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P70175

- DLG3_MOUSE

UniProt

P70175 - DLG3_MOUSE

Protein

Disks large homolog 3

Gene

Dlg3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling.By similarity

    GO - Molecular functioni

    1. phosphatase binding Source: UniProtKB
    2. protein binding Source: UniProtKB
    3. ubiquitin protein ligase binding Source: MGI

    GO - Biological processi

    1. establishment of planar polarity Source: MGI
    2. establishment or maintenance of epithelial cell apical/basal polarity Source: MGI
    3. negative regulation of phosphatase activity Source: UniProtKB

    Enzyme and pathway databases

    ReactomeiREACT_198694. Activation of Ca-permeable Kainate Receptor.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disks large homolog 3
    Alternative name(s):
    Synapse-associated protein 102
    Short name:
    SAP-102
    Short name:
    SAP102
    Gene namesi
    Name:Dlg3
    Synonyms:Dlgh3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1888986. Dlg3.

    Subcellular locationi

    GO - Cellular componenti

    1. alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex Source: MGI
    2. cell-cell junction Source: MGI
    3. cytoplasm Source: MGI
    4. dendritic shaft Source: Ensembl
    5. growth cone Source: Ensembl
    6. neuronal cell body Source: Ensembl
    7. plasma membrane Source: MGI
    8. synapse Source: Ensembl
    9. tight junction Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 849849Disks large homolog 3PRO_0000094558Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei705 – 7051Phosphotyrosine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP70175.
    PaxDbiP70175.
    PRIDEiP70175.

    PTM databases

    PhosphoSiteiP70175.

    Expressioni

    Gene expression databases

    ArrayExpressiP70175.
    BgeeiP70175.
    CleanExiMM_DLG3.
    GenevestigatoriP70175.

    Interactioni

    Subunit structurei

    Interacts through its PDZ domains with NETO1, GRIN2B, SYNGAP1 and APC. Interacts through its first two PDZ domains with ERBB4. Interacts through its third PDZ domain with NLGN1, and probably with NLGN2 and NLGN3. Interacts through its guanylate kinase-like domain with DLGAP1, DLGAP2, DLGAP3 and DLGAP4 By similarity. Interacts with FRMPD4 (via C-terminus) By similarity. Interacts with LRFN1, LRFN2 and LRFN4 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Dlg4Q621083EBI-396969,EBI-300895

    Protein-protein interaction databases

    BioGridi207274. 11 interactions.
    DIPiDIP-31585N.
    IntActiP70175. 8 interactions.
    MINTiMINT-136046.

    Structurei

    3D structure databases

    ProteinModelPortaliP70175.
    SMRiP70175. Positions 61-849.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini149 – 23587PDZ 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini244 – 33087PDZ 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini404 – 48481PDZ 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini519 – 58971SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini659 – 834176Guanylate kinase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MAGUK family.Curated
    Contains 1 guanylate kinase-like domain.PROSITE-ProRule annotation
    Contains 3 PDZ (DHR) domains.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, SH3 domain

    Phylogenomic databases

    eggNOGiCOG0194.
    GeneTreeiENSGT00660000095130.
    HOGENOMiHOG000232102.
    HOVERGENiHBG107814.
    InParanoidiP70175.
    KOiK12075.
    PhylomeDBiP70175.
    TreeFamiTF323171.

    Family and domain databases

    Gene3Di2.30.42.10. 3 hits.
    3.40.50.300. 2 hits.
    InterProiIPR016313. DLG1.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR019590. MAGUK_PEST_N.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR019583. PDZ_assoc.
    IPR001452. SH3_domain.
    [Graphical view]
    PANTHERiPTHR23119. PTHR23119. 1 hit.
    PfamiPF00625. Guanylate_kin. 1 hit.
    PF10608. MAGUK_N_PEST. 1 hit.
    PF00595. PDZ. 3 hits.
    PF10600. PDZ_assoc. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001741. MAGUK_DLGH. 1 hit.
    SMARTiSM00072. GuKc. 1 hit.
    SM00228. PDZ. 3 hits.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 2 hits.
    SSF50156. SSF50156. 3 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEiPS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 3 hits.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70175-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHKHQHCCKC PECYEVTRLA ALRRLEPPGY GDWQVPDPYG PSGGNGASSG    50
    YGGYSSQTLP SQAGATPTPR TKAKLIPTGR DVGPVPPKPV PGKSTPKLNG 100
    SGPGWWPECT CTNRDWYEQA SPAPLLVNPE ALEPSLSVNG SDGMFKYEEI 150
    VLERGNSGLG FSIAGGIDNP HVPDDPGIFI TKIIPGGAAA MDGRLGVNDC 200
    VLRVNEVDVS EVVHSRAVEA LKEAGPVVRL VVRRRQPPPE TIMEVNLLKG 250
    PKGLGFSIAG GIGNQHIPGD NSIYITKIIE GGAAQKDGRL QIGDRLLAVN 300
    NTNLQDVRHE EAVASLKNTS DMVYLKVAKP GSIHLNDMYA PPDYASTFTA 350
    LADNHISHNS SLGYLGAVES KVTYPAPPQV PPTRYSPIPR HMLAEEDFTR 400
    EPRKIILHKG STGLGFNIVG GEDGEGIFVS FILAGGPADL SGELRRGDRI 450
    LSVNGVNLRN ATHEQAAAAL KRAGQSVTIV AQYRPEEYSR FESKIHDLRE 500
    QMMNSSMSSG SGSLRTSEKR SLYVRALFDY DRTRDSCLPS QGLSFSYGDI 550
    LHVINASDDE WWQARLVTPH GESEQIGVIP SKKRVEKKER ARLKTVKFHA 600
    RTGMIESNRD FPGLSDDYYG AKNLKGVTSN TSDSESSSKG QEDAILSYEP 650
    VTRQEIHYAR PVIILGPMKD RVNDDLISEF PHKFGSCVPH TTRPRRDNEV 700
    DGQDYHFVVS REQMEKDIQD NKFIEAGQFN DNLYGTSIQS VRAVAERGKH 750
    CILDVSGNAI KRLQQAQLYP IAIFIKPKSI EALMEMNRRQ TYEQANKIFD 800
    KAMKLEQEFG EYFTAIVQGD SLEEIYNKIK QIIEDQSGHY IWVPSPEKL 849
    Length:849
    Mass (Da):93,482
    Last modified:February 1, 1997 - v1
    Checksum:iEF3EF2D7513538EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87117 mRNA. Translation: BAA13249.1.
    CCDSiCCDS30307.1.
    RefSeqiNP_001171249.1. NM_001177778.2.
    NP_058027.1. NM_016747.4.
    UniGeneiMm.4615.

    Genome annotation databases

    EnsembliENSMUST00000087984; ENSMUSP00000085299; ENSMUSG00000000881.
    GeneIDi53310.
    KEGGimmu:53310.
    UCSCiuc009twm.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D87117 mRNA. Translation: BAA13249.1 .
    CCDSi CCDS30307.1.
    RefSeqi NP_001171249.1. NM_001177778.2.
    NP_058027.1. NM_016747.4.
    UniGenei Mm.4615.

    3D structure databases

    ProteinModelPortali P70175.
    SMRi P70175. Positions 61-849.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207274. 11 interactions.
    DIPi DIP-31585N.
    IntActi P70175. 8 interactions.
    MINTi MINT-136046.

    PTM databases

    PhosphoSitei P70175.

    Proteomic databases

    MaxQBi P70175.
    PaxDbi P70175.
    PRIDEi P70175.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087984 ; ENSMUSP00000085299 ; ENSMUSG00000000881 .
    GeneIDi 53310.
    KEGGi mmu:53310.
    UCSCi uc009twm.2. mouse.

    Organism-specific databases

    CTDi 1741.
    MGIi MGI:1888986. Dlg3.

    Phylogenomic databases

    eggNOGi COG0194.
    GeneTreei ENSGT00660000095130.
    HOGENOMi HOG000232102.
    HOVERGENi HBG107814.
    InParanoidi P70175.
    KOi K12075.
    PhylomeDBi P70175.
    TreeFami TF323171.

    Enzyme and pathway databases

    Reactomei REACT_198694. Activation of Ca-permeable Kainate Receptor.

    Miscellaneous databases

    NextBioi 310085.
    PROi P70175.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70175.
    Bgeei P70175.
    CleanExi MM_DLG3.
    Genevestigatori P70175.

    Family and domain databases

    Gene3Di 2.30.42.10. 3 hits.
    3.40.50.300. 2 hits.
    InterProi IPR016313. DLG1.
    IPR008145. GK/Ca_channel_bsu.
    IPR008144. Guanylate_kin-like.
    IPR020590. Guanylate_kinase_CS.
    IPR019590. MAGUK_PEST_N.
    IPR027417. P-loop_NTPase.
    IPR001478. PDZ.
    IPR019583. PDZ_assoc.
    IPR001452. SH3_domain.
    [Graphical view ]
    PANTHERi PTHR23119. PTHR23119. 1 hit.
    Pfami PF00625. Guanylate_kin. 1 hit.
    PF10608. MAGUK_N_PEST. 1 hit.
    PF00595. PDZ. 3 hits.
    PF10600. PDZ_assoc. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001741. MAGUK_DLGH. 1 hit.
    SMARTi SM00072. GuKc. 1 hit.
    SM00228. PDZ. 3 hits.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 2 hits.
    SSF50156. SSF50156. 3 hits.
    SSF52540. SSF52540. 1 hit.
    PROSITEi PS00856. GUANYLATE_KINASE_1. 1 hit.
    PS50052. GUANYLATE_KINASE_2. 1 hit.
    PS50106. PDZ. 3 hits.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Kohmura N., Makino S., Yagi T.
      Submitted (AUG-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-705, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    3. "Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning."
      Ng D., Pitcher G.M., Szilard R.K., Sertie A., Kanisek M., Clapcote S.J., Lipina T., Kalia L.V., Joo D., McKerlie C., Cortez M., Roder J.C., Salter M.W., McInnes R.R.
      PLoS Biol. 7:E41-E41(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NETO1.

    Entry informationi

    Entry nameiDLG3_MOUSE
    AccessioniPrimary (citable) accession number: P70175
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3