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P70174

- HRH1_MOUSE

UniProt

P70174 - HRH1_MOUSE

Protein

Histamine H1 receptor

Gene

Hrh1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (09 May 2003)
      Previous versions | rss
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    Functioni

    In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses.2 Publications

    GO - Molecular functioni

    1. calcium ion transmembrane transporter activity Source: MGI
    2. histamine receptor activity Source: UniProtKB

    GO - Biological processi

    1. calcium ion import Source: MGI
    2. calcium ion transmembrane transport Source: GOC
    3. cellular response to histamine Source: UniProtKB
    4. eosinophil chemotaxis Source: InterPro
    5. G-protein coupled receptor signaling pathway Source: UniProtKB
    6. manganese ion transmembrane transport Source: MGI
    7. memory Source: MGI
    8. positive regulation of vasoconstriction Source: InterPro
    9. regulation of synaptic plasticity Source: MGI
    10. regulation of vascular permeability Source: InterPro
    11. rhythmic process Source: UniProtKB-KW
    12. visual learning Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Biological rhythms

    Enzyme and pathway databases

    ReactomeiREACT_207651. G alpha (q) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histamine H1 receptor
    Short name:
    H1R
    Short name:
    HH1R
    Gene namesi
    Name:Hrh1
    Synonyms:Bphs
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:107619. Hrh1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. integral component of plasma membrane Source: UniProtKB
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 488488Histamine H1 receptorPRO_0000069677Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi100 ↔ 180PROSITE-ProRule annotation
    Modified residuei140 – 1401PhosphothreonineBy similarity
    Modified residuei142 – 1421PhosphothreonineBy similarity
    Modified residuei397 – 3971PhosphoserineBy similarity
    Modified residuei399 – 3991PhosphoserineBy similarity
    Disulfide bondi442 ↔ 445PROSITE-ProRule annotation

    Post-translational modificationi

    Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiP70174.

    PTM databases

    PhosphoSiteiP70174.

    Expressioni

    Gene expression databases

    BgeeiP70174.
    CleanExiMM_HRH1.
    GenevestigatoriP70174.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP70174.
    SMRiP70174. Positions 28-221, 373-486.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularBy similarityAdd
    BLAST
    Topological domaini53 – 6210CytoplasmicBy similarity
    Topological domaini84 – 10118ExtracellularBy similarityAdd
    BLAST
    Topological domaini124 – 14320CytoplasmicBy similarityAdd
    BLAST
    Topological domaini165 – 18925ExtracellularBy similarityAdd
    BLAST
    Topological domaini211 – 417207CytoplasmicBy similarityAdd
    BLAST
    Topological domaini440 – 45112ExtracellularBy similarityAdd
    BLAST
    Topological domaini472 – 48817CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5223Helical; Name=1By similarityAdd
    BLAST
    Transmembranei63 – 8321Helical; Name=2By similarityAdd
    BLAST
    Transmembranei102 – 12322Helical; Name=3By similarityAdd
    BLAST
    Transmembranei144 – 16421Helical; Name=4By similarityAdd
    BLAST
    Transmembranei190 – 21021Helical; Name=5By similarityAdd
    BLAST
    Transmembranei418 – 43922Helical; Name=6By similarityAdd
    BLAST
    Transmembranei452 – 47120Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni107 – 1126Important for agonist bindingBy similarity
    Regioni425 – 4295Important for agonist bindingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG318797.
    GeneTreeiENSGT00690000102071.
    HOGENOMiHOG000273869.
    HOVERGENiHBG101103.
    InParanoidiP70174.
    KOiK04149.
    OMAiEDKMCEG.
    OrthoDBiEOG70CR7W.
    PhylomeDBiP70174.
    TreeFamiTF333432.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000921. Histamine_H1_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR00530. HISTAMINEH1R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P70174-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPNTSSAS EDKMCEGNRT AMASPQLLPL VVVLSSISLV TVGLNLLVLY    50
    AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLIM TKWSLGRPLC 100
    LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLRYRT KTRASATILG 150
    AWFLSFLWVI PILGWHHFTP LAPELREDKC ETDFYNVTWF KIMTAIINFY 200
    LPTLLMLWFY VKIYKAVRRH CQHRQLTNGS LPTFLEIKLR SEDAKEGAKK 250
    PGKESPWGVQ KRPSRDPTGG LDQKSTSEDP KVTSPTVFSQ EGERETVTRP 300
    CFRLDVMQTQ PVPEGDARGS KANDQTLSQP KMDEQSLSTC RRISETSEDQ 350
    TLVDRQSFSR TTDSDTSIEP GLGKVKARSR SNSGLDYIKV TWKRLRSHSR 400
    QYVSGLHLNR ERKAAKQLGC IMAAFILCWI PYFIFFMVIA FCNSCCSEPV 450
    HMFTIWLGYI NSTLNPLIYP LCNENFKKTF KKILHIRS 488
    Length:488
    Mass (Da):55,682
    Last modified:May 9, 2003 - v2
    Checksum:i82612DF712998B41
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21S → R in BAA08791. (PubMed:8812432)Curated
    Sequence conflicti47 – 471L → G in BAA08791. (PubMed:8812432)Curated
    Sequence conflicti79 – 791V → I in BAA08791. (PubMed:8812432)Curated
    Sequence conflicti215 – 2162KA → NG in BAA08791. (PubMed:8812432)Curated
    Sequence conflicti224 – 2241R → P in BAA08791. (PubMed:8812432)Curated
    Sequence conflicti242 – 2421E → D in AAK66778. (PubMed:12142541)Curated
    Sequence conflicti244 – 2441A → S in BAA08791. (PubMed:8812432)Curated
    Sequence conflicti261 – 2611K → T in BAA08791. (PubMed:8812432)Curated
    Sequence conflicti278 – 2781E → A in BAA08791. (PubMed:8812432)Curated
    Sequence conflicti379 – 3791S → R in BAA08791. (PubMed:8812432)Curated

    Polymorphismi

    Strains C3H/HeJ and CBA/J are resistant to vasoactive amine sensitization elicited by histamine (VAASH) which is induced by pertussis toxin.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti263 – 2631P → L in strain: C3H/HeJ and CBA/J. 1 Publication
    Natural varianti312 – 3121V → M in strain: C3H/HeJ and CBA/J. 1 Publication
    Natural varianti330 – 3301P → S in strain: C3H/HeJ and CBA/J. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50095 Genomic DNA. Translation: BAA08791.1.
    AF387890 mRNA. Translation: AAK71654.1.
    AF387891 mRNA. Translation: AAK71655.1.
    AF387892 mRNA. Translation: AAK71656.1.
    AF387893 mRNA. Translation: AAK71657.1.
    AF387894 mRNA. Translation: AAK71658.1.
    AF387895 mRNA. Translation: AAK71659.1.
    AF387896 mRNA. Translation: AAK71660.1.
    AF388052 mRNA. Translation: AAK66774.2.
    AF388053 mRNA. Translation: AAK66775.1.
    AF388054 mRNA. Translation: AAK66776.1.
    AF388055 mRNA. Translation: AAK66777.1.
    AF388056 mRNA. Translation: AAK66778.1.
    AF388057 mRNA. Translation: AAK66779.1.
    AF388058 mRNA. Translation: AAK66780.1.
    AK032763 mRNA. Translation: BAC28011.1.
    AK038480 mRNA. Translation: BAC30013.1.
    AK046607 mRNA. Translation: BAC32805.1.
    AK047070 mRNA. Translation: BAC32950.1.
    CCDSiCCDS20435.1.
    RefSeqiNP_001239571.1. NM_001252642.1.
    NP_001239572.1. NM_001252643.1.
    NP_032311.2. NM_008285.3.
    XP_006505677.1. XM_006505614.1.
    XP_006505678.1. XM_006505615.1.
    XP_006505679.1. XM_006505616.1.
    UniGeneiMm.333327.

    Genome annotation databases

    EnsembliENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004.
    ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004.
    ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004.
    ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004.
    GeneIDi15465.
    KEGGimmu:15465.
    UCSCiuc009dhw.1. mouse.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D50095 Genomic DNA. Translation: BAA08791.1 .
    AF387890 mRNA. Translation: AAK71654.1 .
    AF387891 mRNA. Translation: AAK71655.1 .
    AF387892 mRNA. Translation: AAK71656.1 .
    AF387893 mRNA. Translation: AAK71657.1 .
    AF387894 mRNA. Translation: AAK71658.1 .
    AF387895 mRNA. Translation: AAK71659.1 .
    AF387896 mRNA. Translation: AAK71660.1 .
    AF388052 mRNA. Translation: AAK66774.2 .
    AF388053 mRNA. Translation: AAK66775.1 .
    AF388054 mRNA. Translation: AAK66776.1 .
    AF388055 mRNA. Translation: AAK66777.1 .
    AF388056 mRNA. Translation: AAK66778.1 .
    AF388057 mRNA. Translation: AAK66779.1 .
    AF388058 mRNA. Translation: AAK66780.1 .
    AK032763 mRNA. Translation: BAC28011.1 .
    AK038480 mRNA. Translation: BAC30013.1 .
    AK046607 mRNA. Translation: BAC32805.1 .
    AK047070 mRNA. Translation: BAC32950.1 .
    CCDSi CCDS20435.1.
    RefSeqi NP_001239571.1. NM_001252642.1.
    NP_001239572.1. NM_001252643.1.
    NP_032311.2. NM_008285.3.
    XP_006505677.1. XM_006505614.1.
    XP_006505678.1. XM_006505615.1.
    XP_006505679.1. XM_006505616.1.
    UniGenei Mm.333327.

    3D structure databases

    ProteinModelPortali P70174.
    SMRi P70174. Positions 28-221, 373-486.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P70174.
    ChEMBLi CHEMBL4322.
    GuidetoPHARMACOLOGYi 262.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P70174.

    Proteomic databases

    PRIDEi P70174.

    Protocols and materials databases

    DNASUi 15465.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088987 ; ENSMUSP00000086383 ; ENSMUSG00000053004 .
    ENSMUST00000160780 ; ENSMUSP00000124320 ; ENSMUSG00000053004 .
    ENSMUST00000161220 ; ENSMUSP00000124037 ; ENSMUSG00000053004 .
    ENSMUST00000161650 ; ENSMUSP00000124460 ; ENSMUSG00000053004 .
    GeneIDi 15465.
    KEGGi mmu:15465.
    UCSCi uc009dhw.1. mouse.

    Organism-specific databases

    CTDi 3269.
    MGIi MGI:107619. Hrh1.

    Phylogenomic databases

    eggNOGi NOG318797.
    GeneTreei ENSGT00690000102071.
    HOGENOMi HOG000273869.
    HOVERGENi HBG101103.
    InParanoidi P70174.
    KOi K04149.
    OMAi EDKMCEG.
    OrthoDBi EOG70CR7W.
    PhylomeDBi P70174.
    TreeFami TF333432.

    Enzyme and pathway databases

    Reactomei REACT_207651. G alpha (q) signalling events.

    Miscellaneous databases

    NextBioi 288290.
    PROi P70174.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70174.
    CleanExi MM_HRH1.
    Genevestigatori P70174.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000921. Histamine_H1_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR00530. HISTAMINEH1R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characteristics of the mouse genomic histamine H1 receptor gene."
      Inoue I., Taniuchi I., Kitamura D., Jenkins N.A., Gilbert D.J., Copeland N.G., Watanabe T.
      Genomics 36:178-181(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Ola.
    2. "Identification of Bphs, an autoimmune disease locus, as histamine receptor H1."
      Ma R.Z., Gao J., Meeker N.D., Fillmore P.D., Tung K.S.K., Watanabe T., Zachary J.F., Offner H., Blankenhorn E.P., Teuscher C.
      Science 297:620-623(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE, VARIANTS LEU-263; MET-312 AND SER-330.
      Strain: 129/SvJ, A/J, B10.S/DvTe, BALB/cByJ, BALB/cJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1, DBA/2, FVB/NCr, NOD, SJL and SWR.
      Tissue: Spleen.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Adipose tissue, Cerebellum, Hypothalamus and Mesonephros.
    4. "Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors."
      Inoue I., Yanai K., Kitamura D., Taniuchi I., Kobayashi T., Niimura K., Watanabe T., Watanabe T.
      Proc. Natl. Acad. Sci. U.S.A. 93:13316-13320(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    5. "Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin."
      Gao J.F., Call S.B., Fillmore P.D., Watanabe T., Meeker N.D., Teuscher C.
      Infect. Immun. 71:1281-1287(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHRH1_MOUSE
    AccessioniPrimary (citable) accession number: P70174
    Secondary accession number(s): Q91V75
    , Q91XN0, Q91XN1, Q91XN2, Q91XN3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 9, 2003
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3