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P70170

- ABCC9_MOUSE

UniProt

P70170 - ABCC9_MOUSE

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Protein
ATP-binding cassette sub-family C member 9
Gene
Abcc9, Sur2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi702 – 7098ATP 1 Reviewed prediction
Nucleotide bindingi1343 – 13508ATP 2 Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  3. sulfonylurea receptor activity Source: InterPro

GO - Biological processi

  1. defense response to virus Source: MGI
  2. potassium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_199102. ATP sensitive Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
Gene namesi
Name:Abcc9
Synonyms:Sur2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1352630. Abcc9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030Extracellular Reviewed prediction
Add
BLAST
Transmembranei31 – 5121Helical; Name=1; Reviewed prediction
Add
BLAST
Topological domaini52 – 7221Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei73 – 9321Helical; Name=2; Reviewed prediction
Add
BLAST
Topological domaini94 – 1018Extracellular Reviewed prediction
Transmembranei102 – 12221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini123 – 13210Cytoplasmic Reviewed prediction
Transmembranei133 – 15321Helical; Name=4; Reviewed prediction
Add
BLAST
Topological domaini154 – 16714Extracellular Reviewed prediction
Add
BLAST
Transmembranei168 – 18821Helical; Name=5; Reviewed prediction
Add
BLAST
Topological domaini189 – 301113Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Name=6; Reviewed prediction
Add
BLAST
Topological domaini323 – 34826Extracellular Reviewed prediction
Add
BLAST
Transmembranei349 – 36921Helical; Name=7; Reviewed prediction
Add
BLAST
Topological domaini370 – 42152Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei422 – 44221Helical; Name=8; Reviewed prediction
Add
BLAST
Topological domaini443 – 45311Extracellular Reviewed prediction
Add
BLAST
Transmembranei454 – 47421Helical; Name=9; Reviewed prediction
Add
BLAST
Topological domaini475 – 52955Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei530 – 55021Helical; Name=10; Reviewed prediction
Add
BLAST
Topological domaini551 – 56919Extracellular Reviewed prediction
Add
BLAST
Transmembranei570 – 59021Helical; Name=11; Reviewed prediction
Add
BLAST
Topological domaini591 – 987397Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei988 – 100821Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini1009 – 103123Extracellular Reviewed prediction
Add
BLAST
Transmembranei1032 – 105221Helical; Name=13; Reviewed prediction
Add
BLAST
Topological domaini1053 – 112472Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei1125 – 114521Helical; Name=14; Reviewed prediction
Add
BLAST
Topological domaini1146 – 124297Extracellular Reviewed prediction
Add
BLAST
Transmembranei1243 – 126321Helical; Name=15; Reviewed prediction
Add
BLAST
Topological domaini1264 – 1546283Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. plasma membrane Source: MGI
  2. sarcolemma Source: MGI
  3. sarcomere Source: MGI
  4. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15461546ATP-binding cassette sub-family C member 9
PRO_0000093403Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...) Reviewed prediction
Glycosylationi330 – 3301N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70170.
PRIDEiP70170.

PTM databases

PhosphoSiteiP70170.

Expressioni

Tissue specificityi

Isoforms SUR2A and SUR2B are found in cerebellum, eye, atrium, ventricle, urinary bladder and skeletal muscle. Isoform SUR2B is also found in forebrain, liver, lung, pancreas, kidney, spleen, stomach, small intestine, colon, uterus, ovary and fat tissue. Isoform SUR2C is expressed exclusively in the heart.

Gene expression databases

ArrayExpressiP70170.
BgeeiP70170.
GenevestigatoriP70170.

Interactioni

Subunit structurei

Interacts with KCNJ11.

Protein-protein interaction databases

MINTiMINT-4996941.

Structurei

3D structure databases

ProteinModelPortaliP70170.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 595299ABC transmembrane type-1 1
Add
BLAST
Domaini669 – 909241ABC transporter 1
Add
BLAST
Domaini991 – 1271281ABC transmembrane type-1 2
Add
BLAST
Domaini1309 – 1543235ABC transporter 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00750000117379.
HOVERGENiHBG101342.
KOiK05033.
OMAiMMVILNG.
OrthoDBiEOG7MWGW0.
PhylomeDBiP70170.
TreeFamiTF105201.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform SUR2A (identifier: P70170-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSLSFCGNNI SSYNIYYGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG     50
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSHRASR 100
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI 150
KLVKYWQLGW GVSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ 200
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK 250
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 300
STFRYLADLL GFAGPLCISG IVQRVNEKTN TTREMFPETL SSKEFLENAH 350
VLAVLLFLAL ILQRTFLQAS YYVTIETGIN LRGALLAMIY NKILRLSTSN 400
LSMGEMTLGQ INNLVAIETN QLMWFLFLCP NLWAMPVQII MGVILLYNLL 450
GSSALVGAAV IVLLAPIQYF IATKLAEAQK STLDYSTERL KKTNEILKGI 500
KLLKLYAWEH IFCKSVEETR MKELSSLKTF ALYTSLSIFM NAAIPIAAVL 550
ATFVTHAYAS GNNLKPAEAF ASLSLFHILV TPLFLLSTVV RFAVKAIISV 600
QKLNEFLLSD EIGEDSWRAG EGTLPFESCK KHTGVQSKPI NRKQPGRYHL 650
DSYEQARRLR PAETEDIAIK VTNGYFSWGS GLATLSNIDI RIPTGQLTMI 700
VGQVGCGKSS LLLAILGEMQ TLEGKVYWNN VNESEPSFEA TRSRSRYSVA 750
YAAQKPWLLN ATVEENITFG SPFNRQRYKA VTDACSLQPD IDLLPFGDQT 800
EIGERGINLS GGQRQRICVA RALYQNTNIV FLDDPFSALD IHLSDHLMQE 850
GILKFLQDDK RTVVLVTHKL QYLTHADWII AMKDGSVLRE GTLKDIQTKD 900
VELYEHWKTL MNRQDQELEK DMEADQTTLE RKTLRRAMYS REAKAQMEDE 950
DEEEEEEEDE EDNMSTVMRL RTKMPWKTCW WYLTSGGFFL LFLMIFSKLL 1000
KHSVIVAIDY WLATWTSEYS INHPGKADQT FYVAGFSILC GAGIFLCLVT 1050
SLTVEWMGLT AAKNLHHNLL NKIILGPIRF FDTTPLGLIL NRFSADTNII 1100
DQHIPPTLES LTRSTLLCLS AIGMISYATP VFLVALAPLG VAFYFIQKYF 1150
RVASKDLQEL DDSTQLPLLC HFSETAEGLT TIRAFRHETR FKQRMLELTD 1200
TNNIAYLFLS AANRWLEVRT DYLGACIVLT ASIASISGSS NSGLVGLGLL 1250
YALTITNYLN WVVRNLADLE VQMGAVKKVN SFLTMESENY EGTMDPSQVP 1300
EHWPQEGEIK IHDLCVRYEN NLKPVLKHVK AYIKPGQKVG ICGRTGSGKS 1350
SLSLAFFRMV DIFDGKIVID GIDISKLPLH TLRSRLSIIL QDPILFSGSI 1400
RFNLDPECKC TDDRLWEALE IAQLKNMVKS LPGGLDATVT EGGENFSVGQ 1450
RQLFCLARAF VRKSSILIMD EATASIDMAT ENILQKVVMT AFADRTVVTI 1500
AHRVSSIVDA GLVLVFSEGI LVECDTGPNL LQHKNGLFST LVMTNK 1546
Length:1,546
Mass (Da):174,239
Last modified:November 1, 1999 - v2
Checksum:i91EEDFA2ECD9DBC2
GO
Isoform SUR2B (identifier: P70170-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1546: SSIVDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

Show »
Length:1,546
Mass (Da):174,458
Checksum:i17C23B6B8F739E7C
GO
Isoform SUR2C (identifier: P70170-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-670: Missing.

Show »
Length:1,511
Mass (Da):170,091
Checksum:iFFA9A2736D51F190
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei636 – 67035Missing in isoform SUR2C.
VSP_000059Add
BLAST
Alternative sequencei1505 – 154642SSIVD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B.
VSP_000060Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86037 mRNA. Translation: BAA12969.2.
D86038 mRNA. Translation: BAA12970.2.
AF003531 mRNA. Translation: AAB58753.1.
U97066 mRNA. Translation: AAB58701.1.
CCDSiCCDS39696.1. [P70170-2]
CCDS39697.1. [P70170-3]
CCDS39699.1. [P70170-1]
PIRiT42711.
T42728.
RefSeqiNP_001038185.1. NM_001044720.1.
NP_035641.1. NM_011511.2. [P70170-2]
NP_066378.1. NM_021041.2. [P70170-1]
NP_066379.2. NM_021042.2. [P70170-3]
XP_006507011.1. XM_006506948.1. [P70170-2]
XP_006507012.1. XM_006506949.1. [P70170-2]
XP_006507013.1. XM_006506950.1. [P70170-2]
XP_006507014.1. XM_006506951.1. [P70170-2]
UniGeneiMm.35670.
Mm.395475.

Genome annotation databases

EnsembliENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249. [P70170-3]
ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249. [P70170-1]
ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249. [P70170-2]
GeneIDi20928.
KEGGimmu:20928.
UCSCiuc009epm.1. mouse. [P70170-1]
uc009epo.1. mouse. [P70170-3]
uc009epp.1. mouse. [P70170-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D86037 mRNA. Translation: BAA12969.2 .
D86038 mRNA. Translation: BAA12970.2 .
AF003531 mRNA. Translation: AAB58753.1 .
U97066 mRNA. Translation: AAB58701.1 .
CCDSi CCDS39696.1. [P70170-2 ]
CCDS39697.1. [P70170-3 ]
CCDS39699.1. [P70170-1 ]
PIRi T42711.
T42728.
RefSeqi NP_001038185.1. NM_001044720.1.
NP_035641.1. NM_011511.2. [P70170-2 ]
NP_066378.1. NM_021041.2. [P70170-1 ]
NP_066379.2. NM_021042.2. [P70170-3 ]
XP_006507011.1. XM_006506948.1. [P70170-2 ]
XP_006507012.1. XM_006506949.1. [P70170-2 ]
XP_006507013.1. XM_006506950.1. [P70170-2 ]
XP_006507014.1. XM_006506951.1. [P70170-2 ]
UniGenei Mm.35670.
Mm.395475.

3D structure databases

ProteinModelPortali P70170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996941.

PTM databases

PhosphoSitei P70170.

Proteomic databases

PaxDbi P70170.
PRIDEi P70170.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073173 ; ENSMUSP00000072914 ; ENSMUSG00000030249 . [P70170-3 ]
ENSMUST00000087527 ; ENSMUSP00000084805 ; ENSMUSG00000030249 . [P70170-1 ]
ENSMUST00000100827 ; ENSMUSP00000098390 ; ENSMUSG00000030249 . [P70170-2 ]
GeneIDi 20928.
KEGGi mmu:20928.
UCSCi uc009epm.1. mouse. [P70170-1 ]
uc009epo.1. mouse. [P70170-3 ]
uc009epp.1. mouse. [P70170-2 ]

Organism-specific databases

CTDi 10060.
MGIi MGI:1352630. Abcc9.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00750000117379.
HOVERGENi HBG101342.
KOi K05033.
OMAi MMVILNG.
OrthoDBi EOG7MWGW0.
PhylomeDBi P70170.
TreeFami TF105201.

Enzyme and pathway databases

Reactomei REACT_199102. ATP sensitive Potassium channels.

Miscellaneous databases

NextBioi 299845.
PROi P70170.
SOURCEi Search...

Gene expression databases

ArrayExpressi P70170.
Bgeei P70170.
Genevestigatori P70170.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
PRINTSi PR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel."
    Isomoto S., Kondo C., Yamada M., Matsumoto S., Higashiguchi O., Horio Y., Matsuzawa Y., Kurachi Y.
    J. Biol. Chem. 271:24321-24324(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SUR2A AND SUR2B).
    Tissue: Heart.
  2. "Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels."
    Chutkow W.A., Simon M.C., Le Beau M.M., Burant C.F.
    Diabetes 45:1439-1445(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SUR2A AND SUR2C).
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 493-498, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiABCC9_MOUSE
AccessioniPrimary (citable) accession number: P70170
Secondary accession number(s): O08902, O08920, P70171
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi