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P70178

- SIX5_MOUSE

UniProt

P70178 - SIX5_MOUSE

Protein

Homeobox protein SIX5

Gene

Six5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter By similarity. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi194 – 25360HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. sequence-specific DNA binding Source: MGI
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. lens development in camera-type eye Source: MGI
    2. negative regulation of cell proliferation Source: MGI
    3. spermatid development Source: MGI
    4. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein SIX5
    Alternative name(s):
    DM locus-associated homeodomain protein homolog
    Sine oculis homeobox homolog 5
    Gene namesi
    Name:Six5
    Synonyms:Dmahp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:106220. Six5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 719719Homeobox protein SIX5PRO_0000049306Add
    BLAST

    Proteomic databases

    PRIDEiP70178.

    PTM databases

    PhosphoSiteiP70178.

    Expressioni

    Gene expression databases

    BgeeiP70178.
    GenevestigatoriP70178.

    Interactioni

    Subunit structurei

    Probably binds DNA dimer. Interacts with EYA3, and probably EYA1 and EYA2.2 Publications

    Protein-protein interaction databases

    IntActiP70178. 2 interactions.
    MINTiMINT-1739334.
    STRINGi10090.ENSMUSP00000045973.

    Structurei

    3D structure databases

    ProteinModelPortaliP70178.
    SMRiP70178. Positions 79-252.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SIX/Sine oculis homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG244874.
    GeneTreeiENSGT00540000070251.
    HOGENOMiHOG000154329.
    HOVERGENiHBG050139.
    InParanoidiP70178.
    OMAiAFQRGEY.
    OrthoDBiEOG7C5M8Z.
    PhylomeDBiP70178.
    TreeFamiTF315545.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70178-1 [UniParc]FASTAAdd to Basket

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    MATSPAEPSA GPAARGEAAA ATEEQEEEAR QLLQTLQAAE GEAAAAGAGD    50
    AAAAADSGSP SGPGSPRETV TEVPTGLRFS PEQVACVCEA LLQAGHAGRL 100
    SRFLGALPPA ERLRGSDPVL RARALVAFQR GEYAELYQLL ESRPFPAAHH 150
    AFLQDLYLRA RYHEAERARG RALGAVDKYR LRKKFPLPKT IWDGEETVYC 200
    FKERSRAALK ACYRGNRYPT PDEKRRLATL TGLSLTQVSN WFKNRRQRDR 250
    TGTGGGAPCK SESDGNPTTE DESSRSPEDL ERGVASMAAE APAQSSIFLA 300
    GATSPATCPA SSSILVNGSF LAASSPPAVL LNGSPVIINS LALGENSSLG 350
    PLLLTGGSAP QPQPSLQGVS EAKNSLVLDP QTGEVRLDEA QSEAPETKGV 400
    HGTTGEEIPG ALPQVVPGPP PASTFPLTPG AVPAVAAPQV VPLSPSSGYP 450
    TGLSPTSPRL NLPQVVPTSQ VVTLPQAVGP LQLLAAGPGS PVKVAAAAGP 500
    TNVHLINSSV GVTALQLPSS TAPGNFLLAN PVSGSPIVTG VAVQQGKIIL 550
    TATFPTSMLV SQVLPPAPSL ALPLKQEPAI TVPEGALPVG PSPTLPEGHT 600
    LGPISTQPLP PASVVTSGTS LPFSPDSSGL LSSFSAPLPE GLMLSPAAVP 650
    VWPAGLELST GVEGLGTQAT HTVLRLPDPD PQGLLLGATT GTEVDEGLEA 700
    EAKVLTQLQS VPVEEPLEL 719
    Length:719
    Mass (Da):73,717
    Last modified:April 13, 2004 - v2
    Checksum:iB559618D3C831CD6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC145199 Genomic DNA. No translation available.
    D83146 mRNA. Translation: BAA11824.1.
    CCDSiCCDS20889.1.
    PIRiS74254.
    RefSeqiNP_035513.1. NM_011383.1.
    UniGeneiMm.3410.

    Genome annotation databases

    EnsembliENSMUST00000049454; ENSMUSP00000045973; ENSMUSG00000040841.
    GeneIDi20475.
    KEGGimmu:20475.
    UCSCiuc009fkr.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC145199 Genomic DNA. No translation available.
    D83146 mRNA. Translation: BAA11824.1 .
    CCDSi CCDS20889.1.
    PIRi S74254.
    RefSeqi NP_035513.1. NM_011383.1.
    UniGenei Mm.3410.

    3D structure databases

    ProteinModelPortali P70178.
    SMRi P70178. Positions 79-252.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P70178. 2 interactions.
    MINTi MINT-1739334.
    STRINGi 10090.ENSMUSP00000045973.

    PTM databases

    PhosphoSitei P70178.

    Proteomic databases

    PRIDEi P70178.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000049454 ; ENSMUSP00000045973 ; ENSMUSG00000040841 .
    GeneIDi 20475.
    KEGGi mmu:20475.
    UCSCi uc009fkr.1. mouse.

    Organism-specific databases

    CTDi 147912.
    MGIi MGI:106220. Six5.

    Phylogenomic databases

    eggNOGi NOG244874.
    GeneTreei ENSGT00540000070251.
    HOGENOMi HOG000154329.
    HOVERGENi HBG050139.
    InParanoidi P70178.
    OMAi AFQRGEY.
    OrthoDBi EOG7C5M8Z.
    PhylomeDBi P70178.
    TreeFami TF315545.

    Miscellaneous databases

    NextBioi 298595.
    PROi P70178.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70178.
    Genevestigatori P70178.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    2. "Identification and expression of Six family genes in mouse retina."
      Kawakami K., Ohto H., Takizawa T., Saito T.
      FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-719, DNA-BINDING.
      Strain: BALB/c.
      Tissue: Retina.
    3. "Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
      Ohto H., Kamada S., Tago K., Tominaga S., Ozaki H., Sato S., Kawakami K.
      Mol. Cell. Biol. 19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH EYA1; EYA2 AND EYA3.
    4. "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1."
      Sato S., Nakamura M., Cho D.H., Tapscott S.J., Ozaki H., Kawakami K.
      Hum. Mol. Genet. 11:1045-1058(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: DNA-BINDING.
    5. "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein."
      Ikeda K., Watanabe Y., Ohto H., Kawakami K.
      Mol. Cell. Biol. 22:6759-6766(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH EYA3.

    Entry informationi

    Entry nameiSIX5_MOUSE
    AccessioniPrimary (citable) accession number: P70178
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 116 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3