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P70170

- ABCC9_MOUSE

UniProt

P70170 - ABCC9_MOUSE

Protein

ATP-binding cassette sub-family C member 9

Gene

Abcc9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi702 – 7098ATP 1PROSITE-ProRule annotation
    Nucleotide bindingi1343 – 13508ATP 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
    2. ATP binding Source: UniProtKB-KW
    3. sulfonylurea receptor activity Source: InterPro

    GO - Biological processi

    1. defense response to virus Source: MGI
    2. potassium ion transmembrane transport Source: GOC

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_199102. ATP sensitive Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-binding cassette sub-family C member 9
    Alternative name(s):
    Sulfonylurea receptor 2
    Gene namesi
    Name:Abcc9
    Synonyms:Sur2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1352630. Abcc9.

    Subcellular locationi

    Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

    GO - Cellular componenti

    1. plasma membrane Source: MGI
    2. sarcolemma Source: MGI
    3. sarcomere Source: MGI
    4. voltage-gated potassium channel complex Source: Ensembl

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 15461546ATP-binding cassette sub-family C member 9PRO_0000093403Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiP70170.
    PRIDEiP70170.

    PTM databases

    PhosphoSiteiP70170.

    Expressioni

    Tissue specificityi

    Isoforms SUR2A and SUR2B are found in cerebellum, eye, atrium, ventricle, urinary bladder and skeletal muscle. Isoform SUR2B is also found in forebrain, liver, lung, pancreas, kidney, spleen, stomach, small intestine, colon, uterus, ovary and fat tissue. Isoform SUR2C is expressed exclusively in the heart.

    Gene expression databases

    ArrayExpressiP70170.
    BgeeiP70170.
    GenevestigatoriP70170.

    Interactioni

    Subunit structurei

    Interacts with KCNJ11.

    Protein-protein interaction databases

    MINTiMINT-4996941.

    Structurei

    3D structure databases

    ProteinModelPortaliP70170.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini52 – 7221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini94 – 1018ExtracellularSequence Analysis
    Topological domaini123 – 13210CytoplasmicSequence Analysis
    Topological domaini154 – 16714ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 301113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini323 – 34826ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini370 – 42152CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini443 – 45311ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini475 – 52955CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini551 – 56919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini591 – 987397CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1009 – 103123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1053 – 112472CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini1146 – 124297ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1264 – 1546283CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei31 – 5121Helical; Name=1PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei73 – 9321Helical; Name=2PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei102 – 12221Helical; Name=3PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei133 – 15321Helical; Name=4PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=5PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei302 – 32221Helical; Name=6PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei349 – 36921Helical; Name=7PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei422 – 44221Helical; Name=8PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei454 – 47421Helical; Name=9PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei530 – 55021Helical; Name=10PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei570 – 59021Helical; Name=11PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei988 – 100821Helical; Name=12PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1032 – 105221Helical; Name=13PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1125 – 114521Helical; Name=14PROSITE-ProRule annotationAdd
    BLAST
    Transmembranei1243 – 126321Helical; Name=15PROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini297 – 595299ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini669 – 909241ABC transporter 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini991 – 1271281ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1309 – 1543235ABC transporter 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
    Contains 2 ABC transporter domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1132.
    GeneTreeiENSGT00750000117379.
    HOVERGENiHBG101342.
    KOiK05033.
    OMAiMMVILNG.
    OrthoDBiEOG7MWGW0.
    PhylomeDBiP70170.
    TreeFamiTF105201.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    InterProiIPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    IPR001475. Sulphonylurea_rcpt-2.
    IPR000388. Sulphorea_rcpt.
    [Graphical view]
    PfamiPF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view]
    PRINTSiPR01094. SULFNYLUR2.
    PR01092. SULFNYLUREAR.
    SMARTiSM00382. AAA. 2 hits.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEiPS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform SUR2A (identifier: P70170-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSLSFCGNNI SSYNIYYGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG     50
    SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSHRASR 100
    HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI 150
    KLVKYWQLGW GVSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ 200
    KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK 250
    LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 300
    STFRYLADLL GFAGPLCISG IVQRVNEKTN TTREMFPETL SSKEFLENAH 350
    VLAVLLFLAL ILQRTFLQAS YYVTIETGIN LRGALLAMIY NKILRLSTSN 400
    LSMGEMTLGQ INNLVAIETN QLMWFLFLCP NLWAMPVQII MGVILLYNLL 450
    GSSALVGAAV IVLLAPIQYF IATKLAEAQK STLDYSTERL KKTNEILKGI 500
    KLLKLYAWEH IFCKSVEETR MKELSSLKTF ALYTSLSIFM NAAIPIAAVL 550
    ATFVTHAYAS GNNLKPAEAF ASLSLFHILV TPLFLLSTVV RFAVKAIISV 600
    QKLNEFLLSD EIGEDSWRAG EGTLPFESCK KHTGVQSKPI NRKQPGRYHL 650
    DSYEQARRLR PAETEDIAIK VTNGYFSWGS GLATLSNIDI RIPTGQLTMI 700
    VGQVGCGKSS LLLAILGEMQ TLEGKVYWNN VNESEPSFEA TRSRSRYSVA 750
    YAAQKPWLLN ATVEENITFG SPFNRQRYKA VTDACSLQPD IDLLPFGDQT 800
    EIGERGINLS GGQRQRICVA RALYQNTNIV FLDDPFSALD IHLSDHLMQE 850
    GILKFLQDDK RTVVLVTHKL QYLTHADWII AMKDGSVLRE GTLKDIQTKD 900
    VELYEHWKTL MNRQDQELEK DMEADQTTLE RKTLRRAMYS REAKAQMEDE 950
    DEEEEEEEDE EDNMSTVMRL RTKMPWKTCW WYLTSGGFFL LFLMIFSKLL 1000
    KHSVIVAIDY WLATWTSEYS INHPGKADQT FYVAGFSILC GAGIFLCLVT 1050
    SLTVEWMGLT AAKNLHHNLL NKIILGPIRF FDTTPLGLIL NRFSADTNII 1100
    DQHIPPTLES LTRSTLLCLS AIGMISYATP VFLVALAPLG VAFYFIQKYF 1150
    RVASKDLQEL DDSTQLPLLC HFSETAEGLT TIRAFRHETR FKQRMLELTD 1200
    TNNIAYLFLS AANRWLEVRT DYLGACIVLT ASIASISGSS NSGLVGLGLL 1250
    YALTITNYLN WVVRNLADLE VQMGAVKKVN SFLTMESENY EGTMDPSQVP 1300
    EHWPQEGEIK IHDLCVRYEN NLKPVLKHVK AYIKPGQKVG ICGRTGSGKS 1350
    SLSLAFFRMV DIFDGKIVID GIDISKLPLH TLRSRLSIIL QDPILFSGSI 1400
    RFNLDPECKC TDDRLWEALE IAQLKNMVKS LPGGLDATVT EGGENFSVGQ 1450
    RQLFCLARAF VRKSSILIMD EATASIDMAT ENILQKVVMT AFADRTVVTI 1500
    AHRVSSIVDA GLVLVFSEGI LVECDTGPNL LQHKNGLFST LVMTNK 1546
    Length:1,546
    Mass (Da):174,239
    Last modified:November 1, 1999 - v2
    Checksum:i91EEDFA2ECD9DBC2
    GO
    Isoform SUR2B (identifier: P70170-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1505-1546: SSIVDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

    Show »
    Length:1,546
    Mass (Da):174,458
    Checksum:i17C23B6B8F739E7C
    GO
    Isoform SUR2C (identifier: P70170-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         636-670: Missing.

    Show »
    Length:1,511
    Mass (Da):170,091
    Checksum:iFFA9A2736D51F190
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei636 – 67035Missing in isoform SUR2C. 1 PublicationVSP_000059Add
    BLAST
    Alternative sequencei1505 – 154642SSIVD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 1 PublicationVSP_000060Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86037 mRNA. Translation: BAA12969.2.
    D86038 mRNA. Translation: BAA12970.2.
    AF003531 mRNA. Translation: AAB58753.1.
    U97066 mRNA. Translation: AAB58701.1.
    CCDSiCCDS39696.1. [P70170-2]
    CCDS39697.1. [P70170-3]
    CCDS39699.1. [P70170-1]
    PIRiT42711.
    T42728.
    RefSeqiNP_001038185.1. NM_001044720.1.
    NP_035641.1. NM_011511.2. [P70170-2]
    NP_066378.1. NM_021041.2. [P70170-1]
    NP_066379.2. NM_021042.2. [P70170-3]
    XP_006507011.1. XM_006506948.1. [P70170-2]
    XP_006507012.1. XM_006506949.1. [P70170-2]
    XP_006507013.1. XM_006506950.1. [P70170-2]
    XP_006507014.1. XM_006506951.1. [P70170-2]
    UniGeneiMm.35670.
    Mm.395475.

    Genome annotation databases

    EnsembliENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249. [P70170-3]
    ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249. [P70170-1]
    ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249. [P70170-2]
    GeneIDi20928.
    KEGGimmu:20928.
    UCSCiuc009epm.1. mouse. [P70170-1]
    uc009epo.1. mouse. [P70170-3]
    uc009epp.1. mouse. [P70170-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D86037 mRNA. Translation: BAA12969.2 .
    D86038 mRNA. Translation: BAA12970.2 .
    AF003531 mRNA. Translation: AAB58753.1 .
    U97066 mRNA. Translation: AAB58701.1 .
    CCDSi CCDS39696.1. [P70170-2 ]
    CCDS39697.1. [P70170-3 ]
    CCDS39699.1. [P70170-1 ]
    PIRi T42711.
    T42728.
    RefSeqi NP_001038185.1. NM_001044720.1.
    NP_035641.1. NM_011511.2. [P70170-2 ]
    NP_066378.1. NM_021041.2. [P70170-1 ]
    NP_066379.2. NM_021042.2. [P70170-3 ]
    XP_006507011.1. XM_006506948.1. [P70170-2 ]
    XP_006507012.1. XM_006506949.1. [P70170-2 ]
    XP_006507013.1. XM_006506950.1. [P70170-2 ]
    XP_006507014.1. XM_006506951.1. [P70170-2 ]
    UniGenei Mm.35670.
    Mm.395475.

    3D structure databases

    ProteinModelPortali P70170.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-4996941.

    PTM databases

    PhosphoSitei P70170.

    Proteomic databases

    PaxDbi P70170.
    PRIDEi P70170.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000073173 ; ENSMUSP00000072914 ; ENSMUSG00000030249 . [P70170-3 ]
    ENSMUST00000087527 ; ENSMUSP00000084805 ; ENSMUSG00000030249 . [P70170-1 ]
    ENSMUST00000100827 ; ENSMUSP00000098390 ; ENSMUSG00000030249 . [P70170-2 ]
    GeneIDi 20928.
    KEGGi mmu:20928.
    UCSCi uc009epm.1. mouse. [P70170-1 ]
    uc009epo.1. mouse. [P70170-3 ]
    uc009epp.1. mouse. [P70170-2 ]

    Organism-specific databases

    CTDi 10060.
    MGIi MGI:1352630. Abcc9.

    Phylogenomic databases

    eggNOGi COG1132.
    GeneTreei ENSGT00750000117379.
    HOVERGENi HBG101342.
    KOi K05033.
    OMAi MMVILNG.
    OrthoDBi EOG7MWGW0.
    PhylomeDBi P70170.
    TreeFami TF105201.

    Enzyme and pathway databases

    Reactomei REACT_199102. ATP sensitive Potassium channels.

    Miscellaneous databases

    NextBioi 299845.
    PROi P70170.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P70170.
    Bgeei P70170.
    Genevestigatori P70170.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    InterProi IPR003593. AAA+_ATPase.
    IPR011527. ABC1_TM_dom.
    IPR003439. ABC_transporter-like.
    IPR017871. ABC_transporter_CS.
    IPR001140. ABC_transptr_TM_dom.
    IPR027417. P-loop_NTPase.
    IPR001475. Sulphonylurea_rcpt-2.
    IPR000388. Sulphorea_rcpt.
    [Graphical view ]
    Pfami PF00664. ABC_membrane. 2 hits.
    PF00005. ABC_tran. 2 hits.
    [Graphical view ]
    PRINTSi PR01094. SULFNYLUR2.
    PR01092. SULFNYLUREAR.
    SMARTi SM00382. AAA. 2 hits.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 2 hits.
    SSF90123. SSF90123. 2 hits.
    PROSITEi PS50929. ABC_TM1F. 2 hits.
    PS00211. ABC_TRANSPORTER_1. 2 hits.
    PS50893. ABC_TRANSPORTER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel."
      Isomoto S., Kondo C., Yamada M., Matsumoto S., Higashiguchi O., Horio Y., Matsuzawa Y., Kurachi Y.
      J. Biol. Chem. 271:24321-24324(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SUR2A AND SUR2B).
      Tissue: Heart.
    2. "Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels."
      Chutkow W.A., Simon M.C., Le Beau M.M., Burant C.F.
      Diabetes 45:1439-1445(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SUR2A AND SUR2C).
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 493-498, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiABCC9_MOUSE
    AccessioniPrimary (citable) accession number: P70170
    Secondary accession number(s): O08902, O08920, P70171
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 26, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3