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P70175

- DLG3_MOUSE

UniProt

P70175 - DLG3_MOUSE

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Protein

Disks large homolog 3

Gene
Dlg3, Dlgh3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling By similarity.

GO - Molecular functioni

  1. phosphatase binding Source: UniProtKB
  2. protein binding Source: UniProtKB
  3. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. establishment of planar polarity Source: MGI
  2. establishment or maintenance of epithelial cell apical/basal polarity Source: MGI
  3. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198694. Activation of Ca-permeable Kainate Receptor.

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 3
Alternative name(s):
Synapse-associated protein 102
Short name:
SAP-102
Short name:
SAP102
Gene namesi
Name:Dlg3
Synonyms:Dlgh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1888986. Dlg3.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
  2. cell-cell junction Source: MGI
  3. cytoplasm Source: MGI
  4. dendritic shaft Source: Ensembl
  5. growth cone Source: Ensembl
  6. neuronal cell body Source: Ensembl
  7. plasma membrane Source: MGI
  8. synapse Source: Ensembl
  9. tight junction Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 849849Disks large homolog 3PRO_0000094558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP70175.
PaxDbiP70175.
PRIDEiP70175.

PTM databases

PhosphoSiteiP70175.

Expressioni

Gene expression databases

ArrayExpressiP70175.
BgeeiP70175.
CleanExiMM_DLG3.
GenevestigatoriP70175.

Interactioni

Subunit structurei

Interacts through its PDZ domains with NETO1, GRIN2B, SYNGAP1 and APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 By similarity. Interacts with FRMPD4 (via C-terminus) By similarity. Interacts with LRFN1, LRFN2 and LRFN4 By similarity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621083EBI-396969,EBI-300895

Protein-protein interaction databases

BioGridi207274. 11 interactions.
DIPiDIP-31585N.
IntActiP70175. 8 interactions.
MINTiMINT-136046.

Structurei

3D structure databases

ProteinModelPortaliP70175.
SMRiP70175. Positions 61-849.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 23587PDZ 1Add
BLAST
Domaini244 – 33087PDZ 2Add
BLAST
Domaini404 – 48481PDZ 3Add
BLAST
Domaini519 – 58971SH3Add
BLAST
Domaini659 – 834176Guanylate kinase-likeAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.
Contains 3 PDZ (DHR) domains.
Contains 1 SH3 domain.

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0194.
GeneTreeiENSGT00660000095130.
HOGENOMiHOG000232102.
HOVERGENiHBG107814.
InParanoidiP70175.
KOiK12075.
PhylomeDBiP70175.
TreeFamiTF323171.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR016313. DLG1.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR019590. MAGUK_PEST_N.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70175-1 [UniParc]FASTAAdd to Basket

« Hide

MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG    50
YGGYSSQTLP SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG 100
SGPGWWPECT CTNRDWYEQA SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI 150
VLERGNSGLG FSIAGGIDNP HVPDDPGIFI TKIIPGGAAA MDGRLGVNDC 200
VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE TIMEVNLLKG 250
PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN 300
NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSIHLNDMYA PPDYASTFTA 350
LADNHISHNS SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR 400
EPRKIILHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDRI 450
LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV AQYRPEEYSR FESKIHDLRE 500
QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI 550
LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA 600
RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP 650
VTRQEIHYAR PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV 700
DGQDYHFVVS REQMEKDIQD NKFIEAGQFN DNLYGTSIQS VRAVAERGKH 750
CILDVSGNAI KRLQQAQLYP IAIFIKPKSI EALMEMNRRQ TYEQANKIFD 800
KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY IWVPSPEKL 849
Length:849
Mass (Da):93,482
Last modified:February 1, 1997 - v1
Checksum:iEF3EF2D7513538EE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87117 mRNA. Translation: BAA13249.1.
CCDSiCCDS30307.1.
RefSeqiNP_001171249.1. NM_001177778.2.
NP_058027.1. NM_016747.4.
UniGeneiMm.4615.

Genome annotation databases

EnsembliENSMUST00000087984; ENSMUSP00000085299; ENSMUSG00000000881.
GeneIDi53310.
KEGGimmu:53310.
UCSCiuc009twm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D87117 mRNA. Translation: BAA13249.1 .
CCDSi CCDS30307.1.
RefSeqi NP_001171249.1. NM_001177778.2.
NP_058027.1. NM_016747.4.
UniGenei Mm.4615.

3D structure databases

ProteinModelPortali P70175.
SMRi P70175. Positions 61-849.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207274. 11 interactions.
DIPi DIP-31585N.
IntActi P70175. 8 interactions.
MINTi MINT-136046.

PTM databases

PhosphoSitei P70175.

Proteomic databases

MaxQBi P70175.
PaxDbi P70175.
PRIDEi P70175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087984 ; ENSMUSP00000085299 ; ENSMUSG00000000881 .
GeneIDi 53310.
KEGGi mmu:53310.
UCSCi uc009twm.2. mouse.

Organism-specific databases

CTDi 1741.
MGIi MGI:1888986. Dlg3.

Phylogenomic databases

eggNOGi COG0194.
GeneTreei ENSGT00660000095130.
HOGENOMi HOG000232102.
HOVERGENi HBG107814.
InParanoidi P70175.
KOi K12075.
PhylomeDBi P70175.
TreeFami TF323171.

Enzyme and pathway databases

Reactomei REACT_198694. Activation of Ca-permeable Kainate Receptor.

Miscellaneous databases

NextBioi 310085.
PROi P70175.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70175.
Bgeei P70175.
CleanExi MM_DLG3.
Genevestigatori P70175.

Family and domain databases

Gene3Di 2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProi IPR016313. DLG1.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR019590. MAGUK_PEST_N.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR23119. PTHR23119. 1 hit.
Pfami PF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001741. MAGUK_DLGH. 1 hit.
SMARTi SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kohmura N., Makino S., Yagi T.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning."
    Ng D., Pitcher G.M., Szilard R.K., Sertie A., Kanisek M., Clapcote S.J., Lipina T., Kalia L.V., Joo D., McKerlie C., Cortez M., Roder J.C., Salter M.W., McInnes R.R.
    PLoS Biol. 7:E41-E41(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NETO1.

Entry informationi

Entry nameiDLG3_MOUSE
AccessioniPrimary (citable) accession number: P70175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: September 3, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi