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P70172

- NTCP2_MOUSE

UniProt

P70172 - NTCP2_MOUSE

Protein

Ileal sodium/bile acid cotransporter

Gene

Slc10a2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism By similarity.By similarity

    GO - Molecular functioni

    1. bile acid:sodium symporter activity Source: InterPro

    Keywords - Biological processi

    Ion transport, Sodium transport, Symport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ileal sodium/bile acid cotransporter
    Alternative name(s):
    Apical sodium-dependent bile acid transporter
    Short name:
    ASBT
    Ileal Na(+)/bile acid cotransporter
    Ileal sodium-dependent bile acid transporter
    Short name:
    IBAT
    Short name:
    ISBT
    Na(+)-dependent ileal bile acid transporter
    Sodium/taurocholate cotransporting polypeptide, ileal
    Solute carrier family 10 member 2
    Gene namesi
    Name:Slc10a2
    Synonyms:Ntcp2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:1201406. Slc10a2.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. microvillus Source: MGI
    4. nucleus Source: Ensembl
    5. proteasome complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 348348Ileal sodium/bile acid cotransporterPRO_0000052340Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP70172.

    PTM databases

    PhosphoSiteiP70172.

    Expressioni

    Gene expression databases

    BgeeiP70172.
    CleanExiMM_SLC10A2.
    GenevestigatoriP70172.

    Interactioni

    Subunit structurei

    Monomer and homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP70172.
    SMRiP70172. Positions 32-305.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini50 – 8738CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini109 – 12618ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini148 – 15710CytoplasmicSequence Analysis
    Topological domaini179 – 19517ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini217 – 2248CytoplasmicSequence Analysis
    Topological domaini246 – 28439ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini306 – 34843CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei29 – 4921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei127 – 14721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei196 – 21621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei225 – 24521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei285 – 30521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0385.
    HOGENOMiHOG000234524.
    HOVERGENiHBG006537.
    InParanoidiP70172.
    KOiK14342.
    OMAiIEPKLWI.
    OrthoDBiEOG7XWPNW.
    PhylomeDBiP70172.
    TreeFamiTF315811.

    Family and domain databases

    InterProiIPR004710. Bil_ac_transpt.
    IPR002657. BilAc/Na_symport.
    [Graphical view]
    PANTHERiPTHR10361. PTHR10361. 1 hit.
    PfamiPF01758. SBF. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00841. bass. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P70172-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNSSVCPPN ATVCEGDSCV VPESNFNAIL NTVMSTVLTI LLAMVMFSMG    50
    CNVEVHKFLG HIKRPWGIFV GFLCQFGIMP LTGFILSVAS GILPVQAVVV 100
    LIMGCCPGGT GSNILAYWID GDMDLSVSMT TCSTLLALGM MPLCLFVYTK 150
    MWVDSGTIVI PYDSIGISLV ALVIPVSFGM FVNHKWPQKA KIILKIGSIT 200
    GVILIVLIAV IGGILYQSAW IIEPKLWIIG TIFPIAGYSL GFFLARLAGQ 250
    PWYRCRTVAL ETGMQNTQLC STIVQLSFSP EDLNLVFTFP LIYTVFQLVF 300
    AAVILGIYVT YRKCYGKNDA EFLEKTDNEM DSRPSFDETN KGFQPDEK 348
    Length:348
    Mass (Da):38,134
    Last modified:January 1, 1998 - v2
    Checksum:iD00B5E43431875D7
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti29 – 291I → V in strain: NZB/BlNJ and C57BL/6. 2 Publications
    Natural varianti36 – 361T → S in strain: NZB/BlNJ and C57BL/6. 2 Publications
    Natural varianti40 – 401I → T in strain: NZB/BlNJ and C57BL/6. 2 Publications
    Natural varianti178 – 1781F → I in strain: NZB/BlNJ and C57BL/6. 2 Publications

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002693 mRNA. Translation: BAA19606.1.
    D87059 mRNA. Translation: BAA13237.1.
    AF271073
    , AF266724, AF266725, AF266726, AF266727, AF266728 Genomic DNA. Translation: AAK55514.1.
    AY529655 mRNA. Translation: AAS20611.1.
    AB078635 Genomic DNA. Translation: BAB84081.1.
    CCDSiCCDS22089.1.
    RefSeqiNP_035518.1. NM_011388.2.
    UniGeneiMm.3500.

    Genome annotation databases

    EnsembliENSMUST00000023835; ENSMUSP00000023835; ENSMUSG00000023073.
    GeneIDi20494.
    KEGGimmu:20494.
    UCSCiuc009kub.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB002693 mRNA. Translation: BAA19606.1 .
    D87059 mRNA. Translation: BAA13237.1 .
    AF271073
    , AF266724 , AF266725 , AF266726 , AF266727 , AF266728 Genomic DNA. Translation: AAK55514.1 .
    AY529655 mRNA. Translation: AAS20611.1 .
    AB078635 Genomic DNA. Translation: BAB84081.1 .
    CCDSi CCDS22089.1.
    RefSeqi NP_035518.1. NM_011388.2.
    UniGenei Mm.3500.

    3D structure databases

    ProteinModelPortali P70172.
    SMRi P70172. Positions 32-305.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    ChEMBLi CHEMBL2073708.

    PTM databases

    PhosphoSitei P70172.

    Proteomic databases

    PRIDEi P70172.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023835 ; ENSMUSP00000023835 ; ENSMUSG00000023073 .
    GeneIDi 20494.
    KEGGi mmu:20494.
    UCSCi uc009kub.1. mouse.

    Organism-specific databases

    CTDi 6555.
    MGIi MGI:1201406. Slc10a2.

    Phylogenomic databases

    eggNOGi COG0385.
    HOGENOMi HOG000234524.
    HOVERGENi HBG006537.
    InParanoidi P70172.
    KOi K14342.
    OMAi IEPKLWI.
    OrthoDBi EOG7XWPNW.
    PhylomeDBi P70172.
    TreeFami TF315811.

    Miscellaneous databases

    NextBioi 298641.
    PROi P70172.
    SOURCEi Search...

    Gene expression databases

    Bgeei P70172.
    CleanExi MM_SLC10A2.
    Genevestigatori P70172.

    Family and domain databases

    InterProi IPR004710. Bil_ac_transpt.
    IPR002657. BilAc/Na_symport.
    [Graphical view ]
    PANTHERi PTHR10361. PTHR10361. 1 hit.
    Pfami PF01758. SBF. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00841. bass. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter."
      Saeki T., Matoba K., Furukawa H., Kirifuji K., Kanamoto R., Iwami K.
      J. Biochem. 125:846-851(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: ICR.
    2. "Disruption of the ileal bile acid transporter gene in mice."
      Dawson P.A., Craddock A.L., Tietjen M.E., Haywood J.H.
      Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE, VARIANTS VAL-29; SER-36; THR-40 AND ILE-178.
      Strain: C57BL/6.
    3. "New genetic determinants of cholesterol gallstone formation revealed in an intercross of mouse strains NZB and SM."
      Lyons M.A., Korstanje R., Li R., Sheehan S.M., Walsh K.A., Carey M.C., Churchill G.A., Paigen B.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE, VARIANTS VAL-29; SER-36; THR-40 AND ILE-178.
      Strain: NZB/BlNJ and SM/J.
    4. "Identification of transcription start sites in mouse ileal sodium-dependent bile acid transporter gene."
      Saeki T., Kirifuji K., Kanamoto R., Iwami K.
      Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 1-125.

    Entry informationi

    Entry nameiNTCP2_MOUSE
    AccessioniPrimary (citable) accession number: P70172
    Secondary accession number(s): Q8VI83, Q925U7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3