Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ileal sodium/bile acid cotransporter

Gene

Slc10a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-MMU-159418. Recycling of bile acids and salts.

Names & Taxonomyi

Protein namesi
Recommended name:
Ileal sodium/bile acid cotransporter
Alternative name(s):
Apical sodium-dependent bile acid transporter
Short name:
ASBT
Ileal Na(+)/bile acid cotransporter
Ileal sodium-dependent bile acid transporter
Short name:
IBAT
Short name:
ISBT
Na(+)-dependent ileal bile acid transporter
Sodium/taurocholate cotransporting polypeptide, ileal
Solute carrier family 10 member 2
Gene namesi
Name:Slc10a2
Synonyms:Ntcp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1201406. Slc10a2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 49HelicalSequence analysisAdd BLAST21
Topological domaini50 – 87CytoplasmicSequence analysisAdd BLAST38
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 126ExtracellularSequence analysisAdd BLAST18
Transmembranei127 – 147HelicalSequence analysisAdd BLAST21
Topological domaini148 – 157CytoplasmicSequence analysis10
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 195ExtracellularSequence analysisAdd BLAST17
Transmembranei196 – 216HelicalSequence analysisAdd BLAST21
Topological domaini217 – 224CytoplasmicSequence analysis8
Transmembranei225 – 245HelicalSequence analysisAdd BLAST21
Topological domaini246 – 284ExtracellularSequence analysisAdd BLAST39
Transmembranei285 – 305HelicalSequence analysisAdd BLAST21
Topological domaini306 – 348CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

  • apical plasma membrane Source: MGI
  • integral component of plasma membrane Source: GO_Central
  • microvillus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073708.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000523401 – 348Ileal sodium/bile acid cotransporterAdd BLAST348

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi10N-linked (GlcNAc...)Sequence analysis1
Modified residuei335PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP70172.
PRIDEiP70172.

PTM databases

iPTMnetiP70172.
PhosphoSitePlusiP70172.

Expressioni

Gene expression databases

BgeeiENSMUSG00000023073.
CleanExiMM_SLC10A2.
ExpressionAtlasiP70172. baseline and differential.
GenevisibleiP70172. MM.

Interactioni

Subunit structurei

Monomer and homodimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023835.

Chemistry databases

BindingDBiP70172.

Structurei

3D structure databases

ProteinModelPortaliP70172.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiP70172.
KOiK14342.
OMAiNSCVDNA.
OrthoDBiEOG091G0GT5.
PhylomeDBiP70172.
TreeFamiTF315811.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030207. SLC10A2.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF19. PTHR10361:SF19. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.

Sequencei

Sequence statusi: Complete.

P70172-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDNSSVCPPN ATVCEGDSCV VPESNFNAIL NTVMSTVLTI LLAMVMFSMG
60 70 80 90 100
CNVEVHKFLG HIKRPWGIFV GFLCQFGIMP LTGFILSVAS GILPVQAVVV
110 120 130 140 150
LIMGCCPGGT GSNILAYWID GDMDLSVSMT TCSTLLALGM MPLCLFVYTK
160 170 180 190 200
MWVDSGTIVI PYDSIGISLV ALVIPVSFGM FVNHKWPQKA KIILKIGSIT
210 220 230 240 250
GVILIVLIAV IGGILYQSAW IIEPKLWIIG TIFPIAGYSL GFFLARLAGQ
260 270 280 290 300
PWYRCRTVAL ETGMQNTQLC STIVQLSFSP EDLNLVFTFP LIYTVFQLVF
310 320 330 340
AAVILGIYVT YRKCYGKNDA EFLEKTDNEM DSRPSFDETN KGFQPDEK
Length:348
Mass (Da):38,134
Last modified:January 1, 1998 - v2
Checksum:iD00B5E43431875D7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti29I → V in strain: NZB/BlNJ and C57BL/6. 2 Publications1
Natural varianti36T → S in strain: NZB/BlNJ and C57BL/6. 2 Publications1
Natural varianti40I → T in strain: NZB/BlNJ and C57BL/6. 2 Publications1
Natural varianti178F → I in strain: NZB/BlNJ and C57BL/6. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002693 mRNA. Translation: BAA19606.1.
D87059 mRNA. Translation: BAA13237.1.
AF271073
, AF266724, AF266725, AF266726, AF266727, AF266728 Genomic DNA. Translation: AAK55514.1.
AY529655 mRNA. Translation: AAS20611.1.
AB078635 Genomic DNA. Translation: BAB84081.1.
CCDSiCCDS22089.1.
RefSeqiNP_035518.1. NM_011388.3.
UniGeneiMm.207250.
Mm.3500.
Mm.395958.

Genome annotation databases

EnsembliENSMUST00000023835; ENSMUSP00000023835; ENSMUSG00000023073.
GeneIDi20494.
KEGGimmu:20494.
UCSCiuc009kub.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB002693 mRNA. Translation: BAA19606.1.
D87059 mRNA. Translation: BAA13237.1.
AF271073
, AF266724, AF266725, AF266726, AF266727, AF266728 Genomic DNA. Translation: AAK55514.1.
AY529655 mRNA. Translation: AAS20611.1.
AB078635 Genomic DNA. Translation: BAB84081.1.
CCDSiCCDS22089.1.
RefSeqiNP_035518.1. NM_011388.3.
UniGeneiMm.207250.
Mm.3500.
Mm.395958.

3D structure databases

ProteinModelPortaliP70172.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023835.

Chemistry databases

BindingDBiP70172.
ChEMBLiCHEMBL2073708.

PTM databases

iPTMnetiP70172.
PhosphoSitePlusiP70172.

Proteomic databases

PaxDbiP70172.
PRIDEiP70172.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023835; ENSMUSP00000023835; ENSMUSG00000023073.
GeneIDi20494.
KEGGimmu:20494.
UCSCiuc009kub.1. mouse.

Organism-specific databases

CTDi6555.
MGIiMGI:1201406. Slc10a2.

Phylogenomic databases

eggNOGiKOG2718. Eukaryota.
COG0385. LUCA.
GeneTreeiENSGT00550000074505.
HOGENOMiHOG000234524.
HOVERGENiHBG006537.
InParanoidiP70172.
KOiK14342.
OMAiNSCVDNA.
OrthoDBiEOG091G0GT5.
PhylomeDBiP70172.
TreeFamiTF315811.

Enzyme and pathway databases

ReactomeiR-MMU-159418. Recycling of bile acids and salts.

Miscellaneous databases

PROiP70172.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000023073.
CleanExiMM_SLC10A2.
ExpressionAtlasiP70172. baseline and differential.
GenevisibleiP70172. MM.

Family and domain databases

InterProiIPR002657. BilAc:Na_symport/Acr3.
IPR004710. Bilac:Na_transpt.
IPR030207. SLC10A2.
[Graphical view]
PANTHERiPTHR10361. PTHR10361. 1 hit.
PTHR10361:SF19. PTHR10361:SF19. 1 hit.
PfamiPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00841. bass. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNTCP2_MOUSE
AccessioniPrimary (citable) accession number: P70172
Secondary accession number(s): Q8VI83, Q925U7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 1, 1998
Last modified: November 2, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.