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P70172

- NTCP2_MOUSE

UniProt

P70172 - NTCP2_MOUSE

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Protein
Ileal sodium/bile acid cotransporter
Gene
Slc10a2, Ntcp2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism By similarity.

GO - Molecular functioni

  1. bile acid:sodium symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Ileal sodium/bile acid cotransporter
Alternative name(s):
Apical sodium-dependent bile acid transporter
Short name:
ASBT
Ileal Na(+)/bile acid cotransporter
Ileal sodium-dependent bile acid transporter
Short name:
IBAT
Short name:
ISBT
Na(+)-dependent ileal bile acid transporter
Sodium/taurocholate cotransporting polypeptide, ileal
Solute carrier family 10 member 2
Gene namesi
Name:Slc10a2
Synonyms:Ntcp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:1201406. Slc10a2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2828Extracellular Reviewed prediction
Add
BLAST
Transmembranei29 – 4921Helical; Reviewed prediction
Add
BLAST
Topological domaini50 – 8738Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei88 – 10821Helical; Reviewed prediction
Add
BLAST
Topological domaini109 – 12618Extracellular Reviewed prediction
Add
BLAST
Transmembranei127 – 14721Helical; Reviewed prediction
Add
BLAST
Topological domaini148 – 15710Cytoplasmic Reviewed prediction
Transmembranei158 – 17821Helical; Reviewed prediction
Add
BLAST
Topological domaini179 – 19517Extracellular Reviewed prediction
Add
BLAST
Transmembranei196 – 21621Helical; Reviewed prediction
Add
BLAST
Topological domaini217 – 2248Cytoplasmic Reviewed prediction
Transmembranei225 – 24521Helical; Reviewed prediction
Add
BLAST
Topological domaini246 – 28439Extracellular Reviewed prediction
Add
BLAST
Transmembranei285 – 30521Helical; Reviewed prediction
Add
BLAST
Topological domaini306 – 34843Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. apical plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. microvillus Source: MGI
  4. nucleus Source: Ensembl
  5. proteasome complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 348348Ileal sodium/bile acid cotransporter
PRO_0000052340Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...) Reviewed prediction
Glycosylationi10 – 101N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP70172.

PTM databases

PhosphoSiteiP70172.

Expressioni

Gene expression databases

BgeeiP70172.
CleanExiMM_SLC10A2.
GenevestigatoriP70172.

Interactioni

Subunit structurei

Monomer and homodimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP70172.
SMRiP70172. Positions 32-305.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0385.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiP70172.
KOiK14342.
OMAiIEPKLWI.
OrthoDBiEOG7XWPNW.
PhylomeDBiP70172.
TreeFamiTF315811.

Family and domain databases

InterProiIPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

P70172-1 [UniParc]FASTAAdd to Basket

« Hide

MDNSSVCPPN ATVCEGDSCV VPESNFNAIL NTVMSTVLTI LLAMVMFSMG    50
CNVEVHKFLG HIKRPWGIFV GFLCQFGIMP LTGFILSVAS GILPVQAVVV 100
LIMGCCPGGT GSNILAYWID GDMDLSVSMT TCSTLLALGM MPLCLFVYTK 150
MWVDSGTIVI PYDSIGISLV ALVIPVSFGM FVNHKWPQKA KIILKIGSIT 200
GVILIVLIAV IGGILYQSAW IIEPKLWIIG TIFPIAGYSL GFFLARLAGQ 250
PWYRCRTVAL ETGMQNTQLC STIVQLSFSP EDLNLVFTFP LIYTVFQLVF 300
AAVILGIYVT YRKCYGKNDA EFLEKTDNEM DSRPSFDETN KGFQPDEK 348
Length:348
Mass (Da):38,134
Last modified:January 1, 1998 - v2
Checksum:iD00B5E43431875D7
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti29 – 291I → V in strain: NZB/BlNJ and C57BL/6. 2 Publications
Natural varianti36 – 361T → S in strain: NZB/BlNJ and C57BL/6. 2 Publications
Natural varianti40 – 401I → T in strain: NZB/BlNJ and C57BL/6. 2 Publications
Natural varianti178 – 1781F → I in strain: NZB/BlNJ and C57BL/6. 2 Publications

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002693 mRNA. Translation: BAA19606.1.
D87059 mRNA. Translation: BAA13237.1.
AF271073
, AF266724, AF266725, AF266726, AF266727, AF266728 Genomic DNA. Translation: AAK55514.1.
AY529655 mRNA. Translation: AAS20611.1.
AB078635 Genomic DNA. Translation: BAB84081.1.
CCDSiCCDS22089.1.
RefSeqiNP_035518.1. NM_011388.2.
UniGeneiMm.3500.

Genome annotation databases

EnsembliENSMUST00000023835; ENSMUSP00000023835; ENSMUSG00000023073.
GeneIDi20494.
KEGGimmu:20494.
UCSCiuc009kub.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB002693 mRNA. Translation: BAA19606.1 .
D87059 mRNA. Translation: BAA13237.1 .
AF271073
, AF266724 , AF266725 , AF266726 , AF266727 , AF266728 Genomic DNA. Translation: AAK55514.1 .
AY529655 mRNA. Translation: AAS20611.1 .
AB078635 Genomic DNA. Translation: BAB84081.1 .
CCDSi CCDS22089.1.
RefSeqi NP_035518.1. NM_011388.2.
UniGenei Mm.3500.

3D structure databases

ProteinModelPortali P70172.
SMRi P70172. Positions 32-305.
ModBasei Search...
MobiDBi Search...

Chemistry

ChEMBLi CHEMBL2073708.

PTM databases

PhosphoSitei P70172.

Proteomic databases

PRIDEi P70172.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023835 ; ENSMUSP00000023835 ; ENSMUSG00000023073 .
GeneIDi 20494.
KEGGi mmu:20494.
UCSCi uc009kub.1. mouse.

Organism-specific databases

CTDi 6555.
MGIi MGI:1201406. Slc10a2.

Phylogenomic databases

eggNOGi COG0385.
HOGENOMi HOG000234524.
HOVERGENi HBG006537.
InParanoidi P70172.
KOi K14342.
OMAi IEPKLWI.
OrthoDBi EOG7XWPNW.
PhylomeDBi P70172.
TreeFami TF315811.

Miscellaneous databases

NextBioi 298641.
PROi P70172.
SOURCEi Search...

Gene expression databases

Bgeei P70172.
CleanExi MM_SLC10A2.
Genevestigatori P70172.

Family and domain databases

InterProi IPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view ]
PANTHERi PTHR10361. PTHR10361. 1 hit.
Pfami PF01758. SBF. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00841. bass. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter."
    Saeki T., Matoba K., Furukawa H., Kirifuji K., Kanamoto R., Iwami K.
    J. Biochem. 125:846-851(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
  2. "Disruption of the ileal bile acid transporter gene in mice."
    Dawson P.A., Craddock A.L., Tietjen M.E., Haywood J.H.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE, VARIANTS VAL-29; SER-36; THR-40 AND ILE-178.
    Strain: C57BL/6.
  3. "New genetic determinants of cholesterol gallstone formation revealed in an intercross of mouse strains NZB and SM."
    Lyons M.A., Korstanje R., Li R., Sheehan S.M., Walsh K.A., Carey M.C., Churchill G.A., Paigen B.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE, VARIANTS VAL-29; SER-36; THR-40 AND ILE-178.
    Strain: NZB/BlNJ and SM/J.
  4. "Identification of transcription start sites in mouse ileal sodium-dependent bile acid transporter gene."
    Saeki T., Kirifuji K., Kanamoto R., Iwami K.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 1-125.

Entry informationi

Entry nameiNTCP2_MOUSE
AccessioniPrimary (citable) accession number: P70172
Secondary accession number(s): Q8VI83, Q925U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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