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P70172 (NTCP2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ileal sodium/bile acid cotransporter
Alternative name(s):
Apical sodium-dependent bile acid transporter
Short name=ASBT
Ileal Na(+)/bile acid cotransporter
Ileal sodium-dependent bile acid transporter
Short name=IBAT
Short name=ISBT
Na(+)-dependent ileal bile acid transporter
Sodium/taurocholate cotransporting polypeptide, ileal
Solute carrier family 10 member 2
Gene names
Name:Slc10a2
Synonyms:Ntcp2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length348 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism By similarity.

Subunit structure

Monomer and homodimer By similarity.

Subcellular location

Membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 348348Ileal sodium/bile acid cotransporter
PRO_0000052340

Regions

Topological domain1 – 2828Extracellular Potential
Transmembrane29 – 4921Helical; Potential
Topological domain50 – 8738Cytoplasmic Potential
Transmembrane88 – 10821Helical; Potential
Topological domain109 – 12618Extracellular Potential
Transmembrane127 – 14721Helical; Potential
Topological domain148 – 15710Cytoplasmic Potential
Transmembrane158 – 17821Helical; Potential
Topological domain179 – 19517Extracellular Potential
Transmembrane196 – 21621Helical; Potential
Topological domain217 – 2248Cytoplasmic Potential
Transmembrane225 – 24521Helical; Potential
Topological domain246 – 28439Extracellular Potential
Transmembrane285 – 30521Helical; Potential
Topological domain306 – 34843Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation101N-linked (GlcNAc...) Potential

Natural variations

Natural variant291I → V in strain: NZB/BlNJ and C57BL/6. Ref.2 Ref.3
Natural variant361T → S in strain: NZB/BlNJ and C57BL/6. Ref.2 Ref.3
Natural variant401I → T in strain: NZB/BlNJ and C57BL/6. Ref.2 Ref.3
Natural variant1781F → I in strain: NZB/BlNJ and C57BL/6. Ref.2 Ref.3

Sequences

Sequence LengthMass (Da)Tools
P70172 [UniParc].

Last modified January 1, 1998. Version 2.
Checksum: D00B5E43431875D7

FASTA34838,134
        10         20         30         40         50         60 
MDNSSVCPPN ATVCEGDSCV VPESNFNAIL NTVMSTVLTI LLAMVMFSMG CNVEVHKFLG 

        70         80         90        100        110        120 
HIKRPWGIFV GFLCQFGIMP LTGFILSVAS GILPVQAVVV LIMGCCPGGT GSNILAYWID 

       130        140        150        160        170        180 
GDMDLSVSMT TCSTLLALGM MPLCLFVYTK MWVDSGTIVI PYDSIGISLV ALVIPVSFGM 

       190        200        210        220        230        240 
FVNHKWPQKA KIILKIGSIT GVILIVLIAV IGGILYQSAW IIEPKLWIIG TIFPIAGYSL 

       250        260        270        280        290        300 
GFFLARLAGQ PWYRCRTVAL ETGMQNTQLC STIVQLSFSP EDLNLVFTFP LIYTVFQLVF 

       310        320        330        340 
AAVILGIYVT YRKCYGKNDA EFLEKTDNEM DSRPSFDETN KGFQPDEK 

« Hide

References

[1]"Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter."
Saeki T., Matoba K., Furukawa H., Kirifuji K., Kanamoto R., Iwami K.
J. Biochem. 125:846-851(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: ICR.
[2]"Disruption of the ileal bile acid transporter gene in mice."
Dawson P.A., Craddock A.L., Tietjen M.E., Haywood J.H.
Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE, VARIANTS VAL-29; SER-36; THR-40 AND ILE-178.
Strain: C57BL/6.
[3]"New genetic determinants of cholesterol gallstone formation revealed in an intercross of mouse strains NZB and SM."
Lyons M.A., Korstanje R., Li R., Sheehan S.M., Walsh K.A., Carey M.C., Churchill G.A., Paigen B.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE, VARIANTS VAL-29; SER-36; THR-40 AND ILE-178.
Strain: NZB/BlNJ and SM/J.
[4]"Identification of transcription start sites in mouse ileal sodium-dependent bile acid transporter gene."
Saeki T., Kirifuji K., Kanamoto R., Iwami K.
Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 1-125.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB002693 mRNA. Translation: BAA19606.1.
D87059 mRNA. Translation: BAA13237.1.
AF271073 expand/collapse EMBL AC list , AF266724, AF266725, AF266726, AF266727, AF266728 Genomic DNA. Translation: AAK55514.1.
AY529655 mRNA. Translation: AAS20611.1.
AB078635 Genomic DNA. Translation: BAB84081.1.
CCDSCCDS22089.1.
RefSeqNP_035518.1. NM_011388.2.
UniGeneMm.3500.

3D structure databases

ProteinModelPortalP70172.
SMRP70172. Positions 32-305.
ModBaseSearch...
MobiDBSearch...

Chemistry

ChEMBLCHEMBL2073708.

PTM databases

PhosphoSiteP70172.

Proteomic databases

PRIDEP70172.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023835; ENSMUSP00000023835; ENSMUSG00000023073.
GeneID20494.
KEGGmmu:20494.
UCSCuc009kub.1. mouse.

Organism-specific databases

CTD6555.
MGIMGI:1201406. Slc10a2.

Phylogenomic databases

eggNOGCOG0385.
HOGENOMHOG000234524.
HOVERGENHBG006537.
InParanoidP70172.
KOK14342.
OMAIEPKLWI.
OrthoDBEOG7XWPNW.
PhylomeDBP70172.
TreeFamTF315811.

Gene expression databases

BgeeP70172.
CleanExMM_SLC10A2.
GenevestigatorP70172.

Family and domain databases

InterProIPR004710. Bil_ac_transpt.
IPR002657. BilAc/Na_symport.
[Graphical view]
PANTHERPTHR10361. PTHR10361. 1 hit.
PfamPF01758. SBF. 1 hit.
[Graphical view]
TIGRFAMsTIGR00841. bass. 1 hit.
ProtoNetSearch...

Other

NextBio298641.
PROP70172.
SOURCESearch...

Entry information

Entry nameNTCP2_MOUSE
AccessionPrimary (citable) accession number: P70172
Secondary accession number(s): Q8VI83, Q925U7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 1, 1998
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot