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Protein

Disks large homolog 3

Gene

Dlg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.By similarity

GO - Molecular functioni

  1. guanylate kinase activity Source: GO_Central
  2. ionotropic glutamate receptor binding Source: GO_Central
  3. kinase binding Source: MGI
  4. phosphatase binding Source: UniProtKB
  5. ubiquitin protein ligase binding Source: MGI

GO - Biological processi

  1. establishment of planar polarity Source: MGI
  2. establishment or maintenance of epithelial cell apical/basal polarity Source: MGI
  3. negative regulation of phosphatase activity Source: UniProtKB
  4. nervous system development Source: GO_Central
  5. nucleotide phosphorylation Source: GOC
  6. receptor clustering Source: GO_Central
  7. receptor localization to synapse Source: GO_Central
  8. synaptic transmission Source: GO_Central
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_278552. Activation of Ca-permeable Kainate Receptor.
REACT_318233. NrCAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Disks large homolog 3
Alternative name(s):
Synapse-associated protein 102
Short name:
SAP-102
Short name:
SAP102
Gene namesi
Name:Dlg3
Synonyms:Dlgh3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1888986. Dlg3.

Subcellular locationi

GO - Cellular componenti

  1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
  2. basolateral plasma membrane Source: GO_Central
  3. cell-cell junction Source: MGI
  4. cytoplasm Source: MGI
  5. dendritic shaft Source: Ensembl
  6. extracellular space Source: MGI
  7. growth cone Source: Ensembl
  8. neuronal cell body Source: Ensembl
  9. plasma membrane Source: MGI
  10. postsynaptic density Source: GO_Central
  11. postsynaptic membrane Source: GO_Central
  12. tight junction Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 849849Disks large homolog 3PRO_0000094558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei705 – 7051Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP70175.
PaxDbiP70175.
PRIDEiP70175.

PTM databases

PhosphoSiteiP70175.

Expressioni

Gene expression databases

BgeeiP70175.
CleanExiMM_DLG3.
ExpressionAtlasiP70175. baseline and differential.
GenevestigatoriP70175.

Interactioni

Subunit structurei

Interacts through its PDZ domains with NETO1, GRIN2B, SYNGAP1 and APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 (By similarity). Interacts with FRMPD4 (via C-terminus) (By similarity). Interacts with LRFN1, LRFN2 and LRFN4 (By similarity). Interacts with FLTP.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621083EBI-396969,EBI-300895

Protein-protein interaction databases

BioGridi207274. 10 interactions.
DIPiDIP-31585N.
IntActiP70175. 8 interactions.
MINTiMINT-136046.

Structurei

3D structure databases

ProteinModelPortaliP70175.
SMRiP70175. Positions 61-849.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 23587PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini244 – 33087PDZ 2PROSITE-ProRule annotationAdd
BLAST
Domaini404 – 48481PDZ 3PROSITE-ProRule annotationAdd
BLAST
Domaini519 – 58971SH3PROSITE-ProRule annotationAdd
BLAST
Domaini659 – 834176Guanylate kinase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAGUK family.Curated
Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiCOG0194.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000232102.
HOVERGENiHBG107814.
InParanoidiP70175.
KOiK12075.
PhylomeDBiP70175.
TreeFamiTF323171.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR016313. DLG1.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR019590. MAGUK_PEST_N.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70175-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG
60 70 80 90 100
YGGYSSQTLP SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG
110 120 130 140 150
SGPGWWPECT CTNRDWYEQA SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI
160 170 180 190 200
VLERGNSGLG FSIAGGIDNP HVPDDPGIFI TKIIPGGAAA MDGRLGVNDC
210 220 230 240 250
VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE TIMEVNLLKG
260 270 280 290 300
PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN
310 320 330 340 350
NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSIHLNDMYA PPDYASTFTA
360 370 380 390 400
LADNHISHNS SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR
410 420 430 440 450
EPRKIILHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDRI
460 470 480 490 500
LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV AQYRPEEYSR FESKIHDLRE
510 520 530 540 550
QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI
560 570 580 590 600
LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA
610 620 630 640 650
RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP
660 670 680 690 700
VTRQEIHYAR PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV
710 720 730 740 750
DGQDYHFVVS REQMEKDIQD NKFIEAGQFN DNLYGTSIQS VRAVAERGKH
760 770 780 790 800
CILDVSGNAI KRLQQAQLYP IAIFIKPKSI EALMEMNRRQ TYEQANKIFD
810 820 830 840
KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY IWVPSPEKL
Length:849
Mass (Da):93,482
Last modified:February 1, 1997 - v1
Checksum:iEF3EF2D7513538EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87117 mRNA. Translation: BAA13249.1.
CCDSiCCDS30307.1.
RefSeqiNP_001171249.1. NM_001177778.2.
NP_058027.1. NM_016747.4.
UniGeneiMm.4615.

Genome annotation databases

EnsembliENSMUST00000087984; ENSMUSP00000085299; ENSMUSG00000000881.
GeneIDi53310.
KEGGimmu:53310.
UCSCiuc009twm.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87117 mRNA. Translation: BAA13249.1.
CCDSiCCDS30307.1.
RefSeqiNP_001171249.1. NM_001177778.2.
NP_058027.1. NM_016747.4.
UniGeneiMm.4615.

3D structure databases

ProteinModelPortaliP70175.
SMRiP70175. Positions 61-849.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207274. 10 interactions.
DIPiDIP-31585N.
IntActiP70175. 8 interactions.
MINTiMINT-136046.

PTM databases

PhosphoSiteiP70175.

Proteomic databases

MaxQBiP70175.
PaxDbiP70175.
PRIDEiP70175.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087984; ENSMUSP00000085299; ENSMUSG00000000881.
GeneIDi53310.
KEGGimmu:53310.
UCSCiuc009twm.2. mouse.

Organism-specific databases

CTDi1741.
MGIiMGI:1888986. Dlg3.

Phylogenomic databases

eggNOGiCOG0194.
GeneTreeiENSGT00760000118866.
HOGENOMiHOG000232102.
HOVERGENiHBG107814.
InParanoidiP70175.
KOiK12075.
PhylomeDBiP70175.
TreeFamiTF323171.

Enzyme and pathway databases

ReactomeiREACT_278552. Activation of Ca-permeable Kainate Receptor.
REACT_318233. NrCAM interactions.

Miscellaneous databases

NextBioi310085.
PROiP70175.
SOURCEiSearch...

Gene expression databases

BgeeiP70175.
CleanExiMM_DLG3.
ExpressionAtlasiP70175. baseline and differential.
GenevestigatoriP70175.

Family and domain databases

Gene3Di2.30.42.10. 3 hits.
3.40.50.300. 2 hits.
InterProiIPR016313. DLG1.
IPR008145. GK/Ca_channel_bsu.
IPR008144. Guanylate_kin-like.
IPR020590. Guanylate_kinase_CS.
IPR019590. MAGUK_PEST_N.
IPR027417. P-loop_NTPase.
IPR001478. PDZ.
IPR019583. PDZ_assoc.
IPR001452. SH3_domain.
[Graphical view]
PANTHERiPTHR23119. PTHR23119. 1 hit.
PfamiPF00625. Guanylate_kin. 1 hit.
PF10608. MAGUK_N_PEST. 1 hit.
PF00595. PDZ. 3 hits.
PF10600. PDZ_assoc. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
SMARTiSM00072. GuKc. 1 hit.
SM00228. PDZ. 3 hits.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 2 hits.
SSF50156. SSF50156. 3 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
PS50052. GUANYLATE_KINASE_2. 1 hit.
PS50106. PDZ. 3 hits.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Kohmura N., Makino S., Yagi T.
    Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  3. "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning."
    Ng D., Pitcher G.M., Szilard R.K., Sertie A., Kanisek M., Clapcote S.J., Lipina T., Kalia L.V., Joo D., McKerlie C., Cortez M., Roder J.C., Salter M.W., McInnes R.R.
    PLoS Biol. 7:E41-E41(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NETO1.
  4. "Flattop regulates basal body docking and positioning in mono- and multiciliated cells."
    Gegg M., Boettcher A., Burtscher I., Hasenoeder S., Van Campenhout C., Aichler M., Walch A., Grant S.G., Lickert H.
    Elife 3:0-0(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FLTP.

Entry informationi

Entry nameiDLG3_MOUSE
AccessioniPrimary (citable) accession number: P70175
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 1, 2015
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.