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P70175 (DLG3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 126. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Disks large homolog 3
Alternative name(s):
Synapse-associated protein 102
Short name=SAP-102
Short name=SAP102
Gene names
Name:Dlg3
Synonyms:Dlgh3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length849 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling By similarity.

Subunit structure

Interacts through its PDZ domains with NETO1, GRIN2B, SYNGAP1 and APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 By similarity. Interacts with FRMPD4 (via C-terminus) By similarity. Interacts with LRFN1, LRFN2 and LRFN4 By similarity. Ref.3

Sequence similarities

Belongs to the MAGUK family.

Contains 1 guanylate kinase-like domain.

Contains 3 PDZ (DHR) domains.

Contains 1 SH3 domain.

Ontologies

Keywords
   DomainRepeat
SH3 domain
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processestablishment of planar polarity

Inferred from mutant phenotype PubMed 21920314. Source: MGI

establishment or maintenance of epithelial cell apical/basal polarity

Inferred from mutant phenotype PubMed 21920314. Source: MGI

negative regulation of phosphatase activity

Inferred from sequence or structural similarity. Source: UniProtKB

   Cellular_componentalpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex

Inferred from direct assay PubMed 22632720. Source: MGI

cell-cell junction

Inferred from direct assay PubMed 21920314. Source: MGI

cytoplasm

Inferred from direct assay PubMed 12351654PubMed 21920314. Source: MGI

dendritic shaft

Inferred from electronic annotation. Source: Ensembl

growth cone

Inferred from electronic annotation. Source: Ensembl

neuronal cell body

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from direct assay PubMed 21920314. Source: MGI

synapse

Inferred from electronic annotation. Source: Ensembl

tight junction

Inferred from direct assay PubMed 21920314. Source: MGI

   Molecular_functionphosphatase binding

Inferred from sequence or structural similarity. Source: UniProtKB

protein binding

Inferred from physical interaction PubMed 12738960Ref.3. Source: UniProtKB

ubiquitin protein ligase binding

Inferred from physical interaction PubMed 21920314. Source: MGI

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Dlg4Q621083EBI-396969,EBI-300895

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 849849Disks large homolog 3
PRO_0000094558

Regions

Domain149 – 23587PDZ 1
Domain244 – 33087PDZ 2
Domain404 – 48481PDZ 3
Domain519 – 58971SH3
Domain659 – 834176Guanylate kinase-like

Amino acid modifications

Modified residue7051Phosphotyrosine Ref.2

Sequences

Sequence LengthMass (Da)Tools
P70175 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: EF3EF2D7513538EE

FASTA84993,482
        10         20         30         40         50         60 
MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG YGGYSSQTLP 

        70         80         90        100        110        120 
SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG SGPGWWPECT CTNRDWYEQA 

       130        140        150        160        170        180 
SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI VLERGNSGLG FSIAGGIDNP HVPDDPGIFI 

       190        200        210        220        230        240 
TKIIPGGAAA MDGRLGVNDC VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE 

       250        260        270        280        290        300 
TIMEVNLLKG PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN 

       310        320        330        340        350        360 
NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSIHLNDMYA PPDYASTFTA LADNHISHNS 

       370        380        390        400        410        420 
SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR EPRKIILHKG STGLGFNIVG 

       430        440        450        460        470        480 
GEDGEGIFVS FILAGGPADL SGELRRGDRI LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV 

       490        500        510        520        530        540 
AQYRPEEYSR FESKIHDLRE QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS 

       550        560        570        580        590        600 
QGLSFSYGDI LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA 

       610        620        630        640        650        660 
RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP VTRQEIHYAR 

       670        680        690        700        710        720 
PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV DGQDYHFVVS REQMEKDIQD 

       730        740        750        760        770        780 
NKFIEAGQFN DNLYGTSIQS VRAVAERGKH CILDVSGNAI KRLQQAQLYP IAIFIKPKSI 

       790        800        810        820        830        840 
EALMEMNRRQ TYEQANKIFD KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY 


IWVPSPEKL 

« Hide

References

« Hide 'large scale' references
[1]Kohmura N., Makino S., Yagi T.
Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[3]"Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning."
Ng D., Pitcher G.M., Szilard R.K., Sertie A., Kanisek M., Clapcote S.J., Lipina T., Kalia L.V., Joo D., McKerlie C., Cortez M., Roder J.C., Salter M.W., McInnes R.R.
PLoS Biol. 7:E41-E41(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH NETO1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D87117 mRNA. Translation: BAA13249.1.
CCDSCCDS30307.1.
RefSeqNP_001171249.1. NM_001177778.2.
NP_058027.1. NM_016747.4.
UniGeneMm.4615.

3D structure databases

ProteinModelPortalP70175.
SMRP70175. Positions 61-849.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid207274. 11 interactions.
DIPDIP-31585N.
IntActP70175. 8 interactions.
MINTMINT-136046.

PTM databases

PhosphoSiteP70175.

Proteomic databases

MaxQBP70175.
PaxDbP70175.
PRIDEP70175.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000087984; ENSMUSP00000085299; ENSMUSG00000000881.
GeneID53310.
KEGGmmu:53310.
UCSCuc009twm.2. mouse.

Organism-specific databases

CTD1741.
MGIMGI:1888986. Dlg3.

Phylogenomic databases

eggNOGCOG0194.
GeneTreeENSGT00660000095130.
HOGENOMHOG000232102.
HOVERGENHBG107814.
InParanoidP70175.
KOK12075.
PhylomeDBP70175.
TreeFamTF323171.

Enzyme and pathway databases

ReactomeREACT_188576. Developmental Biology.

Gene expression databases

ArrayExpressP70175.
BgeeP70175.
CleanExMM_DLG3.
GenevestigatorP70175.

Family and domain databases

Gene3D2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProIPR016313. DLG1.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR019590. MAGUK_PEST_N.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR23119. PTHR23119. 1 hit.
PfamPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFPIRSF001741. MAGUK_DLGH. 1 hit.
SMARTSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310085.
PROP70175.
SOURCESearch...

Entry information

Entry nameDLG3_MOUSE
AccessionPrimary (citable) accession number: P70175
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: July 9, 2014
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot