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P70174 (HRH1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 122. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histamine H1 receptor

Short name=H1R
Short name=HH1R
Gene names
Name:Hrh1
Synonyms:Bphs
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length488 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses. Ref.4 Ref.5

Subcellular location

Cell membrane; Multi-pass membrane protein.

Post-translational modification

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation By similarity.

Polymorphism

Strains C3H/HeJ and CBA/J are resistant to vasoactive amine sensitization elicited by histamine (VAASH) which is induced by pertussis toxin.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processBiological rhythms
   Cellular componentCell membrane
Membrane
   Coding sequence diversityPolymorphism
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Lipoprotein
Palmitate
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcalcium ion import

Inferred from sequence orthology PubMed 10998353. Source: MGI

cellular response to histamine

Inferred from sequence orthology PubMed 10998353. Source: MGI

eosinophil chemotaxis

Inferred from electronic annotation. Source: InterPro

manganese ion transmembrane transport

Inferred from sequence orthology PubMed 10998353. Source: MGI

memory

Inferred from mutant phenotype PubMed 17145090. Source: MGI

positive regulation of vasoconstriction

Inferred from electronic annotation. Source: InterPro

regulation of synaptic plasticity

Inferred from mutant phenotype PubMed 17145090. Source: MGI

regulation of vascular permeability

Inferred from electronic annotation. Source: InterPro

rhythmic process

Inferred from electronic annotation. Source: UniProtKB-KW

visual learning

Inferred from mutant phenotype PubMed 17145090. Source: MGI

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

nucleus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion transmembrane transporter activity

Inferred from sequence orthology PubMed 10998353. Source: MGI

histamine receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 488488Histamine H1 receptor
PRO_0000069677

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 4920Helical; Name=1; Potential
Topological domain50 – 6314Cytoplasmic Potential
Transmembrane64 – 8320Helical; Name=2; Potential
Topological domain84 – 10118Extracellular Potential
Transmembrane102 – 12322Helical; Name=3; Potential
Topological domain124 – 14522Cytoplasmic Potential
Transmembrane146 – 16520Helical; Name=4; Potential
Topological domain166 – 18924Extracellular Potential
Transmembrane190 – 21021Helical; Name=5; Potential
Topological domain211 – 419209Cytoplasmic Potential
Transmembrane420 – 43920Helical; Name=6; Potential
Topological domain440 – 45112Extracellular Potential
Transmembrane452 – 47120Helical; Name=7; Potential
Topological domain472 – 48817Cytoplasmic Potential

Amino acid modifications

Modified residue1401Phosphothreonine By similarity
Modified residue1421Phosphothreonine By similarity
Modified residue3971Phosphoserine By similarity
Modified residue3991Phosphoserine By similarity
Lipidation4461S-palmitoyl cysteine Potential
Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond100 ↔ 180 By similarity

Natural variations

Natural variant2631P → L in strain: C3H/HeJ and CBA/J. Ref.2
Natural variant3121V → M in strain: C3H/HeJ and CBA/J. Ref.2
Natural variant3301P → S in strain: C3H/HeJ and CBA/J. Ref.2

Experimental info

Sequence conflict21S → R in BAA08791. Ref.1
Sequence conflict471L → G in BAA08791. Ref.1
Sequence conflict791V → I in BAA08791. Ref.1
Sequence conflict215 – 2162KA → NG in BAA08791. Ref.1
Sequence conflict2241R → P in BAA08791. Ref.1
Sequence conflict2421E → D in AAK66778. Ref.2
Sequence conflict2441A → S in BAA08791. Ref.1
Sequence conflict2611K → T in BAA08791. Ref.1
Sequence conflict2781E → A in BAA08791. Ref.1
Sequence conflict3791S → R in BAA08791. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P70174 [UniParc].

Last modified May 9, 2003. Version 2.
Checksum: 82612DF712998B41

FASTA48855,682
        10         20         30         40         50         60 
MSLPNTSSAS EDKMCEGNRT AMASPQLLPL VVVLSSISLV TVGLNLLVLY AVRSERKLHT 

        70         80         90        100        110        120 
VGNLYIVSLS VADLIVGAVV MPMNILYLIM TKWSLGRPLC LFWLSMDYVA STASIFSVFI 

       130        140        150        160        170        180 
LCIDRYRSVQ QPLRYLRYRT KTRASATILG AWFLSFLWVI PILGWHHFTP LAPELREDKC 

       190        200        210        220        230        240 
ETDFYNVTWF KIMTAIINFY LPTLLMLWFY VKIYKAVRRH CQHRQLTNGS LPTFLEIKLR 

       250        260        270        280        290        300 
SEDAKEGAKK PGKESPWGVQ KRPSRDPTGG LDQKSTSEDP KVTSPTVFSQ EGERETVTRP 

       310        320        330        340        350        360 
CFRLDVMQTQ PVPEGDARGS KANDQTLSQP KMDEQSLSTC RRISETSEDQ TLVDRQSFSR 

       370        380        390        400        410        420 
TTDSDTSIEP GLGKVKARSR SNSGLDYIKV TWKRLRSHSR QYVSGLHLNR ERKAAKQLGC 

       430        440        450        460        470        480 
IMAAFILCWI PYFIFFMVIA FCNSCCSEPV HMFTIWLGYI NSTLNPLIYP LCNENFKKTF 


KKILHIRS 

« Hide

References

« Hide 'large scale' references
[1]"Characteristics of the mouse genomic histamine H1 receptor gene."
Inoue I., Taniuchi I., Kitamura D., Jenkins N.A., Gilbert D.J., Copeland N.G., Watanabe T.
Genomics 36:178-181(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Ola.
[2]"Identification of Bphs, an autoimmune disease locus, as histamine receptor H1."
Ma R.Z., Gao J., Meeker N.D., Fillmore P.D., Tung K.S.K., Watanabe T., Zachary J.F., Offner H., Blankenhorn E.P., Teuscher C.
Science 297:620-623(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE, VARIANTS LEU-263; MET-312 AND SER-330.
Strain: 129/SvJ, A/J, B10.S/DvTe, BALB/cByJ, BALB/cJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1, DBA/2, FVB/NCr, NOD, SJL and SWR.
Tissue: Spleen.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Adipose tissue, Cerebellum, Hypothalamus and Mesonephros.
[4]"Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors."
Inoue I., Yanai K., Kitamura D., Taniuchi I., Kobayashi T., Niimura K., Watanabe T., Watanabe T.
Proc. Natl. Acad. Sci. U.S.A. 93:13316-13320(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin."
Gao J.F., Call S.B., Fillmore P.D., Watanabe T., Meeker N.D., Teuscher C.
Infect. Immun. 71:1281-1287(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D50095 Genomic DNA. Translation: BAA08791.1.
AF387890 mRNA. Translation: AAK71654.1.
AF387891 mRNA. Translation: AAK71655.1.
AF387892 mRNA. Translation: AAK71656.1.
AF387893 mRNA. Translation: AAK71657.1.
AF387894 mRNA. Translation: AAK71658.1.
AF387895 mRNA. Translation: AAK71659.1.
AF387896 mRNA. Translation: AAK71660.1.
AF388052 mRNA. Translation: AAK66774.2.
AF388053 mRNA. Translation: AAK66775.1.
AF388054 mRNA. Translation: AAK66776.1.
AF388055 mRNA. Translation: AAK66777.1.
AF388056 mRNA. Translation: AAK66778.1.
AF388057 mRNA. Translation: AAK66779.1.
AF388058 mRNA. Translation: AAK66780.1.
AK032763 mRNA. Translation: BAC28011.1.
AK038480 mRNA. Translation: BAC30013.1.
AK046607 mRNA. Translation: BAC32805.1.
AK047070 mRNA. Translation: BAC32950.1.
CCDSCCDS20435.1.
RefSeqNP_001239571.1. NM_001252642.1.
NP_001239572.1. NM_001252643.1.
NP_032311.2. NM_008285.3.
XP_006505677.1. XM_006505614.1.
XP_006505678.1. XM_006505615.1.
XP_006505679.1. XM_006505616.1.
UniGeneMm.333327.

3D structure databases

ProteinModelPortalP70174.
SMRP70174. Positions 28-221, 373-486.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP70174.
ChEMBLCHEMBL4322.
GuidetoPHARMACOLOGY262.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP70174.

Proteomic databases

PRIDEP70174.

Protocols and materials databases

DNASU15465.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004.
ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004.
ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004.
ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004.
GeneID15465.
KEGGmmu:15465.
UCSCuc009dhw.1. mouse.

Organism-specific databases

CTD3269.
MGIMGI:107619. Hrh1.

Phylogenomic databases

eggNOGNOG318797.
GeneTreeENSGT00690000102071.
HOGENOMHOG000273869.
HOVERGENHBG101103.
InParanoidP70174.
KOK04149.
OMAEDKMCEG.
OrthoDBEOG70CR7W.
PhylomeDBP70174.
TreeFamTF333432.

Gene expression databases

BgeeP70174.
CleanExMM_HRH1.
GenevestigatorP70174.

Family and domain databases

Gene3D1.20.1070.10. 2 hits.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288290.
PROP70174.
SOURCESearch...

Entry information

Entry nameHRH1_MOUSE
AccessionPrimary (citable) accession number: P70174
Secondary accession number(s): Q91V75 expand/collapse secondary AC list , Q91XN0, Q91XN1, Q91XN2, Q91XN3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 9, 2003
Last modified: July 9, 2014
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries