ID CALC_MOUSE Reviewed; 136 AA. AC P70160; Q8K1K5; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-FEB-1997, sequence version 1. DT 27-MAR-2024, entry version 176. DE RecName: Full=Calcitonin; DE Flags: Precursor; GN Name=Calca; Synonyms=Calc; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Thyroid; RX PubMed=8806650; DOI=10.1006/bbrc.1996.1371; RA Rehli M., Luger K., Beier W., Falk W.; RT "Molecular cloning and expression of mouse procalcitonin."; RL Biochem. Biophys. Res. Commun. 226:420-425(1996). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=129/Sv; RX PubMed=11761712; DOI=10.3109/10425170109047567; RA Thomas P.M., Nasonkin I., Zhang H., Gagel R.F., Cote G.J.; RT "Structure of the mouse calcitonin/calcitonin gene-related peptide alpha RT and beta genes."; RL DNA Seq. 12:131-135(2001). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Mammary gland; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Causes a rapid but short-lived drop in the level of calcium CC and phosphate in blood by promoting the incorporation of those ions in CC the bones. CC -!- SUBCELLULAR LOCATION: Secreted. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=Calcitonin; CC IsoId=P70160-1; Sequence=Displayed; CC Name=Calcitonin-gene related peptide I; CC IsoId=Q99JA0-1; Sequence=External; CC -!- SIMILARITY: Belongs to the calcitonin family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X97991; CAA66630.1; -; mRNA. DR EMBL; AF325522; AAK18180.1; -; Genomic_DNA. DR EMBL; AF325521; AAK18180.1; JOINED; Genomic_DNA. DR EMBL; BC030071; AAH30071.1; -; mRNA. DR CCDS; CCDS21763.1; -. [P70160-1] DR PIR; JC4977; JC4977. DR RefSeq; NP_001292545.1; NM_001305616.1. [P70160-1] DR RefSeq; NP_031613.2; NM_007587.2. [P70160-1] DR RefSeq; XP_017177447.1; XM_017321958.1. DR RefSeq; XP_017177448.1; XM_017321959.1. DR RefSeq; XP_017177449.1; XM_017321960.1. DR AlphaFoldDB; P70160; -. DR SMR; P70160; -. DR STRING; 10090.ENSMUSP00000032907; -. DR GlyCosmos; P70160; 1 site, No reported glycans. DR GlyGen; P70160; 1 site. DR PhosphoSitePlus; P70160; -. DR PaxDb; 10090-ENSMUSP00000032907; -. DR ProteomicsDB; 265326; -. [P70160-1] DR Antibodypedia; 3493; 1992 antibodies from 46 providers. DR DNASU; 12310; -. DR Ensembl; ENSMUST00000032907.9; ENSMUSP00000032907.8; ENSMUSG00000030669.14. [P70160-1] DR Ensembl; ENSMUST00000206853.2; ENSMUSP00000146328.2; ENSMUSG00000030669.14. [P70160-1] DR GeneID; 12310; -. DR UCSC; uc009jig.2; mouse. [P70160-1] DR AGR; MGI:2151253; -. DR CTD; 796; -. DR MGI; MGI:2151253; Calca. DR VEuPathDB; HostDB:ENSMUSG00000030669; -. DR eggNOG; ENOG502RZI5; Eukaryota. DR GeneTree; ENSGT00940000162876; -. DR HOGENOM; CLU_122444_0_0_1; -. DR InParanoid; P70160; -. DR OrthoDB; 4002581at2759; -. DR PhylomeDB; P70160; -. DR TreeFam; TF333069; -. DR Reactome; R-MMU-418555; G alpha (s) signalling events. DR Reactome; R-MMU-419812; Calcitonin-like ligand receptors. DR BioGRID-ORCS; 12310; 0 hits in 79 CRISPR screens. DR ChiTaRS; Calca; mouse. DR Proteomes; UP000000589; Chromosome 7. DR RNAct; P70160; Protein. DR Bgee; ENSMUSG00000030669; Expressed in facial nucleus and 100 other cell types or tissues. DR ExpressionAtlas; P70160; baseline and differential. DR GO; GO:0030424; C:axon; IDA:MGI. DR GO; GO:0005737; C:cytoplasm; IDA:MGI. DR GO; GO:0005576; C:extracellular region; IDA:MGI. DR GO; GO:0005615; C:extracellular space; ISO:MGI. DR GO; GO:0098686; C:hippocampal mossy fiber to CA3 synapse; ISO:MGI. DR GO; GO:0043005; C:neuron projection; IDA:MGI. DR GO; GO:0043025; C:neuronal cell body; ISO:MGI. DR GO; GO:0098992; C:neuronal dense core vesicle; ISO:MGI. DR GO; GO:0043195; C:terminal bouton; IDA:MGI. DR GO; GO:0031716; F:calcitonin receptor binding; IDA:MGI. DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW. DR GO; GO:0042802; F:identical protein binding; ISO:MGI. DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI. DR GO; GO:0005102; F:signaling receptor binding; IDA:MGI. DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IGI:MGI. DR GO; GO:0001984; P:artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure; IMP:MGI. DR GO; GO:1990090; P:cellular response to nerve growth factor stimulus; IDA:MGI. DR GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl. DR GO; GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:MGI. DR GO; GO:0007566; P:embryo implantation; IEA:Ensembl. DR GO; GO:0007631; P:feeding behavior; IDA:MGI. DR GO; GO:0006954; P:inflammatory response; IDA:MGI. DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IGI:MGI. DR GO; GO:0002548; P:monocyte chemotaxis; IEA:Ensembl. DR GO; GO:0045776; P:negative regulation of blood pressure; IMP:MGI. DR GO; GO:0045779; P:negative regulation of bone resorption; IEA:Ensembl. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl. DR GO; GO:0030279; P:negative regulation of ossification; IMP:MGI. DR GO; GO:0045986; P:negative regulation of smooth muscle contraction; IDA:MGI. DR GO; GO:0001976; P:nervous system process involved in regulation of systemic arterial blood pressure; ISA:MGI. DR GO; GO:0007218; P:neuropeptide signaling pathway; IDA:MGI. DR GO; GO:0001503; P:ossification; IMP:MGI. DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl. DR GO; GO:0051480; P:regulation of cytosolic calcium ion concentration; IBA:GO_Central. DR GO; GO:0009408; P:response to heat; IMP:MGI. DR GO; GO:0048265; P:response to pain; IMP:MGI. DR GO; GO:0006939; P:smooth muscle contraction; IDA:MGI. DR GO; GO:0048240; P:sperm capacitation; ISA:MGI. DR GO; GO:0042311; P:vasodilation; ISO:MGI. DR InterPro; IPR021118; Calcitonin. DR InterPro; IPR021117; Calcitonin-like. DR InterPro; IPR021116; Calcitonin/adrenomedullin. DR InterPro; IPR018360; Calcitonin_CS. DR InterPro; IPR001693; Calcitonin_peptide-like. DR PANTHER; PTHR10505:SF16; CALCITONIN; 1. DR PANTHER; PTHR10505; CALCITONIN-RELATED; 1. DR Pfam; PF00214; Calc_CGRP_IAPP; 1. DR PRINTS; PR00270; CALCITONINA. DR SMART; SM00113; CALCITONIN; 1. DR PROSITE; PS00258; CALCITONIN; 1. DR Genevisible; P70160; MM. PE 2: Evidence at transcript level; KW Alternative splicing; Amidation; Cleavage on pair of basic residues; KW Disulfide bond; Glycoprotein; Hormone; Phosphoprotein; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..25 FT /evidence="ECO:0000255" FT PROPEP 26..82 FT /id="PRO_0000004056" FT PEPTIDE 85..116 FT /note="Calcitonin" FT /id="PRO_0000004057" FT PROPEP 121..136 FT /id="PRO_0000004058" FT REGION 63..84 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 114..136 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 42 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P01257" FT MOD_RES 116 FT /note="Proline amide" FT /evidence="ECO:0000250" FT CARBOHYD 87 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000305" FT DISULFID 85..91 FT /evidence="ECO:0000250" FT CONFLICT 108 FT /note="Q -> K (in Ref. 3; AAH30071)" FT /evidence="ECO:0000305" SQ SEQUENCE 136 AA; 15141 MW; B7F1DD27F7E10DE5 CRC64; MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA ALVQDYMQMK ARELEQEEEQ EAEGSSLDSP RSKRCGNLST CMLGTYTQDL NKFHTFPQTS IGVEAPGKKR DVAKDLETNH QSHFGN //