Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P70170 (ABCC9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
Gene names
Name:Abcc9
Synonyms:Sur2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1546 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Subunit structure

Interacts with KCNJ11.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Isoforms SUR2A and SUR2B are found in cerebellum, eye, atrium, ventricle, urinary bladder and skeletal muscle. Isoform SUR2B is also found in forebrain, liver, lung, pancreas, kidney, spleen, stomach, small intestine, colon, uterus, ovary and fat tissue. Isoform SUR2C is expressed exclusively in the heart.

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform SUR2A (identifier: P70170-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform SUR2B (identifier: P70170-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1546: SSIVDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM
Isoform SUR2C (identifier: P70170-3)

The sequence of this isoform differs from the canonical sequence as follows:
     636-670: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15461546ATP-binding cassette sub-family C member 9
PRO_0000093403

Regions

Topological domain1 – 3030Extracellular Potential
Transmembrane31 – 5121Helical; Name=1; Potential
Topological domain52 – 7221Cytoplasmic Potential
Transmembrane73 – 9321Helical; Name=2; Potential
Topological domain94 – 1018Extracellular Potential
Transmembrane102 – 12221Helical; Name=3; Potential
Topological domain123 – 13210Cytoplasmic Potential
Transmembrane133 – 15321Helical; Name=4; Potential
Topological domain154 – 16714Extracellular Potential
Transmembrane168 – 18821Helical; Name=5; Potential
Topological domain189 – 301113Cytoplasmic Potential
Transmembrane302 – 32221Helical; Name=6; Potential
Topological domain323 – 34826Extracellular Potential
Transmembrane349 – 36921Helical; Name=7; Potential
Topological domain370 – 42152Cytoplasmic Potential
Transmembrane422 – 44221Helical; Name=8; Potential
Topological domain443 – 45311Extracellular Potential
Transmembrane454 – 47421Helical; Name=9; Potential
Topological domain475 – 52955Cytoplasmic Potential
Transmembrane530 – 55021Helical; Name=10; Potential
Topological domain551 – 56919Extracellular Potential
Transmembrane570 – 59021Helical; Name=11; Potential
Topological domain591 – 987397Cytoplasmic Potential
Transmembrane988 – 100821Helical; Name=12; Potential
Topological domain1009 – 103123Extracellular Potential
Transmembrane1032 – 105221Helical; Name=13; Potential
Topological domain1053 – 112472Cytoplasmic Potential
Transmembrane1125 – 114521Helical; Name=14; Potential
Topological domain1146 – 124297Extracellular Potential
Transmembrane1243 – 126321Helical; Name=15; Potential
Topological domain1264 – 1546283Cytoplasmic Potential
Domain297 – 595299ABC transmembrane type-1 1
Domain669 – 909241ABC transporter 1
Domain991 – 1271281ABC transmembrane type-1 2
Domain1309 – 1543235ABC transporter 2
Nucleotide binding702 – 7098ATP 1 Potential
Nucleotide binding1343 – 13508ATP 2 Potential

Amino acid modifications

Glycosylation91N-linked (GlcNAc...) Potential
Glycosylation3301N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence636 – 67035Missing in isoform SUR2C.
VSP_000059
Alternative sequence1505 – 154642SSIVD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B.
VSP_000060

Sequences

Sequence LengthMass (Da)Tools
Isoform SUR2A [UniParc].

Last modified November 1, 1999. Version 2.
Checksum: 91EEDFA2ECD9DBC2

FASTA1,546174,239
        10         20         30         40         50         60 
MSLSFCGNNI SSYNIYYGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG SQSSKVQIHH 

        70         80         90        100        110        120 
NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSHRASR HLHLFMPAVM GFVATTTSIV 

       130        140        150        160        170        180 
YYHNIETSNF PKLLLALFLY WVMAFITKTI KLVKYWQLGW GVSDLRFCIT GVMVILNGLL 

       190        200        210        220        230        240 
MAVEINVIRV RRYVFFMNPQ KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR 

       250        260        270        280        290        300 
KPIDLKAIGK LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS 

       310        320        330        340        350        360 
STFRYLADLL GFAGPLCISG IVQRVNEKTN TTREMFPETL SSKEFLENAH VLAVLLFLAL 

       370        380        390        400        410        420 
ILQRTFLQAS YYVTIETGIN LRGALLAMIY NKILRLSTSN LSMGEMTLGQ INNLVAIETN 

       430        440        450        460        470        480 
QLMWFLFLCP NLWAMPVQII MGVILLYNLL GSSALVGAAV IVLLAPIQYF IATKLAEAQK 

       490        500        510        520        530        540 
STLDYSTERL KKTNEILKGI KLLKLYAWEH IFCKSVEETR MKELSSLKTF ALYTSLSIFM 

       550        560        570        580        590        600 
NAAIPIAAVL ATFVTHAYAS GNNLKPAEAF ASLSLFHILV TPLFLLSTVV RFAVKAIISV 

       610        620        630        640        650        660 
QKLNEFLLSD EIGEDSWRAG EGTLPFESCK KHTGVQSKPI NRKQPGRYHL DSYEQARRLR 

       670        680        690        700        710        720 
PAETEDIAIK VTNGYFSWGS GLATLSNIDI RIPTGQLTMI VGQVGCGKSS LLLAILGEMQ 

       730        740        750        760        770        780 
TLEGKVYWNN VNESEPSFEA TRSRSRYSVA YAAQKPWLLN ATVEENITFG SPFNRQRYKA 

       790        800        810        820        830        840 
VTDACSLQPD IDLLPFGDQT EIGERGINLS GGQRQRICVA RALYQNTNIV FLDDPFSALD 

       850        860        870        880        890        900 
IHLSDHLMQE GILKFLQDDK RTVVLVTHKL QYLTHADWII AMKDGSVLRE GTLKDIQTKD 

       910        920        930        940        950        960 
VELYEHWKTL MNRQDQELEK DMEADQTTLE RKTLRRAMYS REAKAQMEDE DEEEEEEEDE 

       970        980        990       1000       1010       1020 
EDNMSTVMRL RTKMPWKTCW WYLTSGGFFL LFLMIFSKLL KHSVIVAIDY WLATWTSEYS 

      1030       1040       1050       1060       1070       1080 
INHPGKADQT FYVAGFSILC GAGIFLCLVT SLTVEWMGLT AAKNLHHNLL NKIILGPIRF 

      1090       1100       1110       1120       1130       1140 
FDTTPLGLIL NRFSADTNII DQHIPPTLES LTRSTLLCLS AIGMISYATP VFLVALAPLG 

      1150       1160       1170       1180       1190       1200 
VAFYFIQKYF RVASKDLQEL DDSTQLPLLC HFSETAEGLT TIRAFRHETR FKQRMLELTD 

      1210       1220       1230       1240       1250       1260 
TNNIAYLFLS AANRWLEVRT DYLGACIVLT ASIASISGSS NSGLVGLGLL YALTITNYLN 

      1270       1280       1290       1300       1310       1320 
WVVRNLADLE VQMGAVKKVN SFLTMESENY EGTMDPSQVP EHWPQEGEIK IHDLCVRYEN 

      1330       1340       1350       1360       1370       1380 
NLKPVLKHVK AYIKPGQKVG ICGRTGSGKS SLSLAFFRMV DIFDGKIVID GIDISKLPLH 

      1390       1400       1410       1420       1430       1440 
TLRSRLSIIL QDPILFSGSI RFNLDPECKC TDDRLWEALE IAQLKNMVKS LPGGLDATVT 

      1450       1460       1470       1480       1490       1500 
EGGENFSVGQ RQLFCLARAF VRKSSILIMD EATASIDMAT ENILQKVVMT AFADRTVVTI 

      1510       1520       1530       1540 
AHRVSSIVDA GLVLVFSEGI LVECDTGPNL LQHKNGLFST LVMTNK 

« Hide

Isoform SUR2B [UniParc].

Checksum: 17C23B6B8F739E7C
Show »

FASTA1,546174,458
Isoform SUR2C [UniParc].

Checksum: FFA9A2736D51F190
Show »

FASTA1,511170,091

References

[1]"A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel."
Isomoto S., Kondo C., Yamada M., Matsumoto S., Higashiguchi O., Horio Y., Matsuzawa Y., Kurachi Y.
J. Biol. Chem. 271:24321-24324(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SUR2A AND SUR2B).
Tissue: Heart.
[2]"Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels."
Chutkow W.A., Simon M.C., Le Beau M.M., Burant C.F.
Diabetes 45:1439-1445(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SUR2A AND SUR2C).
[3]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 493-498, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D86037 mRNA. Translation: BAA12969.2.
D86038 mRNA. Translation: BAA12970.2.
AF003531 mRNA. Translation: AAB58753.1.
U97066 mRNA. Translation: AAB58701.1.
PIRT42711.
T42728.
RefSeqNP_001038185.1. NM_001044720.1.
NP_035641.1. NM_011511.2.
NP_066378.1. NM_021041.2.
NP_066379.2. NM_021042.2.
XP_006507011.1. XM_006506948.1.
XP_006507012.1. XM_006506949.1.
XP_006507013.1. XM_006506950.1.
XP_006507014.1. XM_006506951.1.
UniGeneMm.35670.
Mm.395475.

3D structure databases

ProteinModelPortalP70170.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-4996941.

PTM databases

PhosphoSiteP70170.

Proteomic databases

PaxDbP70170.
PRIDEP70170.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249. [P70170-3]
ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249. [P70170-1]
ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249. [P70170-2]
GeneID20928.
KEGGmmu:20928.
UCSCuc009epm.1. mouse. [P70170-1]
uc009epo.1. mouse. [P70170-3]
uc009epp.1. mouse. [P70170-2]

Organism-specific databases

CTD10060.
MGIMGI:1352630. Abcc9.

Phylogenomic databases

eggNOGCOG1132.
GeneTreeENSGT00750000117379.
HOVERGENHBG101342.
KOK05033.
OMAMMVILNG.
OrthoDBEOG7MWGW0.
PhylomeDBP70170.
TreeFamTF105201.

Gene expression databases

ArrayExpressP70170.
BgeeP70170.
GenevestigatorP70170.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
InterProIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSPR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio299845.
PROP70170.
SOURCESearch...

Entry information

Entry nameABCC9_MOUSE
AccessionPrimary (citable) accession number: P70170
Secondary accession number(s): O08902, O08920, P70171
Entry history
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 121 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot