRFS PEQVACVCEA LLQAGHAGRL SRFLGALPPA ERLRGSDPVL 

       130        140        150        160        170        180 
RARALVAFQR GEYAELYQLL ESRPFPAAHH AFLQDLYLRA RYHEAERARG RALGAVDKYR 

       190        200        210        220        230        240 
LRKKFPLPKT IWDGEETVYC FKERSRAALK ACYRGNRYPT PDEKRRLATL TGLSLTQVSN 

       250        260        270        280        290        300 
WFKNRRQRDR TGTGGGAPCK SESDGNPTTE DESSRSPEDL ERGVASMAAE APAQSSIFLA 

       310        320        330        340        350        360 
GATSPATCPA SSSILVNGSF LAASSPPAVL LNGSPVIINS LALGENSSLG PLLLTGGSAP 

       370        380        390        400        410        420 
QPQPSLQGVS EAKNSLVLDP QTGEVRLDEA QSEAPETKGV HGTTGEEIPG ALPQVVPGPP 

       430        440        450        460        470        480 
PASTFPLTPG AVPAVAAPQV VPLSPSSGYP TGLSPTSPRL NLPQVVPTSQ VVTLPQAVGP 

       490        500        510        520        530        540 
LQLLAAGPGS PVKVAAAAGP TNVHLINSSV GVTALQLPSS TAPGNFLLAN PVSGSPIVTG 

       550        560        570        580        590        600 
VAVQQGKIIL TATFPTSMLV SQVLPPAPSL ALPLKQEPAI TVPEGALPVG PSPTLPEGHT 

       610        620        630        640        650        660 
LGPISTQPLP PASVVTSGTS LPFSPDSSGL LSSFSAPLPE GLMLSPAAVP VWPAGLELST 

       670        680        690        700        710 
GVEGLGTQAT HTVLRLPDPD PQGLLLGATT GTEVDEGLEA EAKVLTQLQS VPVEEPLEL 

« Hide

References

« Hide 'large scale' references
[1]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[2]"Identification and expression of Six family genes in mouse retina."
Kawakami K., Ohto H., Takizawa T., Saito T.
FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-719, DNA-BINDING.
Strain: BALB/c.
Tissue: Retina.
[3]"Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
Ohto H., Kamada S., Tago K., Tominaga S., Ozaki H., Sato S., Kawakami K.
Mol. Cell. Biol. 19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH EYA1; EYA2 AND EYA3.
[4]"Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1."
Sato S., Nakamura M., Cho D.H., Tapscott S.J., Ozaki H., Kawakami K.
Hum. Mol. Genet. 11:1045-1058(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING.
[5]"Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein."
Ikeda K., Watanabe Y., Ohto H., Kawakami K.
Mol. Cell. Biol. 22:6759-6766(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH EYA3.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC145199 Genomic DNA. No translation available.
D83146 mRNA. Translation: BAA11824.1.
CCDSCCDS20889.1.
PIRS74254.
RefSeqNP_035513.1. NM_011383.1.
UniGeneMm.3410.

3D structure databases

ProteinModelPortalP70178.
SMRP70178. Positions 79-252.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP70178. 2 interactions.
MINTMINT-1739334.
STRING10090.ENSMUSP00000045973.

PTM databases

PhosphoSiteP70178.

Proteomic databases

PRIDEP70178.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000049454; ENSMUSP00000045973; ENSMUSG00000040841.
GeneID20475.
KEGGmmu:20475.
UCSCuc009fkr.1. mouse.

Organism-specific databases

CTD147912.
MGIMGI:106220. Six5.

Phylogenomic databases

eggNOGNOG244874.
GeneTreeENSGT00540000070251.
HOGENOMHOG000154329.
HOVERGENHBG050139.
InParanoidP70178.
OMAAFQRGEY.
OrthoDBEOG7C5M8Z.
PhylomeDBP70178.
TreeFamTF315545.

Gene expression databases

BgeeP70178.
GenevestigatorP70178.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio298595.
PROP70178.
SOURCESearch...

Entry information

Entry nameSIX5_MOUSE
AccessionPrimary (citable) accession number: P70178
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot