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Protein

Ileal sodium/bile acid cotransporter

Gene

Slc10a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processIon transport, Sodium transport, Symport, Transport
LigandSodium

Enzyme and pathway databases

ReactomeiR-MMU-159418 Recycling of bile acids and salts

Names & Taxonomyi

Protein namesi
Recommended name:
Ileal sodium/bile acid cotransporter
Alternative name(s):
Apical sodium-dependent bile acid transporter
Short name:
ASBT
Ileal Na(+)/bile acid cotransporter
Ileal sodium-dependent bile acid transporter
Short name:
IBAT
Short name:
ISBT
Na(+)-dependent ileal bile acid transporter
Sodium/taurocholate cotransporting polypeptide, ileal
Solute carrier family 10 member 2
Gene namesi
Name:Slc10a2
Synonyms:Ntcp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1201406 Slc10a2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 87CytoplasmicSequence analysisAdd BLAST38
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 126ExtracellularSequence analysisAdd BLAST18
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 157CytoplasmicSequence analysis10
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 195ExtracellularSequence analysisAdd BLAST17
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224CytoplasmicSequence analysis8
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 284ExtracellularSequence analysisAdd BLAST39
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 348CytoplasmicSequence analysisAdd BLAST43

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073708

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523401 – 348Ileal sodium/bile acid cotransporterAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei335PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70172
PRIDEiP70172

PTM databases

iPTMnetiP70172
PhosphoSitePlusiP70172

Expressioni

Gene expression databases

BgeeiENSMUSG00000023073
CleanExiMM_SLC10A2
ExpressionAtlasiP70172 baseline and differential
GenevisibleiP70172 MM

Interactioni

Subunit structurei

Monomer and homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023835

Chemistry databases

BindingDBiP70172

Structurei

3D structure databases

ProteinModelPortaliP70172
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718 Eukaryota
COG0385 LUCA
GeneTreeiENSGT00550000074505
HOGENOMiHOG000234524
HOVERGENiHBG006537
InParanoidiP70172
KOiK14342
OMAiMEIGIHN
OrthoDBiEOG091G0GT5
PhylomeDBiP70172
TreeFamiTF315811

Family and domain databases

InterProiView protein in InterPro
IPR002657 BilAc:Na_symport/Acr3
IPR004710 Bilac:Na_transpt
IPR030207 SLC10A2
PANTHERiPTHR10361 PTHR10361, 1 hit
PTHR10361:SF19 PTHR10361:SF19, 1 hit
PfamiView protein in Pfam
PF01758 SBF, 1 hit
TIGRFAMsiTIGR00841 bass, 1 hit

Sequencei

Sequence statusi: Complete.

P70172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSSVCPPN ATVCEGDSCV VPESNFNAIL NTVMSTVLTI LLAMVMFSMG
60 70 80 90 100
CNVEVHKFLG HIKRPWGIFV GFLCQFGIMP LTGFILSVAS GILPVQAVVV
110 120 130 140 150
LIMGCCPGGT GSNILAYWID GDMDLSVSMT TCSTLLALGM MPLCLFVYTK
160 170 180 190 200
MWVDSGTIVI PYDSIGISLV ALVIPVSFGM FVNHKWPQKA KIILKIGSIT
210 220 230 240 250
GVILIVLIAV IGGILYQSAW IIEPKLWIIG TIFPIAGYSL GFFLARLAGQ
260 270 280 290 300
PWYRCRTVAL ETGMQNTQLC STIVQLSFSP EDLNLVFTFP LIYTVFQLVF
310 320 330 340
AAVILGIYVT YRKCYGKNDA EFLEKTDNEM DSRPSFDETN KGFQPDEK
Length:348
Mass (Da):38,134
Last modified:January 1, 1998 - v2
Checksum:iD00B5E43431875D7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti29I → V in strain: NZB/BlNJ and C57BL/6. 2 Publications1
Natural varianti36T → S in strain: NZB/BlNJ and C57BL/6. 2 Publications1
Natural varianti40I → T in strain: NZB/BlNJ and C57BL/6. 2 Publications1
Natural varianti178F → I in strain: NZB/BlNJ and C57BL/6. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002693 mRNA Translation: BAA19606.1
D87059 mRNA Translation: BAA13237.1
AF271073
, AF266724, AF266725, AF266726, AF266727, AF266728 Genomic DNA Translation: AAK55514.1
AY529655 mRNA Translation: AAS20611.1
AB078635 Genomic DNA Translation: BAB84081.1
CCDSiCCDS22089.1
RefSeqiNP_035518.1, NM_011388.3
UniGeneiMm.207250
Mm.3500
Mm.395958

Genome annotation databases

EnsembliENSMUST00000023835; ENSMUSP00000023835; ENSMUSG00000023073
GeneIDi20494
KEGGimmu:20494
UCSCiuc009kub.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNTCP2_MOUSE
AccessioniPrimary (citable) accession number: P70172
Secondary accession number(s): Q8VI83, Q925U7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 1, 1998
Last modified: March 28, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health