Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P70175

- DLG3_MOUSE

UniProt

P70175 - DLG3_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Disks large homolog 3

Gene

Dlg3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.By similarity

GO - Molecular functioni

  1. phosphatase binding Source: UniProtKB
  2. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. establishment of planar polarity Source: MGI
  2. establishment or maintenance of epithelial cell apical/basal polarity Source: MGI
  3. negative regulation of phosphatase activity Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198694. Activation of Ca-permeable Kainate Receptor.
REACT_230679. NrCAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 3
Alternative name(s):
Synapse-associated protein 102
Short name:
SAP-102
Short name:
SAP102
Gene namesi
Name:Dlg3
Synonyms:Dlgh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1888986. Dlg3.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
  2. cell-cell junction Source: MGI
  3. cytoplasm Source: MGI
  4. dendritic shaft Source: Ensembl
  5. extracellular space Source: Ensembl
  6. growth cone Source: Ensembl
  7. neuronal cell body Source: Ensembl
  8. plasma membrane Source: MGI
  9. synapse Source: Ensembl
  10. tight junction Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 849849Disks large homolog 3PRO_0000094558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP70175.
PaxDbiP70175.
PRIDEiP70175.

PTM databases

PhosphoSiteiP70175.

Expressioni

Gene expression databases

BgeeiP70175.
CleanExiMM_DLG3.
ExpressionAtlasiP70175. baseline and differential.
GenevestigatoriP70175.

Interactioni

Subunit structurei

Interacts through its PDZ domains with NETO1, GRIN2B, SYNGAP1 and APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts with FRMPD4 (via C-terminus) (By similarity). Interacts with LRFN1, LRFN2 and LRFN4 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621083EBI-396969,EBI-300895

Protein-protein interaction databases

BioGridi207274. 11 interactions.
DIPiDIP-31585N.
IntActiP70175. 8 interactions.
MINTiMINT-136046.

Structurei

3D structure databases

ProteinModelPortaliP70175.
SMRiP70175. Positions 61-849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 23587PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini244 – 33087PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini404 – 48481PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini519 – 58971SH3PROSITE-ProRule annotationAdd
BLAST
Domaini659 – 834176Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0194.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000232102.
HOVERGENiHBG107814.
InParanoidiP70175.
KOiK12075.
PhylomeDBiP70175.
TreeFamiTF323171.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR016313. DLG1.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR019590. MAGUK_PEST_N.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70175-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG
60 70 80 90 100
YGGYSSQTLP SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG
110 120 130 140 150
SGPGWWPECT CTNRDWYEQA SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI
160 170 180 190 200
VLERGNSGLG FSIAGGIDNP HVPDDPGIFI TKIIPGGAAA MDGRLGVNDC
210 220 230 240 250
VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE TIMEVNLLKG
260 270 280 290 300
PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN
310 320 330 340 350
NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSIHLNDMYA PPDYASTFTA
360 370 380 390 400
LADNHISHNS SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR
410 420 430 440 450
EPRKIILHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDRI
460 470 480 490 500
LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV AQYRPEEYSR FESKIHDLRE
510 520 530 540 550
QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI
560 570 580 590 600
LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA
610 620 630 640 650
RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP
660 670 680 690 700
VTRQEIHYAR PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV
710 720 730 740 750
DGQDYHFVVS REQMEKDIQD NKFIEAGQFN DNLYGTSIQS VRAVAERGKH
760 770 780 790 800
CILDVSGNAI KRLQQAQLYP IAIFIKPKSI EALMEMNRRQ TYEQANKIFD
810 820 830 840
KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY IWVPSPEKL
Length:849
Mass (Da):93,482
Last modified:February 1, 1997 - v1
Checksum:iEF3EF2D7513538EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87117 mRNA. Translation: BAA13249.1.
CCDSiCCDS30307.1.
RefSeqiNP_001171249.1. NM_001177778.2.
NP_058027.1. NM_016747.4.
UniGeneiMm.4615.

Genome annotation databases

EnsembliENSMUST00000087984; ENSMUSP00000085299; ENSMUSG00000000881.
GeneIDi53310.
KEGGimmu:53310.
UCSCiuc009twm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87117 mRNA. Translation: BAA13249.1 .
CCDSi CCDS30307.1.
RefSeqi NP_001171249.1. NM_001177778.2.
NP_058027.1. NM_016747.4.
UniGenei Mm.4615.

3D structure databases

ProteinModelPortali P70175.
SMRi P70175. Positions 61-849.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207274. 11 interactions.
DIPi DIP-31585N.
IntActi P70175. 8 interactions.
MINTi MINT-136046.

PTM databases

PhosphoSitei P70175.

Proteomic databases

MaxQBi P70175.
PaxDbi P70175.
PRIDEi P70175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087984 ; ENSMUSP00000085299 ; ENSMUSG00000000881 .
GeneIDi 53310.
KEGGi mmu:53310.
UCSCi uc009twm.2. mouse.

Organism-specific databases

CTDi 1741.
MGIi MGI:1888986. Dlg3.

Phylogenomic databases

eggNOGi COG0194.
GeneTreei ENSGT00760000118866.
HOGENOMi HOG000232102.
HOVERGENi HBG107814.
InParanoidi P70175.
KOi K12075.
PhylomeDBi P70175.
TreeFami TF323171.

Enzyme and pathway databases

Reactomei REACT_198694. Activation of Ca-permeable Kainate Receptor.
REACT_230679. NrCAM interactions.

Miscellaneous databases

NextBioi 310085.
PROi P70175.
SOURCEi Search...

Gene expression databases

Bgeei P70175.
CleanExi MM_DLG3.
ExpressionAtlasi P70175. baseline and differential.
Genevestigatori P70175.

Family and domain databases

Gene3Di 2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProi IPR016313. DLG1.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR019590. MAGUK_PEST_N.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view ]
PANTHERi PTHR23119. PTHR23119. 1 hit.
Pfami PF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF001741. MAGUK_DLGH. 1 hit.
SMARTi SM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Kohmura N., Makino S., Yagi T.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning."
    Ng D., Pitcher G.M., Szilard R.K., Sertie A., Kanisek M., Clapcote S.J., Lipina T., Kalia L.V., Joo D., McKerlie C., Cortez M., Roder J.C., Salter M.W., McInnes R.R.
    PLoS Biol. 7:E41-E41(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NETO1.

Entry informationi

Entry nameiDLG3_MOUSE
AccessioniPrimary (citable) accession number: P70175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3