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Protein

Histamine H1 receptor

Gene

Hrh1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system. Involved in circadian rhythm of locomotor activity and exploratory behavior. Also involved in responsiveness to pertussis toxin through its control of susceptibility to histamine hypersensitivity and enhancement of antigen-specific delayed-type hypersensitivity responses.2 Publications

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Biological rhythms

Enzyme and pathway databases

ReactomeiR-MMU-390650. Histamine receptors.
R-MMU-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H1 receptor
Short name:
H1R
Short name:
HH1R
Gene namesi
Name:Hrh1
Synonyms:Bphs
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107619. Hrh1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularBy similarityAdd BLAST29
Transmembranei30 – 52Helical; Name=1By similarityAdd BLAST23
Topological domaini53 – 62CytoplasmicBy similarity10
Transmembranei63 – 83Helical; Name=2By similarityAdd BLAST21
Topological domaini84 – 101ExtracellularBy similarityAdd BLAST18
Transmembranei102 – 123Helical; Name=3By similarityAdd BLAST22
Topological domaini124 – 143CytoplasmicBy similarityAdd BLAST20
Transmembranei144 – 164Helical; Name=4By similarityAdd BLAST21
Topological domaini165 – 189ExtracellularBy similarityAdd BLAST25
Transmembranei190 – 210Helical; Name=5By similarityAdd BLAST21
Topological domaini211 – 417CytoplasmicBy similarityAdd BLAST207
Transmembranei418 – 439Helical; Name=6By similarityAdd BLAST22
Topological domaini440 – 451ExtracellularBy similarityAdd BLAST12
Transmembranei452 – 471Helical; Name=7By similarityAdd BLAST20
Topological domaini472 – 488CytoplasmicBy similarityAdd BLAST17

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696771 – 488Histamine H1 receptorAdd BLAST488

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...)Sequence analysis1
Glycosylationi18N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi100 ↔ 180PROSITE-ProRule annotation
Modified residuei140PhosphothreonineBy similarity1
Modified residuei142PhosphothreonineBy similarity1
Modified residuei230PhosphoserineBy similarity1
Modified residuei344PhosphoserineCombined sources1
Modified residuei347PhosphoserineCombined sources1
Modified residuei381PhosphoserineCombined sources1
Modified residuei383PhosphoserineCombined sources1
Modified residuei397PhosphoserineBy similarity1
Modified residuei399PhosphoserineBy similarity1
Disulfide bondi442 ↔ 445PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylation at sites in the second and third cytoplasmic loops independently contribute to agonist-induced receptor downregulation.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70174.
PRIDEiP70174.

PTM databases

iPTMnetiP70174.
PhosphoSitePlusiP70174.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053004.
CleanExiMM_HRH1.
ExpressionAtlasiP70174. baseline and differential.
GenevisibleiP70174. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086383.

Chemistry databases

BindingDBiP70174.

Structurei

3D structure databases

ProteinModelPortaliP70174.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni107 – 112Important for agonist bindingBy similarity6
Regioni425 – 429Important for agonist bindingBy similarity5

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000273869.
HOVERGENiHBG101103.
InParanoidiP70174.
KOiK04149.
OMAiYIKFTWK.
OrthoDBiEOG091G06VI.
PhylomeDBiP70174.
TreeFamiTF333432.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P70174-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPNTSSAS EDKMCEGNRT AMASPQLLPL VVVLSSISLV TVGLNLLVLY
60 70 80 90 100
AVRSERKLHT VGNLYIVSLS VADLIVGAVV MPMNILYLIM TKWSLGRPLC
110 120 130 140 150
LFWLSMDYVA STASIFSVFI LCIDRYRSVQ QPLRYLRYRT KTRASATILG
160 170 180 190 200
AWFLSFLWVI PILGWHHFTP LAPELREDKC ETDFYNVTWF KIMTAIINFY
210 220 230 240 250
LPTLLMLWFY VKIYKAVRRH CQHRQLTNGS LPTFLEIKLR SEDAKEGAKK
260 270 280 290 300
PGKESPWGVQ KRPSRDPTGG LDQKSTSEDP KVTSPTVFSQ EGERETVTRP
310 320 330 340 350
CFRLDVMQTQ PVPEGDARGS KANDQTLSQP KMDEQSLSTC RRISETSEDQ
360 370 380 390 400
TLVDRQSFSR TTDSDTSIEP GLGKVKARSR SNSGLDYIKV TWKRLRSHSR
410 420 430 440 450
QYVSGLHLNR ERKAAKQLGC IMAAFILCWI PYFIFFMVIA FCNSCCSEPV
460 470 480
HMFTIWLGYI NSTLNPLIYP LCNENFKKTF KKILHIRS
Length:488
Mass (Da):55,682
Last modified:May 9, 2003 - v2
Checksum:i82612DF712998B41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2S → R in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti47L → G in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti79V → I in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti215 – 216KA → NG in BAA08791 (PubMed:8812432).Curated2
Sequence conflicti224R → P in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti242E → D in AAK66778 (PubMed:12142541).Curated1
Sequence conflicti244A → S in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti261K → T in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti278E → A in BAA08791 (PubMed:8812432).Curated1
Sequence conflicti379S → R in BAA08791 (PubMed:8812432).Curated1

Polymorphismi

Strains C3H/HeJ and CBA/J are resistant to vasoactive amine sensitization elicited by histamine (VAASH) which is induced by pertussis toxin.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti263P → L in strain: C3H/HeJ and CBA/J. 1 Publication1
Natural varianti312V → M in strain: C3H/HeJ and CBA/J. 1 Publication1
Natural varianti330P → S in strain: C3H/HeJ and CBA/J. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50095 Genomic DNA. Translation: BAA08791.1.
AF387890 mRNA. Translation: AAK71654.1.
AF387891 mRNA. Translation: AAK71655.1.
AF387892 mRNA. Translation: AAK71656.1.
AF387893 mRNA. Translation: AAK71657.1.
AF387894 mRNA. Translation: AAK71658.1.
AF387895 mRNA. Translation: AAK71659.1.
AF387896 mRNA. Translation: AAK71660.1.
AF388052 mRNA. Translation: AAK66774.2.
AF388053 mRNA. Translation: AAK66775.1.
AF388054 mRNA. Translation: AAK66776.1.
AF388055 mRNA. Translation: AAK66777.1.
AF388056 mRNA. Translation: AAK66778.1.
AF388057 mRNA. Translation: AAK66779.1.
AF388058 mRNA. Translation: AAK66780.1.
AK032763 mRNA. Translation: BAC28011.1.
AK038480 mRNA. Translation: BAC30013.1.
AK046607 mRNA. Translation: BAC32805.1.
AK047070 mRNA. Translation: BAC32950.1.
CCDSiCCDS20435.1.
RefSeqiNP_001239571.1. NM_001252642.2.
NP_001239572.1. NM_001252643.2.
NP_001304053.1. NM_001317124.1.
NP_001304054.1. NM_001317125.1.
NP_001304055.1. NM_001317126.1.
NP_032311.2. NM_008285.4.
UniGeneiMm.333327.

Genome annotation databases

EnsembliENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004.
ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004.
ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004.
ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004.
GeneIDi15465.
KEGGimmu:15465.
UCSCiuc009dhw.1. mouse.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50095 Genomic DNA. Translation: BAA08791.1.
AF387890 mRNA. Translation: AAK71654.1.
AF387891 mRNA. Translation: AAK71655.1.
AF387892 mRNA. Translation: AAK71656.1.
AF387893 mRNA. Translation: AAK71657.1.
AF387894 mRNA. Translation: AAK71658.1.
AF387895 mRNA. Translation: AAK71659.1.
AF387896 mRNA. Translation: AAK71660.1.
AF388052 mRNA. Translation: AAK66774.2.
AF388053 mRNA. Translation: AAK66775.1.
AF388054 mRNA. Translation: AAK66776.1.
AF388055 mRNA. Translation: AAK66777.1.
AF388056 mRNA. Translation: AAK66778.1.
AF388057 mRNA. Translation: AAK66779.1.
AF388058 mRNA. Translation: AAK66780.1.
AK032763 mRNA. Translation: BAC28011.1.
AK038480 mRNA. Translation: BAC30013.1.
AK046607 mRNA. Translation: BAC32805.1.
AK047070 mRNA. Translation: BAC32950.1.
CCDSiCCDS20435.1.
RefSeqiNP_001239571.1. NM_001252642.2.
NP_001239572.1. NM_001252643.2.
NP_001304053.1. NM_001317124.1.
NP_001304054.1. NM_001317125.1.
NP_001304055.1. NM_001317126.1.
NP_032311.2. NM_008285.4.
UniGeneiMm.333327.

3D structure databases

ProteinModelPortaliP70174.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000086383.

Chemistry databases

BindingDBiP70174.
ChEMBLiCHEMBL4322.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP70174.
PhosphoSitePlusiP70174.

Proteomic databases

PaxDbiP70174.
PRIDEiP70174.

Protocols and materials databases

DNASUi15465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088987; ENSMUSP00000086383; ENSMUSG00000053004.
ENSMUST00000160780; ENSMUSP00000124320; ENSMUSG00000053004.
ENSMUST00000161220; ENSMUSP00000124037; ENSMUSG00000053004.
ENSMUST00000161650; ENSMUSP00000124460; ENSMUSG00000053004.
GeneIDi15465.
KEGGimmu:15465.
UCSCiuc009dhw.1. mouse.

Organism-specific databases

CTDi3269.
MGIiMGI:107619. Hrh1.

Phylogenomic databases

eggNOGiKOG4220. Eukaryota.
ENOG410YCQR. LUCA.
GeneTreeiENSGT00780000121874.
HOGENOMiHOG000273869.
HOVERGENiHBG101103.
InParanoidiP70174.
KOiK04149.
OMAiYIKFTWK.
OrthoDBiEOG091G06VI.
PhylomeDBiP70174.
TreeFamiTF333432.

Enzyme and pathway databases

ReactomeiR-MMU-390650. Histamine receptors.
R-MMU-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP70174.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053004.
CleanExiMM_HRH1.
ExpressionAtlasiP70174. baseline and differential.
GenevisibleiP70174. MM.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000921. Histamine_H1_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00530. HISTAMINEH1R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHRH1_MOUSE
AccessioniPrimary (citable) accession number: P70174
Secondary accession number(s): Q91V75
, Q91XN0, Q91XN1, Q91XN2, Q91XN3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 9, 2003
Last modified: November 2, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.