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P70174

- HRH1_MOUSE

UniProt

P70174 - HRH1_MOUSE

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Protein

Histamine H1 receptor

Gene

Hrh1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses.2 Publications

GO - Molecular functioni

  1. calcium ion transmembrane transporter activity Source: MGI
  2. histamine receptor activity Source: UniProtKB

GO - Biological processi

  1. calcium ion import Source: MGI
  2. calcium ion transmembrane transport Source: GOC
  3. cellular response to histamine Source: UniProtKB
  4. eosinophil chemotaxis Source: InterPro
  5. G-protein coupled receptor signaling pathway Source: UniProtKB
  6. manganese ion transmembrane transport Source: MGI
  7. memory Source: MGI
  8. positive regulation of vasoconstriction Source: InterPro
  9. regulation of synaptic plasticity Source: MGI
  10. regulation of vascular permeability Source: InterPro
  11. rhythmic process Source: UniProtKB-KW
  12. visual learning Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.
REACT_257161. Histamine receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H1 receptor
Short name:
H1R
Short name:
HH1R
Gene namesi
Name:Hrh1
Synonyms:Bphs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:107619. Hrh1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularBy similarityAdd
BLAST
Transmembranei30 – 5223Helical; Name=1By similarityAdd
BLAST
Topological domaini53 – 6210CytoplasmicBy similarity
Transmembranei63 – 8321Helical; Name=2By similarityAdd
BLAST
Topological domaini84 – 10118ExtracellularBy similarityAdd
BLAST
Transmembranei102 – 12322Helical; Name=3By similarityAdd
BLAST
Topological domaini124 – 14320CytoplasmicBy similarityAdd
BLAST
Transmembranei144 – 16421Helical; Name=4By similarityAdd
BLAST
Topological domaini165 – 18925ExtracellularBy similarityAdd
BLAST
Transmembranei190 – 21021Helical; Name=5By similarityAdd
BLAST
Topological domaini211 – 417207CytoplasmicBy similarityAdd
BLAST
Transmembranei418 – 43922Helical; Name=6By similarityAdd
BLAST
Topological domaini440 – 45112ExtracellularBy similarityAdd
BLAST
Transmembranei452 – 47120Helical; Name=7By similarityAdd
BLAST
Topological domaini472 – 48817CytoplasmicBy similarityAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 488488Histamine H1 receptorPRO_0000069677Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi100 ↔ 180PROSITE-ProRule annotation
Modified residuei140 – 1401PhosphothreonineBy similarity
Modified residuei142 – 1421PhosphothreonineBy similarity
Modified residuei397 – 3971PhosphoserineBy similarity
Modified residuei399 – 3991PhosphoserineBy similarity
Disulfide bondi442 ↔ 445PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiP70174.

PTM databases

PhosphoSiteiP70174.

Expressioni

Gene expression databases

BgeeiP70174.
CleanExiMM_HRH1.
ExpressionAtlasiP70174. baseline and differential.
GenevestigatoriP70174.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP70174.
SMRiP70174. Positions 28-221, 373-486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni107 – 1126Important for agonist bindingBy similarity
Regioni425 – 4295Important for agonist bindingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG318797.
GeneTreeiENSGT00770000120457.
HOGENOMiHOG000273869.
HOVERGENiHBG101103.
InParanoidiP70174.
KOiK04149.
OMAiEDKMCEG.
OrthoDBiEOG70CR7W.
PhylomeDBiP70174.
TreeFamiTF333432.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70174-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLPNTSSAS EDKMCEGNRT AMASPQLLPL VVVLSSISLV TVGLNLLVLY
60 70 80 90 100
AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLIM TKWSLGRPLC
110 120 130 140 150
LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLRYRT KTRASATILG
160 170 180 190 200
AWFLSFLWVI PILGWHHFTP LAPELREDKC ETDFYNVTWF KIMTAIINFY
210 220 230 240 250
LPTLLMLWFY VKIYKAVRRH CQHRQLTNGS LPTFLEIKLR SEDAKEGAKK
260 270 280 290 300
PGKESPWGVQ KRPSRDPTGG LDQKSTSEDP KVTSPTVFSQ EGERETVTRP
310 320 330 340 350
CFRLDVMQTQ PVPEGDARGS KANDQTLSQP KMDEQSLSTC RRISETSEDQ
360 370 380 390 400
TLVDRQSFSR TTDSDTSIEP GLGKVKARSR SNSGLDYIKV TWKRLRSHSR
410 420 430 440 450
QYVSGLHLNR ERKAAKQLGC IMAAFILCWI PYFIFFMVIA FCNSCCSEPV
460 470 480
HMFTIWLGYI NSTLNPLIYP LCNENFKKTF KKILHIRS
Length:488
Mass (Da):55,682
Last modified:May 9, 2003 - v2
Checksum:i82612DF712998B41
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21S → R in BAA08791. (PubMed:8812432)Curated
Sequence conflicti47 – 471L → G in BAA08791. (PubMed:8812432)Curated
Sequence conflicti79 – 791V → I in BAA08791. (PubMed:8812432)Curated
Sequence conflicti215 – 2162KA → NG in BAA08791. (PubMed:8812432)Curated
Sequence conflicti224 – 2241R → P in BAA08791. (PubMed:8812432)Curated
Sequence conflicti242 – 2421E → D in AAK66778. (PubMed:12142541)Curated
Sequence conflicti244 – 2441A → S in BAA08791. (PubMed:8812432)Curated
Sequence conflicti261 – 2611K → T in BAA08791. (PubMed:8812432)Curated
Sequence conflicti278 – 2781E → A in BAA08791. (PubMed:8812432)Curated
Sequence conflicti379 – 3791S → R in BAA08791. (PubMed:8812432)Curated

Polymorphismi

Strains C3H/HeJ and CBA/J are resistant to vasoactive amine sensitization elicited by histamine (VAASH) which is induced by pertussis toxin.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti263 – 2631P → L in strain: C3H/HeJ and CBA/J. 1 Publication
Natural varianti312 – 3121V → M in strain: C3H/HeJ and CBA/J. 1 Publication
Natural varianti330 – 3301P → S in strain: C3H/HeJ and CBA/J. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50095 Genomic DNA. Translation: BAA08791.1.
AF387890 mRNA. Translation: AAK71654.1.
AF387891 mRNA. Translation: AAK71655.1.
AF387892 mRNA. Translation: AAK71656.1.
AF387893 mRNA. Translation: AAK71657.1.
AF387894 mRNA. Translation: AAK71658.1.
AF387895 mRNA. Translation: AAK71659.1.
AF387896 mRNA. Translation: AAK71660.1.
AF388052 mRNA. Translation: AAK66774.2.
AF388053 mRNA. Translation: AAK66775.1.
AF388054 mRNA. Translation: AAK66776.1.
AF388055 mRNA. Translation: AAK66777.1.
AF388056 mRNA. Translation: AAK66778.1.
AF388057 mRNA. Translation: AAK66779.1.
AF388058 mRNA. Translation: AAK66780.1.
AK032763 mRNA. Translation: BAC28011.1.
AK038480 mRNA. Translation: BAC30013.1.
AK046607 mRNA. Translation: BAC32805.1.
AK047070 mRNA. Translation: BAC32950.1.
CCDSiCCDS20435.1.
RefSeqiNP_001239571.1. NM_001252642.1.
NP_001239572.1. NM_001252643.1.
NP_032311.2. NM_008285.3.
XP_006505677.1. XM_006505614.1.
XP_006505678.1. XM_006505615.1.
XP_006505679.1. XM_006505616.1.
UniGeneiMm.333327.

Genome annotation databases

EnsembliENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004.
ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004.
ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004.
ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004.
GeneIDi15465.
KEGGimmu:15465.
UCSCiuc009dhw.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50095 Genomic DNA. Translation: BAA08791.1 .
AF387890 mRNA. Translation: AAK71654.1 .
AF387891 mRNA. Translation: AAK71655.1 .
AF387892 mRNA. Translation: AAK71656.1 .
AF387893 mRNA. Translation: AAK71657.1 .
AF387894 mRNA. Translation: AAK71658.1 .
AF387895 mRNA. Translation: AAK71659.1 .
AF387896 mRNA. Translation: AAK71660.1 .
AF388052 mRNA. Translation: AAK66774.2 .
AF388053 mRNA. Translation: AAK66775.1 .
AF388054 mRNA. Translation: AAK66776.1 .
AF388055 mRNA. Translation: AAK66777.1 .
AF388056 mRNA. Translation: AAK66778.1 .
AF388057 mRNA. Translation: AAK66779.1 .
AF388058 mRNA. Translation: AAK66780.1 .
AK032763 mRNA. Translation: BAC28011.1 .
AK038480 mRNA. Translation: BAC30013.1 .
AK046607 mRNA. Translation: BAC32805.1 .
AK047070 mRNA. Translation: BAC32950.1 .
CCDSi CCDS20435.1.
RefSeqi NP_001239571.1. NM_001252642.1.
NP_001239572.1. NM_001252643.1.
NP_032311.2. NM_008285.3.
XP_006505677.1. XM_006505614.1.
XP_006505678.1. XM_006505615.1.
XP_006505679.1. XM_006505616.1.
UniGenei Mm.333327.

3D structure databases

ProteinModelPortali P70174.
SMRi P70174. Positions 28-221, 373-486.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P70174.
ChEMBLi CHEMBL4322.
GuidetoPHARMACOLOGYi 262.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P70174.

Proteomic databases

PRIDEi P70174.

Protocols and materials databases

DNASUi 15465.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000088987 ; ENSMUSP00000086383 ; ENSMUSG00000053004 .
ENSMUST00000160780 ; ENSMUSP00000124320 ; ENSMUSG00000053004 .
ENSMUST00000161220 ; ENSMUSP00000124037 ; ENSMUSG00000053004 .
ENSMUST00000161650 ; ENSMUSP00000124460 ; ENSMUSG00000053004 .
GeneIDi 15465.
KEGGi mmu:15465.
UCSCi uc009dhw.1. mouse.

Organism-specific databases

CTDi 3269.
MGIi MGI:107619. Hrh1.

Phylogenomic databases

eggNOGi NOG318797.
GeneTreei ENSGT00770000120457.
HOGENOMi HOG000273869.
HOVERGENi HBG101103.
InParanoidi P70174.
KOi K04149.
OMAi EDKMCEG.
OrthoDBi EOG70CR7W.
PhylomeDBi P70174.
TreeFami TF333432.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.
REACT_257161. Histamine receptors.

Miscellaneous databases

NextBioi 288290.
PROi P70174.
SOURCEi Search...

Gene expression databases

Bgeei P70174.
CleanExi MM_HRH1.
ExpressionAtlasi P70174. baseline and differential.
Genevestigatori P70174.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characteristics of the mouse genomic histamine H1 receptor gene."
    Inoue I., Taniuchi I., Kitamura D., Jenkins N.A., Gilbert D.J., Copeland N.G., Watanabe T.
    Genomics 36:178-181(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Ola.
  2. "Identification of Bphs, an autoimmune disease locus, as histamine receptor H1."
    Ma R.Z., Gao J., Meeker N.D., Fillmore P.D., Tung K.S.K., Watanabe T., Zachary J.F., Offner H., Blankenhorn E.P., Teuscher C.
    Science 297:620-623(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE, VARIANTS LEU-263; MET-312 AND SER-330.
    Strain: 129/SvJ, A/J, B10.S/DvTe, BALB/cByJ, BALB/cJ, C3H/HeJ, C57BL/6J, CBA/J, DBA/1, DBA/2, FVB/NCr, NOD, SJL and SWR.
    Tissue: Spleen.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Adipose tissue, Cerebellum, Hypothalamus and Mesonephros.
  4. "Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors."
    Inoue I., Yanai K., Kitamura D., Taniuchi I., Kobayashi T., Niimura K., Watanabe T., Watanabe T.
    Proc. Natl. Acad. Sci. U.S.A. 93:13316-13320(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Analysis of the role of Bphs/Hrh1 in the genetic control of responsiveness to pertussis toxin."
    Gao J.F., Call S.B., Fillmore P.D., Watanabe T., Meeker N.D., Teuscher C.
    Infect. Immun. 71:1281-1287(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHRH1_MOUSE
AccessioniPrimary (citable) accession number: P70174
Secondary accession number(s): Q91V75
, Q91XN0, Q91XN1, Q91XN2, Q91XN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 9, 2003
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3