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P70170

- ABCC9_MOUSE

UniProt

P70170 - ABCC9_MOUSE

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Protein

ATP-binding cassette sub-family C member 9

Gene

Abcc9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi702 – 7098ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1343 – 13508ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. sulfonylurea receptor activity Source: InterPro

GO - Biological processi

  1. defense response to virus Source: MGI
  2. potassium ion transmembrane transport Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_199102. ATP sensitive Potassium channels.
REACT_237882. ABC-family proteins mediated transport.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family C member 9
Alternative name(s):
Sulfonylurea receptor 2
Gene namesi
Name:Abcc9
Synonyms:Sur2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:1352630. Abcc9.

Subcellular locationi

Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3030ExtracellularSequence AnalysisAdd
BLAST
Transmembranei31 – 5121Helical; Name=1PROSITE-ProRule annotationAdd
BLAST
Topological domaini52 – 7221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei73 – 9321Helical; Name=2PROSITE-ProRule annotationAdd
BLAST
Topological domaini94 – 1018ExtracellularSequence Analysis
Transmembranei102 – 12221Helical; Name=3PROSITE-ProRule annotationAdd
BLAST
Topological domaini123 – 13210CytoplasmicSequence Analysis
Transmembranei133 – 15321Helical; Name=4PROSITE-ProRule annotationAdd
BLAST
Topological domaini154 – 16714ExtracellularSequence AnalysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=5PROSITE-ProRule annotationAdd
BLAST
Topological domaini189 – 301113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei302 – 32221Helical; Name=6PROSITE-ProRule annotationAdd
BLAST
Topological domaini323 – 34826ExtracellularSequence AnalysisAdd
BLAST
Transmembranei349 – 36921Helical; Name=7PROSITE-ProRule annotationAdd
BLAST
Topological domaini370 – 42152CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei422 – 44221Helical; Name=8PROSITE-ProRule annotationAdd
BLAST
Topological domaini443 – 45311ExtracellularSequence AnalysisAdd
BLAST
Transmembranei454 – 47421Helical; Name=9PROSITE-ProRule annotationAdd
BLAST
Topological domaini475 – 52955CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei530 – 55021Helical; Name=10PROSITE-ProRule annotationAdd
BLAST
Topological domaini551 – 56919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei570 – 59021Helical; Name=11PROSITE-ProRule annotationAdd
BLAST
Topological domaini591 – 987397CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei988 – 100821Helical; Name=12PROSITE-ProRule annotationAdd
BLAST
Topological domaini1009 – 103123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1032 – 105221Helical; Name=13PROSITE-ProRule annotationAdd
BLAST
Topological domaini1053 – 112472CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei1125 – 114521Helical; Name=14PROSITE-ProRule annotationAdd
BLAST
Topological domaini1146 – 124297ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1243 – 126321Helical; Name=15PROSITE-ProRule annotationAdd
BLAST
Topological domaini1264 – 1546283CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. plasma membrane Source: MGI
  2. sarcolemma Source: MGI
  3. sarcomere Source: MGI
  4. voltage-gated potassium channel complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 15461546ATP-binding cassette sub-family C member 9PRO_0000093403Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi9 – 91N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP70170.
PRIDEiP70170.

PTM databases

PhosphoSiteiP70170.

Expressioni

Tissue specificityi

Isoforms SUR2A and SUR2B are found in cerebellum, eye, atrium, ventricle, urinary bladder and skeletal muscle. Isoform SUR2B is also found in forebrain, liver, lung, pancreas, kidney, spleen, stomach, small intestine, colon, uterus, ovary and fat tissue. Isoform SUR2C is expressed exclusively in the heart.

Gene expression databases

BgeeiP70170.
ExpressionAtlasiP70170. baseline and differential.
GenevestigatoriP70170.

Interactioni

Subunit structurei

Interacts with KCNJ11.

Protein-protein interaction databases

MINTiMINT-4996941.

Structurei

3D structure databases

ProteinModelPortaliP70170.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini297 – 595299ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini669 – 909241ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini991 – 1271281ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1309 – 1543235ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1132.
GeneTreeiENSGT00770000120514.
HOVERGENiHBG101342.
InParanoidiP70170.
KOiK05033.
OMAiMMVILNG.
OrthoDBiEOG7MWGW0.
PhylomeDBiP70170.
TreeFamiTF105201.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
PRINTSiPR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform SUR2A (identifier: P70170-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLSFCGNNI SSYNIYYGVL QNPCFVDALN LVPHVFLLFI TFPILFIGWG
60 70 80 90 100
SQSSKVQIHH NTWLHFPGHN LRWILTFALL FVHVCEIAEG IVSDSHRASR
110 120 130 140 150
HLHLFMPAVM GFVATTTSIV YYHNIETSNF PKLLLALFLY WVMAFITKTI
160 170 180 190 200
KLVKYWQLGW GVSDLRFCIT GVMVILNGLL MAVEINVIRV RRYVFFMNPQ
210 220 230 240 250
KVKPPEDLQD LGVRFLQPFV NLLSKATYWW MNTLIISAHR KPIDLKAIGK
260 270 280 290 300
LPIAMRAVTN YVCLKEAYEE QKKKAADHPN RTPSIWLAMY RAFGRPILLS
310 320 330 340 350
STFRYLADLL GFAGPLCISG IVQRVNEKTN TTREMFPETL SSKEFLENAH
360 370 380 390 400
VLAVLLFLAL ILQRTFLQAS YYVTIETGIN LRGALLAMIY NKILRLSTSN
410 420 430 440 450
LSMGEMTLGQ INNLVAIETN QLMWFLFLCP NLWAMPVQII MGVILLYNLL
460 470 480 490 500
GSSALVGAAV IVLLAPIQYF IATKLAEAQK STLDYSTERL KKTNEILKGI
510 520 530 540 550
KLLKLYAWEH IFCKSVEETR MKELSSLKTF ALYTSLSIFM NAAIPIAAVL
560 570 580 590 600
ATFVTHAYAS GNNLKPAEAF ASLSLFHILV TPLFLLSTVV RFAVKAIISV
610 620 630 640 650
QKLNEFLLSD EIGEDSWRAG EGTLPFESCK KHTGVQSKPI NRKQPGRYHL
660 670 680 690 700
DSYEQARRLR PAETEDIAIK VTNGYFSWGS GLATLSNIDI RIPTGQLTMI
710 720 730 740 750
VGQVGCGKSS LLLAILGEMQ TLEGKVYWNN VNESEPSFEA TRSRSRYSVA
760 770 780 790 800
YAAQKPWLLN ATVEENITFG SPFNRQRYKA VTDACSLQPD IDLLPFGDQT
810 820 830 840 850
EIGERGINLS GGQRQRICVA RALYQNTNIV FLDDPFSALD IHLSDHLMQE
860 870 880 890 900
GILKFLQDDK RTVVLVTHKL QYLTHADWII AMKDGSVLRE GTLKDIQTKD
910 920 930 940 950
VELYEHWKTL MNRQDQELEK DMEADQTTLE RKTLRRAMYS REAKAQMEDE
960 970 980 990 1000
DEEEEEEEDE EDNMSTVMRL RTKMPWKTCW WYLTSGGFFL LFLMIFSKLL
1010 1020 1030 1040 1050
KHSVIVAIDY WLATWTSEYS INHPGKADQT FYVAGFSILC GAGIFLCLVT
1060 1070 1080 1090 1100
SLTVEWMGLT AAKNLHHNLL NKIILGPIRF FDTTPLGLIL NRFSADTNII
1110 1120 1130 1140 1150
DQHIPPTLES LTRSTLLCLS AIGMISYATP VFLVALAPLG VAFYFIQKYF
1160 1170 1180 1190 1200
RVASKDLQEL DDSTQLPLLC HFSETAEGLT TIRAFRHETR FKQRMLELTD
1210 1220 1230 1240 1250
TNNIAYLFLS AANRWLEVRT DYLGACIVLT ASIASISGSS NSGLVGLGLL
1260 1270 1280 1290 1300
YALTITNYLN WVVRNLADLE VQMGAVKKVN SFLTMESENY EGTMDPSQVP
1310 1320 1330 1340 1350
EHWPQEGEIK IHDLCVRYEN NLKPVLKHVK AYIKPGQKVG ICGRTGSGKS
1360 1370 1380 1390 1400
SLSLAFFRMV DIFDGKIVID GIDISKLPLH TLRSRLSIIL QDPILFSGSI
1410 1420 1430 1440 1450
RFNLDPECKC TDDRLWEALE IAQLKNMVKS LPGGLDATVT EGGENFSVGQ
1460 1470 1480 1490 1500
RQLFCLARAF VRKSSILIMD EATASIDMAT ENILQKVVMT AFADRTVVTI
1510 1520 1530 1540
AHRVSSIVDA GLVLVFSEGI LVECDTGPNL LQHKNGLFST LVMTNK
Length:1,546
Mass (Da):174,239
Last modified:November 1, 1999 - v2
Checksum:i91EEDFA2ECD9DBC2
GO
Isoform SUR2B (identifier: P70170-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1505-1546: SSIVDAGLVL...LFSTLVMTNK → HTILTADLVI...VFASFVRADM

Show »
Length:1,546
Mass (Da):174,458
Checksum:i17C23B6B8F739E7C
GO
Isoform SUR2C (identifier: P70170-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     636-670: Missing.

Show »
Length:1,511
Mass (Da):170,091
Checksum:iFFA9A2736D51F190
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei636 – 67035Missing in isoform SUR2C. 1 PublicationVSP_000059Add
BLAST
Alternative sequencei1505 – 154642SSIVD…VMTNK → HTILTADLVIVMKRGNILEY DTPESLLAQEDGVFASFVRA DM in isoform SUR2B. 1 PublicationVSP_000060Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86037 mRNA. Translation: BAA12969.2.
D86038 mRNA. Translation: BAA12970.2.
AF003531 mRNA. Translation: AAB58753.1.
U97066 mRNA. Translation: AAB58701.1.
CCDSiCCDS39696.1. [P70170-2]
CCDS39697.1. [P70170-3]
CCDS39699.1. [P70170-1]
PIRiT42711.
T42728.
RefSeqiNP_001038185.1. NM_001044720.1.
NP_035641.1. NM_011511.2. [P70170-2]
NP_066378.1. NM_021041.2. [P70170-1]
NP_066379.2. NM_021042.2. [P70170-3]
XP_006507011.1. XM_006506948.1. [P70170-2]
XP_006507012.1. XM_006506949.1. [P70170-2]
XP_006507013.1. XM_006506950.1. [P70170-2]
XP_006507014.1. XM_006506951.1. [P70170-2]
UniGeneiMm.35670.
Mm.395475.

Genome annotation databases

EnsembliENSMUST00000073173; ENSMUSP00000072914; ENSMUSG00000030249. [P70170-3]
ENSMUST00000087527; ENSMUSP00000084805; ENSMUSG00000030249. [P70170-1]
ENSMUST00000100827; ENSMUSP00000098390; ENSMUSG00000030249. [P70170-2]
GeneIDi20928.
KEGGimmu:20928.
UCSCiuc009epm.1. mouse. [P70170-1]
uc009epo.1. mouse. [P70170-3]
uc009epp.1. mouse. [P70170-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86037 mRNA. Translation: BAA12969.2 .
D86038 mRNA. Translation: BAA12970.2 .
AF003531 mRNA. Translation: AAB58753.1 .
U97066 mRNA. Translation: AAB58701.1 .
CCDSi CCDS39696.1. [P70170-2 ]
CCDS39697.1. [P70170-3 ]
CCDS39699.1. [P70170-1 ]
PIRi T42711.
T42728.
RefSeqi NP_001038185.1. NM_001044720.1.
NP_035641.1. NM_011511.2. [P70170-2 ]
NP_066378.1. NM_021041.2. [P70170-1 ]
NP_066379.2. NM_021042.2. [P70170-3 ]
XP_006507011.1. XM_006506948.1. [P70170-2 ]
XP_006507012.1. XM_006506949.1. [P70170-2 ]
XP_006507013.1. XM_006506950.1. [P70170-2 ]
XP_006507014.1. XM_006506951.1. [P70170-2 ]
UniGenei Mm.35670.
Mm.395475.

3D structure databases

ProteinModelPortali P70170.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4996941.

PTM databases

PhosphoSitei P70170.

Proteomic databases

PaxDbi P70170.
PRIDEi P70170.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000073173 ; ENSMUSP00000072914 ; ENSMUSG00000030249 . [P70170-3 ]
ENSMUST00000087527 ; ENSMUSP00000084805 ; ENSMUSG00000030249 . [P70170-1 ]
ENSMUST00000100827 ; ENSMUSP00000098390 ; ENSMUSG00000030249 . [P70170-2 ]
GeneIDi 20928.
KEGGi mmu:20928.
UCSCi uc009epm.1. mouse. [P70170-1 ]
uc009epo.1. mouse. [P70170-3 ]
uc009epp.1. mouse. [P70170-2 ]

Organism-specific databases

CTDi 10060.
MGIi MGI:1352630. Abcc9.

Phylogenomic databases

eggNOGi COG1132.
GeneTreei ENSGT00770000120514.
HOVERGENi HBG101342.
InParanoidi P70170.
KOi K05033.
OMAi MMVILNG.
OrthoDBi EOG7MWGW0.
PhylomeDBi P70170.
TreeFami TF105201.

Enzyme and pathway databases

Reactomei REACT_199102. ATP sensitive Potassium channels.
REACT_237882. ABC-family proteins mediated transport.

Miscellaneous databases

NextBioi 299845.
PROi P70170.
SOURCEi Search...

Gene expression databases

Bgeei P70170.
ExpressionAtlasi P70170. baseline and differential.
Genevestigatori P70170.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
InterProi IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR001140. ABC_transptr_TM_dom.
IPR027417. P-loop_NTPase.
IPR001475. Sulphonylurea_rcpt-2.
IPR000388. Sulphorea_rcpt.
[Graphical view ]
Pfami PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view ]
PRINTSi PR01094. SULFNYLUR2.
PR01092. SULFNYLUREAR.
SMARTi SM00382. AAA. 2 hits.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEi PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel."
    Isomoto S., Kondo C., Yamada M., Matsumoto S., Higashiguchi O., Horio Y., Matsuzawa Y., Kurachi Y.
    J. Biol. Chem. 271:24321-24324(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SUR2A AND SUR2B).
    Tissue: Heart.
  2. "Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels."
    Chutkow W.A., Simon M.C., Le Beau M.M., Burant C.F.
    Diabetes 45:1439-1445(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS SUR2A AND SUR2C).
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 493-498, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiABCC9_MOUSE
AccessioniPrimary (citable) accession number: P70170
Secondary accession number(s): O08902, O08920, P70171
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3