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P70178

- SIX5_MOUSE

UniProt

P70178 - SIX5_MOUSE

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Protein
Homeobox protein SIX5
Gene
Six5, Dmahp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter By similarity. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi194 – 25360Homeobox2 Publications
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. sequence-specific DNA binding Source: MGI
  3. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. lens development in camera-type eye Source: MGI
  2. negative regulation of cell proliferation Source: MGI
  3. spermatid development Source: MGI
  4. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein SIX5
Alternative name(s):
DM locus-associated homeodomain protein homolog
Sine oculis homeobox homolog 5
Gene namesi
Name:Six5
Synonyms:Dmahp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:106220. Six5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 719719Homeobox protein SIX5
PRO_0000049306Add
BLAST

Proteomic databases

PRIDEiP70178.

PTM databases

PhosphoSiteiP70178.

Expressioni

Gene expression databases

BgeeiP70178.
GenevestigatoriP70178.

Interactioni

Subunit structurei

Probably binds DNA dimer. Interacts with EYA3, and probably EYA1 and EYA2.2 Publications

Protein-protein interaction databases

IntActiP70178. 2 interactions.
MINTiMINT-1739334.
STRINGi10090.ENSMUSP00000045973.

Structurei

3D structure databases

ProteinModelPortaliP70178.
SMRiP70178. Positions 79-252.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG244874.
GeneTreeiENSGT00540000070251.
HOGENOMiHOG000154329.
HOVERGENiHBG050139.
InParanoidiP70178.
OMAiAFQRGEY.
OrthoDBiEOG7C5M8Z.
PhylomeDBiP70178.
TreeFamiTF315545.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70178-1 [UniParc]FASTAAdd to Basket

« Hide

MATSPAEPSA GPAARGEAAA ATEEQEEEAR QLLQTLQAAE GEAAAAGAGD    50
AAAAADSGSP SGPGSPRETV TEVPTGLRFS PEQVACVCEA LLQAGHAGRL 100
SRFLGALPPA ERLRGSDPVL RARALVAFQR GEYAELYQLL ESRPFPAAHH 150
AFLQDLYLRA RYHEAERARG RALGAVDKYR LRKKFPLPKT IWDGEETVYC 200
FKERSRAALK ACYRGNRYPT PDEKRRLATL TGLSLTQVSN WFKNRRQRDR 250
TGTGGGAPCK SESDGNPTTE DESSRSPEDL ERGVASMAAE APAQSSIFLA 300
GATSPATCPA SSSILVNGSF LAASSPPAVL LNGSPVIINS LALGENSSLG 350
PLLLTGGSAP QPQPSLQGVS EAKNSLVLDP QTGEVRLDEA QSEAPETKGV 400
HGTTGEEIPG ALPQVVPGPP PASTFPLTPG AVPAVAAPQV VPLSPSSGYP 450
TGLSPTSPRL NLPQVVPTSQ VVTLPQAVGP LQLLAAGPGS PVKVAAAAGP 500
TNVHLINSSV GVTALQLPSS TAPGNFLLAN PVSGSPIVTG VAVQQGKIIL 550
TATFPTSMLV SQVLPPAPSL ALPLKQEPAI TVPEGALPVG PSPTLPEGHT 600
LGPISTQPLP PASVVTSGTS LPFSPDSSGL LSSFSAPLPE GLMLSPAAVP 650
VWPAGLELST GVEGLGTQAT HTVLRLPDPD PQGLLLGATT GTEVDEGLEA 700
EAKVLTQLQS VPVEEPLEL 719
Length:719
Mass (Da):73,717
Last modified:April 13, 2004 - v2
Checksum:iB559618D3C831CD6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC145199 Genomic DNA. No translation available.
D83146 mRNA. Translation: BAA11824.1.
CCDSiCCDS20889.1.
PIRiS74254.
RefSeqiNP_035513.1. NM_011383.1.
UniGeneiMm.3410.

Genome annotation databases

EnsembliENSMUST00000049454; ENSMUSP00000045973; ENSMUSG00000040841.
GeneIDi20475.
KEGGimmu:20475.
UCSCiuc009fkr.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC145199 Genomic DNA. No translation available.
D83146 mRNA. Translation: BAA11824.1 .
CCDSi CCDS20889.1.
PIRi S74254.
RefSeqi NP_035513.1. NM_011383.1.
UniGenei Mm.3410.

3D structure databases

ProteinModelPortali P70178.
SMRi P70178. Positions 79-252.
ModBasei Search...

Protein-protein interaction databases

IntActi P70178. 2 interactions.
MINTi MINT-1739334.
STRINGi 10090.ENSMUSP00000045973.

PTM databases

PhosphoSitei P70178.

Proteomic databases

PRIDEi P70178.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049454 ; ENSMUSP00000045973 ; ENSMUSG00000040841 .
GeneIDi 20475.
KEGGi mmu:20475.
UCSCi uc009fkr.1. mouse.

Organism-specific databases

CTDi 147912.
MGIi MGI:106220. Six5.

Phylogenomic databases

eggNOGi NOG244874.
GeneTreei ENSGT00540000070251.
HOGENOMi HOG000154329.
HOVERGENi HBG050139.
InParanoidi P70178.
OMAi AFQRGEY.
OrthoDBi EOG7C5M8Z.
PhylomeDBi P70178.
TreeFami TF315545.

Miscellaneous databases

NextBioi 298595.
PROi P70178.
SOURCEi Search...

Gene expression databases

Bgeei P70178.
Genevestigatori P70178.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  2. "Identification and expression of Six family genes in mouse retina."
    Kawakami K., Ohto H., Takizawa T., Saito T.
    FEBS Lett. 393:259-263(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 53-719, DNA-BINDING.
    Strain: BALB/c.
    Tissue: Retina.
  3. "Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
    Ohto H., Kamada S., Tago K., Tominaga S., Ozaki H., Sato S., Kawakami K.
    Mol. Cell. Biol. 19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH EYA1; EYA2 AND EYA3.
  4. "Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1."
    Sato S., Nakamura M., Cho D.H., Tapscott S.J., Ozaki H., Kawakami K.
    Hum. Mol. Genet. 11:1045-1058(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DNA-BINDING.
  5. "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein."
    Ikeda K., Watanabe Y., Ohto H., Kawakami K.
    Mol. Cell. Biol. 22:6759-6766(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH EYA3.

Entry informationi

Entry nameiSIX5_MOUSE
AccessioniPrimary (citable) accession number: P70178
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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